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Matches 1,351 - 1,400 out of 6,656

Document Document Title
WO/2000/077017A1
This invention relates to novel amorphous form of 6-0-methylerythromycin A (Clarithromycin), to a process for the preparation thereof and to a composition containing it.  
WO/2000/075156A1
The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compoun...  
WO/2000/073317A1
Compounds represented by general formula (I) or salts thereof: wherein R?$g(a)¿ is C¿1? C¿10? alkyl, C¿3?-C¿10? alkenyl, C¿7?-C¿15? aralkyl, quinolinylalkyl, quinolinylalkenyl, C¿2?-C¿10? alkylcarbonyl, C¿7?-C¿15? aralkylcarbo...  
WO/2000/071557A1
The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?17¿, R?f¿, A, X, and Y are as defined herein. The invention also re...  
WO2000040589A3
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of general formula (I).  
WO2000037608A3
An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding for proteins and enzymes used in the biosynthetic production of calicheamicin, inclu...  
WO/2000/069874A1
Novel crystalline forms of a compound of formula (1) are disclosed. Also disclosed are pharmaceutical compositions comprising theses forms, and methods of their preparation and use.  
WO/2000/069875A1
A compound having the formula selected from the group consisting of a compound of formula (I), a compound of formula (II), and a compound of formula (III) as well as pharmaceutically acceptable salts, esters, solvates, metabolites, and p...  
WO2000034295A3
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or pharmaceutically acceptable salts thereof.  
WO2000026224A3
This invention relates to compounds of formula (I) wherein a, R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and X are each as defined above, and to pharmaceutically acceptable salts thereof, useful as potent antibacterial and antiprotozoal agents t...  
WO2000024907A3
Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical ...  
WO/2000/068413A1
Fermentattion of Nocardia sp- ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic act...  
WO/2000/066602A1
The present invention relates to derivatives of 3-deoxy desmycosin of formula (I), wherein, starting from triply protected desmycosin, there are performed an oxidation at C-3 in the first step and then, optionally, a hydrogenation of dou...  
WO/2000/066603A1
The invention relates to halo derivatives of 9a-$i(N)-($i(N')-arylcarbamoyl)- and 9a-$i(N)-($i(N')- arylthiocarbamoyl) -9- deoxo-9a-aza-9a-homoerythromycin A of general formula (I) wherein R has the meaning of a substituted aryl group of...  
WO/2000/064484A2
Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the...  
WO/2000/063361A2
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potenti...  
WO/2000/063224A2
Compounds of formula (1), (2) or (3), wherein R¿a? is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); ...  
WO/2000/062783A2
A series of ketolide antibacterials in the macrolide family of formula (a), intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bact...  
WO/2000/063223A1
The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-$i(O)-methyl-erythromycin A of general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wh...  
WO/2000/063225A2
Compounds of formula (1), (2) or (3) or the 10,11-anhydro forms thereof, wherein R¿a? is H or OH; R¿b? is H or halogen; R¿c? is H or a protecting group; R¿d? is methyl; unsubstituted alkyl(3-10C); substituted alkyl(1-10C); substitute...  
WO/2000/063222A2
Compounds of formula (I); wherein R¿1? = alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R¿2? = hydrogen or halogen; R¿3? = hydrogen, alkyl or halogen; R¿4?= NHR' or NHOR'', ...  
WO/2000/061593A1
Erythromycin derivatives of general formula (1) or salts of the same, extremely useful as antimicrobial agents: wherein R is H or lower alkyl; R?1¿ is alkyl, cycloalkyl, (cycloalkyl)alkyl, aralkyl, or -(CH¿2?)¿n?-X-R?4¿; R?2¿ is H o...  
WO/2000/061549A2
Compounds or their salts of general formula (I): A-(B) wherein A = R-T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1C?, R¿1C? is H or an alkyl having from 1 to 5 carbon atoms, or a free va...  
WO/2000/059889A1
$g(a)-Substituted carboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts of the same, or pharmacologically acceptable esters or amides thereof, which are useful as therapeutic and/or preventive...  
WO/2000/058327A1
A method for reducing imidate intermediates arising from Beckmann stereospecific rearrangement of a compound of general formula (II), characterized in that said intermediates are not isolated from the pyridine-based reaction medium and a...  
WO/2000/058328A2
The invention relates to novel avermectin derivatives of formula (I), in which R?1¿, R?2¿, R?3¿ and R?4¿ have the meanings defined in the description. The invention also relates to various methods for producing them, to agents contai...  
WO/2000/058326A2
The invention relates to a method for the production of etoposide wherein 2,3 - diphenoxyacetyl -1-O-triethylsilyl -$g(b)-D- glucopyranoside is condensed with 4'-phenoxyacetyl-4'-demethylepipodophyllotoxine.  
