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Matches 1 - 50 out of 1,525

Document Document Title
WO/2022/169855A1
The present invention includes compositions and methods for preventing or treating a patient for kidney injury comprising administering an effective amount of a compound of Formula I: where n = 0-5; X = NH, O, S, or CH2; Y = phenyl, or a...  
WO/2022/163846A1
The purpose of the present invention is to provide: a novel stereoselective method for producing a cyclic dinucleotide derivative that can be used for an antibody-immunostimulator conjugate; and a production intermediate thereof. Another...  
WO/2022/150726A1
The present disclosure provides hypoimmunogenic biotherapeutic compositions that suppress the development of an immune response to themselves in an individual. The present disclosure also provides pharmaceutical compositions that include...  
WO/2022/141227A1
The present application provides a preparation method for sucralose and a crude product solution thereof. The preparation method comprises: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solutio...  
WO/2022/141229A1
A sucralose preparation method, a crude product solution, and sucralose, the method comprising: dissolving sucralose-6-ethyl ester in ethanol to form a sucralose-6-ethyl ester reaction solution; distilling the sucralose-6-ethyl ester rea...  
WO/2022/141228A1
A preparation method for sucralose, a crude product solution, and sucralose, the method comprising: dissolving a sucralose-6-acetate into methanol, adding calcium oxide into the reaction solution of the sucralose-6-acetate for a deacylat...  
WO/2022/110017A1
A method for purifying sucralose-6-ethyl ester, comprising: a preparation step: obtaining an ethyl acetate saturated solution of crude sucralose-6-ethyl ester heated to a predetermined temperature; a gradient crystallization step: perfor...  
WO/2022/099606A1
A method for purifying sucralose, comprising: removing a solvent from a sucralose reaction liquid to obtain a concentrated solution of a sucralose crude product; under stirring, adding ethyl acetate to the concentrated solution of the su...  
WO/2022/083106A1
The present invention relates to the field of pharmaceutical chemicals, and relates to a method for preparing a glucosamine sulfate composite salt. The method comprises: adding N-acetylglucosamine and a solvent into a reaction vessel, th...  
WO/2022/067621A1
A sucralose purification method, sequentially comprising: putting sucralose in ultrapure water, heating for dissolving and then filtering, and extracting with an extraction solvent to remove non-polar impurities; evaporating an extracted...  
WO/2022/038198A1
Monosaccharide compounds, in particular deoxy-pentose compounds and preferably 5-azido-5-deoxy-D-arabinofuranose, for use in for use in labelling and/or concentrating and/or targeting and/or diagnosis of cell secretions from eukaryotic c...  
WO/2022/011554A1
The invention relates to a compound represented by general formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable hydrate thereof or pha...  
WO/2021/261444A1
The present invention relates to a compound that is useful as a vaccine adjuvant, a method for producing the same, a pharmaceutical composition that contains the compound, and use of the compound as a vaccine adjuvant.  
WO/2021/248697A1
Provided are a glucosamine salt produced by means of an enzymatic method, and a purification method therefor. According to the enzymatic method, N-acetylglucosamine is taken as a raw material and is subjected to deacetylase hydrolysis to...  
WO/2021/248696A1
A separation and purification method for N-acetylglucosamine of the present invention relates to the technical field of bioengineering. In the present invention, a raw material liquid containing N-acetylglucosamine is obtained by means o...  
WO/2021/247722A1
The present invention relates to seleno-NSAID compounds, compositions comprising such compounds, and methods of use. In particular, provided herein are compounds, pharmaceutical compositions, and methods of using of the same for treating...  
WO/2021/231397A1
Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.  
WO/2021/231751A1
The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection ...  
WO/2021/227441A1
A compound inhibiting a sodium-glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer thereof. The compound is used in a pharmaceutical composition. Also disclosed are methods for preparing and using the pharm...  
WO/2021/227439A1
Provided in the present invention are a compound for inhibiting sodium glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer of the compound. The compound is used for a pharmaceutical composition, and further...  
WO/2021/222727A1
Described herein are methods of treating a Nontuberculosis Mycobacteria (NTM) infection in a subject in need thereof, the methods comprising administering an effective amount of a polyglucosamine derivative or a composition comprising a ...  
WO/2021/187559A1
The purpose of the present invention is to provide an efficient method for producing 2-deoxy-2-[18F]-fluorosorbitol. The present invention can provide, by bringing an alumina-supported reducing agent into contact with 2-deoxy-2-[18F]-flu...  
WO/2021/170620A1
The present invention relates to a method for producing a glycosyl fluoride of interest, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can...  
WO/2021/160667A1
The present invention is directed to a new cross-linked chitosan, preparations, compositions and uses thereof. In particular, the invention relates to nanoparticles and compositions thereof useful as active agents and delivery systems fo...  
WO/2021/156340A1
The present invention relates to the human Interleukin 1 Receptor antagonist anakinra for use in the treatment of pancreatic ductal adenocarcinoma (PDAC), wherein said treatment comprises administration of a daily dose of approximately a...  
