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WO/1993/007167A1 |
Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceut...
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WO/1993/006114A1 |
The invention concerns the reaction mixture obtained in the solvent-free production of saccharose esters of fatty acids by the esterification of saccharose with alkyl esters, preferably methyl esters, of fatty acids in the presence of a ...
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WO/1993/003051A1 |
Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalys...
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WO/1993/002657A1 |
Cosmetic or pharmaceutical use of alkylpolyglycosides and/or O-acylated derivatives of glucose for treating hair loss. The compounds have the developed formula (II) where R1 is a radical or a mixture of alkyl or alkenyl radicals; x is fr...
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WO/1993/002094A1 |
Disclosed herein is a process for producing novel DMEP-beta-D-glucosides of formula (I), wherein R1 is lower alkanoyl group, haloacetyl group, or both R1, taken together, form an alkylidene, arylalkylidene or heteroarylalkylidene group; ...
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WO/1993/001200A1 |
A method for preparing partially acylated carbohydrate derivatives, particularly saccharose acetate, by reacting the initial carbohydrate with an acylating agent, wherein the method is carried out in a reaction medium consisting of an or...
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WO/1992/022662A1 |
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound $g(b)Gal(1-4)$g(b)GlcNAc(1-3)$g(b)Gal(1-4)$g(b)GlcNAc-R. In particular, the methods of this invention provide for a multi-step synthe...
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WO/1992/022301A1 |
Disclosed are methods of and pharmaceutical compositions for suppressing cell-mediated immune responses including cell-mediated inflammatory responses. The disclosed methods and compositions employ oligosaccharide glycosides.
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WO/1992/021688A1 |
Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to formulae (Ia), (Ib) wherein V is O or S; R1, R2 and R3 are H or substituted or unsubstituted perfluoroalkylated or hydrocarbon radicals; provided that R1, R2 or R3 is ...
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WO/1992/020345A1 |
An antiretroviral agent containing as the active ingredient a compound of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 may be the same or different from each other and each represents hydrogen, sod...
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WO/1992/018457A1 |
An organic polyol ester of a polycarboxylic acid having formulae (Para) and/or (Meta) and/or (Ortho), wherein R�6? is -(COOR�1?)x, or (I), R�7? is H; or R�6? and R�7? together form (II); R�1? and R�2? are hydrogen or -OR�...
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WO/1992/018591A2 |
Polyol fatty acid polyesters having improved oxidative stability are prepared using the addition of an alkaline material to the synthesized crude polyol fatty acid polyesters before conducting the finishing of the crude. The alkaline mat...
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WO/1992/018610A2 |
Novel methods and compositions are provided for modulating homing of leukocytes, particularly lymphocytes, where the compounds are cross-reactive with or contain Neu5Ac2-3Gal$g(b)1-x[Fuc$g(a)1-y]GlcNAc, where one of x and y is 3 and the ...
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WO/1992/017570A1 |
A method for inactivating viruses in a protein-containing solution, wherein: a) a liposaccharide belonging to the disubstituted urethane family of general formula (I), wherein n is an integer from 1 to 20, preferably between 3 and 12, an...
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WO/1992/016230A1 |
The invention relates to lipid A analog/immunogenic carrier conjugates and the use thereof as vaccines for the prophylaxis of septic shock in animals. The invention provides for a polyvalent vaccine which contains the lipid A analog/immu...
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WO/1992/016493A1 |
Esters are disclosed of citric acid or acetylcitric acid anhydride with compounds containing at least 3 OH groups selected in the group formed by polyglycerine, sucrocarboxylic acids, alkylglucosides, derivates of oligosaccharides, amino...
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WO/1992/016541A1 |
An efficient synthesis of sialic acid (N-acetylneuramic acid) useful as the starting material of medicines, a synthetic intermediate therefor, isosialic acid as an isomer of sialic acid, synthesis thereof, and a synthetic intermediate th...
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WO/1992/016640A1 |
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is also disclosed. An $i(E. coli) transformed...
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WO/1992/013866A1 |
The invention concerns derivatives of disaccharide alcohols of the general formulae (I) and (II), in which X is hydrogen, an acyl group derived from a satured or unsatured fatty acid with 8 to 20 carbon atoms or the group (III) in which ...
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WO/1992/009612A1 |
Glycosyl phosphate triesters are prepared by reacting an anomeric mixture of a substituted hexopyranose with 4-N,N-dimethylaminopyridine and diphenyl chlorophosphate wherein using a specific order of addition determines the stereochemist...
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WO/1992/009586A1 |
An active oxygen inhibitor which contains an azole derivative represented by general formula (1) or a salt thereof as the active ingredient, wherein R1 represents phenyl which may be substituted by 1 to 3 lower alkoxy groups or by a lowe...
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WO/1992/008790A1 |
Polymer protein compounds, which include a polymer, such as a polyvinyl polymer, acrylic polymer, polyester polymer or polyamide polymer having a main chain, a linker which separates the polymer from the protein by at least two carbons, ...
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WO/1992/007572A1 |
Identification of the sialyl Lewis X determinant as the determinant responsible for ELAM-1-dependent adhesion of neutrophils to endothelium has resulted in the development of a number of agents for binding to ELAM-1 and methods for treat...
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WO/1992/006984A1 |
Amines such as methyl amine are reacted with materials such as reducing sugars in hydroxy solvents such as methanol to prepare N-alkyl polyhydroxy amines. Accordingly, glucose is reacted with methyl amine and the resulting adduct is hydr...
