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WO/2018/185495A1 |
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...
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WO/2018/187738A1 |
The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6', C2' and/or C5''. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasi...
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WO/2018/185494A1 |
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...
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WO/2018/181515A1 |
The purpose of the present invention is to: determine the structure of a novel steviol glycoside which is detected from species containing a large amount of Reb. C (also referred to as dulcoside B), and a trace amount of which is capable...
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WO/2018/177381A1 |
The invention relates to the field of pharmaceutical chemistry, and particularly relates to a compound represented by formula (I), a preparation method thereof, and a medical use thereof. In the compound represented by formula (I), a lac...
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WO/2018/175994A1 |
The present invention provides improved processes for the preparation of drug-linkers with a β-glucuronide cleavable unit, as well as intermediates thereof.
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WO/2018/174725A1 |
The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neur...
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WO/2018/175622A1 |
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides anthracycline compounds that are chemically modified to have one or more moieties that include hydrophobic portions....
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WO/2018/173068A1 |
The present invention relates to novel synthetic Neisseria meningitidis Serogroup A (hereinafter MenA) capsular polysaccharide repeating unit oligomer and a process for synthesizing said synthetic MenA capsular polysaccharide repeating u...
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WO/2018/172129A1 |
The invention relates to sialic acid derivatives of formula (I) which contain a C-C triple bond, methods for the preparation thereof, conjugates produced therefrom and drugs containing same, wherein the symbols have the meanings defined ...
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WO/2018/169853A1 |
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists ar...
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WO/2018/166475A1 |
The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparat...
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WO/2018/167259A1 |
The invention relates to a method of transglycosylation for producing glycoconjugates and multivalent carbohydrates structures, comprising the transfer via a 4-α-glucanotransferase (EC 2.4.1.25) of at least one terminal non-reducing end...
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WO/2018/167794A1 |
Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of...
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WO/2018/167230A1 |
The invention relates to polymers comprising carbohydrate ligands and moieties, respectively, that bind to carbohydrate-binding proteins (CBPs), as well as to these carbohydrate ligands, and to their use in diagnosis and therapy of disea...
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WO/2018/170420A1 |
Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use th...
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WO/2018/165330A1 |
Stevia varieties with a high content of RebM, are disclosed Further provided are methods for producing Stevia plants having a high RebM content by negatively regulating certain genes selecting the resulting plants, and breeding with such...
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WO/2018/161979A1 |
The present invention provides lincosamides of general formula I, (I) wherein R1 is selected from C2-C8 alkyl or C2-C8 alkenyl; R3 is selected from OH, 0(C1-C4 alkyl), SH, S(C1-C4 alkyl) or halogen; R4 is H or C1-C3 alkyl; each of R21, R...
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WO/2018/163194A1 |
The present invention relates to a process for the preparation of D-glucitol, 1,5- anhydro-1-C-[4-chloro-3-[[ 4-[[(3S)-tetrahydro-3-furanyl)oxy )phenyl] methyl]phenyl]-, (IS) formula-1.
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WO/2018/162806A1 |
The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing ...
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WO/2018/165250A1 |
The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising...
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WO/2018/159393A1 |
The purpose of the present invention is to provide a component that promotes the growth of leguminous plants. Provided are: a promoter for leguminous plant growth, which contains a glycoside of Soyasapogenol B as an effective component; ...
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WO/2018/155970A1 |
The present invention relates to a novel glucose derivative, and said novel compound is useful as an SGLT-2 inhibitor. In addition, the novel glucose derivative according to the present invention has a relatively higher melting point, lo...
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WO/2018/153966A1 |
The present invention relates to novel compounds useful for visualizing cell sen es c en ce in vitro and in vivo, the preparation of said compounds and their use. In particular, the present invention pertains to novel hexose and particul...
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WO/2018/156950A1 |
A pharmaceutical composition for shifting a Th2 immune response to a Th1 response by natural killer T cells (NKT cells) including a therapeutically effective amount of a glycolipid of one or more of Formulas II- V or a pharmaceutically a...
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WO/2018/151872A1 |
2-pyrrolino- 13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino- 13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amou...
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WO/2018/152470A1 |
The present invention is directed to the method for selecting an RNA molecule that binds to a target molecule and a kit for carrying out the method. This method includes: providing a pool of oligonucleotide complexes that each comprise a...
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WO/2018/149945A1 |
The present invention relates to a compound bearing at least two fucose moieties for its use as a drug in the prevention or treatment of infections caused by Aspergillus spp, said compound having a molecular weight comprised from 0.6 to ...
