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Patent Searching and Data


Matches 1,401 - 1,450 out of 6,656

Document Document Title
WO/2000/040589A2
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of general formula (I).  
WO2000015174A3
A use of bioflavonoid of formula (I) or a plant extract containing same for lowering the blood glucose level in a mammal.  
WO/2000/039141A1
The application relates to the design and synthesis of novel hexasaccharides of general formula (I), wherein: each R is independently selected from hydrogen, an alkyl or substituted alkyl group, an acyl or substituted acyl group, a phosp...  
WO/2000/039142A1
The present invention relates to a new erythromycin A 9-oxime compound which can be effectively used as intermediates for the preparation of erythromycin A oxime compound, a process for preparing the same and a process for preparing 6-O-...  
WO/2000/038700A1
Saponins of formula (I), a stereoisomeric form thereof or a pharmaceutically acceptable addition salt thereof, wherein R¿1? to R¿12? have the meaning given in the description, can be isolated from plants of the family $i(Myrsinaceae) a...  
WO/2000/039249A1
Ume ($i(Prunus mume) SIEB. et Zucc.) leaf, stem, nucleus and flower are extracted 5 times by volume as much methanol. The obtained extract has an antioxidative effect, an inhibitory effect on gastric mucosa damage, an aldose reductase in...  
WO/2000/037608A2
An isolated gene cluster of $i(Micromonospora echinospora) which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding for proteins and enzymes used in the biosynthetic production of calicheamicin, i...  
WO2000015237A9
A pharmaceutical composition for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises an effective amount...  
WO2000011009A3
The invention concerns a method comprising the following steps: a) preparing a reaction medium by mixing hesperidin, iodine, pyridine and an alkaline or alkaline-earth metal base, said reaction medium being substantially water-free and t...  
WO/2000/035944A1
A compound represented by structure (I) is described where R?4¿ and/or R?8¿ represent a sugar moiety. The compounds are shown to be useful as an antifungal and antiparatic agent or as an intermediate to such an agent. Methods of treatm...  
WO/2000/035934A1
The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.  
WO/2000/035933A1
The invention concerns novel troxerutin with high trihydroxy-ethyl-rutin content. Said troxerutin has at least 92 wt. % of 7,3',4'-trihydroxyethyl rutin and a wettability expressed in minutes less than 10 minutes, when said wettability i...  
WO2000006531A3
Nitric acid esters and nitrate salts with medicines active in the respiratory system pathology treatment.  
WO/2000/034295A2
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or pharmaceutically acceptable salts thereof.  
WO/2000/034297A1
This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof wherein X?1¿, X?2¿, R?2¿, R?15¿, R?16¿ and R?6¿ are as defined herein. The compounds of formula (1) are antibacterial ...  
WO/2000/032203A1
A novel, non-hygroscopic form of azithromycin is disclosed, as well as a method for preparing it by the gradual crystallization of azithromycin from ethanol by the addition of a minimal amount of water to effect crystal formation. Pharma...  
WO/2000/031099A1
The present invention provides a process for preparing a high yield of purified clarithromycin having broad antimicrobial activity as a macrolide antibiotic agent by using 1,3-benzodithiol-2-ylium tetrafluoroborate (BDFT), which can easi...  
WO/2000/031097A1
The invention relates to a method of preparing compounds of formula (1) and to pharmaceutically acceptable salts thereof. The compounds of formula (1) are antibacterial agents that may be used to treat various bacterial and protozoa infe...  
WO/2000/027857A2
The invention concerns novel chemical products, compounds of formula (I) wherein X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or an acid radical and the additive salts with acids. The compounds of formu...  
WO/2000/027856A1
The present invention relates to the preparation of 9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-9a-homoeryth romycin A, of Formula (I) in the form of a stable hydrate and its use as an intermediate in the production of azithromycin.  
WO/2000/026224A2
This invention relates to compounds of formula (I) wherein a, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and X are each as defined above, and to pharmaceutically acceptable salts thereof, useful as potent antibacterial and antiprotozoal ag...  
WO/2000/026399A2
Disclosed is a method for the production of compounds of formula (I), whereby m, n, p and R?1¿ have the meanings given in Claim 1. Said compounds can be used in an advantageous manner as food supplements. They are particularly suitable ...  
WO/2000/025764A2
Compositions comprising one or more active ingredients and, optionally, one or more nutritional substances, solid, liquid and/or semiliquid excipients or auxiliaires, wherein the active ingredients consist of a) a component A consisting ...  
