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Matches 1,451 - 1,500 out of 6,656

Document Document Title
WO/2000/008033A1
The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.  
WO1999020261A3
The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contacts mucus in an amount, at a freque...  
WO/2000/006586A1
The present invention discloses an erythromycin derivative with antibiotic activity and pharmaceutically acceptable salts thereof, a process for their preparation and pharmaceutical compositions containing them as active principle.  
WO/2000/006606A2
The invention discloses erythromycin derivatives with antibiotic activity and pharmaceutically acceptable salts thereof, a process for preparing them and pharmaceutical compositions containing them as active principle (I).  
WO/2000/006531A2
Nitric acid esters and nitrate salts with medicines active in the respiratory system pathology treatment.  
WO1999064430A3
The invention provides a novel method for synthesising M6G, and intermediates therefor. In order to synthesise M6G the major problem to overcome is to obtain the glycoside linkage with very high beta -selectivity since prior methods prod...  
WO/2000/005239A1
The invention concerns compounds of formula (I) wherein: X represents a (NH)a, CH¿2? or SO¿2? radical or an oxygen atom; a represents 0 or 1; Y represents a (CH¿2?)m-(CH=CH)n-(CH¿2?)o radical with m+n+o $m(F) 8, n = 0 or 1; Ar repres...  
WO1999063929A3
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...  
WO1999061599A3
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyket...  
WO1999058541A3
A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-h...  
WO/2000/002567A1
Water miscible pharmaceutical compositions containing up to about 40 % of a macrolide such as an azalide antibiotic are prepared by reaction of the macrolide with acid in a non-aqueous water miscible organic solvent system.  
WO/2000/000500A2
A polyketide synthase ('PKS') of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. Ths first extension module receives an acyl starter unit from the loading domain and each extensio...  
WO/2000/000618A2
A polyketide synthase ('PKS') of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extensio...  
WO/1999/064040A1
Novel multibinding compounds are disclosed. The compounds of the invention comprise 2-10 polyene macrolide antibiotic ligands covalently connected, each of said ligands being capable of binding to a ligand binding site in a cellular or v...  
WO/1999/064047A1
Novel compounds are disclosed, useful as antiviral agents.  
WO/1999/064051A1
Novel multibinding compounds are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of inhibiting bacterial Type II DNA topoisomerase, thereby modulating the biol...  
WO/1999/063929A2
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...  
WO/1999/064430A2
The invention provides a novel method for synthesising M6G, and intermediates therefor. In order to synthesise M6G the major problem to overcome is to obtain the glycoside linkage with very high $g(b)-selectivity since prior methods prod...  
WO/1999/063940A2
Disclosed are multibinding compounds which inhibit H?+¿/K?+¿-ATPase, an enzyme which is involved in the control of acid secretion in the stomach. The multibinding compounds of this invention containing from 2 to 10 ligands covalently a...  
WO/1999/064048A1
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 l...  
WO/1999/064054A1
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently at...  
WO/1999/064049A1
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...  
WO/1999/064037A1
Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate o...  
WO/1999/064033A1
This invention relates to novel multibinding compounds that bind to the enzyme phosphodiesterase V (PDE V) and modulate its activity. The compounds of this invention comprise 2-10 PDE V modulator (particularly inhibitor) ligands covalent...  
WO/1999/063988A1
Disclosed are multibinding compounds which inhibit nitric oxide synthases (NOSs), enzymes which form nitric oxide and L-citrulline from L-arginine. The multibinding compounds of this invention contain from 2 to 10 ligands covalently atta...  
WO/1999/063937A2
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more prot...  
WO/1999/062517A1
A method of enhancing the activity of lysosomal $g(a)-Galactosidase A ($g(a)-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.  
WO/1999/062920A1
The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts thereof, wherein R?7¿, R?1¿, R?3¿ and R?2¿ are as defined herein. The invention also relates to pharmaceutical compositions containing the com...  
WO/1999/061599A2
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyket...  
WO/1999/060019A1
The EDG3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG3sb polypeptides and polynucleotides in therapy, and diagnostic ...  
WO/1999/058541A2
A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-h...  
WO/1999/058545A1
Conjugation of 4,5-Epoxymorphinan-6-ols with Bromoglucuronides in the presence of Zinc containing compounds as activator under conditions capable of forming 4,5-Epoxymorphinan-6-oxyglucuronides is disclosed. This novel approach provides ...  
WO1999046402A3
Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient ...  
WO1999038858A8
To provide an external agent for the skin that not only exhibits excellent effects of prevention and amelioration of skin pigmentation but also has no fear of giving adverse influences to the skin and can be used safely, there is added t...  
WO/1999/054319A1
The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.  
WO/1999/054318A1
The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.  
WO/1999/052920A1
The invention concerns a method for preparing Laminaribiose comprising a step for glycoside binding between a donor and an acceptor of glycosyl. The invention is characterised in that the glycosyl donor is in pyranose form and correspond...  
WO1999035156B1
The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention are antibacterial agents that may be used...  
WO/1999/052922A1
Compositions and methods for treating microbial infections, such as $i(Candida) infection, are disclosed. Specifically, derivatives of $g(b)GalNAc(1$m(7)4)$g(b)Gal have been found to be superior to the parent compound in inhibiting adhes...  
WO/1999/051274A1
The invention concerns a composition comprising: a negatively molecule of interest; and a compound comprising a cationic part capable of interacting with said molecule, covalently bound to an active part derived from a macrolide polyene ...  
WO/1999/051616A1
The present invention relates to the new 15-membered ketoazalides from the class of 6-$i(O)-methyl-8a-aza-8a-homo- and 6-$i(O)-methyl-9a-aza-9a-homoerythromycin A with general formula (I), wherein A represents NH group and B at the same ...  
WO1999035157B1
The invention relates to novel erythromycin derivatives, particularly ones with novel C-13 R<13> substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention are useful as antibacterial agents and antip...  
WO/1999/050276A1
Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-d eoxy-11,12-cyclic carbamate erythromycin A derivatives of formula (I) which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pha...  
WO/1999/050275A2
Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions co...  
WO1999038877A3
There are provided according to the invention, novel compounds of formula (I) wherein R<1>, R<2> and R<3> are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the ...  
WO/1999/047523A1
The invention relates to A apicularene of formula (I) and apicularene of formula (II), to a method for producing same and to a substance containing A apicularene.  
WO/1999/046273A1
The invention concerns a composition capable of being hydrolysed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two $g(a) carbons are free. The inventio...  
WO/1999/046402A2
Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient ...  
WO/1999/044619A1
The invention is directed to the use of tilmicosin and other compounds of U.S. Patent No. 4,820,695 for the treatment of viral infection in swine.  
WO1999032500A3
Erythromycin A oxime wherein the hydroxyl group of the oxime group is in reacted form resulting from reaction with a strong organic base or with a silylation agent; a process for its production and its use as an intermediate in the produ...  

Matches 1,451 - 1,500 out of 6,656