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Patent Searching and Data


Matches 1,301 - 1,350 out of 6,641

Document Document Title
WO2000063222A3
Compounds of formula (I); wherein R1 = alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R2 = hydrogen or halogen; R3 = hydrogen, alkyl or halogen; R4= NHR' or NHOR'', R' or R'' ar...  
WO/2001/036434A1
Subject of the invention is a process for the preparation of a compound of formula (I) in which R¿1?-R¿9? represent, independently of each other hydrogen a substituent; m is 0, 1 or 2; n is 0, 1, 2 or 3; and the bonds marked with A, B,...  
WO/2001/036437A1
The invention concerns a 4-methyl-2-oxo-2H-1-benzopyran-7-yl 5-thio-$g(b)-d-xylopyranoside compound of formula (I) wherein: R represents a C¿1?-C¿5? alkyl group, which is linear, branched or cyclized, a mono-unsaturated C¿2?-C¿3? alk...  
WO/2001/030794A1
The invention concerns novel enzymatic substrates of general formula (I) wherein: X represents a nitrogen atom or a carbon atom substituted with a phenyl group, said phenyl group being optionally substituted in meta or para position; Y a...  
WO2000058328A3
The invention relates to novel avermectin derivatives of formula (I), in which R<1>, R<2>, R<3> and R<4> have the meanings defined in the description. The invention also relates to various methods for producing them, to agents containing...  
WO/2001/025246A2
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention pr...  
WO/2001/022971A1
Sebum production inhibitors which contain as the active ingredient compounds having glucuronic acid derivatives and glucosamine derivatives in the structure as represented by general formula (1) or pharmacologically acceptable salts ther...  
WO/2001/021608A2
Described are novel flavonoids of formula (I) wherein: A and E form together a C-C or C=C bond, R1, R2, R3, and R4 are chosen from: H, OH, and from the substituents, O(CH¿2?)¿n?-aromatic group, n=0-8, O(CH¿2?)¿n? N(CH¿3?)¿q? with n...  
WO/2001/019839A1
This invention provides tissue selective estrogens of formula (I) having structure (I) wherein: R¿1? and R¿2? are independently, hydrogen, alkyl chain of 1-6 carbon atoms, benzyl, acyl of 2-7 carbon atoms, benzoyl, (1) or (2); X is hyd...  
WO/2001/019840A1
Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.  
WO/2001/016147A1
Glucopyranosyloxypyrazole derivatives represented by general formula (I), which have an effect of inhibiting human SGLT2 activity and are useful as preventives or remedies for diabetes, complication of diabetes or obesity, or pharmacolog...  
WO/2001/016148A1
20,23-disubstituted mycaminosyltylonolide derivatives and use of the same in the field of the prophylaxis and treatment of pasteurellosis are disclosed. The di-substituents are peperidino optionally substituted with one or two methyl gro...  
WO1999064047A8
Novel compounds are disclosed, useful as antiviral agents.  
WO/2001/014396A1
The present invention relates to a use of a flavonoid derived from citrus peels for inhibiting a collagen-induced platelet aggregation in a mammal.  
WO/2001/014397A1
Compounds of formula (I), formula (II), formula (III), and formula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds, processes for making the compounds, synthe...  
WO/2001/014393A2
The invention relates to spherical telithromycin clusters and to a method for the production thereof characterized in that a telithromycin crystal suspension is prepared, said crystals are coated with a telithromycin insoluble phase whic...  
WO1999050275A3
Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions co...  
WO2000078773A3
In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the pr...  
WO/2001/011963A1
The invention provides single-dose oral formulations for controlling an ectoparasite infestation on a companion animal for a prolonged time, said formulations comprising a spinosyn component, or a physiologically acceptable derivative or...  
WO2000062783A3
A series of ketolide antibacterials in the macrolide family of formula (a), intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bact...  
WO/2001/010879A1
Novel erythromycin derivatives of general formula (1), characterized by an acyl group introduced at the 3-position, a cyclic carbamate structure fused at the 11- and 12-positions, and an aryl-substituted five-membered heterocycle, one of...  
WO/2001/010878A1
Novel erythromycin derivatives of general formula (1), characterized by an acyl group introduced at the 3-position, a cyclic carbamate structure fused at the 11- and 12-positions, and a five-membered heterocycle on the 11-position substi...  
WO/2001/010881A1
Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compo...  
WO/2001/010880A1
Novel erythromycin derivatives of general formula (1), characterized by an acyl group introduced at the 3-position, a cyclic carbamate structure fused at the 11- and 12-positions, and a fused ring composed of a five-membered nitrogenous ...  
