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Matches 1,051 - 1,100 out of 6,641

Document Document Title
WO/2003/072589A1
A compound represented by the general formula (I), which has excellent antifungal activity, or a salt of the compound: (I) (a) (c) wherein R1 represents hydrogen or alkylcarbonyl; R2 represents hydrogen, oxygen, hydroxy, or alkylcarbonyl...  
WO/2003/070908A2
The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.  
WO/2003/070254A1
This invention features a compound of the following formula (I): wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently bonded to the antibiotic therapeutic agen...  
WO/2003/068793A1
Crystal form F of [2S, 4R, 5R, 8R, 9S, 10S, 11R, 12R]-9-[(2,6-dideoxy-3-C-methyl-3-O-methyl-&agr -L-ribo-hexopyranosyl)oxy]-5-ethyl-4-methoxy-2,4,8,10,12,14- hexamethyl-11-[[3,4,6-trideoxy-3-(isopropylmethylamino)-β-D -xylo-hexopyranosy...  
WO/2003/068792A1
A process for efficiently producing a 11,12-cyclic carbamate 6-O-substituted ketolide derivative of the natural type at the 10-position.  
WO/2003/068791A2
Compounds having activity against methicillin-resistant staphylococcus aureus (MRSA), the compounds having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the ...  
WO/2003/068790A2
Antibacterial compounds having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxi...  
WO/2003/068171A2
A method of treating inflammation, an inflammatory condition, or AIDS−associated neurological disorder in a subject in need of such treatment is disclosed. The method includes administering to said subject a pharmaceutically effective ...  
WO/2003/066009A1
A topical gel composition comprising between about 0.005 and 1.0 % ivermectin, between about 30 and 40 % of a pharmaceutically acceptable alcohol, between about 30 and 40 % of a pharmaceutically acceptable glycol, and a pharmaceutically ...  
WO/2003/066059A1
4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3- yl)pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutical acceptable salt thereof can be used in the treatment of neuroblastoma. The invention also relates to a combination ...  
WO/2003/064439A2
The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and in the prevention and treatment of infec...  
WO2003048375B1
Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also p...  
WO/2003/061671A1
Various macrolide compounds such as those having the following formulas are provided where the variables have the values provided herein.  
WO/2003/062241A1
Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.  
WO/2003/059255A2
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing wate...  
WO/2003/057707A1
The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(&agr -D-glucopyranosyl)ascorbic acid. The composit...  
WO2002048331A3
The present invention provides mutant nucleotidylyltransferases, such as E>p<, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyltransferases....  
WO2002094861A3
Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein families include a polyketide synthase and thioesterase protei...  
WO/2003/053988A2
A compound of formula (I) wherein the bond marked by formula (II) indicates either the S or the R isomer at the 4''−position&semi and wherein R1 is C1−C12alkyl, C3−C8cycloalkyl&semi or C2−C12alkenyl&semi R2 is, for example, hydro...  
WO2002058734A3
The present invention provides compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor; and (b) at least one blood modifier, which can be useful for treating vascular conditions and lowe...  
WO2003010116A3
The invention provides compositions and methods for isolating phenolic compounds, particularly isoflavones, from aqueous extracts of plant materials that contain such compounds. The process comprising: (a) providing an aqueous plant extr...  
WO/2003/051900A1
A compound called NATURA, which is derivative of Isoindigo is useful in aiding the general health of a patient and specifically is beneficial in preventing or treating cancer. This compound and other related Isoindigo, Indigo and Indirub...  
WO2001097778A8
Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD50 of atleast 400mg/kg in mice and process for making the same have been described. The process essentially requires dispersing Amphotericin B in ...  
WO/2003/051864A1
The invention relates to compounds, formulations, drinks, foodstuffs, methods and therapeutic uses involving, containing, comprising, including and/or for preparing isoflavone conjugate compounds and analogues thereof. More preferably th...  
WO/2003/050132A1
6-O-Acyl ketolide antibacterials of formula (I): wherein R?1¿, R?2¿, R?3¿, R?4¿, W, X, X', Y, and Y' are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as a...  
WO/2003/047601A1
There are described novel 11-O-substituted ketolide derivatives of clarithromycin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pha...  
WO/2003/048375A1
Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also p...  
WO/2003/047600A1
There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceut...  
WO/2003/048166A1
The invention relates to podophyllotoxins, uses thereof and methods of their production.  
WO/2003/046194A1
Novel &agr -galactosyl-containing non-reducing disaccharides Gal&agr 1-1βGal and Gal&agr 1-1βGlc expected as useful food materials and medicinal materials which would not damage amino acids or proteins when added to foods or preserved....  
WO/2003/044209A1
Using the expression of a molecular chaperone GRP78 as an indication, attempts have been made to search for a substance capable of controlling the expression of GRP78. As a result, versipelostatin (also called JL68) represented by the fo...  
WO/2003/044208A1
It is attempted to search for a substance capable of controlling the expression of GRP78, which is one of molecule chaperones, from natural materials using the expression of GRP78 as an indication. As a result, a novel tetronic acid deri...  
WO/2003/043642A1
There are described novel substituted tylosin analogs and pharmaceutically acceptable compositions comprinsing a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. A...  
WO/2003/042228A1
The present invention relates to 14 or 15 membered macrolides substitued at the 4' position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophyl...  
WO2002024146A3
Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.  
WO2003004509A3
Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections ...  
WO/2003/040094A2
The invention features a new solid supports having at least one amino functionality and a linker bound to the solid support through at least a portion of the amino functional groups. The invention also features solid support bound substr...  
WO/2003/040162A1
A novel method using novel intermediate products, suitable for advantageous production of desclarithromycin.  
WO/2003/039558A1
There are described novel 4' substituted tylosin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier....  
WO/2003/040127A1
Mono-fluorinated and di-fluorinated benzothiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as we...  
WO/2003/035897A2
This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a β-D-ribofuranosyl group and the chromogenic po...  
WO/2003/035896A2
This invention provides novel chromogenic enzyme substrates which are indoxyl β-D-ribofuranosides. A process for their production is provided. Methods for detecting β-D-ribofuranosidase activity are given. The advantages of these novel...  
WO/2003/035661A1
The invention relates to compounds having the following formula (I), in which: R¿a? represents a sugar moiety, an arylamino group, or an alkyl group comprising at least one amino group, R¿b? represents an halogen atom, an halogenoalkyl...  
WO2002060436A8
This invention provides a method for treating a Pin1-associated state in a subject including administering to a subject an effective amount of a fredericamycin A compound such that the Pin1-associated state is treated. In another aspect,...  
WO2002083700A3
Provided are compounds and compositions thereof that are useful for treating inflammation, particularly pulmonary inflammations including asthma and asthma-related pathologies such as allergy. Also provided are methods for using such com...  
WO/2003/031430A2
The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such c...  
WO/2003/029269A1
The present invention relates to an improved extraction process for an alkaloid glycoside extract from the species $i(Solanum).  
WO/2003/027049A1
A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble organic compound and a saccharide into c...  
WO/2003/026644A1
The present invention provides methods for treating or preventing vascular inflammation or for reducing blood levels of c-reactive protein by administering at least one sterol absorption inhibitor and/or at least one 5-stanol absorption ...  
WO2002026220A3
Compounds according to formula (I): T1-L-T2, wherein T1 is a taxoid group, preferably of Formula (II): wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, a...  

Matches 1,051 - 1,100 out of 6,641