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WO/2005/099338A2 |
[PROBLEMS] To provide a sugar-chain primer for making a cell to synthesize O-glycan from among glycoprotein type sugar chains. [MEANS FOR SOLVING PROBLEMS] A sugar-chain primer for the synthesis of an O-glycan type sugar chain in a cultu...
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WO/2005/092931A1 |
A sugar donor having a glucuronic acid or iduronic acid derivative at the reducing end and in which a leaving group is added to the reducing end hydroxyl group to be glycosylated and the other hydroxyl groups and the carboxyl groups are ...
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WO/2005/093102A2 |
The present invention relates to compositions suitable for spotting compounds onto a substrate, and methods employing these compositions. The composition can include one or more organic anions of formula 1: R(X)m(Y)n. In an embodiment of...
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WO/2005/090376A1 |
Disclosed herein is a process for producing chlorinated sucrose, mainly 1',6'-Dichloro-1',6'-Dideoxy-β-D-Fructo-Furanosyl-4-Chloro-
4-Deoxy-&agr -D-Galactopyranoside by chlorination of 6-acetyl sucrose in the presence of a solvent such ...
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WO/2005/090374A1 |
Present invention relates to disclosure of application of some innovative techniques useful for substantially improving process efficiency of production of chlorinated sucrose including their intermediates and derivatives. Application of...
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WO/2005/085264A1 |
The invention relates to compounds which are polysufated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds;...
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WO/2005/082918A1 |
[PROBLEMS] A novel glycolipid capable of forming a tubular aggregate which can be stabilized by polymerization; and a fine fiber or tubular aggregate comprising the glycolipid. [MEANS FOR SOLVING PROBLEMS] An asymmetric polymerizable bol...
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WO/2005/080489A1 |
The present invention discloses a solution of metal-polymer chelate(s) and applications thereof. The solution is prepared as follows: the carbohydrate ,and/or the polymer having hydroxyl, and/or the polymer having hydroxyl , amino and/or...
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WO/2005/061523A1 |
The invention relates to compounds that are designed to mimic the structure of GAGs; methods for the preparation of the compounds; compositions comprising the compounds; and use of the compounds and compositions thereof for the anti-angi...
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WO/2005/056525A2 |
The invention provides methods of deacetylating N-acetylglucosamine by solid acid hydrolysis on a cation exchange resin. These methods advantageously reduce the amount of acid used and the need for acid recycle facilities. The isolated g...
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WO/2005/056786A2 |
One preferred embodiment of the present invention provides a GalK variant comprising a R28, E34, D37, D174, Y233, C339, Y371, Y371H, M173, M173L, Y371H-M173L and C353 mutation. The GalK variants display catalytic activity toward a variet...
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WO/2005/056783A1 |
Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor specificity which can catalyze formation of...
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WO2005007076B1 |
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group - C(O)-(CHR4)m-AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond; R...
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WO/2005/044758A1 |
An on-column process by which various radioactive-fluorine-labeled compounds can be obtained in a high yield. The process comprises a step in which [18O]water containing [18F]fluoride ions is introduced into a column packed with an anion...
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WO/2005/044832A1 |
Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-deoxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activ...
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WO/2005/030677A1 |
A process for producing a radioactive fluorine compound which comprises a step in which [18O] water containing [18F] fluoride ions is introduced into a column packed with an ion-exchange resin to collect the [18F] fluoride ions and a ste...
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WO/2005/028490A1 |
Methods of labeling targeting molecules with radioactive halogens through the conversion of saccharides to the corresponding aldehyde, and reacting this aldehyde with a hydrazine derivatized targeting molecule are described. The methods ...
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WO/2005/024025A1 |
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis AT...
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WO/2005/012318A2 |
This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
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WO/2005/012319A1 |
The invention relates to a compound of formula (I): wherein P1, P2,P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18F-FDG.
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WO/2005/005485A1 |
A chitin oligomer composition and/or chitosan oligomer composition in which the content of oligomers having a degree of polymerization of 3 to 10 is 60% or higher; and a process for producing the oligomer composition(s). The process comp...
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WO/2005/000862A2 |
Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The m...
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WO/2004/111188A2 |
Disclosed is a process for the deacetylation of chitin and a process for the treatment of chitinaceous materials to obtain chitin which processes are conducted in a non-saponifiable, non-aqueous, water insoluble liquid having a flash poi...
