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WO/1994/000489A2 |
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somat...
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WO/1993/025562A1 |
A process is described for the preparation of a manganese complex catalyst having formula (1) wherein Mn is manganese in a III or IV oxidation state; each X is independently a coordinating or bridging species; L is an organic ligand cont...
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WO/1993/021962A1 |
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a ...
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WO/1993/020088A1 |
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M)x'x(L)y(R1R2N-N2O2)z], and M is a pharmaceutilcally acceptable metal, or where x is at least two, M may...
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WO/1993/019788A1 |
Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a parmagnetic metal cluster. Magnetic resonance contrast media containing Z+[Mn12X12(OYR)16(L)4]-, where OYR is an oxyacid such as b...
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WO/1993/017026A1 |
A process for preparing compounds of formula (B) wherein: one of A1' or A2' represents hydrogen and the other represents a group CF3-Y- wherein Y represents -CF2-, > C=O, or -CH(OH)-, or A1' and A2' are groups convertible to A1 and A2 re...
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WO/1993/015770A1 |
The present invention relates to novel ligands and labelling techniques. The present invention further relates to a diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or hirudin or a molec...
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WO/1993/015771A1 |
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include an amine to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to or co...
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WO/1993/013800A1 |
The composition of a new radiopharmaceutical for use as a tumor imaging agent comprising methyl glyoxal Bis (guanyl hydrazone), SnCl2.2H2O, and 99mTc in the form of 99mTcO-4, obtained from a generator and formulated in a mixture for use ...
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WO/1993/014031A1 |
Manganese bromide solution used in forming organo-manganous compounds, for application in synthesizing of organic products, particularly ketones.
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WO/1993/011801A1 |
Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are discl...
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WO/1993/012256A1 |
This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.
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WO/1993/011800A1 |
Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complex...
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WO/1993/010747A2 |
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targete...
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WO/1993/010822A1 |
Disclosed are cationic complexes of Tc-99m and ligands having structure (A), wherein: R1 is hydrogen or is selected from the group consisting of C1 to C20 alkyl; C3 to C12 cycloalkyl; C7 to C24 aralkyl; C2 to C16 alkyl ethers, thioethers...
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WO/1993/010823A1 |
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1993/008839A1 |
A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, o...
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WO/1993/003838A1 |
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention,...
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WO/1993/003351A1 |
The present invention relates to the preparation of amino acid containing compounds which also have multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for u...
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WO/1993/001839A1 |
A radiopharmaceutical product having in particular a cerebral tropism comprising a transition metal nitride complex, and a preparation method therefor, are provided. Said complex has formula (I): (M N)L1L2, wherein M is a transition meta...
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WO/1993/002090A1 |
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?, R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'...
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WO/1993/001813A1 |
Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagonists of PAF and...
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WO/1992/021017A1 |
Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspendin...
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WO/1992/019235A2 |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from th...
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WO/1992/019573A2 |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from th...
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WO/1992/019274A1 |
The invention relates to a technetium chelate of general formula (I), wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho...
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WO/1992/014492A1 |
The present invention relates to a process of making radiopharmaceuticals in situ, i.e. wherein a radionuclide and an acyclic ligand react with constituents of the complex forming reaction solution to produce an administratable radiophar...
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WO/1992/010465A1 |
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1992/010466A1 |
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes. They have general formula (I), w...
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WO/1992/010460A1 |
The present invention relates to a process for preparing platinum group metal and rhenium salts of organic carboxylic acids and products obtained using the disclosed process. The process comprises reacting an alkali or alkaline earth met...
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WO/1992/007859A1 |
The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the complexes, to the use of the compositions...
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WO/1992/007860A2 |
The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to a radiopharmaceutical composition comprising the complexes, to the use of the composition...
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WO/1992/005154A1 |
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1992/000982A1 |
Process for the preparation of transition metal nitrido complexes for use as radiopharmaceutical products or for the synthesis of novel pharmaceutical products. The process consists in reacting an oxygenic transition metal compound such ...
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WO/1991/019516A1 |
The invention relates to a metal-radionuclide complex comprising isonitrile ligands, said complex having general formula (I), wherein M is a metal-radionuclide selected from radioisotopes of Tc, Ru, Fe, Cr, Mn, Cu, Pb, Ga, As and In; R1 ...
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WO/1991/018908A1 |
The invention concerns ?99m�Tc cyclopentadienyl carbonyl complexes of general formula (I), in which -XR can have various meanings. These new technetium-99m complexes can be used in the field of medical diagnosis. The invention also con...
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WO/1991/017999A1 |
The invention relates to a method for labelling substances, including cells such as blood cells, which contain one or more amino groups, with a radioisotope, the substance to be labelled being combined in the presence of a reductor with ...
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WO/1991/016076A1 |
The invention relates to a method of preparing a radiolabeled technetium complex by bringing together a pertechnetate solution in a complex-forming reaction with a compound of general formula (I) wherein R1-R12 independently represent H,...
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WO/1991/015466A2 |
Chelants of formula (I) (as given in claim 1) are disclosed. The chelants are of particular use in producing therapeutic, diagnostic and detoxification agents.
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WO/1991/015467A1 |
Aminopolycarboxylic acid chelating agents and the metal chelates thereof, which may be useful in producing agents for radiotherapy, diagnostic imaging or heavy metal detoxification are described.
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WO/1991/014685A1 |
Technetium-99m complexes of crown thioethers having 3 to 6 donor sulphur atoms joined into a macrocyclic ring by C2 or C3 groups, for example 1,4,7-trithiacyclononane (9S3); and of tripodal ligands having more than 3 donor sulphur atoms ...
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WO/1991/014694A1 |
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general str...
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WO/1991/012822A1 |
Preparations for MR diagnosis containing complexes of compounds of general formula (I), where R1 stands for hydrogen and C1-C4 alkyl, R2 stands for -PO(OH)2, -OPO(OH)2 and -SO3H and X is a single bond and -(CH2)n, where n stands for 1 an...
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WO/1991/010645A2 |
There are provided novel chelating agents useful in the preparation of contrast media for diagnostic imaging or of radiotherapeutic or detoxification compositions.
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WO/1991/009825A1 |
The invention pertains to rhenium (VII) compounds which are catalysts for metathesis of ordinary olefins (hydrocarbons) and functionalized olefins in a homogeneous phase and to methods of synthesizing these compounds. The rhenium compoun...
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WO/1991/003261A1 |
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid (''DTPA'') or ethylenediaminetetraacetic acid (''EDTA'') or other polyaminocarboxylic ...
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WO/1991/003262A1 |
Novel complexes of technetium (99Tc or 99mTc) which contain the moiety Tc=NR, Tc-N=NY or Tc(-N=NY)2, and a ligand which confers biological target-seeking properties on the complex, wherein R represents an aryl group, a substituted or uns...
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WO/1991/001806A1 |
Novel oxidation catalysts of functional organic compounds consisting of synthetic metalloporphyrins fixed on a substrate. These novel catalysts involve the use of polymer-type substrates which are insoluble in the liquid phase comprising...
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WO/1990/015808A1 |
Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies. The radiolabeled antibodies, or catabolites thereof, demonstrate improved biodistribution properties, including reduced locali...
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WO/1990/014881A2 |
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of m...
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