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WO/1991/018911A2 |
This invention relates to a method of producing peracetyloxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reagent combination, to directly produce the peracetyl oxa...
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WO/1991/018910A1 |
A compound of general formula (I), in which each of R1, R2, R3 and R4 independently represent a hydrogen atom or a group -(CO)nR5 in which n is 0 or 1 and R5 represents an alkyl, aryl, cycloalkyl, alkaryl or aralkyl group, or R1 or R2 to...
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WO/1991/002739A1 |
Methods of stereoselectively preparing a substituted 1,2-anhydrosugar wherein a substituted glycal is converted into a 1,2-anhydrosugar that is utilized to glycosylate a hydroxyl group containing glycal, are disclosed. Methods of prepari...
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WO/1988/000951A1 |
Method of producing peracetyl oxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reactive compound, such as trifilic acid, to directly produce the peracetyl oxazoline.
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WO/1987/006592A1 |
The preparation method comprises the reaction of an aldose or a polyaldoside in hydrogen fluoride, in the presence of water or not, and is characterized in that the concentration of aldose or polyaldoside in the reaction, calculated when...
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WO/1987/002366A2 |
Novel derivatives of the oligosaccharide antibiotic complex 13-384, the derivatives being of general formula (I), wherein R is hydrogen or Z, where Z is a moiety of general formula (II) in which R1 is nitroso, N-hydroxylamino, N-acyl-N-h...
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WO/1987/000529A1 |
Sugar-containing dipeptides of a new type, their manufacture and use in various pharmaceutical, biological and medical applications, in particular for prophylactic purposes against infections, combating infections diseases of various ori...
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WO/1986/005186A1 |
Selective esterification of only one of the hydroxy groups in polyols is achieved using an acetalized or a ketalized polyol as the starting material and an enzyme catalysing esterification. Furthermore, the selective esterified polyols m...
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WO/1985/000814A1 |
The invention relates to a process for the dehydration of glucids, which is applicable to glucids of which the molecule comprises at least one unit of the ketose type, characterized in that the glucid is reacted without addition of water...
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WO/1980/002112A1 |
Novel heterocyclic anthracycline compounds having antitumor activity against murine P388 leukemia in mice.
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WO/1979/001068A1 |
Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido, 2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,...
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WO/1979/001088A1 |
New glucosamin silyl compounds of formula: (FORMULA) wherein X is a carbonyl group, R1, R4 and R6 a tri-alkyl-lower-sylil group, in particular trimethyl-silyl, R2 is an alkyl group eventually substituted or an aryl carbocylic group, R3 i...
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JP2024512568A |
Compounds and pharmaceutically acceptable salts and stereoisomers thereof suitable for the diagnosis and treatment of diseases and disorders characterized by, associated with, or indicative of tissue hypoxia, such as solid tumors, are di...
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JP2024506979A |
This application relates to disaccharide linkers, disaccharide-small molecule drug conjugates and glycoside-specific antibody-drug conjugates, and methods of making and uses thereof. The structure of the disaccharide linker is shown in F...
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JP2024014933A |
The present invention provides compounds for use in the prevention or treatment of joint and bone disorders, such as arthritis and osteoporosis, in mammals. [Solution] Formula (A) [C1] The above-mentioned problems are solved by the compo...
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JP7353281B2 |
The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts th...
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JP2023078126A |
To provide diazaspiro[4.5]decane intermediates and salts thereof useful for preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase 1 (TPH1), and to provide methods for preparing them.This invention relates to...
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JP2023075302A |
To provide guanidine crosslinked artificial nucleic acid.The present invention provides a compound represented by general formula VIII in the figure or a salt thereof. [In the formula, B is a base moiety of nucleic acid optionally substi...
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JP7229917B2 |
The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the int...
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JP7198482B2 |
To provide a compound for endo-β-N-acetylglucosaminidase activity detection.The present invention provides a compound expressed by a formula I in which a combination of a fluorescent group and an extinction group causing fluorescence re...
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JP7187471B2 |
Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of...
