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WO/2008/096904A1 |
Disclosed are: a compound which can impart a high accumulation property in the blood, high stability in the blood and excellent target cell tropism to a substance of interest; a complex of the compound and a substance of interest; and an...
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WO/2008/092690A1 |
The present invention relates to paromamine-based compounds according to formula (I) having selective antimicrobial activity directed at ribosomal 16S RNA. Furthermore, the invention is directed to the use of said compounds for preparing...
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WO/2008/093678A1 |
[PROBLEMS] To provide: a novel agent having an inhibitory activity on hyaluronidase; and an anti-aging agent for the skin, an anti-inflammatory agent and others each of which comprises the agent. [MEANS FOR SOLVING PROBLEMS] Disclosed is...
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WO/2008/089602A1 |
The present invention provides aminoside tetracyclic anthraquinones represented by formula I or II, wherein the piptides are introduced to connect tetracyclic anthraquinones and fatty acid saturated or unsaturated in order to make the an...
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WO/2008/088806A1 |
Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment inhibitor, a viral sequence integration inhibit...
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WO/2008/086857A1 |
5-[4-(2-Methyl-phenyl)-3-hydroxy-4H-[1,2,4]triazol-5-yl]-2,4
-dihydroxy-Λ/- methyl-Λ/-butyl-benzamide is an HSP90 inhibitor and can be used for producing a medicament for treating diseases in which the inhibition, regulation and/or mod...
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WO/2008/089403A2 |
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy...
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WO/2008/088047A1 |
Disclosed is a method for producing a glycoside of a flavonoid, which comprises the step of reacting the flavonoid and a sugar donor with an enzymatic agent having a glycosylation activity and derived from a bacterium belonging to the ge...
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WO/2008/083461A1 |
There is provided a method of producing a plant composition comprising dehydrosoyasaponin I (D-I), the method comprising the steps of extracting a plant flour with a solvent capable of extracting soyasaponins to produce an extract, and t...
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WO/2008/082156A1 |
Disclosed are novel α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant containing the same as an active ingredient. The...
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WO/2008/078362A1 |
An antitumor agent containing at least one compound selected from the group consisting of nerigoside, oleandrigenin, sarmentoside, oleaside A, oleandrin, 8β-hydroxy odoroside A, narciclasine, trans-dihydronarciclasine and bisdeoxynarcic...
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WO/2008/075983A2 |
The invention relates to compounds which are immunomodulatory compounds and, in particular, can induce IL-12 secretion. The invention also relates to compositions containing the compounds, precursors, and prodrugs of these compounds, use...
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WO/2008/075959A1 |
The present invention is in the field of Fabry disease and concerns a pathogenic factor allowing diagnosis of Fabry disease. In particular lyso-ceramide trihexosamide (lyso-CTH) has been found to function as a diagnostic marker for Fabry...
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WO/2008/071009A1 |
This application relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on both the poly(ethylene oxide) block and the poly(ester) block therein. The biodegradability of these copolymers...
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WO/2008/069303A1 |
Disclosed is a method for producing a β-anomer of a ribofuranose derivative with high selectivity, in high yield, and in an industrially proper manner. Specifically disclosed is a method for producing a ribofuranose derivative, which is...
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WO/2008/062842A1 |
Disclosed are a sodium salt represented by the average formula (I) below, and a method for producing such a sodium salt. (In the formula, m1, n1, m2 and n2 independently represent 0 or a positive number not more than 2, while satisfying ...
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WO/2008/059035A2 |
The present invention relates to a novel process for the chemical synthesis of β-(1->6)-linked glucosamine disaccharides of the fomula (1) and (intermediate) compounds relating to the process. According to further aspects the invention ...
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WO/2008/060378A2 |
Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
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WO/2008/049974A2 |
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WO/2008/047658A1 |
An object is to provide a safe and convenient means for preventing or treating a disease in an avian or mammal, particularly a farm animal, specifically to provide a means for preventing or treating an inflammatory disease in a farm anim...
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WO/2008/047174A1 |
The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of m...
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WO/2008/046463A1 |
The invention relates to the subject matters characterized in the claims, namely metal chelates having a perfluorinated PEG group, a method for the production thereof, and the use thereof, a method for the production thereof, and the use...
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WO/2008/039492A2 |
Provided are polymorphic forms of valrubicin and processes for their preparation.
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WO/2008/037923A1 |
The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or prevent...
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WO/2008/032817A1 |
It is intended to provide a novel sugar chain which has an activity against Helicobacter pylori and a method of producing the same. Namely, a compound represented by the following general formula (1) is provided: (1)wherein Ac represents...
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WO/2008/029294A2 |
The present invention relates to methods of synthesizing anthracycline derivatives. Among other advantages, these methods offer simple and efficient manipulation of substituents on the sugar ring of anthracyclines. For example, the C-3 '...
