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JP3271259B2 |
PURPOSE: To obtain as new compound useful for radiolabelling of macromolecules such as monoclonal antibodies or the like. CONSTITUTION: A complex of 99mTc with a ligand L of formula I (R is H, OH, an alkyl or the like, R and R1 together ...
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JP2002506445A |
Synthetic low molecular weight catalysts for the dismutation of superoxide are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions such as arthritis, and also operate to prevent or reverse tole...
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JP2002506095A |
A polyethylene having the following properties: an annealed density D/weight average molecular weight Mw relationship defined by the equation D>1104.5Mw-0.0116, and a Charpy Impact I/High Load Melt Index H relationship defined by the equ...
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JP2002020388A |
To provide an organometallic zeolite which improves the defects of conventional organometallic zeolites and has the desirable properties and high rigidity.This organometallic zeolite is constituted with multiple unit bodies represented b...
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JP3249129B2 |
A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the cen...
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JP2002500629A |
The present invention provides for substituted metal chelating compounds of the formula: in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has ...
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JP2002500674A |
The present invention provides novel radiopharmaceuticals useful for imaging the heart, brain, lungs, liver or kidneys, kits useful for preparing the radiopharmaceuticals, and methods of imaging the heart, brain, lungs, liver or kidneys ...
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JP2001527031A |
The invention relates to the use of transitional metal (III) complexes of the formula (I), in which UM represents manganese, iron, cobalt, ruthenium, molybdenum or vanadium; R represents an alkylene-, alkenylene-, phenylene- or cycloalky...
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JP2001354766A |
To provide a new bleaching activator having dendrimer ligand and its metal complex.The dendrimer ligand comprises a compound represented by the formula (R1R1)N-X-N(R1R1) [wherein R1 is a group represented by the formula: (R2R3)N-(CH2)n-;...
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JP3228296B2 |
A beta , beta '-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having the formula (I) or (II): (I) or (II) wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comp...
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JP2001294589A |
To obtain PDT photosensitizer compounds of new class having excellent biodistribution of medicine than that of a well-known compound and to provide an extremely practical and economic method for producing the compounds in a high yield by...
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JP3221875B2 |
Novel complexes of technetium (<99>Tc or <99m>Tc) which contain the moiety Tc=NR, Tc-N=NY or Tc(-N=NY)2, and a ligand which confers biological target-seeking properties on the complex, wherein R represents an aryl group, a substituted or...
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JP2001516730A |
The invention relates to a method for treating proliferative diseases by therapy, characterised in that an application catheter is first placed at the site of the lesion and a radioactive substance is applied locally. The catheter is the...
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JP2001516360A |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with ...
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JP2001233883A |
To provide a contrast agent or a sensitizer which comprises a porphyrin metal complex to which a cage-like boron compound is bonded and is used for diagnosis and/or treatment of cancer by MRI or neutron-irradiation.This porphyrin complex...
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JP2001512502A |
A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y)m-A-NHR)k can function as a substrate for the fibrin-stabilizing Factor XIIIa. The...
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JP2001509535A |
The present invention relates to cleaning compositions, including laundry, dishwashing, hard surface cleaner, oral/dental cleaning compositions, comprising a proteinic substrate based oxygenase, which provide effective and efficient clea...
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JP3190615B2 |
To obtain the subject medicine useful for the imaging of anoxic tissues and radiotherapy by reacting a radioactive metal with a substituted or non- substituted diaminedioxime to form the radioactive metal complex of the diaminedioxime. T...
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JP3181885B2 |
To obtain a new organic derivative of rhenium oxide. This compound is represented by the general formula: R1aRebOc [(a) is 1-6; (b) is 1-4; (c) is 1-14 and total of (a), (b) and (c) just concides with pentavalent to hexavalent atomic val...
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JP3162465B2 |
PURPOSE: To convert apocarotenal and lycopene, i.e., polyenes insoluble in polar solvents, into soluble inclusion complexes and enable them to be effectively utilized in drug administration to human bodies and in coloring by causing them...
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JP2001114792A |
To provide a bisphosphonic acid derivative and its radioactive isotope- labeled bisphosphonic acid derivative which are quickly accumulated in bones and rapidly excreted in urine. The bisphosphonic acid derivative and its radioactive iso...
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JP2001114793A |
To provide a bleach-activating agent which increases the bleaching power of a peroxide-based compound even at low temperature without affecting fibers or fiber product dyes. A compound of the general formula (D: [LnMmXp]zYq [M is mangane...
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JP3155552B2 |
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: wherein R, R min , R1, R min 1, R2, R min 2, R3, R min 3, R4, R min 4, R5, R min 5, R6, R min 6, R7, R min 7, R8, ...
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JP3135917B2 |
PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrol...
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JP2001039982A |
To obtain a new compound which has porphyrin skeletons multiply condensed linearly and makes it possible to expect improvement in conventional electrical and optical properties and electro-optical properties and use for new fields such a...
