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JP3217112B2 |
PURPOSE: To obtain a new sulfated saccharide useful as a raw material for an improver for lipid metabolism by reacting an organic base salt of sulfated saccharide with N,O-bis(trimethylsilyl)acetamide and selectively desulfating a sulfat...
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JP3202762B2 |
PURPOSE: To obtain the subject new compound useful as a base for hair and skin cosmetics, a detergent, a conditioning agent, an emulsifying agent, etc., due to its manifestation of excellent conditioning effects without any irritancy. CO...
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JP2001224394A |
To develop a compound having apoptosis inducing action and high safety, provide an apoptosis-inducing agent, a carcinostatic agent and a carcinogenesis preventing agent containing the compound, provide an apoptosis inducing method using ...
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JP3194777B2 |
PURPOSE: To efficiently and stereoselectively carry out the D-ribofuranosylation of a hydroxy compound useful as an intermediate, etc., for synthesizing glucide- related physiologically active substances under mild reactional conditions ...
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JP2001507665A |
The novel cyanophosphonate compounds of the present invention include cyanophosphonate salts, cyanophosphonate monoacid salts, cyanophosphonate monoacid esters, cyanophosphonate monoester salts and cyanophosphonate methylester salts.
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JP3174189B2 |
PURPOSE: To obtain an immunological function suppressor, containing a specific enopyranose derivative which is a new substance as an active ingredient, having suppressing action on the immunological function with hardly any side effects ...
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JP3170241B2 |
To obtain a new nucleic acid monomer comprising a specific polyfunctional nucleic acid monomer, and useful for contamination of a selective cleaving site and an abasic site to an oligonucleotide chain, and determination of the oligonucle...
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JP2001506486A |
The invention makes available, by means of an increased provision of intracellular metabolic intermediates, in particular of erythrose 4-phosphate, alternative processes for the microbial preparation of substances, in particular of aroma...
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JP3163359B2 |
To obtain a new sulfonated oligosaccharide compound having an amphipathic property and useful as a biological surfactant, its synthetic intermediate or the like. A compound of formula I [R10, R11 and R16 are each H, an acyl or a silyl; R...
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JP3163358B2 |
To obtain the subject new amphipathic compound useful as a biodegradable surfactant or as an intermediate for synthesizing glycolipid-based biosurfactants. This new compound is a compound of formula I [(n) is 1-3; R17 to R21 are each H, ...
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JP3149964B2 |
PURPOSE:To obtain a new betaine being low in irritation to skin, capable of providing preferable feeling to the skin and useful as a base for hair or skin cosmetic, cleaning agent, emulsifier or conditioning agent, etc. CONSTITUTION:A co...
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JP2001501580A |
This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to i...
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JP3130070B2 |
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JP2001019698A |
To provide a new oligosaccharide having Galβ (1-6) glycoside bond and provide a new process for producing the oligosaccharide using an enzyme β-D-galactosidase.The objective new oligosaccharide having Galβ (1-6) glycoside bond, especi...
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JP3101710B2 |
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JP3083521B2 |
The stereochemistry of sialylation of an acceptor saccharide to obtain an alpha (2-3) or alpha (2-6) linkage is controlled to favor the alpha anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate alpha (2-3...
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JP2000226397A |
To produce a new compound useful as a chemical synthetic intermediate for mass-producing lipid A and its derivative in good yield on an industrial scale. This compound is represented by formula I (R1 is allyl; R2 is a group reductively e...
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JP3061363B2 |
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JP3056408B2 |
The invention concerns a process for preparing glycoconjugates of phosphoramides of general formula (1) and (1a) in which the sugar is linked to the phosphoramide mustard function or the ifosfamide mustard function preferably in the 1 po...
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JP3055910B2 |
Sugars and partly protected sugar derivatives are chlorinated by reaction of unprotected hydroxyl groups with thionyl chloride to form a persulphite followed by decomposition of the sulphite groups to form chlorosulphites, displacement o...
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JP3054699B2 |
A process is provided which can easily produce a hydroxyl groups-containing cyclic ether compound in which at least one of the hydroxyl groups except a primary hydroxyl group thereof and its neighboring secondary hydroxyl group is protec...
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JP3048198B2 |
PURPOSE: To provide the medically useful subject derivative contg. specified, functionalized sugar units and having antithrombotic activity and an activity of inhibiting smooth muscle cell proliferation, which is produced by a shortened ...
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JP2000143686A |
To obtain the subject new amphipathic compound useful as a biodegradable surfactant or as an intermediate for synthesizing glycolipid-based biosurfactants. This new compound is a compound of formula I [(n) is 1-3; R6 to R9 are each H, an...