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WO/1992/006699A1 |
The subject invention relates to methods for providing mucosal-protection comprising administering to a human or lower animal a safe and effective amount of an extract from plant species of the genera Wedelia, Eclipta and Aspilia.
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WO/1992/006987A1 |
A glucosamine derivative represented by general formula (I) or its salt and a liposome containing the same as a membrane component, wherein R?1¿ and R?2¿ are each a hydrogen atom or a -CO(CH¿2?)¿n?CH¿3? group wherein n is an integer...
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WO/1992/006691A1 |
A pharmacologically active composition of the invention comprises (i) a virus-inhibiting amount of a compound that binds the active site of influenza virus neuraminidase and that displays in vivo activity against orthomyxovirus or paramy...
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WO/1992/005764A1 |
Shampoo compositions comprising performance ingredients such as hair conditioners, antidandruff agents, anti-lice agents, styling agents and mixtures thereof are improved by means of polyhydroxy fatty acid amide surfactants. Glucose amid...
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WO/1992/005183A1 |
Glycolipids can be purified and concentrated with the aid of a diaphragm separation method at acid pH values and by the use of a diaphragm with a separation limit of 30,000.
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WO/1992/004360A1 |
Polyol polyesters useful as nondigestible fat substitutes are prepared by improved heterogeneous interesterification processes between fatty acid esters of easily removable alcohol and polyol characterized by having one or more improveme...
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WO/1992/004359A2 |
Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune disorders. This invention also encompasses pharm...
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WO/1992/004361A1 |
An improved, solvent-free, two-stage transesterification process for preparing, from a polyol and fatty acid esters of an easily removable alcohol, highly esterified polyol fatty acid polyesters having reduced levels of difatty ketones a...
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WO/1992/003060A1 |
The method for producing saccharide polyesters comprising admixing lower acyl ester saccharide, a fatty acid lower alkyl ester, and an alkaline metal catalyst to form a reaction mixture. Thereafter, the reaction mixture is heated to a re...
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WO/1992/002525A1 |
A glucofuranose derivative substituted at the 3,5,6- or 3,6-positions with a radical that provides an anionic charge at physiological pH values is disclosed, as are pharmaceutical compositions, and methods of making and using the same. T...
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WO/1992/002484A1 |
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes, aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class and from polyacetates, diaminobe...
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WO/1992/002527A1 |
Ligands that bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. These ligands have the formula (I) wherein each of the saccharide rings shown is connected at its 1-position to the next saccharide at its 3-position ...
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WO/1992/001700A1 |
The instant invention is drawn to 2'-fluoroarabinofuranosyl compounds and a process for preparing same.
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WO/1992/001701A1 |
Method for the preparation of monomers including at least one polymerisable carbonyloxyvinyl group of a saccharide selected amongst mono-, di- and trisaccharides, particularly amongst non reducer mono-, di- and trisaccharides, comprising...
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WO/1992/001475A1 |
The invention relates to any composition caracterized in that it is comprised of: on the one hand, an active principle of a medicament or a pharmacologically active substance, water insoluble, said substance being substituted by at least...
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WO/1992/001718A2 |
Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with ''selectins'', including GMP-140, ELAM-1, and lymphocyte homing receptor. The three regions include amino acids 19-3...
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WO/1992/000308A1 |
Process for producing acylated glycosyl fluorides by the fluoridation of saccharides which are at least partly O-acylated in non-aqueous hydrogen fluoride in which the corresponding carboxylic acid anhydride is added to the hydrogen fluo...
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WO/1991/018911A2 |
This invention relates to a method of producing peracetyloxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reagent combination, to directly produce the peracetyl oxa...
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WO/1991/018910A1 |
A compound of general formula (I), in which each of R1, R2, R3 and R4 independently represent a hydrogen atom or a group -(CO)nR5 in which n is 0 or 1 and R5 represents an alkyl, aryl, cycloalkyl, alkaryl or aralkyl group, or R1 or R2 to...
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WO/1991/016900A1 |
We disclose DNA sequences designated clone 7.2 and clone 1, which cause cells transformed with them to express 1,3-fucosyl transferases and which are involved in CDX expression. We also disclose protein 7.2 and protein 1 which are encode...
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WO/1991/015960A1 |
Fatty acid esters of polyols having at least 4 hydroxyl groups wherein the fatty acid groups consist essentially of: (1) long chain unsaturated fatty acid radicals containing at least 12 carbon atoms or mixtures of said unsaturated radic...
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WO/1991/016332A1 |
A 4,6-O-hydroxyphosphorylglucosamine derivative of general formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 and R2 represent each hydrogen or hydroxyl; one of R3 and R4 represents -OCO(CH2)nCH3, -CH2(CH2)nCH3or -O-C...
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WO/1991/016049A1 |
The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to suppress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin...
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WO/1991/015496A1 |
An essentially pure substance has a structure of a Nod factor or one of its analogues. The Nod factor is characterized by the fact that its biosynthesis is controlled by at least one nodulation gene (nodA,B,C) common to the Rhizobiaceae,...
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WO/1991/015217A1 |
Low molecular weight polysaccharides related to dermatan sulfate have been shown to be the effective minimal structures to prevent or reduce coagulation in warm blooded animals.
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WO/1991/014434A1 |
Novel multi-functional pharmaceutical compounds are disclosed incorporating at least two biologically active chemical structural moieties linked by at least one chemical bridging group. The chemical moieties are chosen to exhibit specifi...
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