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WO/2004/104016A1 |
A process for the preparation of 4, 1', 6'- trichoro-4, 1', 6'-trideoxygalactosucrose is characterized by that raw material sucrose is added into N,N-dimethylformamide, and transesterification is conducted between sucrose and ethyl aceta...
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WO/2004/096821A1 |
A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providi...
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WO/2004/093787A2 |
The present invention is directed to glyodendrimeric proteases, composition with glycodendrimeric proteases and methods for inhibiting adhesion binding in microorganisms by contacting microorganisms with a glycodendrimeric protease or a ...
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WO/2004/093867A2 |
The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation o...
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WO/2004/084912A1 |
It is intended to provide a remedy for nerve damage caused by spinal injury, nerve trauma or the like which contains, as the active ingredient, a low-molecular weight saccharide at least having glucuronic acid and/or N-acetylglucosamine ...
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WO/2004/080409A2 |
The present invention relates to compositions and methods for inhibiting the interaction of a ligand and receptor, In particular, compositions are methods are provided for inhibition of interaction between a virus, especially HIV, and a ...
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WO/2004/078769A1 |
The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of general formula (I), wherein X, R1, R3, R4, R5 and R6 are as described in the specification.
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WO/2004/075843A2 |
It is taught here that enkephalin peptides which are glycosylated with a disaccharide will be transported across the blood brain barrier and deliver analgesic effects superior to morphine when introduced into the bloodstream. Glycosylate...
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WO/2004/066915A2 |
The present invention relates to the old-35 gene, its encoded protein, and its promoter sequence. The old-35 gene is associated with terminal differentiation and senescence of cells, and as such the gene and its related molecules may be ...
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WO/2004/065401A1 |
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains...
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WO/2004/064754A2 |
Disclosed are compounds having the formula (I) wherein R2 is hydrogen, a monomeric glycoside or an oligomeric glycoside, R3 is hydrogen, a monomeric glycoside, an oligomeric glycoside, or a group having the formula (II), R is a lower alk...
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WO/2004/065399A1 |
It is intended to provide a novel hollow fiber type organic nanotube and a microtube which can be conveniently produced within a short time and are widely usable. An N-glycoside type glycolipid represented by the following general formul...
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WO/2004/063209A2 |
Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
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WO/2004/062599A2 |
Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for us...
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WO/2004/060347A2 |
The invention relates to pharmaceutical compositions comprising propylene glycol solvates of active pharmaceutical ingredients (APIs).
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WO/2004/058786A1 |
The present invention provides a process for the synthesis of 2-deoxy-D-glucose comprising haloalkoxylation of R-D-Glucal wherein R is selected from H and 3, 4, 6-tri-O-benzyl, to obtain alkyl 2-deoxy-2-halo-R-$g(a)/$g(b)-D-gluco/mannopy...
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WO/2004/045545A2 |
The present invention provides novel methods for the treatment of cancer, methods for screening compounds having anti-cancer activity, and methods of assessing cancer progression.
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WO/2004/045371A2 |
The present invention provides antibodies to truncated isoforms of CCAAT-displacement protein/Cut homeobox (CDP/Cux) which are useful in diagnostic and prognostic methods for detecting cancer. Further provided are methods for detecting R...
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WO/2004/043982A2 |
Novel compounds, derivatives of $g(a)-C-phenylN-tert-butyl nitrone, a method for production and use thereof for the preparation of medicaments for the prevention or treatment of diseases related to oxidative stress.
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WO/2004/041199A2 |
Food products and beverages which include N-acetyl-D-glucosamine (NAG) are provided, as are methods of thier use and preparation. Embodiments of the supplemented food products and beverages are heated to high temperatures, such as those ...
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WO/2004/032826A2 |
An active pharmaceutical ingredient is combined with tannic acid to form a tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then blended with pharmaceutically ...
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WO/2004/031244A1 |
The present invention is directed to novel methods to produce carbohydrate polymers and oligomers especially for pharmaceutical and food industries. The invention is directed to methods to remodel monosaccharides, and/or oligosaccharides...
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WO/2004/031396A2 |
Methods for cell-free production of glucosamine from starch, maltodextrin or glycogen or from fructose and a source of amino groups are disclosed. Also disclosed are cellular extracts comprising glucosamine-6-phosphate synthase activity,...
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WO2003097657A9 |
The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering mi...
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WO/2004/017810A2 |
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific termin...
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WO/2004/014929A1 |
New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide.
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WO/2004/005308A2 |
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are prod...
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