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JP3129431B2 |
The invention relates to a technetium-99m complex of the general formula (I) wherein Z is a sulphur atom or an amino group of the general formula R17-N-(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1...
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JP2001011077A |
To obtain a compound having properties of forming a triplet state of long life in a high yield and acting an efficient photosensitizer in the formation of a singlet oxygen and improving availabilities of the properties in combination wit...
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JP2000302795A |
To obtain the subject compound being recognized as an energy substrate in vivo, being subjected to β oxidation and metabolized, capable of grasping the energy metabolic state from outside the body by labeling a specific compound with a ...
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JP2000513322A |
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z and n are as defined herein, u...
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JP3097755B2 |
PCT No. PCT/FR91/00536 Sec. 371 Date Jan. 21, 1993 Sec. 102(e) Date Jan. 21, 1993 PCT Filed Jul. 3, 1991 PCT Pub. No. WO92/00982 PCT Pub. Date Jan. 23, 1992.Process for the preparation of nitride complexes of transition metals for use as...
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JP3083157B2 |
PCT No. PCT/GB94/01705 Sec. 371 Date Apr. 9, 1996 Sec. 102(e) Date Apr. 9, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/04552 PCT Pub. Date Feb. 16, 1995Methods of imaging and radiotherapy of hypoxic tissues are provided using radiometa...
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JP3080984B2 |
The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within the range of about 5x10-6M to about 2x10-3...
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JP2000510838A |
Compounds of formula (I) [M6Q8BnL6-n]x where M is Re or Rh; each Q is a bridging atom selected from O, S, Se and Te; B is a monovalent non-bridging atom or moiety; L is a PR3 group in which R is C1-6 alkyl or aryl, optionally substituted...
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JP2000219674A |
To obtain a new aralkyl guanidine compound comprising a specific aralkyl guanidine compound, having a metal complex formability and excellent as a ligand used as an imaging agent in a heart disease region or the like. This new compound i...
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JP2000212145A |
To produce a new compound more improved in functionalities such as antioxidant actions, water repellency imparting actions and/or lubricating actions as compared with those of a known N-long-chain acylated basic amino acid and useful as ...
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JP3067030B2 |
This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.
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JP2000508625A |
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I) wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z, M and n are as defined herein,...
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JP3049505B2 |
Compounds of the formula (R11Re)kO1R12 mxLn (III) in which R11 is a hydrocarbon group which is bonded to the rhenium via a carbon atom to which at least one hydrogen atom is still attached, R12 is aliphatic hydrocarbon radical which may ...
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JP2000506511A |
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo cont...
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JP3039739B2 |
PURPOSE: To obtain the subject new compound useful for optically recording media excellent in light resistance, durability, and stability in storage and for photodeterioration in playback. CONSTITUTION: This compound is an aminium chlori...
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JP3036602B2 |
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention r...
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JP2000109554A |
To obtain the subject polymer useful for the production of a urethane plastic, or the like, by reacting an alkylene oxide with an active hydrogen atom-containing starting compound in the presence of a specific metal compound for capable ...
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JP3021496B2 |
The invention relates to the use of compounds of the general formula R<1>aRebOc in which a is 1 to 6, b is 1 to 4 and c is 1 to 14, and the total of a, b and c is appropriate for the 5- to 7-valency of rhenium, with the proviso that c is...
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JP3015970B2 |
PCT No. PCT/FR89/00608 Sec. 371 Date May 10, 1991 Sec. 102(e) Date May 10, 1991 PCT Filed Nov. 24, 1989 PCT Pub. No. WO90/06137 PCT Pub. Date Jun. 14, 1990.The invention relates to a radiopharmaceutical product more particularly having a...
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JP3005943B2 |
PCT No. PCT/US91/02450 Sec. 371 Date Aug. 21, 1992 Sec. 102(e) Date Aug. 21, 1992 PCT Filed Apr. 10, 1991.The invention relates to a method of preparing a radiolabelled technetium complex by bringing Tc-99m in the form of a pertechnetate...
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JP3003940B2 |
A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivale...
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JP2000500763A |
Process for the preparation of synthetic metallated bacterio chlorophyll derivatives of formula (M)-BChl (I) involves: (a) reacting an appropriate bacterio pheophytin derivative dissolved in DMF with dehydrated Cd acetate in an Ar atmosp...
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JPH11514368A |
This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the ...
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JP2953670B2 |
Heterocyclic chelating agents and salts thereof of formula I: (I) wherein X represents a bond, O or S, or a group CHR1 or NR3, each R1 represents H, a group OR3 or NR3R3, or an alkyl or alkoxyalkyl group optionally substituted by a hydro...
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JPH11255700A |
To obtain the subject new compound useful as a luminescent layer of an organic multilayer type EL element exhibiting sufficient luminescence at low voltage and having long life by introducing an atomic group having a specific structure i...
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