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JP3040847B2 |
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JP3030087B2 |
2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin have now been synthesized by a multistage reaction via 3,5-di-O-benzoyl-2-deoxy-2-fluoro- alpha - and - beta -D-ribofuranosyl bromide. Also 2'-deoxy-2'-epi-2'-fluorocofo...
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JP3032058B2 |
PURPOSE: To provide the title new, nontoxic compound having a specific molecular structure, excellent in bacterial infection control effect, immunoadjuvant activity, tumor necrotic effect and macrophage-activating effect, thus useful as ...
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JP3009731B2 |
Methods are provided for the sequential removal of monosaccharides from the reducing end of oligosaccharides. The present invention also discloses the use of such methods for structural determinations of oligosaccharides and to enable ne...
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JP3009164B2 |
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JP2000014395A |
To obtain a new saccharide derivative useful as a diagnostic marker for diabetes, a control index for blood sugar, etc., comprising a saccharide derivative prepared by converting a specific hydroxy group of a saccharide into another subs...
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JP2997768B2 |
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JPH11349485A |
To obtain the subject medicine having activities for decreasing fat in hepatocytes, hardly providing anxiety to side effects, capable of being administered for a long term, and useful for improvement of fatty liver by including a specifi...
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JP2980693B2 |
NEW MATERIAL:A compound expressed by the formula (either of R<1> and R<4> is OH or protected OH and the other is F; R<2> and R<3> are 6-20C aliphatic acyl which may be substituted with a group selected from halogen, aryl, aralkyl, OH and...
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JPH11315092A |
To obtain a new sulfated galactose compound which is recognized by human influenza virus and/or aids virus, and can be used as an alternative capturing material to trisaccharide-based one. This compound is expressed by the formula [where...
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JP2964179B2 |
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JP2960226B2 |
PURPOSE: To obtain a medicine containing a glucopyronoside derivative as an active ingredient and useful for prevention and treatment for infectious diseases of microorganisms such as Pseudomonas aeruginos, Escherichia coli, Streptococcu...
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JP2960158B2 |
The invention comprises: mucopolysaccharides consisting of dermatan sulfate fragments in which the unsulfated uronic acid moieties have been opened, by oxidation of the C(2)-C(3) bonds with periodic acid, and the process for the preparat...
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JPH11269076A |
To obtain an anti-fibrillating agent, namely, a medicament for inhibiting the progression of fibrillation. This anti-fibrillating agent contains a keratan sulfate oligosaccharide or a pharmaceutically acceptable salt thereof as active in...
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JP2956090B2 |
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JP2951590B2 |
Novel reagents useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable...
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JP2951975B2 |
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JPH11510179A |
The present invention concerns analogues of Mannose-6-phosphate for use in promoting the healing of wounds or fibrotic disorders with reduced scarring.
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JPH11228442A |
To effectively suppressing allograft rejection in a recipient of an implant, further interdependently enhancing immunodepression effect and reduce a cyclosporin dose after an organ transplantation by using fructose diphosphate. (A) A cyc...
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JP2938193B2 |
The present invention relates to an efficient new route for the preparation of (+)-nojirimycin and (+)-1-deoxynojirimycin which involves the steroselective reductive amination of 1,2-O-isopropylidene-5-oxo- alpha -D-glucuronolactone. The...
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JP2931935B2 |
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JP2927850B2 |
The use of a sulphated saccharide or a salt or a complex thereof as an ingredient in a topical preparation for the prophylaxis or treatment of diseases or conditions of the tooth or tooth-supporting tissue, in particular for the prophyla...
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JP2926046B2 |
Disclosed herein are a L-ascorbic acid derivative having an improved water-in-stability, represented by a following general formula (I): and a method for preparation thereof, and to a skin-whitening cosmetic composition containing the sa...
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JPH11508565A |
This invention relates to a conjugate, comprising a saccharide and one or more therapeutic or diagnostic agents, as well as the use of the conjugate. The conjugate of the present invention may be used for diagnosing cancer or viral disea...
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JPH11508564A |
A transamination reaction of glycosyl-1-amine with a nucleophilic reagent containing an -NH2 or -NHNH2 group is used to prepared a broad spectrum of glycoconjugates by substitution of the 1-amino group. The substitution reaction does not...
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JP2881688B2 |
To obtain a new sulfonamide derivative expressed by a specific formula and having an in inhibiting action on an elastase, high in safety and useful for treatment and prevention of chronic embolic pulmonary diseases, etc., such as pulmona...
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JPH11503307A |
PCT No. PCT/GB96/00669 Sec. 371 Date Feb. 2, 1998 Sec. 102(e) Date Feb. 2, 1998 PCT Filed Mar. 20, 1996 PCT Pub. No. WO96/29425 PCT Pub. Date Sep. 26, 1996A hormone or growth factor mimetic second messenger is derived from a microorganis...
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