Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1,001 - 1,050 out of 3,272

Document Document Title
WO/1995/005389A1
The invention provides glycoconjugates which bind polynucleotides in a sequence-selective manner and/or preferentially displace or inhibit binding of transcription factors to their recognition sites on DNA. The DNA-binding glycoconjugate...  
WO/1995/005155A1
Composition for the treatment or prevention of the symptoms of connective tissue ageing, characterized in that it contains one or more oligosaccharides with 2 to 5 oligosaccharide residues or a derivative of said oligosaccharide(s) conta...  
WO/1995/005182A1
The present invention relates to bridged oligosaccharide(s) compounds and sulfated derivatives thereof having the structure R1-[X1-R2]n-X2-R3 wherein R1, R2 and R3 are independently one or more saccharide(s); X1 and X2 are independently ...  
WO/1995/003059A1
The invention relates to bivalent sialyl lewis X saccharide compounds that inhibit cellular binding to a selectin receptor. Pharmaceutical compositions comprising the compound of Formula (I) and processes for making and using the same ar...  
WO/1995/003315A2
A library comprises at least six different sugar-containing molecules selected from (i) carbohydrates each derived from at least two saccharide monomers, and (ii) glycoconjugates. Such a library may comprise disaccharides or linear or br...  
WO/1995/002398A1
Pharmaceutical composition for immunomodulating and adjuvant therapy containing a metabolic stressor, 2-deoxy-D-ribose and further active components, i.e. ribose, DL-alanine, nicotonic acid, L-ascorbic acid, thiamin and glutamic acid ami...  
WO/1994/028889A1
The present invention relates to individual, well-defined compounds and the uses of these compounds, alone or in conjunction with bioactive molecules such as growth factors or metalloproteinase inhibitors, for the repair of cartilage dam...  
WO/1994/028909A1
Anti-cancer compositions containing chiral monosaccharides and methods of their use are disclosed herein. The compositions, exhibiting cytostatic and cytotoxic properties with regard to neoplastic cells are formulated using the L-isomeri...  
WO/1994/028008A1
Fluorescent tagging compounds of formula (I), wherein A is a member selected from the group consisting of an aromatic ring, a heteroaromatic ring, and a heterocyclic ring, and R is a linking moiety having from 1 to 20 carbon atoms, optio...  
WO/1994/027562A1
Foaming shampoo compositions which contain no anionic surfactant and are mild to the skin and eyes are comprised of alkyl polyglycosides, betaines, and polymeric slip agents.  
WO/1994/026760A1
The present invention relates to analogues of Sialyl Lewisx that inhibit cellular adhesion between a selectin receptor and cells that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates...  
WO/1994/026759A1
Selectin receptor binding is modulated by a method which utilizes heparin-like oligosaccharides. The figure shows a schematic drawing of the molecules involved in leukocyte adhesion to the vessel wall.  
WO/1994/024139A1
An improved process for preparing an alkylpolyglycoside wherein the alkyl group contains about 8 to about 20 carbon atoms, prepared by reacting a saccharide and an alcohol in the presence of an acid catalyst, and subsequently removing ex...  
WO/1994/021689A1
Oligosaccharides having a high specific binding affinity for HGF growth factors and made up of relatively low molecular weight sulphated oligosaccharide chains are disclosed. The chains are composed of at least three disaccharide units i...  
WO/1994/020448A1
In the method proposed for the production of monocarboxylic acids from carbohydrates, carbohydrate derivatives or primary alcohols, the carbohydrates, carbohydrate derivatives or primary alcohols are oxidized continuously in aqueous solu...  
WO/1994/020514A1
A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R1 and R3 represent each hydrogen, SO3H or CH2COOH; R2 represents hydrogen, SO3H, CH2COOH or N-acetyl-ne...  
WO/1994/019361A1
In this invention oligosaccharides obtainable by degradation of zona pellucida glycoproteins are presented, specifically O-linked oligosaccharides, which can be used for immunecontraceptive vaccines. Also copolymers and conjugates compri...  
WO/1994/018986A1
Helicobacter pylori has been implicated as a contributing factor in a number of pathological conditions, including acute (type B) gastritis, gastric and duodenal ulcers, gastric adenocarcinoma, and gastric lymphoma. The present invention...  
WO/1994/019360A1
The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage...  
WO/1994/018213A1
A method of manufacturing lactulose anhydride, comprising the step of drying lactulose trihydrate at a temperature of 45-75 �C and with a degree of vacuum of 25-100 Torr so as to remove water of crystallization therefrom. The method is...  
WO/1994/015944A1
Antiparasitic compounds of formula (I) wherein the broken line at the 22-23 position represents an optional bond and either this bond is present and R1 is absent or this bond is absent and R1 is H, OH, oxo or oximino optionally substitut...  
WO/1994/014826A1
The present invention provides a process which comprises isomerizing a compound having an aldose structure into a compound having a ketose structure, by the use of or in the presence of an organogermanium compound having a structural por...  
WO/1994/014849A1
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of coditions characterized by unwanted smooth m...  
WO/1994/012540A1
The invention concerns compounds of the formulae (I) R-Y-CO-R3-CO-O-A and (Ia) R-Y-CO-R3-CO-O-CH2-A1, in which R is a hydrocarbon group which can be polymerized by a radical-initiated reaction; R3 is a single bond or straight-chain or br...  
