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WO/2002/002554A1 |
The invention relates to compounds which are represented by the general formula (I) wherein R?1¿, R?2¿, R?3¿ and n are as defined in the specification. The invention further relates to medicaments containing these compounds and to a p...
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WO/2002/000606A1 |
A novel biphenyl compound having GPR14 antagonism. It is a compound represented by the formula (I) or a salt thereof, wherein R?1¿ represents hydrogen, etc.; X represents 1 to 12 spacers; A represents amino, etc.; R?2¿ and R?3¿ each r...
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WO/2002/000648A1 |
Imidazole derivatives of the general formula (1) or salts thereof; and drugs containing the derivatives or the salts as the active ingredient wherein R?1¿ and R?2¿ are each aryl, heteroaryl, or the like; A, X?1¿ and X?2¿ are each N o...
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WO/2001/098289A1 |
Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingre...
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WO/2001/096323A1 |
Compounds of formula (I) in which R¿2?, X, Y, Cy, L and Lp(D)¿n? have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
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WO/2001/096330A2 |
Heterocyclic-substituted compounds of formula (I) ]or a pharmaceutically acceptable salt thereof, are disclosed, wherein: Z is — (CH2)n-; (a) ; (b), wherein R?10¿ is absent; or, (c) wherein R?3¿ is absent; the single dotted line repr...
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WO/2001/095856A2 |
The present invention relates to a novel urea derivative which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer c...
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WO/2001/093682A1 |
The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or ...
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WO/2001/092215A2 |
The invention provides a compounds comprising a [N(O)NO] functional group and a superoxide-generating moiety, wherein said compound is capable of generating nitric oxide and superoxide. The invention also provides compositions comprising...
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WO/2001/092241A1 |
The present invention relates to a compound of formula (I); wherein R?1¿ represents isopropyl or trifluoromethyl; R?2¿ represents hydrogen, C¿1-4?alkyl, chloro, fluoro or trifluoromethyl; R?3¿ represents(i) phenyl, optionally substit...
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WO/2001/092280A1 |
This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1¿, R?2¿, R?3¿ and R?10¿ are as defined herein. The compounds of formula (1) are antibacter...
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WO/2001/090091A1 |
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparat...
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WO/2001/090092A1 |
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparat...
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WO/2001/090093A1 |
The present invention relates to compounds with formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation ...
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WO/2001/090108A1 |
A class of 3-phenylimidazo(1,2-a) pyrimidine derivatives (of Formula I, or salt or prodrug thereof : I) wherein Y represents a chemical bond, an oxygen atom, or a -NH- linkage; Z represents an optionally substituted aryl or heteroaryl gr...
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WO/2001/090094A1 |
The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C¿1-6?-alkyl; E is a bond, -CH¿2?-...
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WO/2001/090090A1 |
The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of thecompounds in medicine and for the preparat...
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WO/2001/089447A2 |
The substituted propyl triazole compounds of formula (I) and the salts thereof having the structure (II): (I), (II) wherein X is hydrogen or alkyl group; M is hydrogen, hydroxy or ester group; Ar is selected from phenyl, naphthyl, thieny...
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WO/2001/087845A2 |
A compound of the formula (I): wherein A is a hydrogen atom, an optionally substituted, unsaturated, N-containing heterocyclic group or a group of the formula (a) : wherein R is an optionally substituted aryl group or an optionally subst...
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WO/2001/087848A2 |
Synthesis of Bifonazole by reducing 4-phenylbenzophenone to the alcohol and reacting the alcohol in solid phase under microwave irradiation with imidazole.
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WO/2001/087293A1 |
Excellent -secretase inhibitors are provided, which contain compounds of the general formula (I) or salts thereof, wherein Ar is an aromatic group; X is a divalent group selected from among O-, -S-, -CO-, -SO-, -SO¿2?-, -NR?8¿-, -CONR?...
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WO/2001/087834A1 |
A melanin-concentrating hormone antagonist which contains a compound represented by the formula or a salt thereof: (I) wherein R represents hydrogen, halogeno, or an optionally substituted cyclic group; X represents a bond or a spacer in...
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WO/2001/085716A1 |
The present invention provides 2-piperidone compounds or pharmaceutically acceptable salts thereof, which have a potent activity of inhibiting the proliferation of tumor cells and thus are useful as medicaments, as well as antitumor agen...
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WO/2001/083427A1 |
To provide PPAR$g(g) modulators seemingly usable in remedies for involutional osteoporosis which inhibit the accelerated differentiation of adipocytes and promote the formation and differentiation of osteoblasts from stem cells, or remed...
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WO2001044242A9 |
The present invention describes compounds of formula (I): and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula (I) compounds are protein kinase inhibitors and are useful in the treatment of proliferat...
