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WO/2008/115805A2 |
The present invention is directed to methods and compositions including a taxane covalently bonded to the cobalt atom of a cobalamin. The composition can be delivered by any effective route, but is particularly useful as an oral anti-can...
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WO/2008/113686A2 |
The present invention is related to photoreactive Ru (II) complexes anchored on a G- containing oligonucleotide, e.g. compound 1, the method for obtaining them and their use, especially for targeting specific nucleotide sequences that be...
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WO/2008/104486A1 |
The present invention refers to diagnostically or radiotherapeutically useful compounds which are able to selectively bind to lectins, having formula (I) wherein R, R', R1, R2 and R3 are as defined in the specification; the process for t...
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WO/2008/087135A1 |
The invention relates to an iron-hydrocarbon complex compound which is characterized by an iron (II) content. The invention also relates to methods for producing said iron-hydrocarbon complex compound as well as the use thereof for the t...
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WO/2008/082440A2 |
Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or analog thereof, and a modified sugar moiety ...
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WO/2008/044443A1 |
A novel gadolinium compound which (1) has a high T1 relaxation ability and can form an image with high sensitivity even when administered in a small amount, (2) is highly effective in imaging systemic blood vessels and the liver, (3) is ...
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WO/2008/025886A1 |
The invention relates to novel chelating agents and metal chelates containing 1,2,3-triazolyl subunits, and their conjugates with biomolecules or particles. The invention concerns also a process for the preparation of the novel chelating...
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WO/2008/012945A1 |
Disclosed is a compound which has excellent anti-tumor activity and excellent oral absorbability and is useful as an anti-tumor agent. Specifically disclosed is a 3'-ethynylcytidine derivative represented by the general formula (1) [wher...
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WO/2007/149098A1 |
A stable pharmaceutical aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and yields a bi...
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WO/2007/132005A2 |
The invention relates to novel hybrid compounds comprising at least one polyol entity (Po) - for example oligomer or polymer - in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a...
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WO/2007/104834A1 |
This invention concerns novel terminating substrates for DNA polymerases. The substrates are nucleoside triphosphates labeled with lanthanide chelates.
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WO/2007/097404A1 |
[PROBLEMS] To provide a method for production of a composite material, such as a nanoglass, which contains a luminescent substance or a particulate substance having a functional sugar chain carried on its surface by a simple process, and...
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WO/2007/092916A2 |
Methods and materials are disclosed for rapid and simple extraction and isolation of RNA from a biological sample involving the use of an acidic solution and a solid phase binding material that has the ability to liberate nucleic acids f...
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WO/2007/072208A2 |
An oil product comprises a metal complex polymer solution for its esterification and fermentation reactions. The metal complex polymer is composed of oil, water, R-COOHs soluble saccharide (including sugar-metal) molecules, polymer with ...
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WO/2007/049736A1 |
This invention provides a process for producing a natural product having stable quality with high recovery. There is also provided a method for concentration-crystallizing a natural product, characterized by comprising continuously measu...
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WO2007012494B1 |
The invention relates to stable nicotinamide adenine dinucleotide (NAD/NADH) derivatives or nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of said derivatives, and the use thereof in...
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WO2005061527A9 |
The invention relates to cobalamin derivatives (a) having no binding affinity or low binding affinity to the transport protein transcobalamin II TCII) and (b) retaining activity as a vitamin B12 substitute, optionally carrying a therapeu...
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WO/2006/100059A1 |
The present invention relates to a new process for the production of methylcobalamin that comprises the methylation of cyanocobalamin or hydroxocobalamin with dimethyl carbonate in the presence of a reducing agent.
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WO/2006/061685A1 |
The present invention relates to a cost-effective process for manufacture of iron sucrose complex.
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WO/2005/116040A1 |
A process for preparing an iron saccharose complex has the following steps: (a) an iron salt in an aqueous solution is mixed at low temperature with sucrose and an inorganic base, either simultaneously or in any given order, so that the ...
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WO/2005/116046A1 |
The invention relates to a method for producing an iron sucrose complex by (a) mixing, in an aqueous solution and at low temperature, an iron salt with sucrose and an inorganic base, simultaneously or in a random order, so that the react...
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WO/2005/080490A1 |
The present invention relates to a solution of metal-polymer chelate(s) and applications thereof, the solution contains one kind or more kinds of metal-polymer chelate(s) , the metal-polymer chelate(s) is/are prepared as follows: a polym...
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WO/2005/080489A1 |
The present invention discloses a solution of metal-polymer chelate(s) and applications thereof. The solution is prepared as follows: the carbohydrate ,and/or the polymer having hydroxyl, and/or the polymer having hydroxyl , amino and/or...
