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Matches 201 - 250 out of 6,645

Document Document Title
WO/2016/019682A1
The present invention relates to a chemical synthesis method for phillyrin. The method of the present invention comprises: first dissolving a glycosyl acceptor, phillygenin and a glycosyl donor in an organic solvent and conducting glycos...  
WO/2016/014779A1
Provided are antifungal C2'-epi-polyene macrolides with dramatically improved therapeutic index compared to corresponding mycosamine-bearing polyene macrolides. Also provided are methods for making the antifungal C2'-epi-polyene macrolid...  
WO/2016/004848A1
A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain...  
WO/2016/005049A1
The present invention relates to a compound according to general formula (I), which exhibits bioactivity; methods for the production of the compound; to pharmaceutical compositions comprising one or more of the compound(s); and to the us...  
WO/2015/190587A1
Provided is an amphotericin B derivative represented by formula (I). [In formula (I), each symbol is as defined in the description.] The aforesaid compound, which is characterized by having a urea structure, cyclic structure, hydroxyalky...  
WO/2015/003082A3
The present invention includes novel chemical formulations having antimicrobial activity and their methods of use thereof. In some embodiments, the formulation further comprises at least one fungus.  
WO/2015/175875A1
Disclosed is a derivative of amphotericin B (AmB), denoted C2'epiAmB, with an improved therapeutic index over amphotericin B, pharmaceutical compositions comprising the AmB derivative, methods of making the AmB derivative and the pharmac...  
WO/2015/174460A1
Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly a cell capable of expressing a reporter enzyme such as β-galactosidase, and ...  
WO/2015/169121A1
The present invention relates to the field of pharmaceutical synthesis and pharmacology, in particular to a method for preparing a class of quercetin-O-glycoside derivatives and the use thereof in treating lipid metabolism disorders. The...  
WO/2015/156264A1
A purpose of the present invention is to provide a novel glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Another purpose of the present invention is to provide an ima...  
WO/2015/153653A1
A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immurtostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizi...  
WO/2015/152145A1
The present invention provides a process for producing a crystalline 2-O-α-D-glucosyl-L-ascorbic acid (AG) powder, the process making it possible to more improve the recovery than in conventional processes, shorten the time required for...  
WO/2015/144731A1
The invention relates to a method for producing derivatives of O-α-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is mo...  
WO/2015/140153A1
The present invention relates to new polymorphs consiting in crystallines solvates of Tiacumicin B, the solvates being propanol, isopropanol, acetic acid, isopropyl acetate, chlorobenzene and methyl-ethyl-ketone. The present invention al...  
WO/2015/135467A1
A sixteen-membered macrolide compound and applications thereof, the compound structure being represented in formula (I), wherein R is CH3 or C2H5. The present compound has a wide range of application in the preparation of chemicals to co...  
WO/2015/138458A1
The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The present invention also pertains to compositions comprising derivatives of tylos...  
WO/2015/133483A1
 The present invention addresses the problem of providing a novel glucosyl hesperetin in which the unpleasant taste characteristic of conventional glucosyl hesperetin-containing products is significantly reduced, a method for manufactu...  
WO/2015/127956A1
The present invention relates to a process for obtaining Tiacumicin B with a well defined crystal habit and particle size. The process according to the invention comprises repeating cycles of heating and cooling under controlled conditio...  
WO/2015/127955A1
The invention refers to acrystalline polymorph form (Form II) of Tiacumicin B and to a process for preparing said solid state form. The process according to this invention is more efficient than methods known in the art and is easily sca...  
WO/2015/127118A1
This invention describes a simple, rapid and cost-effective method to isolate bulk quantities of relatively pure and enriched anthocyanidins and other plant bioactives. The method is based on the principle of solubility. Some bioactives ...  
WO/2015/124114A1
Disclosed are a phenolic hydroxyl flavone compound semisynthesis method and iodine recovery method, relating to approaches A and B and iodine recovery. In approach A, flavone is dissolved in a pyridine solvent of ethylene glycol or glyce...  
WO/2015/124113A1
Provided is a semi-synthesis method for luteolin, galuteolin and luteolin rutinoside. In the method, two steps of dehydrogenation and demethylation are combined into one step, and reaction conditions of dehydrogenation and demethylation ...  
WO/2015/123256A1
Compounds, compositions, and methods are described herein for treating diabetes, fatty liver diseases, fibrotic diseases, such as liver and pulmonary fibrosis, and hepatocellular carcinoma.  
WO/2015/116248A1
The invention provides nucleoside/nucleotide compounds and pharmaceutically acceptable salts, esters, stereoisomers, tautomers, solvates, and combinations thereof, pharmaceutical compositions comprising. these compounds and the use of th...  