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WO/2018/147306A1 |
The present invention addresses the problem of providing a method for glycosylating a hydroxylated stilbene compound. The means for solving the problem is a method for glycosylating a hydroxylated stilbene compound by the conventional Ko...
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WO/2018/148650A1 |
Disclosed are compounds for the selective labeling of cell-surface sugars in cancer cells. The compounds are activatable by triggers specific to cancer cells, and, when metabolized, label a cancer cell surface sugar with an azide chemica...
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WO/2018/143140A1 |
Through the fusicoccin compound according to the present invention represented by general formula (1A), PPI stabilization effect can be enhanced. [In the formula, Y represents a carbonyl group, a sulfonyl group, or a substituted or unsub...
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WO/2018/144053A1 |
Provided is a method for decolorizing and optionally neutralizing a rhamnolipid composition comprising treating said composition with a percarbonate salt as well as the decolorized and optionally neutralized composition obtainable theref...
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WO/2018/138591A1 |
The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising...
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WO/2018/139698A1 |
The present invention relates to a newly developed norbornene-based amphipathic compound, a method for producing the same, and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein by using the...
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WO/2018/140594A1 |
Described herein are prodrugs of cysteamine and pharmaceutically acceptable salts, solvates, and esters thereof. Also described herein are pharmaceutical compositions comprising prodrugs of cysteamine, or pharmaceutically acceptable salt...
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WO/2018/130282A1 |
The present invention relates to (guanidyl)x-oligosaccharidic compounds having a star-like structure having the capacity of carrying and delivering drugs or biological molecules such as oligonucleotides, polypetides and proteins across b...
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WO/2018/124696A1 |
The present invention relates to a novel caffeic acid compound separated from a Stauntonia hexaphylla leaf, and a pharmaceutical or food composition, for promoting bone formation or cartilage formation or for preventing, remedying or tre...
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WO/2018/124143A1 |
The purpose of the present invention is to determine the structure of a novel steviol glycoside that is detected in breeds containing an abundance of Reb.C (also called dulcoside B) and that affects the quality of taste in a small amount...
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WO/2018/124139A1 |
Provided are: a compound that induces a new type of stereoselective reaction that exhibits stereoselectivity during carbohydrate chain synthesis and produces acetal compounds; a production method for an acetal compound (e.g. a compound h...
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WO/2018/113285A1 |
Disclosed is a method for preparing sodium aescinate, relating to the technical field of plant extraction. The method comprises: semen aesculi is taken and subjected to alcohol extraction, the resulting extracting solution is subjected t...
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WO/2018/114933A1 |
The invention relates to novel glycosidase substrates of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R'9, V, X, Y and Z are as defined in claim 1, and a method for detecting the presence of a catalytically active glycosidase...
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WO/2018/112189A1 |
Methods of preparing novel steviol glycosides are described herein. The methods utilize biocatalysts for converting a starting steviol glycoside to a target steviol glycoside. Compositions and consumables comprising said novel steviol gl...
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WO/2018/109348A1 |
The present invention relates to a novel method for preparing surfactant compositions made from alkyl-L-iduronamides, alkyl-L-rhamnosides and alkyl-D-glucuronamides, the compositions obtained by said method and the uses thereof.
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WO/2018/102447A2 |
The invention relates to a process for producing food ingredients from Stevia rebaudiana plant and their use in food products, beverages and other consumables. Obtained compositions are useful as flavors, sweeteners, antioxidants, and ot...
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WO/2018/101434A1 |
The present invention addresses the problem of providing a glycosylated chlorin e6 derivative which has excellent tumor cell-killing properties (phototoxic property) and growth-inhibiting effect on tumor tissues and which is used for pho...
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WO/2018/100560A1 |
The present invention concerns Au and Cu-based mononuclear coordination compounds, drug formulations thereof, the relating synthesis and encapsulation method in macromolecules or supramolecular aggregates or nanostructures, as well as th...
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WO/2018/100561A1 |
The present invention relates to mononuclear coordination compounds of Au and Cu, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecular aggregates...
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WO/2018/100562A1 |
The present invention relates to mononuclear and dinuclear coordination compounds of Ru and Ga, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecu...
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WO/2018/098342A1 |
The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
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WO/2018/095975A1 |
The invention relates to the use of a triacylated mannosylerythritol lipid as a corrosion inhibitor, to compositions comprising a triacylated mannosylerythritol lipid, and to methods implementing a triacylated mannosylerythritol lipid.
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