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Matches 1 - 50 out of 13,532

Document Document Title
WO/2021/142581A1
The present invention relates to the technical fields of chemistry and medicine, and disclosed therein is a glycoside analog with a highly active immune anti-cancer effect. By means of introducing multiple hydroxyl groups on a side chain...  
WO/2021/139621A1
The present invention relates to a method for preparing a glycoside compound, having a short synthesis process, a single product configuration, high selectivity, high yield, simple production and operation, and low equipment requirements...  
WO/2021/140203A1
The present invention relates to a new family of iNKT stimulators, referred to as 6"-O-PEGm-NHR-GalCer, which are potent analogues of KRN7000. These iNKT stimulators can advantageously be used in therapy, in particular for the prevention...  
WO/2021/134408A1
The present invention relates to preparation, impurity removal and purification methods for glycyrrhizic acid monovalent salt. The preparation method for glycyrrhizic acid monovalent salt comprises mixing a glycyrrhizinate mixture and a ...  
WO/2021/135335A1
The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. More specifically, the present invention relates to a liver-targeting compound having thyroid hormone receptor agonist ch...  
WO/2021/137369A1
As a result of efforts to improve the problems of empagliflozin, that is, low stability and water solubility, an empagliflozin cocrystal having at least 120-fold increase in stability and water solubility was developed. The empagliflozin...  
WO/2021/137646A1
The present invention relates to a pyrrolobenzodiazepine derivative compound, a conjugate thereof with a ligand, and a use thereof, wherein the pyrrolobenzodiazepine derivative compound is more stable in plasma and is also stable in circ...  
WO/2021/134407A1
A method for extracting a crude product of glycyrrhizic acid and glycyrrhizic flavone from licorice and purifying to obtain glycyrrhizinate. In the method, a medicinal material of licorice and an organic solvent are mixed at a certain ra...  
WO/2021/129241A1
Provided is an application of a salidroside derivative in a skin-whitening agent for external use, belonging to the technical field of skincare products. The present invention can enhance the whitening activity of salidroside, and can ut...  
WO/2021/108518A1
The invention relates to a citrate-functionalized polyglucoside derivatives, and crosslinked variants thereof, that are made by the reaction of an epichlorohydrin/citric acid ester with an alkyl polyglycoside. These functionalized alkyl ...  
WO/2021/098847A1
A clindamycin phosphate purification method, comprising: dissolving surfactant trioctylmethylammonium chloride (TOMAC) in organic solvent ethyl acetate to make a reverse micelle extraction system; dissolving surfactant actyl-β-D-glucopy...  
WO/2021/101003A1
The present invention relates to a method for synthesis of gliflozin and provides a synthesis method comprising: a first step of reacting a stream containing an initial reactant and a lactone with a stream containing n-butyllithium to pr...  
WO/2021/096921A1
Disclosed are antimicrobial vaccines comprising oligosaccharide β-(1→6)-glucosamine groups.  
WO/2021/096811A1
Disclosed herein are tucaresol derivative compound and composition containing the same. Also disclosed herein are methods of enhancing immune response in a subject by administering the tucaresol derivative compound or by co-administering...  
WO/2021/089729A1
The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds a...  
WO/2021/085643A1
There is demand for a novel method for manufacturing a RebD crystallized product. The present invention provides a method for manufacturing a RebD-containing crystallized product, including: a step for mixing a stevia plant-derived crude...  
WO/2021/083735A1
Method for synthesizing 1,6-anhydro sugars – in particular sugars that may be used as intermediates for making fondaparinux.  
WO/2021/085644A1
There is demand for a novel method for manufacturing a RebD crystallized product. The present invention provides a method for manufacturing a RebD-containing crystallized product, characterized in including: a step for mixing a stevia pl...  
WO/2021/032777A8
The disclosure relates to GalNAc moieties comprising at least one GalNAc monomer. The disclosure also relates to GalNAc-oligonucleotide conjugates comprising GalNAc moieties and oligonucleotides, e.g., saRNAs or siRNAs useful in regulati...  
WO/2021/072339A1
Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed...  
WO/2021/071800A1
The present application is directed to pharmaceutical combinations comprising mithramycin and immunotherapy to target cancer initiating stem cells (CSCs). The present application also discloses methods of treating cancer comprising admin...  
WO/2021/069773A1
The invention relates to a detection compound or probe that exhibits high diuretic activity and comprises a signalling unit (fluorophore) bearing negatively charged functional groups (anionic groups). The recognition unit, which consists...  
WO/2021/064052A1
The present invention relates to the field of medicine, in particular of oncology. Especially, it provides new compounds useful in the treatment of various cancers, such as glioblastoma, colorectal or breast cancers. The present disclosu...  
WO/2021/062882A1
A method for synthesizing rosavin, comprising the steps of: using trimethylsilyl trifluoromethanesulfonate to catalyze 2,3,4-tri-O-acetyl-L-arabinofuranoside trichloroacetimide ester and ethyl 2,3,4-tri-O-acetyl-beta-D-thioglucopyranosid...  
WO/2021/063075A1
The present invention relates to the technical field of biomedicine, and disclosed are an albiziae cortex lignan compound and an application thereof. The compound prepared by the present invention can effectively treat FFAs-induced lipid...  