WO/1994/009122A1
An enzyme, exo-alpha-1,4-glucan lyase, capable of successively cleaving the terminal alpha-1,4-D-glucosidic bonds from the non-reducing ends of an alpha-1,4-glucan is disclosed. The enzyme is e.g. selected from the group consisting of al...  
WO/1994/005704A1
A method for preparing high-purity levoglucosan from pyrolysis oil derived from cellulose, comprising: mixing pyrolysis oil with water and a basic metal salt in amount sufficient to elevate pH values to a range of from about 12 to about ...  
WO/1994/002624A1
An enzymatic process is disclosed for the preparation of galactosylbeta1,3glycal disaccharides such as Galbeta1,3Glucal, an intermediate useful in Lea preparation and an inhibitor of beta-galactosidase. The process utilizes beta-galactos...  
WO/1994/000149A1
Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol...  
WO/1994/000477A1
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (I), R1 ...  
WO/1994/000596A1
A biologically active oligosaccharide compound comprising at least two L hexose rings connected together by an ether oxygen atom. The ether oxygen atom is connected to a first of the rings at the first carbon atom to the right of the hex...  
WO/1993/024505A1
Disclosed are methods for reducing the degree of antigen induced inflammation in a sensitized mammal. The disclosed methods employ oligosaccharide glycosides related to blood group determinants having a type I or type Ii core structure w...  
WO/1993/024506A1
Disclosed are novel Lewis?C¿ and LacNAc analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.  
WO/1993/024503A1
Methods are provided for the sequential removal of monosaccharides from the reducing end of oligosaccharides. The present invention also discloses the use of such methods for structural determinations of oligosaccharides and to enable ne...  
WO/1993/023387A1
A process for producing an epoxide represented by general formula (1a) or (1b), which comprises reacting an olefin represented by general formula (2) with a compound containing iodine and an acyloxy ion and treating the reaction product ...  
WO/1993/018777A1
Mannose-6- and 1-phosphates and their pharmaceutically acceptable salts and bioprecursors thereof are useful in the treatment of fibrotic disorders. They accelerate wound healing and the 6-phosphate prevents or mitigates scar formation. ...  
WO/1993/018787A1
Polypeptides are provided having trans-sialidase enzymatic activity in substantially pure form, nucleic acids coding therefor, antibodies specific for such polypeptides, processes for producing the enzyme and methods of use of the enzyme...  
WO/1993/019096A1
Oligosaccharides having a high specific binding affinity for FGF growth factors and made up of less than ten disaccharide units in all are disclosed which include sulphated disaccharide units composed of an N-sulphated glucosamine residu...  
WO/1993/016088A1
Water-free aldoses may be prepared by mixing aqueous starch degradation products having 50 to 85 wt % solid matter content with (a) 0,1 to 5 wt % of a primary alcohol having 8 to 22 carbon atoms and (b) 0,1 to 5 wt % water-free glucose, ...  
WO/1993/015098A1
A novel SLe-type sugar chain derivative represented by general formula [I], which is useful as a medicine and has a novel structure containing moranoline, wherein R?1¿ represents hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R?...  
WO/1993/010796A1
Simple lactose or lactosamine related compounds which behave as ligands for the ELAM-1 and related receptors are described. These compounds are of formula (1) wherein each R1 is independently H or lower alkyl (1-4C); R2 is H, lower alkyl...  
WO/1993/009755A1
The method for obtaining oligosaccharides starts with the allylation of position (3') of beta-lactosides followed by the controlled benzylation which leads to perbenzylated and partially benzylated compounds. The latter are glycosylated ...  
WO/1993/008205A1
This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. ...  
WO/1993/007159A1
Sucrose is treated with an acid catalyst to form an amorphous sucrose anhydrous melt. Heating of the anhydrous melt at 80-100 °C forms three known kestoses and the novel products, viz. $g(a)-fructosylsucrose anomers of 6-kestose, neokes...  
WO/1993/005789A1
Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.  
WO/1993/004185A1
The present invention relates to a method for the enzymatic production of alpha-glucosides, characterized by contacting at least one alcohol whose only functional group or groups is/are a hydroxyl group or groups, with starch, maltodextr...  
WO/1993/001810A1
Chimeric analogs of calicheamicin that include an analog of calicheamicinone linked to an ester or glycoside, (-)-calicheamicinone, and intermediates useful in the synthesis of calicheamininone and its analogs are disclosed.  
WO/1993/001200A1
A method for preparing partially acylated carbohydrate derivatives, particularly saccharose acetate, by reacting the initial carbohydrate with an acylating agent, wherein the method is carried out in a reaction medium consisting of an or...  
WO/1993/000067A1
Cosmetic compositions providing a suitable medium for the development of beneficial endogenous flora, and including at least one oligosaccharide selected from the group consisting of gluco-oligosaccharides, fructo-oligosaccharides, alpha...  
WO/1992/022563A1
The present invention is drawn to methods for the synthesis of Lewis?a� derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemoenzymatic synthesis. The derivatives find use in the treatment and prevention of disea...  
WO/1992/022662A1
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound $g(b)Gal(1-4)$g(b)GlcNAc(1-3)$g(b)Gal(1-4)$g(b)GlcNAc-R. In particular, the methods of this invention provide for a multi-step synthe...  

Matches 1,001 - 1,050 out of 3,272