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Matches 1 - 50 out of 1,051

Document Document Title
WO/2021/070507A1
A purpose of the present invention is to provide a method for producing a high-purity glycoside compound. The present invention provides a method for producing a glycoside compound of formula (3) (in the formula, Ba, i-Pr, and n are as d...  
WO/2020/236903A1
The present disclosure provides pharmaceutical formulations and methods for delivering a therapeutic, diagnostic, or imaging agent to CD206. In an aspect, the present disclosure encompasses a pharmaceutical formulation for administration...  
WO/2020/185681A3
The present disclosure provides a gold-containing compound including an aurous gold atom and a nucleic acid strand that forms a toehold-stem-loop structure, in which the aurous gold atom is complexed with a mismatched pair of residues in...  
WO/2020/190073A1
The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of cancer comprising a novel azolopyrimidine heterocyclic compound as an active ingredient, and the pharmaceutical composition for the prophyl...  
WO/2020/180645A1
The present invention is directed to assay methods and compounds and kits used in such assays.  
WO/2020/168283A1
The present disclosure relates to methods of managing cancer by modulating/inhibiting cap methyltransferase enzyme. The modulation/inhibition is carried out by pharmacological or biological inhibitors, including but not limited to compou...  
WO/2019/145713A9
The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and d...  
WO/2020/158910A1
Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside according to the present invention is represented by formula (I). The 5'-modified nucleoside according to the present invention is usable as a substit...  
WO/2020/157439A1
The invention relates to compounds of formula (I), in which X, Y, L and Ln3+ are as defined in the description.  
WO/2020/073657A1
Provided by the present invention are carbohydrate monophosphines represented by general formula Ia, Ib, IIa or IIb, comprising mixtures represented by Ia and Ib having different phosphorus atom configurations, or mixtures represented by...  
WO/2020/014776A1
An oral dispersible film composition comprising at least one active ingredient and a film forming agent, as well as a method of manufacture of same. The oral dispersible film composition can be free of gum resin, and can be utilized to a...  
WO/2020/014386A1
The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy.  
WO/2020/001812A1
The present invention relates to a novel process for the preparation of SGLT-2 inhibitors via addition of a hydroxymethylene group in an open chain intermediate, readily accessible from D-glucose.  
WO/2019/228286A1
The invention falls within the field of biomedical technology, and invents a new anti-tumor compound which forms an immune activator cisplatin complex by means of a reaction with a cisplatin drug molecule via an innate immune pathway ago...  
WO/2019/172210A1
[Problem] To provide a novel compound having great potential as a prodrug-type anticancer agent. [Solution] A compound represented by general formula (I) or a salt thereof  
WO/2019/155639A1
The present invention relates to a production method and a production intermediate for guanosine-3',5'-bisdiphosphate.  
WO/2019/145713A1
The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and d...  
WO/2016/199165A9
This invention comprises a method of transmucosal delivery of process of Vitamin B 12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B 12 and at least one bifunctional macromolecule...  
WO/2019/092572A1
The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase ...  
WO/2019/088179A1
Provided are: a nucleoside that is more suitable for practical use such as an RNA medicine or the like; and the use of the nucleoside. For this purpose, provided is a nucleoside derivative represented by formula (1) or (2) or a salt ther...  
WO/2018/230479A1
[Problem] To provide a drug that replaces nucleoside anti-cancer agents or anti-virus agents clinically used as therapeutic medicines for cancer or virus infection, that is highly stable against various hydrolytic metabolic enzymes, that...  
WO/2018/215578A1
The present invention concerns a cobalamin derivative of formula (I), wherein X is a ligand having a formula selected from the group consisting of: -(CH2)1-5-S-(CH2)0-3-CH3( -S-(CH2)1-5-NH2 or -S-CH-C-N-H R1 R2 R3 Il wherein R1 = H, meth...  
WO/2018/211392A1
A metal contamination detection system, forming part of a cyanide detection system, comprising a solid buffer, the buffer being adapted to provide a pH of from 9-10. The system is especially useful when used in conjunction with a corrino...  
WO/2018/190493A1
The present invention relates to a method for synthesizing sucralfate and sucralfate thereby. More specifically, sucralfate is obtained through: a first step for sulfating sucrose to prepare sucrose polysulfate; a second step for neutral...  
WO/2018/189546A1
The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical link...  
WO/2018/171816A1
Disclosed in the present invention are a deuterated dipeptide boronic acid or an ester compound thereof, or a crystalline form, pharmaceutically acceptable hydrate or solvate thereof, the structure thereof being shown in formula (a), whe...  
