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JP2013063933A |
To provide a hNEU2 inhibitor or a composition showing a chemical chaperone effect on hNEU2.The human neuraminidase (hNEU2) inhibitor includes: a thiosialooligosaccharide binding dendrimer compound represented by formula (I), a pharmaceut...
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JP5168145B2 |
It is an object of the invention to provide a simple and economical method for introducing the following substituent (I) at the 2'-hydroxyl group of the ribose of a ribonucleic acid derivative whose 3'-hydroxyl group and 5'-hydroxyl grou...
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JP5134547B2 |
The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). The composition contains adenosyl cobalamin (coenzyme B12), optionally in admixture with other cobalamins. The composi...
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JP5116972B2 |
The present invention provides an improved process for preparing ²-D and ²-L 2'-C-methyl-nucleosides and 2'-C-methyl-3'-O-ester nucleosides
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JP5026420B2 |
A surface-modified inorganic material and a preparation method thereof. A surface-modified inorganic material is provided which is obtained by allowing an organosilane compound having allyl or an allyl derivative to react with an inorgan...
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JP2012167067A |
To clarify a molecular structure of a metal salen complex exhibiting a pharmacological effect, and to provide a metal salen complex including such a molecular structure, as well as a derivative of the complex.This metal salen complex com...
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JP5011489B2 |
The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in w...
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JP4989649B2 |
To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug. The invention provides a 3'-ethynylcytidine derivative represented by formula (1): (wherein X represe...
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JP4981197B2 |
The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which linker is a platinum compound having a s...
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JP4930929B2 |
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JP4927560B2 |
The invention relates to cobalamin derivatives having no or low binding affinity to the transport protein transcobalamin II (TCII) and retaining activity as a vitamin B12 substitute, optionally carrying a therapeutic and/or diagnostic ag...
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JP4915721B2 |
The present invention has an object to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in wate...
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JP4823385B2 |
The present invention relates to compounds represented by Formulas (IVb) and (VI):and to a process for preparing a compound represented by Formula (I) using compound (IVb):
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JP4814520B2 |
The invention relates to folate-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harbouring the pathogenic cells, and to a method of preparation of the c...
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JP2011224016A |
To provide novel nucleotides and/or nucleosides having blocking groups at 2'-positions of sugar moieties.The invention provides compositions that comprise the nucleotides and/or nucleosides having blocking groups at 2'-positions of sugar...
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JP4814084B2 |
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JP4805143B2 |
The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contributi...
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JP4794735B2 |
This invention relates to methods for preparing vitamin B12 (VB12) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide. The methods involve reacting the 5'OH group of VB12 or an analogue t...
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JP4783149B2 |
An object of the present invention is to provide a novel structure that enables one-dimensional arraying of metal atoms and can stably exist. The present invention relates to a double-stranded oligonucleotide derivative, which contains t...
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JP2011184318A |
To provide a ribonucleoside H-boranophosphonate compound useful for efficiently synthesizing boranophosphate and other modified RNAs containing phosphorus-boron bonds.The ribonucleoside H-boranophosphonate represented by formula (I) (whe...
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JP4753717B2 |
The present invention provides a freeze-dried preparation containing a high content of methylcobalamin which is highly stable over time and can be used in high-concentration methylcobalamin therapy. Disclosed is the freeze-dried preparat...
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JP4688414B2 |
Preparation of synthetic monosaccharides, disaccharides and trisaccharides for use in the preparation of synthetic heparinoids.
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JP4667798B2 |
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JP2011046714A |
To provide a lactone-containing compound such as discodermolides; a compound which mimics chemical and/or biological activity thereof; and a method and an intermediate, both of which are useful for producing the above compounds.There are...
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JP4643017B2 |
The present invention is directed to salt-free and essentially salt-free p-boronophenylalanine-carbohydrate or p-boronophenylalanine-polyol complexes, as well as methods for making such compounds. In addition, the present invention provi...