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WO/2008/028667A2 |
The present invention relates to adjuvants of the glycolipid type and their uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new uses of compounds useful as adjuvants for prophylactic a...
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WO/2008/030121A1 |
The invention relates to sweetening compositions obtained from the Luo Han Guo fruit, a member of the Cucurbiticeae family. The compositions are free of bitter-tasting impurities, have a light colour and contain about 16-75% mogroside V ...
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WO/2008/030112A1 |
The invention relates to methods of preparing compounds of formula (II) wherein Z represents -OR1 or -N(R2)R2a-, where R1 is lower alkylene (C1-C6), R2 is lower alkyl or H and R2a is lower alkylene (C1-C6) or H;Q is absent when R2a is H ...
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WO/2008/028966A1 |
The novel crystalline and polymorphic forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy)-phen
yl] hexane have advantageous properties and can be used in pharmaceutical and dermatological compositions.
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WO/2008/028050A2 |
The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot rea...
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WO/2008/020490A1 |
Disclosed is a substance having an ability of inhibiting a testosteron-5α-reductase activity, an ability of inhibiting or reducing the proliferation of a cancer cell, an ability of inhibiting a cyclooxygenase, an ability of inhibiting a...
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WO/2008/018448A1 |
At least one kind of a biosurfactant, in particular, a mannosyl alditol lipid (MEL, MML or the like) or a triacyl derivative of the same is used as an active ingredient. Thus, it becomes possible to provide an activator or an anti-aging ...
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WO/2008/016007A1 |
A phthalic acid derivative represented by the general formula (1) has an inhibitory activity on metallo-β-lactamase. Therefore, when used in combination with a β-lactam antibiotic, the derivative can inhibit the deactivation of the β-...
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WO/2008/016132A1 |
Disclosed is a benzyl phenyl glucopyranoside derivative having excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. Specifically disclosed is a compound represented by the general formula (I) or a pharmacologically acceptabl...
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WO2007099557B1 |
A process for controlling the emission of gaseous by-products in the preparation of a Vilsmeier reagent, and its use as a chlorinating reagent in the production of high intensity sweeteners, such as trichlorogalactosucrose, from partiall...
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WO/2008/010324A1 |
The invention relates to a fusicoccin derivative and a cell differentiation-inducing agent containing the same as an active ingredient, an anti-hematologic malignancy agent, an antitumor agent, an agent for enhancing an antitumor effect,...
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WO/2008/003314A1 |
The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally mil...
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WO/2007/148631A1 |
The object is to provide a composition which can significantly promote the production of an equol. When added to a pharmaceutical agent or a beverage/food, the composition can exerts an effect of preventing a vascular disease because of ...
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WO/2007/145362A1 |
It is intended to provide a novel glyceroglycolipid produced by Mycoplasma pneumoniae. This glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.
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WO/2007/142150A1 |
Disclosed are: a novel aminoglycoside antibiotic which has an excellent anti-bacterial activity against an infection-inducing bacterium, particularly MRSA, and also has low renal toxicity; and a process for production of the antibiotic. ...
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WO/2007/143052A1 |
Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudo...
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WO/2007/139556A1 |
A method of treating cancer in a subject comprising administering to the subject in need of the treatment a therapeutically effective amount of an alkylating agent such as temozolomide and a substituted anthracycline compound.
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WO/2007/131444A1 |
The present invention provides two kinds of new crystallographic form of the compound 3,4',5-trihydroxyl-stilbene-3-beta-D-glucoside, their manufature and medication combination comprising II-crystallographic form or III- crystallographi...
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WO/2007/128480A2 |
The present invention relates to thioglycosides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds, as well as pharmaceutical compositions containing at least one of these thioglycosi...
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WO/2007/126117A1 |
The object is to provide a novel phenyl 5-thioglucoside compound which can control IGT (impaired glucose tolerance) by inhibiting the SGLT1 activity and inhibiting the absorption of glucose through a digestive tract. Provided is a phenyl...
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WO/2007/125176A1 |
The invention relates to an improved process for the production of a sugar alcohol from the corresponding sugar through catalytic hydrogenation. Especially, the invention relates to a process for reducing the interference of sugar-derive...
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WO/2007/123403A1 |
The present invention discloses a therapeutic target for the treatment of cyst ic fibrosis. It was found that inhibition of non-lysosomal glucosylceramidase (GBA2) sufficiently restores chloride current in cells from CF patients carrying...
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WO/2007/124102A2 |
The present invention concerns the isolation of phlorizin from plants of the genus Lithocarpus, phlorizin-containing compositions and their uses.
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WO/2007/118947A1 |
Compounds derived from α-C-phenyl-N-tert-butylnitrone, a process for the preparation thereof and use thereof for the preparation of medicaments for use in preventing or treating oxidative stress-related diseases.
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