WO/2021/141979A1
Disclosed are C-glycoside amine derivatives of the formula: R-CH2-C(CH3)-NH-R2 wherein R is a saccharide (e.g., as described in U.S. Patent 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3-C(O)-R3 wherein R3 ...  
WO/2021/122793A1
The present invention relates to disaccharide compounds and their use as enhancers of transmucosal drug uptake.  
WO/2021/122738A1
The present invention relates to cell culture media comprising 5-Thio-L- fucose and the use of 5-Thio-L-fucose for modulating the glycosylation profile of antibodies or other Fc containing proteins and thereby modulating the binding affi...  
WO/2021/124234A1
The present invention relates to the separation and isolation of sialylated human milk oligosaccharides (HMOs) from the reaction mixture in which they are produced.  
WO/2021/097619A1
A glucosamine sulfate chloride double salt and a preparation method therefor, said method comprising: (1) carrying out a dissolution reaction with glucosamine hydrochloride and a sulfate; (2) then carrying out an ion exchange reaction be...  
WO/2021/096811A1
Disclosed herein are tucaresol derivative compound and composition containing the same. Also disclosed herein are methods of enhancing immune response in a subject by administering the tucaresol derivative compound or by co-administering...  
WO/2021/055753A1
Methods for inhibiting CMP-sialic acid synthetases and other CMP-sugar synthetases using sugar derivatives such as dehydro-sugars and anhydro-sugars are described, as well as methods for treating conditions including bacterial infections...  
WO/2021/019448A1
The present invention relates to Tafamidis free acid of Formula (I) solid dispersion with a pharmaceutically acceptable carrier as well as process for the preparation of Tafamidis meglumine of compound of Formula (IA).  
WO/2021/015622A1
The current invention concerns methods for the synthesis of 6-azido-6-deoxy-2-N-acetyl-monosaccharide-nucleoside diphosphate, in particular 6-azido-6-deoxy-2-N-acetyl-D- galactosamine-nucleoside diphosphate or 6-azido-6-deoxy-2-N-acetyl-...  
WO/2020/260351A1
The present invention relates to a process for preparing a compound of formula (I), wherein said process is suitable for large scale synthesis.  
WO/2020/239687A1
Novel 18F-labelled tetrazines are provided which are highly reactive to be effective in vivo, suitable for pretargeted positron emission tomography (PET) and accessible in radiochemical yields (RCYs) which allow access to 18F-labeled tet...  
WO/2020/232534A1
Low permeability across the outer membrane is a major reason why most antibiotics are ineffective against Gram-negative bacteria. Agents that permeabilize the outer membrane are typically toxic at their effective concentrations. Here, we...  
WO/2020/227027A1
The present invention provides methods to improve the sensitivity of detecting glycosylamines released from glycoconjugates, such as glycoproteins or glycopeptides, by enzymatic digestion when labeling them with amine-reactive dyes.  
WO/2020/216281A1
A use of a cell wall or a cell wall skeleton of Rhodococcus ruber in preparing a drug for treating a thermal injury. The thermal injury comprises a burn, a scald and a chemical burn. Applying the Rhodococcus ruber product to a subject ha...  
WO/2020/191183A1
Targeting ligand clusters, and methods of preparing same, are described. A targeting ligand cluster may include first linkers attached to phenolic hydroxyl groups of gallic acid, and one or more targeting ligands attached to each of the ...  
WO/2020/175440A1
The present invention provides a method for producing a sugar chain, which achieves an excellent yield of a stereocontrolled sugar chain. The present invention also provides building blocks for sugar donors and for sugar acceptors, which...  
WO/2020/163415A1
The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.  
WO/2019/089080A9
Aspects of the invention relate to novel synthetic compounds having a binding affinity with galectin proteins for the treatment of systemic insulin resistance disorders.  
WO/2020/127417A2
The present invention relates to methods for producing 3-fucosyllactose (3-FL) as well as novel fucosyltransferases, more specifically novel lactose binding alpha-1,3-fucosyltransferase polypeptides, and their applications. Furthermore, ...  
WO/2020/090211A1
Provided is a method of adjusting the stability of double-stranded RNA, the method comprising (1) a step of introducing a modification into the backbone of double-stranded RNA; and (2) a step of bringing the double-stranded RNA provided ...  
WO/2020/040071A1
[Problem] To provide a method for decomposing chondroitin sulfate contained in a sample into disaccharides. [Solution] A method which comprises heating chondroitin sulfate contained in a sample at a temperature of 60-90°C for 50-180 min...  
WO/2020/014386A1
The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy.  
WO/2019/236327A1
Described herein are sulfur-containing glycosaminoglycans, and methods of making and using them. For example, heparosan and hyaluronan analogs are described which incorporate one or more sulfur-containing sugar units that include one or ...  
WO/2019/215164A1
The present invention relates to a composite friction lining material comprising a friction mix and a binder resin, wherein the binder resin comprises a carbohydrate based binder resin, the carbohydrate based binder resin being obtained ...  
WO/2019/179325A1
The present invention relates to the field of carbohydrate chemistry, and discloses a preparation method for a surface capsular polysaccharide structural derivative of Gram-positive bacteria. In the present invention, glucose is used as ...  

Matches 1 - 50 out of 1,525