WO/2018/130865A1
A composition for treating headaches and migraines and methods of using same for preventative use to decrease the frequency, duration and severity of headaches and migraines in children and adults.  
WO/2018/070543A1
The purpose of the present invention is to provide a method for producing a phosphoramidite suitable for nucleic acid production (synthesis) with high efficiency and high purity. A phosphoramidite which allows for efficient nucleic acid ...  
WO/2018/048937A1
The use of described compounds or pharmaceutically acceptable salts or compositions thereof for the treatment of a host infected with an RNA virus other than HCV, or other disorder more fully described herein.  
WO/2018/047090A1
The present invention pertains to a method of treating cancer or its relapse in mammals by employing platinum based compounds. More particularly, the present invention provides to enhance immunity in a mammal, using a compound of Formula...  
WO/2018/019196A1
A substituted boric acid compound, a pharmaceutical composition comprising same, and an application thereof. The substituted boric acid compound is a compound represented by formula (I), or a crystal form, a pharmaceutically acceptable s...  
WO/2018/007035A1
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exch...  
WO/2018/005630A1
The invention provides a compound of the formula (I), and a capture support of the formula (9), wherein R1, R2, R3, R6, A, B, D, E, J, K, Q, W, and Z are as defined herein. The invention also provides a method of purifying an oligonucleo...  
WO/2017/144099A1
The present invention relates to a compound of formula (I) wherein the substituents are as defined in the claims. Said compound may be used as a ligand in order to purify glycosylated bio molecules. The present invention further relates ...  
WO/2017/133465A1
The present invention relates to a baicalin magnesium and further relates to a preparation method and extraction method of the baicalin magnesium. The preparation method comprises the steps of preparing a suspension of a baicalin, prepar...  
WO/2017/134176A1
The present invention relates to a process for producing 2'-O-fucosyllactose, to the intermediates obtainable by this process and to the use of these intermediates. Production comprises the reaction of a protected fucose of general formu...  
WO/2017/112787A1
Anti-proliferative iron prochelator compounds conjugated with a carbohydrate moiety or a derivative thereof. The glycoconjugate molecules may feature thiosemicarbazone iron prochelators. The glycoconjugates are prochelators that are acti...  
WO/2016/199165A3
This invention comprises a method of transmucosal delivery of process of Vitamin B 12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B 12 and at least one bifunctional macromolecule...  
WO/2016/194000A1
The present invention relates to aqueous solutions of iron sucrose and a process for its preparation. The molecular weight of said complexes is in the range 45000 to 60000 Dalton. The compositions are used in the treatment of anaemia.  
WO/2016/173425A1
This present invention relates to a glucopyranosyl derivative as sodium dependent glucose cotransporters (SGLTs) inhibitor, preparation processes thereof, and pharmaceutical uses thereof, pharmaceutical compositions containing the compou...  
WO/2016/119004A1
The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment of vitamin B12 deficiency.  
WO/2015/191303A2
The present disclosure provides a unique methodology and protecting groups that enable synthesis of oligonucleotides having Z nucleotide in an easy, clean and site-specific fashion with high yield. In particular, the method causes little...  
WO/2015/128622A1
A method of detecting peroxynitrite in a sample is described comprising the steps of: (a) providing a complex of a saccharide with an aryl boronate compound of formula (I): Fp - L1 - Z - L2 - Ar - B(OH)2 (I) wherein: Fp comprises a fluor...  
WO/2015/101916A1
An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are also disclosed, wherein R1 and R2 are independently hydrogen or hydroxyl protec...  
WO/2014/142640A1
The invention relates to a novel method for the production and purification of hydroxocobalamin and the pharmaceutically acceptable salts of same, wherein the method consists in converting cyanocobalamin into hydroxocobalamin by reductio...  
WO/2014/144907A1
Compounds have been identified and tested in a zebrafish model of dystroglycanopathy and found to be efficacious based on an increase in the survival rate of dystroglycan deficient fish. Several of the compounds affect the GABA and acety...  
WO/2014/027203A1
An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or...  
WO/2014/010250A1
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (-NO2), a halogen atom, a cyano group (-CN), a group of ...  
WO/2013/191129A1
A compound represented by general formula (III), which is an intermediate for an oligonucleotide analogue that is stable and has an excellent antisense antigene activity or an excellent activity for acting as a detecting agent (a probe) ...  
WO/2013/191549A1
The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, c...  

Matches 1 - 50 out of 1,051