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WO/2021/142312A1 |
Novel compositions comprising heparinoid-related compounds, manufacturing and treatment methods, kits and dosage forms thereof, are provided.
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WO/2021/140471A1 |
A method of making nucleoside 1, which has a 3-hydrocarbyl-5-fluoro-5-(hydroxy-methyl)tetrahydrofuran-3,4
-diol ring system, where hydrocarbyl group R1 is lower alkyl, lower alkenyl, or lower alkynyl and R2 may be an adenine moiety havin...
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WO/2021/141979A1 |
Disclosed are C-glycoside amine derivatives of the formula: R-CH2-C(CH3)-NH-R2 wherein R is a saccharide (e.g., as described in U.S. Patent 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3-C(O)-R3 wherein R3 ...
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WO/2021/134408A1 |
The present invention relates to preparation, impurity removal and purification methods for glycyrrhizic acid monovalent salt. The preparation method for glycyrrhizic acid monovalent salt comprises mixing a glycyrrhizinate mixture and a ...
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WO/2021/135335A1 |
The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. More specifically, the present invention relates to a liver-targeting compound having thyroid hormone receptor agonist ch...
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WO/2021/134407A1 |
A method for extracting a crude product of glycyrrhizic acid and glycyrrhizic flavone from licorice and purifying to obtain glycyrrhizinate. In the method, a medicinal material of licorice and an organic solvent are mixed at a certain ra...
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WO/2021/129241A1 |
Provided is an application of a salidroside derivative in a skin-whitening agent for external use, belonging to the technical field of skincare products. The present invention can enhance the whitening activity of salidroside, and can ut...
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WO/2021/133148A1 |
The present invention provides a method for separating polysaccharides from a seaweed and polysaccharides obtained by the method, the method comprising: a pretreatment step of aging a seaweed at 20-50 °C and extracting same with a solve...
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WO/2021/122719A1 |
The present invention relates to a process for preparing a compound of formula (I), wherein said process is suitable for large scale synthesis.
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WO/2021/127642A1 |
Disclosed are methods of forming an epimer or a dehydrated isomer of a pyranose monosaccharide or a pyranose saccharide residue in an oligosaccharide or a glycoside.
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WO/2021/121270A1 |
A method for purifying an SGLTs inhibitor and an application thereof. The SGLTs inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)
methyl)-4- ethyl phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,
4-tri...
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WO/2021/122103A1 |
The present invention relates to a method for producing a human milk oligosaccharide (HMO) containing at least one HMO compound, characterized in that an aqueous solution containing the at least one HMO compound and at least one acid is ...
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WO/2021/124234A1 |
The present invention relates to the separation and isolation of sialylated human milk oligosaccharides (HMOs) from the reaction mixture in which they are produced.
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WO/2021/115380A1 |
Disclosed is a compound having a neuroprotective effect, a preparation method therefor and a use thereof. Specifically, the compound has the structure shown by formula A, the definition of each group and substituent being as described in...
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WO/2021/114200A1 |
A preparation method for sugar esters, wherein sucrose and hydrogenated palm oil undergo a transesterification reaction without the addition of a solvent to obtain a crude products of sugar esters. The preparation method does not use sol...
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WO/2021/119333A1 |
The present disclosure provides methods, compositions, and kits for the rapid release, labeling, and detection of O-glycans present on a glycoconjugate, such as a glycoprotein, glycopeptide, peptidoglycan, or proteoglycan of interest. Th...
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WO/2021/110773A1 |
The present invention provides apparatuses and methods for the synthesis of oligonucleotides and related compounds. In particular, the present invention allows to effectively prepare reagents to be fed into an apparatus for the synthesis...
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WO/2021/108291A1 |
The disclosure is directed to monomers and methods for synthesizing oligonucleotides comprising at least one nucleoside comprising a 3'-hydroxyl group.
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WO/2021/107235A1 |
The present invention relates to a method for extracting PDRN from adhesive diatoms, and more specifically relates to an optimal method for extracting PDRN, via bead beating, grinding and plasma processing, from diatoms taken in together...
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WO/2021/098847A1 |
A clindamycin phosphate purification method, comprising: dissolving surfactant trioctylmethylammonium chloride (TOMAC) in organic solvent ethyl acetate to make a reverse micelle extraction system; dissolving surfactant actyl-β-D-glucopy...
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WO/2021/101003A1 |
The present invention relates to a method for synthesis of gliflozin and provides a synthesis method comprising: a first step of reacting a stream containing an initial reactant and a lactone with a stream containing n-butyllithium to pr...
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WO/2021/098843A1 |
An abamectin extraction method, comprising: performing extraction on abamectin residues using a dynamic ultrasonic extraction method, and concentrating the obtained liquid extract into extractum; performing extractive desugarization on t...
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WO/2021/097619A1 |
A glucosamine sulfate chloride double salt and a preparation method therefor, said method comprising: (1) carrying out a dissolution reaction with glucosamine hydrochloride and a sulfate; (2) then carrying out an ion exchange reaction be...
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WO/2021/092919A1 |
Disclosed are a nicotinamide mononucleotide intermediate and a method for synthesizing nicotinamide mononucleotide, and the present invention belongs to the field of chemical synthesis. Provided is a method for synthesizing a nicotinamid...
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WO/2021/094459A1 |
The present invention relates to a method for drying human milk oligosaccharides (HMOs). More specifically, the present invention is related to a method of roller drying or drum drying of human milk oligosaccharides in a simple and econo...