WO1999063988A9
Disclosed are multibinding compounds which inhibit nitric oxide synthases (NOSs), enzymes which form nitric oxide and L-citrulline from L-arginine. The multibinding compounds of this invention contain from 2 to 10 ligands covalently atta...  
WO/2000/024907A2
Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical ...  
WO/2000/024402A1
The invention concerns the use of antifungal agents active on $i(Candida) genus fungi for preparing medicines for preventing or treating tissue scleroses in human or animal.  
WO/2000/024753A1
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In par...  
WO/2000/024403A1
The invention concerns the use of active antifungal agents on fungi of the $i(Candida) genus, and as the case may be of the $i(Rodhotorula) genus, for preparing medicines for preventing or treating tissue scleroses, and other derived pat...  
WO2000006606A3
The invention discloses erythromycin derivatives with antibiotic activity and pharmaceutically acceptable salts thereof, a process for preparing them and pharmaceutical compositions containing them as active principle (I).  
WO/2000/023081A1
A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from E...  
WO2000000618A3
A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extensio...  
WO1999040097A8
Clarithromycin is prepared from erythromycin A 9-alkylidenehydrazones, erythromycin A 9-alkyl- and arylsulfonylhydrazones, erythromycin A 9-N-alkylhydrazones or erythromycin A 9-N,N-dialkylhydrazones.  
WO/2000/017217A1
A process of obtaining easy and efficiently an isoflavone composition having a high genistin content and being useful as food material or the like, by subjecting an isoflavone solution to pH regulation to thereby precipitate genistin sel...  
WO/2000/017218A1
This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof wherein X?1¿, X?2¿, R?2¿ and R?6¿ are as defined herein. The compounds of formula (1) are antibacterial and an...  
WO/2000/015174A2
A use of bioflavonoid of formula (I) or a plant extract containing same for lowering the blood glucose level in a mammal.  
WO/2000/015237A1
A pharmaceutical composition for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises an effective amount...  
WO/2000/015647A2
A synthetic method for the preparation of the anti-tumor drug Etoposide. In one embodiment, the method includes the direct condensation of 4'-demethyl epipodophylloxin with 2,3-di-O-dichloroacetyl-(4,6-O-ethylidene)-$g(b)-D-glucopyra nos...  
WO1999064047A9
Novel compounds are disclosed, useful as antiviral agents.  
WO/2000/014100A1
Fermentation of Actinoplanes sp. ATCC 53771 or Amycolata autotrophica ATCC 35204 in the presence of nocathiacin yields a new compound nocathiacin 6-deoxyglycoside which has broad spectrum antibiotic activity against Gram-positive bacteri...  
WO2000000500A3
A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. Ths first extension module receives an acyl starter unit from the loading domain and each extensio...  
WO/2000/014099A1
Form II crystals of clarithromycin can be easily prepared by treating clarithromycin of different crystal forms with water or with a mixture of water and a water-immiscible organic solvent and isolating treated crystals by filtration.  
WO1999063929A9
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...  
WO/2000/012522A1
Disclosed are 3'-N-desmethyl-3'-N-substituted-6-O-methyl-11,12-cyclic carbamate erythrolide A derivatives of formula (I) which are antagonists of luteinizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical composition...  
WO/2000/012494A1
Apoptosis inducing agents which contain as the active ingredient tetrocarcin derivatives represented by general formula (I) or salts thereof. These agents are useful as drugs for preventing and/or treating diseases caused by the accelera...  
WO/2000/012521A1
Disclosed are 3',3'N-bis-desmethyl-3'-N-cycloalkyl-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives of formula (I) which are antagonists of lutenizing hormone releasing hormone (LHRH). Also disclosed are pharmaceuti...  
WO1999064054A9
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently at...  
WO/2000/011009A2
The invention concerns a method comprising the following steps: a) preparing a reaction medium by mixing hesperidin, iodine, pyridine and an alkaline or alkaline-earth metal base, said reaction medium being substantially water-free and t...  
WO1999063937A3
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more prot...  
WO/2000/009530A1
A process for the preparation of compounds represented by general formula (V) or salts thereof: (wherein R?1¿ and R?2¿ are each H, OH or the like; R?3¿ is H, OH or the like; R?4¿ is H or OH; R?5¿ is H or lower alkyl; R?6¿ is C¿1?-...  
WO/2000/009529A2
A computer-related system for visually representing a supply chain includes a supply chain physical window (12). The supply chain physical window (12) displays a plurality of supply chain entities (24), at least one supply chain bar (28)...  

Matches 1,401 - 1,450 out of 6,656