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WO/2011/089561A1 |
A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to...
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WO/2011/079494A1 |
Halogenated dideoxy saccharide derivatives with the following general formula I are disclosed, wherein X and R1 - R4 are defined as in the description. It is shown that compounds 1-14 have better effect for inhibiting the growth of many ...
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WO/2011/077095A1 |
There is provided compounds of formula (I), wherein R1, R2, X1, X2, and X3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as positron emission tomography (PET) imaging ag...
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WO/2011/073492A1 |
The present invention relates to compounds of general formula (I) and to the uses thereof as pharmaceutical compositions for the treatment of diseases related with lysosomal accumulation of sphingolipids, such as Gaucher disease, Tay-Sac...
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WO/2011/060807A1 |
The present invention relates to a novel process for producing N-acetyl-D-Glucosamine from Glucosamine hydrochloride. More particularly this invention pertains to a novel and simple environmentally acceptable process for producing glucos...
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WO/2011/054364A1 |
The present invention relates to a process for preparing a mixed salt of glucosamine sulfate and an alkali metal chloride. The process comprises the consecutive steps of: a) suspending glucosamine hydrochloride in a non-aqueous solvent, ...
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WO/2011/047047A2 |
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypept...
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WO/2011/032034A2 |
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be f...
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WO/2011/023374A1 |
Enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-β-D-ribofurano...
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WO/2011/011907A1 |
A preparation method of D-glucosamine hydrochloride originated from plant is disclosed, which comprises using waste hypha residue of citric acid as initial raw material, acidolyzing the waste hypha residue with hydrochloric acid, condens...
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WO/2011/006237A1 |
Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their preparation are also described. The thera...
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WO/2010/151489A1 |
A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used a...
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WO/2010/126435A1 |
The present invention relates to novel compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding...
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WO/2010/122232A1 |
The present invention revealed novel antibody-saccharide-complexes and methods and uses related to analysis of cells. The present invention is further related to a method of selection of new antibody with CHO-specificity and to a use of ...
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WO/2010/122234A1 |
The present invention provides a complex of Tra-antibody bound to an isolated glycan comprising type I- N-acetyllactosamine comprising target structure. The invention is also directed to methods and uses utilizing said complex.
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WO/2010/118951A2 |
The invention relates to a method for producing monoethylenically unsaturated glycosylamines, in which an aldehyde sugar is reacted with a primary aliphatic amine or ammonia in an aqueous medium and with the anhydride of a simple unsatur...
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WO/2010/118950A2 |
The invention relates to a method for producing unsaturated acylamidoalkyl polyhydroxy acid amides, in which the reaction product from polyhydroxy acid lactone and aliphatic diamine is reacted with the anhydride of a simple unsaturated c...
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WO/2010/117803A2 |
The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesi...
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WO/2010/112813A1 |
A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dim...
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WO/2010/109189A1 |
A method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro- 4, 1',6'-trideoxy-galactosucrose-β-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction ve...
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WO/2010/107487A2 |
New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements ...
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WO/2010/106215A1 |
Aminocyclitol compounds, procedure for the obtainment and uses thereof. Aminocyclitol compounds and uses thereof as pharmaceutical compositions for the treatment of diseases associated with alterations in iNKT cells, more specifically au...
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WO/2010/104192A1 |
Disclosed is an oligoamino sugar compound which has a high affinity for a double-stranded nucleic acid and has 3 to 6 sugars bound thereto, such as 2,6-diamino-2,6-dideoxy-α-(1→4)-D-glucopyranose oligomer, or a salt of the oligoamino ...
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WO/2010/090591A1 |
The present invention relates to a method for reductive amination of a water soluble carbohydrate. An aminated water soluble carbohydrate is a prerequisite in processes for further modification of cellulose. The synthesis of this molecul...
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WO/2010/079579A1 |
Disclosed are a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide via a halogen-substituted saccharide synthesis reaction with the use of a subcritical fluid or a supercritical fluid as ...
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WO/2010/077623A1 |
The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-p
yrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity ...
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WO/2010/071824A2 |
Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments,...
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WO/2010/066643A1 |
The invention relates to a method for producing 4-fluoro-4-deoxy-a-D-glucopyranosides of the general formula (I), where: R1 is CO-R3; R2 is (C1-C6) alkyl; R3 is (C1-C6) alkyl, phenyl, which can be substituted.
