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Patent Searching and Data


Matches 401 - 450 out of 1,341

Document Document Title
WO/1995/033757A1
Preparations of radiolabelled bone scanning agents are improved by adding energy to the reconstituted kit in the form of heat. The preparations may be heated by autoclaving, boiling, microwaving, or sonicating. The improved agent exhibit...  
WO/1995/032192A1
The present invention provides aromatic amine substituted metal chelating compounds of formula (I) in which the variables are as defined in the claims, chelates and chelate-targeting moiety conjugates formed from the chelating compounds,...  
WO/1995/031197A1
The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a co...  
WO/1995/031425A1
The invention includes the synthesis of multivalent metal complexes with boron containing complex organic anions. The complexes include or may include ligands. Complexes capable of being so synthesised are also disclosed as is their use ...  
WO/1995/031221A1
This invention relates to diagnostic and radiodiagnostic agents, including radiolabeled scintigraphic imaging agents, and therapeutic and radiotherapeutic agents. The invention provides such agents and reagents for preparing such agents,...  
WO/1995/030681A1
Single or multi-nuclear metal complexes [LnMmXp]zY, in which M is manganese in the oxidation number (II, III, IV, V and/or VI), copper in the oxidation number (I and/or II), cobalt in the oxidation number (II and/or III) or zinc in the o...  
WO/1995/029669A2
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from th...  
WO/1995/029924A1
A compound, in metal-free or metal complex form of formula (1) to (3) in which R is hydrogen or C1-30 alkyl; X is hydrogen, halogen (preferably Cl or Br) or C1-30 alkyl.  
WO/1995/028968A1
The present invention is directed to complexes represented by formula (I) wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, R10, R11, R12, R13, R14, M, X, Y, Z and N are defined herein for us...  
WO/1995/029180A1
Compounds of formula (1) and the metalated forms and salts thereof; wherein n is an integer of 1-4; and wherein each Pi is independently a pyrrole residue of formula (II), wherein each Ria and Rib is independently a noninterfering substi...  
WO/1995/028179A1
Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in particular as hepatobiliary MRI contrast ag...  
WO/1995/028380A1
The present invention provides compounds of formula (I) wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic carbocyclic or heterocyclic ring system, said Z1 and Z2 independently optionally substitu...  
WO/1995/027701A1
Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is pref...  
WO/1995/021172A1
A process for enantioselectively epoxidising a prochiral olefin, which process comprises reacting the prochiral olefin with a source of oxygen in the presence of a salen catalyst and a source of an electron donating ligand, characterised...  
WO/1995/019791A1
Radiolabeled annexins useful for imaging vascular thrombi are discussed. Methods for making such radiolabeled annexins are also addressed.  
WO/1995/019338A1
Novel compounds of formula (I) and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods, wherein R, R* an Q have the meanings given in the description and one of G, and G2 is -N(R2)2, the other ...  
WO/1995/015979A1
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.  
WO/1995/005388A1
A compound which can be complexed with 99mTc, has the formula T-R-Y wherein T is a targeting group derived from a molecule T' which has an affinity to a specific body tissue said targeting group essentially retaining the specific affinit...  
WO/1995/005398A1
Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies, ligands such as biotin and anti-ligands such as streptavidin with radionuclide metals such as 99mTc, 18...  
WO/1995/004552A2
The invention concerns ligands, e.g. based on alkylene amine oxime particularly butylene amine oxime ring structures, and radiometal complexes thereof. The radiometal complexes are intrinsically capable of localising in tumours or hypoxi...  
WO/1995/004114A1
Tris(isonitrile)copper(I) sulfate complexes and their use in synthetic methods for making radionuclide isonitrile coordination complexes such as [99mTc(1-isocyano-2-methoxy-2-methylpropane)6]+. The coordination complexes are useful as ra...  
WO/1995/003280A1
Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labelled targeting molecules may be used in diagnosis and therapy.  
WO/1995/003330A1
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labelled radiodiagnostic agents. Specifically, the invention relates to linear peptide derivatives and analogs ...  
WO/1995/002418A1
Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, ...  
