Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1,201 - 1,250 out of 6,642

Document Document Title
WO/2002/036601A2
The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of can...  
WO/2002/036612A1
The invention concerns agents with anti-bacterial activity and methods and intermediates for their production. The present invention further concerns the use of such agents for the treatment of bacterial infections in animals, including ...  
WO/2002/036602A1
Pyrazole-O-glycoside derivatives represented by the formulae (i) and (ii), which are useful as diabetes remedies.  
WO2001003681A3
The invention provides the use of flavin compounds or coumarins, as well as 2-(3',4'-dibenzyloxy)-4,5,6-trimethoxy acetophenone or 3',4'-dibenzyloxy-2-hydroxy-4,5,6-trimethoxy dibenzoylmethane or derivatives thereof, more particularly ci...  
WO/2002/032917A1
The present invention relates to a compound of formula (I) wherein R¿1? is hydrogen or together with R¿2? is oxo; R¿2? represents hydroxy, OC(O)XR¿7?, OC(O)NHXR¿7? or R¿2? together with R¿1? is an oxo group; R¿3? is hydrogen or a...  
WO/2002/032919A2
Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are al...  
WO/2002/032233A2
The use of aivlosin, as much or as a pharmacologically acceptable (non-toxic) derivative such as an acid addition salt, for the preparation of a veterinary medicament for the treatment or prophylaxis of diseases and infections of pigs an...  
WO/2002/032918A2
The present invention includes compounds of the formula wherein: X is hydrogen or halide; R?2¿ is hydrogen, acyl, or a hydroxy protecting group; R?6¿ is hydrogen, hydroxyl, or -OR?a¿ wherein R?a¿ is a substituted or unsubstituted moi...  
WO/2002/032916A2
The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and metho...  
WO/2002/030943A1
Form E crystals of N-demethyl-N isopropyl-12-methoxy-11 -oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate produced by treating form E crystals of N-demethyl-N-isopropyl -12-methoxy-11-oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fum...  
WO/2002/026220A2
Compounds according to formula (I): T¿1?-L-T¿2?, wherein T¿1? is a taxoid group, preferably of Formula (II): wherein R¿1? is C¿6?H¿5?; R¿2? is O; L is a linking group; and T¿2? is a substituent selected from the group consisting ...  
WO/2002/026753A1
Erythromycin derivatives of the following general formula or their salts, which exhibit excellent antimicrobial activities against atypical acid-fast microorganisms and are useful as antimicrobial agents, wherein R?1¿ and R?2¿ are each...  
WO2001047507A3
This invention relates to combinations of an abl-, PDGF-Receptor-and/or Kit receptor-tyrosine kinase inhibitor with an organic compound capable of binding to alpha 1-acidic glycoprotein (AGP), as well as to pharmaceutical preparations an...  
WO/2002/024146A2
Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.  
WO/2002/022847A1
A process for producing purified anthocyanidin glucoside characterized by comprising cleaving the rhamnose end of anthocyanidin rutinoside with rhamnosidase, converting the anthocyanidin rutinoside component into anthocyanidin glucoside ...  
WO2000078772A3
Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of such treatment a therapeutically effective ...  
WO2001059126A3
The invention provides a nucleic acid molecule comprising: a nucleotide sequence as shown in SEQ ID No. 35; wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof. Also...  
WO/2002/017909A1
The present invention relates to a therapeutic agent of osteoporosis which comprises an active ingredient of quercetin derivatives. The quercetin derivatives of the invention can be practically applied for the treatment and prevention of...  
WO/2002/018403A1
A process for producing a fumaric acid salt of a compound represented by the general formula (II) (wherein R¿1? represents hydrogen or lower alkyl; and R¿2? represents lower alkyl) which comprises converting a compound represented by t...  
WO/2002/015842A2
The present invention provides a stable form of azithromycin derivatives that act as antibiotics. These compounds are in anhydrous form and have increased stability over the hydrated forms.  
WO/2002/016380A1
The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R?1¿ is hydrogen, cyano, -S(L)¿m?R?2¿, -S(O)(L)¿m?R?2¿, or -S(O)¿2?(L)¿m?R?2¿; L rep...  
WO/2002/014338A1
Pseudoerythromycin derivatives represented by the general formula [I] and serving as novel anti-inflammatory agents having decreased antibacterial activities and increased anti-inflammatory activities: [I] wherein R¿1? and R¿2 ?are eac...  
WO2000069875A9
A compound having the formula selected from the group consisting of a compound of formula (I), a compound of formula (II), and a compound of formula (III) as well as pharmaceutically acceptable salts, esters, solvates, metabolites, and p...  
WO/2002/013834A1
Novel nocathiacin derivatives have been prepared by both biotransformation and chemical methods. A novel nocathiacin derivative, nocathiacin IV, was prepared by either incubation of protease from Streptomyces griseus (Sigma, Cat# P5147) ...  
WO/2002/014251A1
The invention concerns a method for obtaining extracts based on polyphenol compounds contained in cocoa, characterised in that it consists in: using fresh beans, which have not been pre-treated or defatted, said fresh beans whereof their...  
