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WO/2019/191830A1 |
The present application relates generally to the treatment of integumentary wounds (including chronic and acute wounds involving both cutaneous and mucous membranes), and in particular to topical formulations and instillates comprising o...
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WO/2019/182087A1 |
The present invention provides a novel process for preparing an oligosaccharide C-glycoside derivative of formula I, comprising reacting a compound of formula II with compound of formula III in the presence of at least one primary or sec...
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WO/2019/180265A1 |
The present invention provides a combination of immune stimulating macrolides with checkpoint inhibitors. The combinations have synergistic effects and can be used in treating viral diseases and cancer.
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WO/2019/180417A1 |
Amorphous ivermectinis provided, suitably in isolated solid form, and is suitably free of any additives or a support matrix, such as a solid dispersion. Also provided is a pharmaceutical formulation, for animal including human or veterin...
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WO/2019/178119A1 |
Disclosed are aminocoumarin compounds, pharmaceutical compositions containing aminocoumarin compounds, and methods of their use, e.g., in the treatment of a Gram- negative bacterial infection.
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WO/2019/141209A1 |
A pyranoglucose-substituted pyrazole compound, used as a pharmaceutical intermediate, having the structural formula represented by formula (9c). The present invention further relates to an intermediate compound represented by formula (10...
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WO/2019/135010A1 |
The invention relates to a compound according to formula (1), wherein R1 to R4 and X are independently from each other a small functional group and R5 is -OH, or a moiety consisting of specific combinations of -L-, -Ra-, -Rb-, -Rd- and R...
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WO/2019/119628A1 |
Disclosed in the present invention is a method for preparing tulathromycin.
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WO/2019/120830A1 |
The invention relates to ascorbic 3-xyloside derivative compounds of formula (I) and also the salts thereof, the solvates thereof and the optical isomers thereof, the geometric isomers thereof, the tautomers thereof, and/or the racemic m...
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WO/2019/112567A1 |
This invention provides protease activity screening matrices that contain a solid support conjugated to a substrate moiety that can be specifically cleaved by a specific protease. The invention also provides methods for utilizing the pro...
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WO/2019/091287A1 |
The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among c...
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WO/2019/069297A2 |
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes de...
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WO/2019/047848A1 |
The invention belongs to the field of quality analysis and control of traditional Chinese medicine, and provides a method for separating eighteen components in a traditional Chinese medicine composition, comprising: (1) preparing the tra...
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WO/2019/044941A1 |
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structu...
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WO/2019/036537A1 |
In one aspect, the present disclosure provides trioxacarcin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein ...
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WO/2019/030367A1 |
The present invention relates to a method for the synthesis of compounds useful in the preparation of antibody drug conjugates (ADC), namely, monoprotected dimeric bifunctional prodrugs based on duocarmycin analogs. In a further aspect, ...
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WO/2019/028185A1 |
In some aspects, the disclosure relates to methods for screening clinical samples for the presence of L-form bacteria associated with endometriosis and/or ovarian fibroid tumors. The disclosure is based, in part, on screening methods use...
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WO/2019/020767A1 |
The present application relates to compounds of formula (I), their process of preparation and the therapeutic uses thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.
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WO/2019/020759A1 |
The present invention relates to the compounds of formula (I), this process of preparation, and the therapeutic uses thereof. These macrolides of formula (I) are useful in the treatment of tuberculosis.
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WO/2019/021510A1 |
This method for producing a flavonoid clathrate includes a detachment step in which a poorly-soluble flavonoid having a rhamnoside structure is treated with an enzyme having rhamnosidase activity in the presence of cyclodextrin, to detac...
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WO/2019/020763A1 |
The present invention relates to compounds of formula (I), their process of preparation and the therapeutic use thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.
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WO/2019/018286A1 |
This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, includin...
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WO/2019/004693A1 |
The present invention relates to a method for preparing an N-glycoside compound from an alkoxyallene compound using a metal catalyst regioselectively and stereoselectively. According to the method for preparing an N-glycoside compound ac...