WO/1995/002423A1
Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.  
WO/1995/001124A1
The present invention provides new and structually diverse compositions for diagnostic imaging comprising compounds of general formula (I), wherein A is N or CR1; D, E, and F are independently O, -O(CH2)2O-, O(CH2)3O-, or NR5; X is CO2H,...  
WO/1994/027977A1
The invention concerns the use, as temperature probes, of macrocyclic metal complexes consisting of a complexing agent of the formula I, in which n, R1, R2, R3 and A are defined differently, plus at least one metal ion with an atomic num...  
WO/1994/027978A1
The invention concerns fluorine-containing macrocyclic metal complexes consisting of a complexing agent of formula (I), in which n, m, R1, R2, R3 and A are defined differently, plus at least one metal ion with an atomic number of 21 to 2...  
WO/1994/026754A1
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently...  
WO/1994/026275A1
2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization....  
WO/1994/026263A2
The use of transition metal complexes in the treatment of septic shock, in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexe...  
WO/1994/022816A1
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A' = -SZ or Y, B = O or S, Y = (c), Z = H or a thiol pro...  
WO/1994/022491A1
New technetium and rhenium chelate compounds are disclosed, as well as a process for preparing the same, radiopharmaceuticals containing these compounds, conjugates of these compounds with substances which selectively accumulate in disea...  
WO/1994/022492A1
New bifunctional chalcogen-atom interrupted chelators, pharmaceutical containing these compounds, their use in radiodiagnosis and radiotherapy as well as a process for producing these compounds are disclosed. In the compound having gener...  
WO/1994/022493A1
New bifunctional chalcogen-atom interrupted chelators, pharmaceuticals containing these compounds, their use in radiodiagnosis and radiotherapy as well as a process for producing these compounds are disclosed. In the compound having the ...  
WO/1994/022497A1
Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the gener...  
WO/1994/021304A1
The present invention relates particularly to novel heterocycle based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1994/020148A1
The present invention relates particularly to novel imidazole based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1994/017083A1
A compound which is, or which contains at least two repeating units, represented by formula (1): (LnMn1)n2An3 or by formula (2): (LnMn1)n2L'n4An3 wherein L and L' are the same or different bis-lactam ligand represented by formula (3) or ...  
WO/1994/015925A1
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, R10 and R'10, X, Y...  
WO/1994/013300A1
The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.  
WO/1994/010182A1
The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to paramagnetic metal clusters having oxygen and/or nitrogen containing ligands useful as contrast agents for magnet...  
WO/1994/008949A2
The invention concerns novel metal chelating compounds, and radiometal, e.g. technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and act...  
WO/1994/009128A1
A composition suitable for administration to a warm-blooded animal comprising antisense MCP-1 peptide or oligonucleotide or a molecule capable of interacting with MCP-1 peptide or information for its synthesis which may or may not be lab...  
WO/1994/005422A1
A process for preparing a manganese complex catalyst having the formula: [LMn(OR)3] Y, wherein Mn is manganese in the +4 oxidation state; R is a C1-C20 radical selected from the group consisting of alkyl, cycloalkyl, aryl, benzyl and rad...  
WO/1994/004141A1
Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich pi-clo...  
WO/1994/003271A1
A compound of formula (I), in which M is a transition metal ion; A is a counter-ion if required; r, s and t are independently 0 to 3 such that r+s+t is in the range of 1 to 3; Ra, Rb, Rc are each independently hydrogen or CH2OR\' where R...  
WO/1994/002456A1
Hydroxyphenylthioalkyl amines represented by formula (I), wherein R1 is H or C1-C8 alkyl; R2 is H or C1-C8 alkyl; R3 is H, C1-C8 alkyl or C1-C8 alkanoyl; R4 is H or C1-C8 alkanoyl; Ra is a radioactive material useful in radioimaging and/...  
WO/1994/001406A1
Complexing agents of general formula (I) in which R1, R2, R3 and R4 are the same or different and stand for H, COOH, C(O)NHR5, where R5 is H and C1-C4 alkyl, PO3H2, SO3H and a radical of general formula (IIa) or (IIb) in which R6 and R7 ...  
WO/1994/001426A1
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  

Matches 401 - 450 out of 1,341