WO/2002/013836A1
Preventive or therapeutic drugs for cancers containing as the active ingredient cyanidin compounds of the general formula (I): (I) (wherein R is H, -$g(b)-D-glucopyranoside, or 6-malonyl-$g(b)-D- glucopyranoside) The cyanidin compounds a...  
WO/2002/014339A1
A method of introducing a 6-position substituent into a 6,9-cyclic acetal of a 5-O-desosaminylerythronolide derivative, characterized by cleaving the cyclic acetal selectively at the 9-position C-O bond; and a process for efficiently syn...  
WO/2002/012259A1
The invention relates to erythromycin 2'-proprionate dedecyl sulfanate (salt) represented by general formula (I), a process for its preparation, pharmaceutical composition comprising this compound and its use as antibiotics.  
WO/2002/012256A1
The present invention relates to a novel process for the preparation of acarbose. Said process comprises the steps of: 1) acidifying a fermentation broth containing an acarbose; 2) removing particulates from the fermentation broth; 3) ad...  
WO/2002/012248A1
Compounds represented by the general formula (I) or salts thereof wherein -X---Y- is -CH=CH-, -CH¿2?-CH¿2?-, or the like; the symbol ---- between R?1¿ and the 4'-position carbon atom represents a single bond or a double bond; and the ...  
WO/2002/012261A1
Compounds of the general formula (I) or salts thereof, exhibiting antiparasitic activities wherein -X---Y- is -CH=CH- or the like; the symbol ---- between R?2¿ and the 5-position carbon atom is a single bond or a double bond; R?1¿ is l...  
WO/2002/012260A1
A macrolide antibiotic of formula (I) wherein the variables are defined as described herein.  
WO/2002/009699A2
The present invention relates to methods of treating conditions and/or symptoms related to common cold of the upper and/or lower respiratory tract and/or eyes. In particular the invention relates to the methods of treating conditions and...  
WO/2002/009640A2
The present invention provides a stable form of azithromycin derivatives that act as antibiotics. These compound are in anhydrous form and have increased stability over the hydrated forms.  
WO/2002/010144A1
The invention relates to an improved method for preparing 7,16-deoxy-2-aza-10-O-cladinosil-12-O-desosaminil-4,5-dihydr oxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle[11.2.1]hexa-dec a-1(2)-en-8-ona from erythromycin A, wherein said compoun...  
WO/2002/010148A1
The present invention relates to novel coumarin derivatives of formula (I) wherein: X= O or S; n= zero, 1, 2, 3 or 4; R¿5? and R¿6?, which can be the same or different, are optionally unsaturated C¿1?-C¿4? alkyl groups, or together w...  
WO/2002/010181A1
The improved form of azitromycin monohydrate of lower hydroscopicity and greater density and hardness that presents values of: apparent filling density not lower than 0.35 g/ml; and apparent knocked density not lower than 0.50 g/ml. The ...  
WO2001060832A3
The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is -CH2-O-(R7)m, R7 representing a sugar, or R2 is -COOH; R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at le...  
WO2001060833A3
The present invention provides novel macrolide compounds of the formulas (I, II, III or IV) wherein: R is hydroxyl or methoxy; R<1> is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR<9>, (a, b, c, and d) where R...  
WO2001040242A3
The present invention relates to a novel 6-O-methylerythromycin A crystal form, a process for preparing the crystal form, and methods for using the crystal form to prepare a 6-O-methylerythromycin A crystal form II.  
WO2001041775A3
Methylated procyanidins which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. They can be in...  
WO2000061549A3
Compounds or their salts of general formula (I): A-(B) wherein A = R-T1-, wherein R is the drug radical and T1 = (CO)t or (X)t', wherein X = O, S, NR1C, R1C is H or an alkyl having from 1 to 5 carbon atoms, or a free valence, t and t' ar...  
WO/2002/000663A2
A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus $m(f)i$m(g)Actinomadura sp.$m(f)/i$m(g)), of a compound designated IB-00208. The class of...  
WO/2001/097778A2
Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD¿50? of atleast 400mg/kg in mice and process for making the same have been described. The process essentially requires dispersing Amphotericin B ...  
WO2000066602A9
The present invention relates to derivatives of 3-deoxy desmycosin of formula (I), wherein, starting from triply protected desmycosin, there are performed an oxidation at C-3 in the first step and then, optionally, a hydrogenation of dou...  
WO2001040241A3
The present invention relates to 6-O-alkyl-2-nor-2-substituted ketolide compound or a derivative thereof, a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and pre...  
WO/2001/092341A1
This invention provides an hexaglucal compounds of formula (III), which is a new kind of bio-pesticide. And also provides the processes for preparing them, which include the regioselective reaction of compounds presented by formula (I) a...  
WO/2001/091758A1
The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble...  
WO/2001/092281A1
The invention concerns a method for preparing a compound of general formula (I) by reducing amination of a corresponding (4'')-carbonyl derivative. The invention is characterised in that it consists in: bringing said (4'')-carbonyl deriv...  
WO2001025246A3
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention pr...  

Matches 1,201 - 1,250 out of 6,642