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WO/2021/083735A1 |
Method for synthesizing 1,6-anhydro sugars – in particular sugars that may be used as intermediates for making fondaparinux.
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WO/2021/081999A1 |
Disclosed are a low-molecular-weight chondroitin sulfate and a preparation method therefor. Macromolecular chondroitin sulfate is used as a raw material. A low-molecular-weight chondroitin sulfate having an average molecular weight of le...
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WO/2021/083384A1 |
Disclosed are a low molecular weight chondroitin sulfate and a preparation method therefor. The method comprises: using a macromolecular chondroitin sulfate as a raw material, and subjecting same to production processes of chondroitin su...
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WO/2021/075734A1 |
Provided is a method for separating disodium 5'-inosinate from a microorganism culturing medium containing same.
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WO/2021/075882A1 |
The present invention relates to a coagulant that is added to effectively recover a sugar solution from a saccharified product that contains insoluble saccharified residues composed mainly of lignin, and monosaccharides after acidic sacc...
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WO/2021/073064A1 |
A method for improving the yield rate of an Amadori rearrangement product (ARP) on the basis of a mechanism of inhibiting degradation of the ARP by an adduct of a tea polyphenol and deoxyosone. The specific method comprises: dissolving a...
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WO/2021/075904A1 |
The present invention relates to: a newly developed triazine-based amphiphilic compound; a preparation method therefor; and a method for extracting, lysing, stabilizing, crystallizing or analyzing membrane proteins by using same. In addi...
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WO/2021/075423A1 |
The present invention addresses the problem of providing a phosphoramidite activator which improves the solubility of 5-benzylthio-1H-tetrazole in acetonitrile without lowering the yield and purity of a target product. The present inve...
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WO/2021/076630A1 |
In certain embodiments a platform technology for the facilitating immune therapy in the treatement of cancer is provided. In certain embodiments nanocarriers are provided that facilitate delivery of an IDO inhibitor in conjunction with a...
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WO/2021/071890A1 |
The invention relates to methods of synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedu...
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WO/2021/072339A1 |
Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed...
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WO/2021/069502A1 |
The present invention refers to a method for the production of a catalytically active DNA molecule resulting in a significantly decreased amount of impurities in the catalytically active DNA molecule, to a catalytically active DNA molecu...
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WO/2021/071130A1 |
Provided is a method for preparing a disodium 5'-guanylate heptahydrate crystal from an aqueous 5'-guanylate solution.
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WO/2021/062882A1 |
A method for synthesizing rosavin, comprising the steps of: using trimethylsilyl trifluoromethanesulfonate to catalyze 2,3,4-tri-O-acetyl-L-arabinofuranoside trichloroacetimide ester and ethyl 2,3,4-tri-O-acetyl-beta-D-thioglucopyranosid...
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WO/2021/067970A1 |
The present disclosure provides methods of sequencing polynucleotides and compounds, compositions for sequencing of polynucleotides, and synthesis of such compositions. The chemical compounds include nucleotides and their analogs which p...
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WO/2021/063075A1 |
The present invention relates to the technical field of biomedicine, and disclosed are an albiziae cortex lignan compound and an application thereof. The compound prepared by the present invention can effectively treat FFAs-induced lipid...
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WO/2021/064629A1 |
The present invention relates to the separation and isolation of neutral human milk oligosaccharides (HMOs) from the reaction milieu in which they are produced, preferably from a fermentation broth, comprising the steps of: i) optionally...
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WO/2021/056324A1 |
Provided is a green chemical preparation method for alpha-tri-O-acetyl glucuronic acid methyl ester bromo compound. The method uses sodium bromide, sulfuric acid and methyl tertiary ether system to replace the traditional hydrobromic aci...
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WO/2021/058483A1 |
The present invention relates to processes for producing, isolating and recovering various useful components from solid lignocellulosic biomass. More in particular, the invention provides a process for producing lignin components compris...
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WO/2021/056382A1 |
Provided is a preparation method for alpha-penta-O-acetyl mannose. A study is performed using natural mannose as a raw material on the basis of the conventional acetic anhydride acetylation process. A catalytic amount of cesium fluoride ...
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WO/2021/054474A1 |
In the present invention, a disaccharide unit for synthesizing a useful sugar chain for suppressing the development of dystroglycanopathy is obtained and used to reconstitute a post-phosphoryl sugar chain. Provided are: a disaccharide ...
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WO/2021/042922A1 |
Disclosed is a preparation method for tetragalloylglucose. The method comprises: using Camellia ptilophylla Chang as a raw material for extraction, purifying the Camellia ptilophylla Chang extract by using a macroporous adsorption resin,...
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WO/2021/043540A1 |
Disclosed are non-sporulating Bacillus cells for the production of a sialylated oligosaccharide wherein said Bacillus cell has been genetically engineered to possess a lactose permease, a CMP-NeuNAc biosynthesis pathway and a sialyltrans...
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WO/2021/043631A1 |
The present invention provides new chemical compositions, and methods for their preparation, which are industrially relevant in the manufacture of glycosaminoglycans, particularly fondaparinux.
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WO/2021/039935A1 |
Provided are: a nucleic acid compound manufacturing method that uses a nucleic acid compound that is preserved by a structure in which either one of the third position or fifth position of a ribose structure is represented by formula (1)...
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