WO/2000/057888A1
Food compositions for preventing type I allergy which contain as the active ingredient kaempferol-3-glucoside; medicinal compositions for preventing and treating type I allergy which contain as the active ingredient kaempferol-3-glucosid...  
WO/2000/057866A2
The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A ...  
WO/2000/058324A1
The present invention relates to a method for the production of 4'-demethyl -4'- phosphate-2',3' -bispentafluorophenoxyacetyl - 4',6'-ethylidene - $g(b)-D-glucoside epipodophyllotoxin, characterized in that 2,3-bis pentafluorophenoxyacet...  
WO/2000/057889A1
Skin preparations for external use which contain chromanol glycosides represented by general formula (1) wherein R?1¿, R?2¿, R?3¿ and R?4¿ are the same or different and each represents hydrogen or lower alkyl; R?5¿ represents hydrog...  
WO/2000/056746A2
A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds $i(via) the key intermediate of general formula (III), wherein R¿4? and R¿5? are, for instance, sulfonates and R¿7? is, for instanc...  
WO/2000/055167A1
Compounds represented by general formula (I) and reagents for activity measurement of N-acetylglucosaminidase (NAG) containing the same, wherein R?1¿ is hydrogen, lower alkoxy, or NHCOCH¿3?; and R?2¿ is lower alkoxy or NHCOCH¿3?.  
WO/2000/055168A1
The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherei...  
WO/2000/053169A2
The present invention provides a method of inhibiting binding of a chaperone protein with its client protein or client polypeptide. This method comprises contacting coumarin or a coumarin derivative with a chaperone protein, such that th...  
WO/2000/050434A1
Malto-oligosaccharide derivatives represented by general formula (1); hydrates or physiologically acceptable salts thereof; and $g(a)-amylase inhibitors or preventive or therapeutic agents for hyperglycemia including diabetes, containing...  
WO2000027857A3
The invention concerns novel chemical products, compounds of formula (I) wherein X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or an acid radical and the additive salts with acids. The compounds of formu...  
WO/2000/047596A1
A method for purifying a red fruit extract containing anthocyanides wherein said extract is taken up with an aqueous solution, the aqueous solution is subsequently cooled to a homogeneous temperature below 15 °C, the permeate thus obtai...  
WO/2000/047597A1
Avermectin derivatives represented by general formula (I) or salts thereof: wherein -X---Y- is -CH=CH-, -CH¿2?-C(=O)-, -CH¿2?-CH¿2?-, or -CH¿2?-CH(R?13¿)-, for example, (1) when -X---Y- is -CH=CH-, R?1¿ is (R?11¿) (R?12¿)C [where...  
WO2000026399A3
Disclosed is a method for the production of compounds of formula (I), whereby m, n, p and R<1> have the meanings given in Claim 1. Said compounds can be used in an advantageous manner as food supplements. They are particularly suitable f...  
WO2000009529A3
A computer-related system for visually representing a supply chain includes a supply chain physical window (12). The supply chain physical window (12) displays a plurality of supply chain entities (24), at least one supply chain bar (28)...  
WO/2000/044761A2
This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof wherein X?1¿, X?2¿, R?2¿, R?8¿, R?9¿, R?10¿ and R?11¿ are as defined herein. The compounds of formula (1) are antibac...  
WO/2000/044762A1
Novel compounds represented by the general formula (I) or salts thereof, which are reduced in toxicity and improved in anticancer activity as compared with known carcinostatic anthracycline derivatives (I), (wherein A is methyl or CF¿3?...  
WO1999064033A9
This invention relates to novel multibinding compounds that bind to the enzyme phosphodiesterase V (PDE V) and modulate its activity. The compounds of this invention comprise 2-10 PDE V modulator (particularly inhibitor) ligands covalent...  
WO1999064048A9
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 l...  
WO/2000/042055A2
3'-Des-dimethylamino-9-oxyimino macrolides of formula (I) endowed with anti-inflammatory activity and their pharmaceutical use are described.  
WO/2000/042047A1
The invention relates to compounds of general formula (I), wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7? and n have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have advanta...  
WO2000015647A3
A synthetic method for the preparation of the anti-tumor drug Etoposide. In one embodiment, the method includes the direct condensation of 4'-demethyl epipodophylloxin with 2,3-di-O-dichloroacetyl-(4,6-O-ethylidene)- beta -D-glucopyranos...  
WO/2000/042056A1
The invention concerns a method for regioselective preparation of a compound of general formula (I) by regioselective displacement with a nitrogenous nucleophile of the activated alcohol function in position 4'' of a corresponding deriva...  
WO2000025764A3
Compositions comprising one or more active ingredients and, optionally, one or more nutritional substances, solid, liquid and/or semiliquid excipients or auxiliaires, wherein the active ingredients consist of a) a component A consisting ...  

Matches 1,351 - 1,400 out of 6,656