WO/2021/056270A1
Senolytic prodrugs are provided, which are designed from a cytotoxic agent, by chemically modifying the cytotoxic agent to incorporate a site cleavable by SA-β-gal following delivery of the prodrug in vivo, to release the active parent ...  
WO/2021/062273A1
Described herein are methods for evaluating polymer compositions comprising polymers modified with a small molecule compound (e.g., afibrotic compound), including methods for determining the concentration levels of said compounds.  
WO/2021/061873A1
Provided herein are methods of treating polycystic kidney disease (PKD) associated with one or more nonsense mutations in a PKD2 gene in a subject using one or more aminoglycosides selected from NB122, NB124, NB84, NB127, NB118, NB128, N...  
WO/2021/054474A1
In the present invention, a disaccharide unit for synthesizing a useful sugar chain for suppressing the development of dystroglycanopathy is obtained and used to reconstitute a post-phosphoryl sugar chain. Provided are: a disaccharide ...  
WO/2021/043631A1
The present invention provides new chemical compositions, and methods for their preparation, which are industrially relevant in the manufacture of glycosaminoglycans, particularly fondaparinux.  
WO/2021/037077A1
Patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.  
WO/2021/037205A1
Disclosed is a compound with a structure as shown in formula (101) and a corresponding drug conjugate, wherein the drug conjugate can be specifically targeted at cells and has a low toxicity and an excellent delivery efficiency.  
WO/2021/032777A1
The disclosure relates to GalNAc moieties comprising at least one GalNAc monomer. The disclosure also relates to GalNAc-oligonucleotide conjugates comprising GalNAc moieties and oligonucleotides, e.g., saRNAs or siRNAs useful in regulati...  
WO/2021/031594A1
Disclosed are a novel aromatic ring compound represented by general formula (I), an isomer, a prodrug, a solvate, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, and use thereof for preparing medicaments for ...  
WO/2021/034796A1
A process is provided for the synthesis of an intermediate of Formula 15 which is useful in the synthesis of E-selectin inhibitors. Also provided are useful intermediates obtained from the process.  
WO/2021/028935A1
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein R1, R2, R3, R4, X, m and n are as defined in the specification. The present invention also relates to com...  
WO/2021/023512A1
The invention relates to a bifunctional compound that is, on one side, an agonist of the TLR4 and, on the other side, an important inhibitor of the PSMA. Said compound is useful in immunotherapy for the treatment and/or prevention of pro...  
WO/2021/020516A1
The present invention provides a novel steviol glycoside containing xylose. According to the present invention, there is provided a compound represented by formula (1), or a salt or hydrate thereof. (In formula, (i) R1 represents Xyl(1-2...  
WO/2021/020517A1
The present invention provides a plant body that contains a compound represented by formula (1) [in the formula: (i) R1 represents Xyl(1-2)Glc1- and R2 represents Glc(1-2)[Glc(1-3)]Glc1-; or (ii) R1 represents Glc(1-2)[Glc(1-3)]Glc1- and...  
WO/2021/013155A1
Disclosed are a new glycosyl donor, a preparation method therefor, and an application thereof. Specifically, a glycosyl donor represented by formula (I), a preparation method therefor, and a use of the glycosyl donor represented by formu...  
WO/2021/005075A1
The present invention relates to the use of at least one phenolically substituted sugar derivative as a stabiliser of organic materials, in particular plastics, against oxidative, thermal and/or actinic degradation. The present invention...  
WO/2020/260351A1
The present invention relates to a process for preparing a compound of formula (I), wherein said process is suitable for large scale synthesis.  
WO/2020/255989A1
Provided is a novel compound which is contained in a watermelon young fruit and has an antioxidative effect. A novel compound which is contained in a watermelon young fruit and is represented by formula (1) or (2) has an antioxidative ...  
WO/2020/256084A1
A crystal of a compound represented by formula 5. In formula 5, R1 represents a hydroxyl protecting group, and R2 represents a leaving group.  
WO/2020/254369A1
Disclosed herein are new O-biphenyl- and O-phenylheteroaryl- mannoside compounds and compositions and their application as pharmaceuticals for use in the treatment of human disease. Methods of inhibition of FimH activity in human subject...  
WO/2020/252254A1
The application provides macromolecule-supported compounds of Formula I or III comprising a macromolecular support linked by conjugation to one or more aminobenzazepine derivatives. The application also provides aminobenzazepine derivati...  
WO/2020/252294A1
The application relates to immunoconjugates of Formula (I) comprising an antibody linked by conjugation to one or more aminobenzazepine derivatives. The application also provides aminobenzazepine derivative intermediate compositions of F...  
WO/2020/244253A1
Disclosed is an application of a small molecule compound or a pharmaceutically acceptable salt thereof in the preparation of an anti-tumor metastasis drug. The structure of the compound is as shown in formula (I). The small molecule comp...  
WO/2020/247480A1
Described herein are composition of ascarosides, methods of using them, and the like for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of b...  
WO/2020/243815A1
A tetrasaccharide of formula I and a method of production thereof are provided. Furthermore, a conjugate comprising the tetrasaccharide and a molecule attached to the tetrasaccharide, preferably via its amine group, is also provided. Com...  

Matches 1 - 50 out of 13,532