WO2000058326A3
The invention relates to a method for the production of etoposide wherein 2,3 - diphenoxyacetyl -1-O-triethylsilyl - beta -D- glucopyranoside is condensed with 4'-phenoxyacetyl-4'-demethylepipodophyllotoxine.  
WO1999064049A9
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...  
WO/2001/003681A2
The invention provides the use of flavin compounds or coumarins, as well as 2-(3',4'-dibenzyloxy)-4,5,6-trimethoxy acetophenone or 3',4'-dibenzyloxy-2-hydroxy-4,5,6-trimethoxy dibenzoylmethane or derivatives thereof, more particularly ci...  
WO2000063225A3
Compounds of formula (1), (2) or (3) or the 10,11-anhydro forms thereof, wherein Ra is H or OH; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl; unsubstituted alkyl(3-10C); substituted alkyl(1-10C); substituted or unsubst...  
WO2000063224A3
Compounds of formula (1), (2) or (3), wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); sub...  
WO2000053169A8
The present invention provides a method of inhibiting binding of a chaperone protein with its client protein or client polypeptide. This method comprises contacting coumarin or a coumarin derivative with a chaperone protein, such that th...  
WO/2001/002413A1
The invention provides compounds of formula (II), wherein R is -H or -CO-CH=CH-COOH, and pharmaceutically acceptable salts and esters thereof. Processes for the preparation of the compounds, pharmaceutical compositions containing them, a...  
WO/2001/002414A1
This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R) -13- [[2,6-dideoxy-3-C-methyl- 3-O-methyl- 4-C- [(propylamino)methyl] -$g(a)-L-ribo-hexopryanosyl] oxy] -2-ethyl-3,4,10- trihydroxy- 3...  
WO/2001/000640A1
Azithromycin in the form of a stable monohydrate and processes for the preparation of azithromycin in the form of an, e.g. stable, monohydrate.  
WO/2001/000582A1
The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed co...  
WO2000044761A3
This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof wherein X<1>, X<2>, R<2>, R<8>, R<9>, R<10> and R<11> are as defined herein. The compounds of formula (1) are antibacterial ...  
WO/2000/078764A1
A process is provided for the manufacture of morphine-6-glucuronide and related compounds of the general structure shown in Formula (1), wherein optionally substituted morphine is conjugated with an optionally substituted member of a new...  
WO/2000/078773A2
In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the pr...  
WO/2000/078772A2
Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of such treatment a therapeutically effective ...  
WO/2000/078323A1
A use of Icariin in preparing the medicine for preventing and treating sexual disorder and vasoconstrictive diseases.  
WO/2000/077182A1
The invention relates to a halogenation method characterized in that a chemical compound is halogenated in the presence of halogenase and in that (a) said halogenase is coded in the sequence indicated in SEQ ID NO: 1 or in a sequence der...  
WO/2000/077016A1
The invention relates to derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin of formula (I) wherein R represents CHO, CH(OCH¿3?)¿2?) or CH¿2?N[CH¿2?(C¿6?H¿5?)]¿2?, R?1¿ represents H or C¿1?-C¿3? acyl, R?2¿ represents OR?6¿ an...  
WO/2000/077017A1
This invention relates to novel amorphous form of 6-0-methylerythromycin A (Clarithromycin), to a process for the preparation thereof and to a composition containing it.  
WO/2000/075156A1
The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compoun...  
WO/2000/073317A1
Compounds represented by general formula (I) or salts thereof: wherein R?$g(a)¿ is C¿1? C¿10? alkyl, C¿3?-C¿10? alkenyl, C¿7?-C¿15? aralkyl, quinolinylalkyl, quinolinylalkenyl, C¿2?-C¿10? alkylcarbonyl, C¿7?-C¿15? aralkylcarbo...  
WO/2000/071557A1
The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?17¿, R?f¿, A, X, and Y are as defined herein. The invention also re...  
WO2000040589A3
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of general formula (I).  
WO2000037608A3
An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding for proteins and enzymes used in the biosynthetic production of calicheamicin, inclu...  
WO/2000/069874A1
Novel crystalline forms of a compound of formula (1) are disclosed. Also disclosed are pharmaceutical compositions comprising theses forms, and methods of their preparation and use.  
WO/2000/069875A1
A compound having the formula selected from the group consisting of a compound of formula (I), a compound of formula (II), and a compound of formula (III) as well as pharmaceutically acceptable salts, esters, solvates, metabolites, and p...  
WO2000034295A3
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or pharmaceutically acceptable salts thereof.  

Matches 1,301 - 1,350 out of 6,641