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Matches 601 - 650 out of 6,641

Document Document Title
WO/2007/036951A2
The present invention provides a process for the preparation of 6-O-methylerythromycin A Form II comprising treating 6-O-methylerythromycin A with organic acid selected form trifluoroacetic acid, para-toluene sulphonic acid, oxalic acid ...  
WO/2007/035116A1
A method of localising reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.  
WO/2006/087644A3
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4" position, to their pharmaceutically acce...  
WO/2007/029266A2
The invention relates to a process for preparing θ-Deoxo-θa-aza-θa-homoerythromycin A of formula (III), which is an intermediate in the preparation of Azithromycin dihydrate.  
WO/2007/029265A2
The present invention discloses a process for preparing Clarithromycin, comprising selectiviely methylating a 2'I4"-O-bis(trimethylsilyl)erythromycin A 9-[O-(1-methoxy-1- methylethyl)oxime] of formula (II) with methylating agent comprisi...  
WO/2007/025089A2
The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti- infective, antiproliferative, anti-inflammatory, and prokinetic agents. These compounds ar...  
WO/2007/023774A1
Disclosed is an agent for amelioration of impaired ophthalmic arterial blood flow. Also disclosed is a method for amelioration of impaired ophthalmic arterial blood flow. An agent for amelioration of impaired ophthalmic arterial blood fl...  
WO/2007/025284A1
The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti- infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The compounds hav...  
WO/2006/047167A3
9-Alkyl- and 9-alkylidenyl-6-O-alkyl-11,12-carbamate-ketolide and 9-alkylidene-6-O-alkyl-11,12-carbamate-ketolide antimicrobials of the Formula: wherein Ra, Rb, Rc R, L, T, Y, and Z are as described herein and in which the substituents h...  
WO/2006/119313A3
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof (see formula I) which exhibit antibacterial properties. The present invention further relates to pharmaceutical com...  
WO/2007/021721A2
Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudo...  
WO/2007/017898A2
A process of recovery of Pt/C catalyst from the hydrogenation of 6,9-Imino ether is carried out by isolating spent Pt/C by filtration, reactivating the wet spent Pt/C catalyst by treating the spent Pt/C with strong acid like perchloric a...  
WO/2006/138700A3
Fusion proteins comprising a transferrin moiety, a stalk moiety, and cell wall linking member and peptide libraries thereof are disclosed. The present invention includes a method of screening peptide libraries displayed in fusion protein...  
WO/2006/129257A3
The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gra...  
WO/2007/014895A2
The invention relates to methods for preventing or treating metabolic disorders, for improving glycemic control, for preventing progression from impaired glucose tolerance, insulin resistance and/or from metabolic syndrome to type 2 diab...  
WO/2007/015265A2
A process for preparing 6,9-lmino ether from Erythromycin thiocyanate without isolating Erythromycin base and Erythromycin oxime and Beckmann's rearrangement of erythromycin oxime is carried in the presence biphasic solvent system compri...  
WO/2006/049983A3
Modified fusion proteins of transferring and therapeutic proteins or peptides including, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exh...  
WO/2007/012464A1
The present invention relates to macrolide conjugates of pyrrolizine and indolizine derivatives with macrocyclic antibiotics and derivatives thereof. The macrolide conjugates are potent inhibitors of 5-lipoxygenase and cyclooxygenase and...  
WO/2006/089023A3
Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same.  
WO/2007/010015A1
The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 to R6 and R7a, R7b, R7c are defined according to claim 1. Furthermore the present invention relates to processes for prepa...  
WO/2006/083927A3
The present application discloses a therapeutic antimicrobial composition comprising mucocidin antimicrobial peptides or analogue or fragments thereof having antimicrobial activity.  
WO2006124720B1
Daunorubicin ("DNR") compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers.  
WO/2006/056308A3
The invention relates to compounds of formula (I), in which R1 to R10 can be identical or different and are selected among H, OR11, straight-chain or branched C1 to C20 alkyl groups or hydroxyalkyl groups, straight-chain or branched C3 t...  