WO/2015/112013A1
The present invention relates to a process for attaching an N-acetylgalactosamine- (hetero)arylmoiety to an N-acetylglucosaminemoiety, the process comprising the step of contacting the N-acetylgalactosamine-(hetero)arylmoiety with the N-...  
WO/2015/083554A1
The problem addressed by the present invention is to provide a 4G-α-glucosylrutin crystal, a 4G-α-glucosylrutin crystal-containing powder, an application of same as a drug starting material, and applications as a cosmetic product start...  
WO/2015/069541A1
The present invention provides a compound of Formula I or hydrate thereof, useful for the treatment of diabetes.  
WO/2015/066001A1
Methods and compositions are provided for identifying novel ligands for a protein target.  
WO/2015/054148A1
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11,...  
WO/2015/024298A1
The present invention relates to a macrolide compound as shown by formula I and pharmaceutically acceptable salts thereof. The compound of the present invention is an antibacterial agent, and can be used to treat various bacterial and pr...  
WO/2015/014261A1
The present invention discloses a macrolide compound or salt thereof, synthesis method, pharmaceutical composition, and application thereof. The present invention provides a method for preparing a macrolide compound 1, a macrolide compou...  
WO/2015/014907A1
The present invention discloses a novel process for preparation of tulathromycin. The process uses fewer steps due to a more direct route without prior protection of functional groups of the compound of formula (I).  
WO/2014/204104A1
Provided are a method of producing a compound in which a sugar of a glycoside is reduced or removed, and an extract, a pharmaceutical composition, and a food composition including the compound.  
WO/2014/200363A1
The invention relates to sphingoglycolipid analogues which are useful in treating or preventing diseases and conditions such as those relating to infection, atopic disorders, autoimmune diseases or cancer.  
WO/2014/173957A3
A compound of formula (I) wherein R is a C9-23 polyunsaturated alkenyl group; X is SO3R3, SO2R3, PO3R3, PO2R3, COCHal3, or COOR3; R1 and R2 are each independently H, a C1-6 a iky I group optionally substituted with OH, C6-10 aryl group o...  
WO/2014/197703A1
Provided are compounds of formula I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as d...  
WO/2014/194503A1
Provided are compounds useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described abov...  
WO/2014/187364A1
The present invention relates to a preparation method of trihydroxyethyl rutoside. In the method, rutin is firstly prepared into 7-monohydroxyethyl rutoside in a content of greater than or equal to 98% by weight, and then 7-monohydroxyet...  
WO/2014/187957A1
The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (Ila), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for...  
WO/2014/152478A3
The present invention is directed to natural blue anthocyanin-containing colorants comprising fractions of anthocyanin molecules separated from anthocyanin-containing vegetable and fruit juices and extracts. Anthocyanin fractions are sep...  
WO/2014/185717A1
The present invention relates to a novel epothilone derivative having improved water solubility by glucosylation of epothilone, to a method for preparing an epothilone derivative, to a pharmaceutical composition containing the epothilone...  
WO/2014/152417A3
The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity o...  
WO/2014/143864A3
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of ...  
WO/2014/173957A2
A compound of formula (I) wherein R is a C9-23 polyunsaturated alkenyl group; X is SO3R3, SO2R3, PO3R3, PO2R3, COCHal3, or COOR3; R1 and R2 are each independently H, a C1-6 a iky I group optionally substituted with OH, C6-10 aryl group o...  
WO/2014/165676A1
Provided are an amphotericin B (AmB) derivative with an improved therapeutic index over amphotericin B, pharmaceutical compositions comprising the AmB derivative, methods of making the AmB derivative and the pharmaceutical composition, a...  
WO/2014/140699A1
The present invention relates to a novel process for the liberation of Erythromycin from Erythromycin salts such as Erythromycin thiocyanate using water as a solvent in presence of a base. Erythromycin obtained by process of the present ...  
WO/2014/145210A1
The invention described herein relates to processes for preparing ketolide antibacterial agents. In particular, the invention relates to intermediates and processes for preparing ketolides that include a 1,2,3-triazole substituted side c...  
WO/2014/131995A1
A method for the enzymatic synthesis of diosmetin derivatives of formula (III):  
WO/2014/121590A1
Flavonoids compounds of formula (I) or isoflavonoids compounds of formula (II), useful for treatment of HCV diseases, are disclosed. In the compounds, R1 is selected from formula(III), formula(IV) or formula(V); R2, R3, R4, R5 are select...  
WO/2014/073946A3
The invention relates to the use of betanidine and its derivatives, betalains and their derivatives, betalamic acid and its derivatives, including the spatial configurations thereof, for the production of a drug for the treatment, preven...  

Matches 201 - 250 out of 6,645