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WO/2005/026188A1 |
A double-stranded oligonucleotide derivative which contains two oligonucleotide derivatives including at least one nucleotide derivative having been substituted at a nucleotide base part by a metal coordination group being hardly oxidize...
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WO/2005/023829A1 |
It is intended to provide a novel structure in which metal atoms can be one-dimensionally aligned and which can exist in a stable state. Namely, a double-stranded oligonucleotide derivative which contains two oligonucleotide derivatives ...
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WO/2005/014609A2 |
To provide an efficient production method for a highly stereoregular phosphorus atom-modified nucleotide where a conformation on a phosphorus atom is controlled. A production method for a highly stereoregular phosphorus atom-modified nuc...
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WO/2004/044215A2 |
Particles comprising a vitamin B12-containing microbial biomass and a solid carrier and compositions comprising said particles and a method for the production of such particles and compositions.
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WO/2004/014929A1 |
New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide.
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WO/2003/102001A1 |
The invention relates to the preparation of monolithic silica under mild conditions from alkoxysilanes derived from sugars, sugar acids, sugar alcohols and polysaccharides including glycerol, sorbitol, mannose and dextran. Unlike the com...
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WO/2003/097647A1 |
The invention relates to vitamin-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harboring the pathogenic cells, and to a method of preparation of the c...
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WO/2003/078626A2 |
A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be desi...
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WO/2003/078627A2 |
A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be desig...
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WO/2003/078050A2 |
A building block having the dual capabilities of recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or lib...
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WO/2003/074544A1 |
The present invention provides methods and compositions useful for coding and decoding complex mixtures of test units. These methods and compositions use coding and decoding oligonucleotides that comprise standard nucleobases and also no...
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WO/2003/055898A1 |
A modified nucleoside analogue having the formula (I): P - S - B - L - R where: P is a 5' triphosphate or analogue or derivative thereof; S is a substituted or unsubstituted five- or six-membered sugar, sugar analogue or acyclo sugar ana...
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WO/2003/042284A1 |
A ssacharide residue-functional organopolycarbosiloxane containing at least two monosaccharide or polysaccharide groups per molecule in which a specific site on the monosaccharide or polysaccharide is bonded to silicon through a thioethe...
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WO/2003/042283A1 |
A saccharide residue-functional organopolysiloxane containing at least two monosaccharide or polysaccharide groups per molecule in which a specific site on the monosaccharide or polysaccharide is bonded to silicon through a thioether bon...
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WO/2003/026674A1 |
Cobalamin transport proteins are administered in combination with cobalamin coupled to a diagnostic or pharmaceutically active agents to increase the extent of absorption of the diagnostic or pharmaceutically active agent. Cobalamin tran...
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WO/2003/022860A1 |
Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
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WO/2003/018602A1 |
The inventive ferrocene mannose derivatives have the following general structural formula: Wherein n=1-6. Said compositions are capable to activate the killing of intracellularly localised microorganisms.
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WO/2003/016325A1 |
A modified metal ion compound reduced in industrially undesirable properties inherent in metal ion compounds, such as deliquescence, reducing ability, oxidizing ability, and poor solubility in water&semi a process for producing the produ...
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WO/2003/008430A2 |
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells, bacteria, tumorous tissues. The invention also r...
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WO/2002/102820A1 |
Nucleoside derivatives as building blocks for templated libraries are described.
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WO/2002/098896A1 |
A novel process, which is industrially favorable and nondetrimental to the environment, for producing methylcobalamin useful as drugs, etc. More particularly speaking, a process for producing methylcobalamin characterized by comprising r...
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WO/2002/095840A1 |
Organic circuit elements and methods are disclosed. An organic circuit element includes a plurality of members, each of which includes an oligonucleotide duplex. The plurality of members includes at least one donor member for receiving c...
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WO/2002/087632A1 |
The invention relates to a wide variety of different methods and compositions that find use in high throughput screening applications utilizing magnetic resonance imaging (MRI) contrast agents.
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WO/2002/055530A2 |
An agent, composition and method for the treatment, prophylaxis and/or diagnosis of proliferative disorders, which is highly and efficiently absorbed at the site of abnormal cellular proliferation is disclosed.
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WO/2002/051854A1 |
A process for producing a highly purified metal complex of an aminooligosaccharide derivative by effectively removing impurities, by-products, excess eluates, etc. generated in the step of synthesizing the aminooligosaccharide derivative...
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WO/2002/042318A2 |
The present invention is directed to neutron capture agents, such as a molecule comprising Boron-10 or Gadolinium-157, for the treatment, prophylaxis and/or diagnosis of a proliferative disorder via a direct or indirect attachment to a c...
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WO/2002/018405A2 |
The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucle...
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