WO/2007/007148A1
The present invention relates to a process of forming amorphous azithromycin comprises the steps of forming a solution comprising azithromycin and a solvent, atomizing the solution, followed by evaporating at least a portion of the solve...  
WO/2006/074962A3
This invention relates to a novel class of antibiotic agents, more specifically to macrolides comprising an oxazolidinone structure, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using...  
WO/2007/004621A1
[PROBLEMS] To provide a novel anti-cancer agent having a reduced cytotoxicity. [MEANS FOR SOLVING PROBLEMS] A compound represented by the chemical formula 1 or a salt thereof. This compound has an organic group introduced into a given ke...  
WO/2007/003422A1
The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the prepara...  
WO/2006/085228A3
Novel 9a-N'-substituted-carbamoyl- and tMocarbamoyl-aminoalkyl-9a-aza-9-deoxo- 9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro- 9a-homoerythromycin A compounds having antimalarial activity are claimed. More ...  
WO/2006/136945A1
Metabolites of 1 -[6-(1 -ethyl-1 -hydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1 - yl)-benzyl]-pyrrolidin-2-one, and use of same. Metabolites of the present invention are as shown in Formula (II): (II) wherein R1, R2 and R3 are...  
WO/2006/137423A1
A method for administration of clarithromycin or a salt thereof to a mammal for the treatment and/or prevention of a pulmonary disease induced by the destruction of pulmonary alveoli which is caused by smoking, air pollution, a harmful g...  
WO/2006/135083A1
Disclosed are a pharmaceutical for the prevention or treatment of visceral fat syndrome and a beverage/food for the prevention or amelioration of the disease. A prophylactic or therapeutic agent for visceral fat syndrome comprising luteo...  
WO/2006/135084A1
Disclosed are a pharmaceutical for the prevention or treatment of steatohepatitis, particularly non-alcoholic steatohepatitis or fatty liver and a beverage/food for the prevention or amelioration of the disease. A prophylactic or therape...  
WO/2006/134352A1
The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilise a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half ...  
WO/2006/132223A1
Disclosed is a novel application of an enzymatically modified isoquercitrin as an active ingredient for an anti-hypertensive composition. The anti-hypertensive composition comprising an enzymatically modified isoquercitrin as an active i...  
WO/2006/132486A1
This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical compo...  
WO/2006/129257A2
The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gra...  
WO/2006/126633A1
A process for the production of an organic compound having one or more free hydroxyl and/or thiol groups by subjecting an organic compound whose hydroxyl and/or thiol groups are at least partially acylated (hereinafter referred to as “...  
WO/2006/127252A1
Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.  
WO/2006/127906A1
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhib...  
WO2006100330A3
The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl, C1-C3; and R2 represents a functional group selected from CH3- or CONH2- (methyl or primary amide). The aforementioned polyenes have a biocide acti...  
WO/2006/124720A1
Daunorubicin ("DNR") compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers.  
WO2006087238B1
A process for the conversion of 6-11 bridged bicyclic ketolide or erythromycin oximes to 6-11 bridged bicyclic ketolides or erythromycins comprises reacting a 6-11 bridged macrolide with a deoximating agent, preferably an oxidative deoxi...  
WO/2006/120545A1
The present invention relates to 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of syst...  
WO/2006/120541A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) in which R1 is a ether moiety and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their ...  
WO2006077501A3
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to th...  
WO/2006/119384A1
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...  
WO/2006/100413A3
The invention relates to novel compounds derived from 5-thioxylose, preferably 5-thioxylopyranose-type derivatives, and to the preparation method thereof and the use of same as an active principle in medicaments which are intended, for e...  
WO/2006/119313A2
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof (see formula I) which exhibit antibacterial properties. The present invention further relates to pharmaceutical com...  
WO2006075255A3
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a...  
WO2005118610A3
The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.  

Matches 601 - 650 out of 6,641