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WO/2001/083434A2 |
This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compound...
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WO/2001/081350A1 |
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an oxo or thioxo group; and/or by 1 o...
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WO/2001/081353A1 |
The invention concerns ion liquids derived from the reaction of at least a halogenated or oxyhalogenated Lewis acid based on titanium, niobium, tantalum, tin or antimony with an organic salt of formula X?+¿A?-¿ wherein A?-¿ is a halid...
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WO/2001/079189A2 |
N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue...
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WO/2001/078648A2 |
The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The...
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WO/2001/079180A2 |
The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or...
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WO/2001/079178A1 |
The invention concerns the use of hydrophobic, thermostable and not easily volatile 1H pyrazole derivatives of general formula (I) and to their acid addition products as agents for inhibiting or controlling nitrification, wherein R?1¿ a...
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WO/2001/077081A1 |
A process for the preparation of imidazolium carbenes of formula (I) wherein R¿1? and R¿2? which can be the same or different, are hydrogen or linear or branched hydrocarbyl groups comprising heating an imidazolium halide with a strong...
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WO/2001/074808A1 |
The invention concerns compounds of formula (I) wherein: p = 1 or 2; X, X¿1? and X¿2? represent N or CH=; R¿1?, R¿2?, R¿3?, R¿4?, R¿5? and R¿6? represent a hydrogen atom, a halogen atom, alkyl, O-alkyl, S-(O)¿n?alkyl, alkenyl, O...
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WO/2001/072714A2 |
This invention relates to compounds having the Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R�5? - R�8? are set in the specification. The invention also is directed to the use of comp...
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WO/2001/072687A1 |
A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein R?3� is independ ently CF�3?, OCF�3?, C�1?-C�4?alkylthio or C�1?-C�4?alkoxy; n is 1, 2 or 3; and the other var...
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WO/2001/072743A1 |
Compounds of the general formula (I) or pharmacologically acceptable prodrugs or salts thereof, exhibiting excellent antimycotic activity: (I) wherein Ar?1� is phenyl or the like; Ar?2� is phenylene or the like; X is sulfur or methyl...
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WO/2001/072717A1 |
Compounds of formula (I) wherein: R?1� is halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, C�1-6?alkyl, C�2-6?alkenyl or C�2-6?alkynyl; p is 0-4; wherein the values of R?1� may be the same or different; R?2� ...
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WO/2001/072744A1 |
N-Heterocyclic derivatives selected from the group consisting of the formulae (I), (II), (III) and (IV): where Z<1>, Z<2>, Z<3>, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are described herein, are useful as inhibitors of nitric oxide synthas...
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WO/2001/070677A1 |
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures of formula (I) (where the variables are as defined in the claims). The compounds are inhibitors of $g(g)-secretase, and hence are usef...
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WO/2001/068614A2 |
Arylpyrimidine compounds are provided that can act as selective modulators of CRF receptors. These compounds are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascula...
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WO/2001/068605A1 |
The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment...
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WO/2001/068619A1 |
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C¿1-6? alkoxy, or NR¿6?OR¿7?; X is OR¿12?, NR¿13?R¿12?, or NR¿14?; inhibitors of MEK and are useful in the treatment of a ...
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WO/2001/068585A1 |
A compound represented by the general formula (I) and a salt thereof: R?1¿-A-X-NHCO-Y-R?2¿ wherein R?1¿ is an optionally substituted heterocyclic group or optionally substituted phenyl; R?2¿ is optionally substituted fused phenyl, op...
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WO/2001/068610A1 |
Imidazolylbenzophenone derivatives represented by the following general formula (I); and pharmaceutically acceptable salts thereof: (wherein R?1¿ is alkyl having 1 to 5 carbon atoms; R?2¿ is hydrogen or alkyl having 1 to 5 carbon atoms...
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WO/2001/066551A2 |
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation t...
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WO/2001/064656A1 |
Pyrimidine derivatives of formula (I) wherein Q¿1?, Q¿2?, G and R?1¿ are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical c...
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WO/2001/064657A1 |
A compound represented by the following formula (I) or a salt thereof; and a plant growth regulator containing the compound or salt as the active ingredient (wherein R?1¿ represents lower alkenyl or optionally substituted phenyl; and R?...
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WO/2001/064697A1 |
The invention relates to ligands or complexes useful as catalysts for catalytically bleaching substrates with atmospheric oxygen, and as catalysts in the of treatment of textiles such as laundry fabrics whereby bleaching by atmospheric o...
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WO/2001/064642A2 |
Benzamide compounds of formula A-Q-D-E-G-J-X, where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian fact...
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