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WO/2018/223227A1 |
There are provided compositions and methods for prevention or treatment of atherosclerosis and related disorders. More specifically, there are provided desmocollin 1 inhibitor compounds and pharmaceutical compositions thereof for use in ...
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WO/2018/213690A1 |
The present invention relates to the discovery that mutant KCNJ5 is associated with adrenal diseases and disorders. The invention includes compositions and methods for the diagnosis and treatment of adrenal diseases and disorders, based ...
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WO/2018/201076A2 |
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. Th...
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WO/2018/193124A1 |
This invention relates to compounds that can be used to treat bacterial infections. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to method...
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WO/2018/193111A1 |
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...
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WO/2018/193126A1 |
The invention relates to compounds that can be used to treat bacterial infections. The compounds comprise azithromycin derivatives having a phosphonium ion tethered to the azithromycin macrocycle. The invention also relates to methods of...
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WO/2018/193476A2 |
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly in cancer stem cells. Particularly, the invention relates to compounds of Formula III to XIV for the treatment of cancer, such as br...
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WO/2018/193116A1 |
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...
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WO/2018/193117A1 |
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...
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WO/2018/193125A1 |
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...
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WO/2018/191682A1 |
The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
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WO/2018/185684A1 |
The present technology is directed to compounds (e.g., Avermectin derivatives), compositions, and methods related to modulation of FXR. In particular the present compounds and compositions may be used to treat FXR-mediated disorders and ...
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WO/2018/183512A1 |
A single-dose oral formulation of spinosad and lufenuron and methods for its use in the extended control of a flea infestation on a domestic animal such as a dog without emesis.
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WO/2018/177381A1 |
The invention relates to the field of pharmaceutical chemistry, and particularly relates to a compound represented by formula (I), a preparation method thereof, and a medical use thereof. In the compound represented by formula (I), a lac...
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WO/2018/167675A1 |
A process for preparing ketolide compounds is disclosed. (Formula I) (I)
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WO/2018/165250A1 |
The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising...
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WO/2018/161039A1 |
Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer a...
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WO/2018/153954A1 |
The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating viral diseases and cancer.
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WO/2018/153957A1 |
The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating intracellular bacterial, fungal, and protozoal infections.
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WO/2018/153960A1 |
The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in the claims. The macrolides have utility in treating viral diseases and cancer.
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WO/2018/153966A1 |
The present invention relates to novel compounds useful for visualizing cell sen es c en ce in vitro and in vivo, the preparation of said compounds and their use. In particular, the present invention pertains to novel hexose and particul...
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WO/2018/153959A1 |
The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in claim 1. The macrolides have utility in treating intracellular bacterial, fungal, and protozoal infections.
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WO/2018/028511A9 |
Provided are a myricetin derivative, a preparing method and pharmaceutical composition thereof, an application of same in treating colitis, preventing and treating colitis tumorigenesis, and treating colorectal cancer, and a use of same ...
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WO/2018/140594A1 |
Described herein are prodrugs of cysteamine and pharmaceutically acceptable salts, solvates, and esters thereof. Also described herein are pharmaceutical compositions comprising prodrugs of cysteamine, or pharmaceutically acceptable salt...
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WO/2018/133600A1 |
Disclosed is a method for preparing high-activity sugarcane anthocyanin. The method comprises: 1) airing and crushing bagasse obtained after juice extraction, and adding distilled water to the bagasse; mixing cellulase, hemicellulase and...
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WO/2018/134412A1 |
The present invention generally relates to a class of antimicrobial compounds, to compositions containing said compounds and to the use of said compounds for medical and non-medical purposes. More specifically, the present invention rela...
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WO/2018/124695A1 |
The present invention relates to a novel flavonoid compound separated from a Stauntonia hexaphylla leaf, and a pharmaceutical or food composition, for promoting bone formation or cartilage formation or for preventing, remedying or treati...
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