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JP4604515B2 |
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JP4599295B2 |
An ±-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a monosaccharide or a reducing end of an oligosacch...
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JP2010529039A |
Therapeutically active nucleosides and associated methods are provided. In one aspect, a nucleoside molecule having a general structural similar to ATP. Such nucleosides have a structure that allows binding to, and subsequent regulation ...
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JP2010166914A |
To provide improved methods for labeling nucleotides.The method for labeling the nucleotides comprises: a step for reacting a reactive moiety of a linker with an electron-donating moiety of a spacer; a step for reacting the reactive moie...
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JP4477774B2 |
The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, witho...
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JP4473445B2 |
The ribonucleoside-derivatives serve for the synthesis of ribonucleic acids and comprise a triple substituted silyloxymethyl-group as a protection-group on the oxygen atom in 2'-position. The ribonucleoside-derivatives may be suitably pr...
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JP2010006763A |
To provide a porphyrin derivative having introduced a functional molecule therein and an intermediate thereof, and a production method of these.The new porphyrin derivative has introduced a plurality of functional molecules thereinto via...
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JP2009538913A |
The present invention relates to troches, patches, gels, or viscous liquids for topical treatment or prevention of mucosal surfaces containing as an active ingredient molecules of cobalamin for the treatment of inflammatory, ulcerative a...
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JP4358615B2 |
The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cy...
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JP4344959B2 |
Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
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JP4340151B2 |
The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in w...
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JP2009197024A |
To provide a chemically modified oligonucleotide conjugate containing a complexing agent or a complex, bonded with a component connecting to the oligonucleotide.The oligonucleotide is modified for preventing or at least significantly inh...
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JP4278118B2 |
To obtain new phosphatase KU-8 capable of recognizing the bond position of phosphate group of phosphorylated saccharide and carrying out dephosphorylation, to efficiently and readily obtain a 3-phosphrylated saccharide from a phosphoryla...
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JP2009102379A |
To provide an improved synthetic method for preparing polyhydroxy-dienyl-lactone such as discodermolide, and to further provide a compound having the similar chemical and/or biological activity thereof.The synthetic method is the one for...
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JP2009067777A |
To provide a new class of a boron-containing nucleoside and an oligonucleotide that exhibit a desirable profile of cell selectivity, stability in a living body and ability of easily passing through a cell membrane used for the boron neut...
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JP4236812B2 |
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs ( L ocked Nucleoside A nalogues), are able to provi...
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JP4212652B2 |
The present invention is concerned with a trans-platinum based compound for use in a method for labeling a bio-organic molecule, having the formula: wherein A represents a reactive moiety for attachment to a label, D represents a reactiv...
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JP2008273977A |
To require an improved synthetic method for preparing polyhydroxy dienyllactone such as discodermolide or the like, and further to require a compound with the same chemical and/or biological activities.A method for synthesizing the lacto...
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JP2008247790A |
To provide a means effective for preventing the relapse of the infectious disease of herpes simplex, preferably, herpes labialis and herpes progenitalis.The agent and the food for preventing the herpes simplex infectious disease contain ...
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JP4161047B2 |
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JP4156667B2 |
A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comp...
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JP2008208138A |
To overcome prior art defects and other defects by providing a new radiolabeling strategy for targeting the tissue for imaging.A radiolabeled tissue-specific ligand, a method for preparing this radiolabeled ligand, a method of using this...
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JP2008534458A |
Production of methylcobalamin involves methylation of cyanocobalamin/hydroxocobalamin with dimethyl carbonate, in the presence of a reducing agent, and optionally in the presence of a sequestering agent of cyano ion in an aqueous/hydro-o...
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JP2008531496A |
A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose)-O-Snbutyl.sub.2-O-(6-O-sucrose...
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JP2008179578A |
To provide a water-soluble sugar-modified silicone derivative having excellent feeling.The sugar-modified cyclic silicone derivative is expressed by general formula. In the formula, n is 4 or 5, and A is -CH2CH2CH2-(O-CH2CH2)p-O-Gq, wher...
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