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WO/2010/049921A1 |
A disaccharide having the structure (Formula I), and a disaccharide having the structure (Formula II) exhibit immunomodulatory activity.
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WO/2009/139719A9 |
The present invention relates to novel synthesis routes for preparation of thiodigalactosides of the general formula (12). The method comprises the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corres...
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WO/2010/049947A2 |
The present patent application relates to a process for the preparation gemcitabine or a salt thereof. More particularly it relates to preparation of 3,5- dihydroxy protected -2-deoxy-2,2-difluoro -1-oxoribose, an intermediate used in th...
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WO/2010/044371A1 |
A sweet taste receptor agonist such as acesulfame K, sucralose, saccharin or glycyrrhizin can be used as an active ingredient for an insulin secretion stimulator. A candidate substance for an insulin secretion stimulator can be screened...
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WO/2010/040880A1 |
Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl ...
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WO/2010/037179A1 |
The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates t...
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WO/2010/029574A2 |
An improved process for preparing gemcitabine or salts thereof, comprising the following steps, dissolved 2-Deoxy-2,2- difluoro-D-ribofuranose-3,5-dibenzoate in an organic solvent and allowed to cool to 0 to 10 degree centigrade temperat...
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WO/2010/027028A1 |
Disclosed are an effective and highly safe agent or pharmaceutical preparation for ameliorating various disorders caused by an impaired brain function, and others. Specifically disclosed are: an agent for preventing or ameliorating an i...
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WO/2010/018834A1 |
Provided is a method for releasing a glycan which can be applied to construction of a system for automatizing glycan analysis, particularly a method for releasing a glycan with which O-linked glycan analysis can be performed. It was ach...
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WO/2010/016587A1 |
Disclosed is a method for accurately evaluating the specific incorporation of D-glucose into cells. The method is characterized by: contacting each of a D-glucose derivative that can be incorporated into cells specifically and has a flu...
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WO/2010/009197A1 |
Solid forms of anhydrous (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(me
thylthio)tetrahydro-2H-pyran-3,4,5-triol are disclosed, in addition to methods of their use in the treatment of various diseases and disorders.
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WO/2009/141486A1 |
The invention relates to a glycolipid having formula (I) in which: R is a carbohydrate selected from a mono-, di- and polysaccharide; X is oxygen, sulphur, -CH 2- or -NH-;n, m, j and k are identical or different integers between 0 and 20...
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WO/2009/138600A2 |
The invention relates to the use of certain derivatives of D-mannopyranoside for controlling angiogenesis. These compounds have a pro-angiogenic activity, and can particularly be used for preparing a pharmaceutical composition for treati...
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WO/2003/083074A9 |
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WO/2009/124113A1 |
A process for the purification of sucralose containing aqueous feed streams is disclosed. The process comprises the step of extracting an aqueous feed stream comprising sucralose and impurities less polar than sucralose, such as tetrachl...
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WO/2009/124116A1 |
A process for the extraction of sucralose from an aqueous solution containing at least sucralose, other chlorinated saccharides, sodium chloride and dimethyl ammonium chloride into an organic solvent for sucralose by contacting said orga...
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WO/2009/118532A1 |
The present invention provides a method for producing sucralose from a feed stream comprising a sucrose-6-acylate in a reaction vehicle, wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in order...
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WO/2009/098400A1 |
The invention relates to a chemical compound of the disaccharide type of the following general formula (A): where, Z = O or S; X1 = azido or NHCOR3 where R3 = 1 -5 c alkyl or aryl, X2 = benzyl, H or sulfonate, X3 = -CH2φ, -CHφ forming ...
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WO/2009/089684A1 |
The invention discloses a process for synthesizing sucralose, which comprises reacting sucrose with acetic anhydride in N-amide solvent in the presence of organic complex alkali metal salt catalyst to form sucrose-6-acetate, then chlorid...
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WO/2009/087676A1 |
The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose (6-PAS) (V) from sucrose. Formula (V)
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WO/2009/087362A2 |
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, wat...
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WO/2009/087677A1 |
The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose 6-PAS), formula (V) and sucralose, formula (I).
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