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Patent Searching and Data


Matches 851 - 900 out of 6,641

Document Document Title
WO/2004/111070A1
A compound of formula (I) wherein the bond between carbon atoms 22 and 23 may be a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl, or C2-C12alkenyl; R2 and R3 are, for example, independently of each other hydrogen, C1-C12alk...  
WO2004096822A3
Antimicrobial macrolide and ketolide compounds are provided having formulas (XII), as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacte...  
WO/2004/108745A2
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...  
WO/2004/108744A2
The present invention relates to novel azalides and azaketolides having antimicrobial activity, methods for their preparation, pharmaceutical compositions containing the compounds and methods of treating microbial infections with the com...  
WO/2004/108746A2
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...  
WO2004087728A3
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...  
WO/2004/106355A1
Said addition salts have a molar ratio between azithromycin and citric acid such as to provide a pH comprised between 4.0 and 8.0 in a 10 % aqueous solution. The process for preparing said salts comprises: a) dissolving azithromycin in a...  
WO/2004/106353A1
The present invention relates to a process for selective alkylation of macrolide and azalide derivatives comprising reacting an macrolide or azalide derivative having a vicinal hydroxyl system with diazoalkane of the formula: R-CHN2 wher...  
WO/2004/106354A1
The present disclooure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation...  
WO2003080582A3
The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases.  
WO/2004/101586A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis ...  
WO/2004/101585A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis ...  
WO/2004/101591A1
The present invention relates to the new 3-decladinosyl derivatives of 9a-N-carbamoyl­and 9a-N-thiocarbamoyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythromy cin A of the general formula (I), their pharmaceutically acceptable addition salts wi...  
WO/2004/101588A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis ...  
WO/2004/101584A1
The present invention relates to 14- or 15-membered macrolides substituted at the 3-position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis o...  
WO/2004/101592A1
A process for producing 9-deoxo-9-hydroxyerythromycin A 11,12-cyclic carbonate derivatives useful as an intermediate in the synthesis of novel erythromycin A derivatives, which comprises reacting a compound represented by the general for...  
WO/2004/101589A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis ...  
WO/2004/101590A1
The present invention relates to 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of syst...  
WO/2004/101587A1
The present invention relates to 14- or 15-membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis ...  
WO2004062629A3
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivat...  
WO/2004/099230A1
A monosaccharide compound of the formula (I), wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkoxy; R3 is hydrogen or hydroxy; R4 is hydrogen, lower alkoxycarbonyl or hydroxymethyl; and (a) represents single bond or doub...  
WO2004066725A3
Disclosed are compounds of the formulain which nis0orl; X-Y is -CH=CH- or -CH2-CH2-; Z is -C(=O)-, -C(=S)- or -S02-; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and R2 is R3-Z-, R3-O-Z-, R4 or -Z-N(R6)(R7); Q is O or -N-R5; R3 a...  
WO2004087729A9
The invention is directed to degradation products of azithromycin, methods for the preparation and identification of the degradation products which may be produced during storage and/or synthesis of azithromycin.  
WO/2004/096822A2
Antimicrobial macrolide and ketolide compounds are provided having formulas (XII), as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacte...  
WO/2004/096823A2
Antimierobial ketolide compounds are provided having the formula (A), as well as pharmaceutically acceptable salts, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds, methods of treating bacterial infectio...  
WO/2004/094449A1
The present invention relates to new compounds represented by Formula (I); wherein M represents a macrolide subunit of the substructure II, Formula (II); L represents the chain of the substructure III, Formula (III); D represents the ste...  
WO/2004/094446A1
It is intended to provide novel preventives/remedies for diseases caused by the growth of vascular smooth muscle, for example, re-occlusion occurring after a ballon-dilation treatment for cardiac coronary occlusion. Namely, vascular smoo...  
WO2003070908A3
The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.  
WO/2004/092736A2
The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.  
WO2003080593A8
The present invention discloses conjugates of polyethylene glycol and flavonoid drugs, wherein said conjugates the flavonoids, such as puerarin, daidzein, baicalein and baicalin, were modification by PEGylation, in order to increase wate...  
WO/2004/092192A1
The present invention relates to compounds of the following general formula: (I) wherein R1 and R2 are fatty acyl groups, a process to extract them from Mycobacterium tuberculosis, and their use in the treatment or the prophylaxis of tub...  
WO/2004/089966A1
A method for preparing a heteroaryl 5-thio-β -D-aldohexopyranoside compound of the formula (III), which comprises reacting 5-thio-D-aldohexopyranose compound of the formula (I) with A-OH of the formula (II) in the presence of a phosphin...  
WO2003062241A8
Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.  
WO/2004/089967A1
It is intended to provide heteroaryl 5-thio-β-D-glucopyranoside compounds represented by the following general formula which show an effect of inhibiting the activity of SGLT2, pharmaceutically acceptable salts thereof or hydrates of th...  
WO2004056843A3
The application provides antibiotic 10-substituted 10-desmethyl macrolides. In a preferred embodiment the macrolides have an erythromycin basic structure according the formula, wherein the variable substituents have the meaning indicated...  
WO/2004/087729A1
The invention is directed to degradation products of azithromycin, methods for the preparation and identification of the degradation products which may be produced during storage and/or synthesis of azithromycin.  
WO/2004/087727A1
A fused heterocyclic derivative represented by the general formula (I) (wherein R1 is hydrogen, OH, etc.; R2 is hydrogen, halogeno, or alkyl; R3 and R4 each is hydrogen, OH, halogeno, etc.; Q is alkylene, etc.; ring A is aryl or heteroar...  
WO/2004/087728A2
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...  
WO2004016632A8
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are us...  
WO/2004/083227A1
Azithromycin isopropanolate of the empirical formula azithromycin: [H20]x: [isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is confirmed by single X-ray diffraction determin...  
WO/2004/080391A2
This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacteria...  
WO/2004/078770A1
The invention provides a family of bifunctional heterocyclic compounds useful as anti­infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic c...  
WO/2004/078771A1
A 2-fluoro-6-O-substituted ketolide derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof. The compound has potent antibacterial activity against Haemophilus influenzae and erythromycin-resistant Pneumoc...  
WO2004004646A3
The present invention provides compounds of formula (I) having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.  
WO/2004/073658A2
Isoflavones are modified by esterification at one or more of the C4', C5, C6, and C7 positions to promote bioavailability, and especially to enhance solubility over the corresponding unesterified isoflavones. Preferred modifications prod...  
WO2004052904A3
The invention relates to N"-substituted 9a-N-(N'-carbamoyl-gamma-aminopropyl), 9a--N-(N'-thiocarbamoyl-gamma-aminopropyl), 9a-N-[N'-((beta-cyanoethyl)-N'-carbamoyl-gamma -aminopropyl] and 9a-N-[N'-((beta-cyanoethyl)-N'-thiocarbamoyl-gamm...  
WO/2004/074132A1
A method of packaging of azithromycin in a gas impermeable container which provides improved stability of azithromycin upon storage.  
WO2004029066A3
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional hetercyclic com...  
WO2004035598A3
The invention relates to novel chalcomycin derivatives, medicaments containing said derivatives or the salts thereof, and the use of chalcomycin derivatives for treating diseases, especially infections. The inventive chalcomycin derivati...  
WO2004016632B1
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are us...  

Matches 851 - 900 out of 6,641