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JP2022551187A |
Described are compounds having structures (I), (II), or (V), formulas (I), (II), (V), where R1is -H, -CH2OH or -CH(OH)CH2OH; R2is -H, -OH, or -CH2OH; R3is -H, -OH, or -CH2OH; n is 0 or 1; p is 0 or 1;10is hydrogen or a hydrocarbon moiety...
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JP2022132981A |
To provide a new sugar derivative created by replacing a primary hydroxy group of a sugar.For example, illustrated is a compound to be produced from the following reaction.SELECTED DRAWING: None
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JP2022536712A |
The present invention relates to novel spiro-bicyclic intermediates useful for the synthesis of spiro-bicyclic nucleoside analogues.
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JP7067867B2 |
A compound of formula I:or a salt thereof, wherein:R1 is —OC (H) (X) (CH2)nC(═O)OH;R2 is —OH, —N3, or —N(H)C(═O)CH3; orR1 and R2 together with the carbon atoms to which they are attached formR3 is —H, —CH3, —CH2C(═O)O...
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JP2022068297A |
To provide compounds for treating Filoviridae virus infections, and methods for preparing pharmaceutical compositions.The invention provides a compound for treating Filoviridae virus infection, and a method for preparing a pharmaceutical...
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JP7029572B2 |
A catalyst-free electrochemical deuteration method using deuterium oxide as a deuterium source, adding an electrolyte, an organic compound containing an ethylenic bond or acetylenic bond, deuterium oxide, and an organic solvent into a re...
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JP2022033869A |
To provide a method for producing guanidine crosslinked artificial nucleic acid (GuNA), and an intermediate compound for production thereof.A method for producing a compound represented by general formula I or a salt thereof comprises in...
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JP7025064B2 |
Current synthesis methods for 4'-substituted nucleoside derivatives include a step in which stereoisomers are produced and therefore have problems such as decreased yield and complication of a refinement step. Thus, a synthesis method ha...
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JP6994197B2 |
The present invention provides a method for preparing intermediate compounds for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate compound for the production thereof. Specific...
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JP6923520B2 |
The invention relates to new compounds of formulae: Wherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C...
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JP6916180B2 |
This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containi...
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JP6889232B2 |
The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves sub...
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JP6857359B2 |
There is provided a novel gelator including a sugar derivative. A gelator comprising a compound of Formula (1) or Formula (2):wherein R1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group hav...
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JP2021508737A |
The present invention relates to secondary functional moieties including transition metal based linkers and primary functional moieties attached thereto. The secondary functional moiety according to the present invention comprises a tran...
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JP2021508732A |
Provided are compounds of formula (A) used in the prevention or treatment of joint and bone disorders in mammals, such as arthritis and osteoporosis, as well as pharmaceutically acceptable salts and esters thereof, and pharmaceutical com...
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JP2020158489A |
To provide a bicyclic ulosonic acid derivative and a method for producing an ulosonic acid derivative, with which the intended bicyclic ulosonic acid derivative and the ulosonic acid derivative of α-form which has a specifically high α...
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JP6761564B2 |
Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)meth
yl]pheny...
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JP6749644B2 |
To provide: a method of chemically synthesizing α(1→4) glycoside cyclic trimers and tetramers; and α(1→4) glycoside cyclic trimers and tetramers that have not been synthesized before.The present invention provides α(1→4) glycosi...
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JPWO2018143140A1 |
General formula (1A):[In the formula, Y is a carbonyl group, a sulfonyl group or a substituted or unsubstituted alkylene group; R1And R2Are the same or different, hydrogen atom or hydroxyl group; R3Is a hydrogen atom, a substituted or un...
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JP2019520342A |
The present invention describes a novel conjugate of a drug and part of formula (I) that can bind to a glucose-sensing protein that allows the reversible release of the drug depending on the glucose concentration.
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JP6455857B2 |
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JP2018203621A |
To provide novel amide compounds modified with N-linked sugar chain.The amide compound modified with N-linked sugar chain of the invention is represented by Formula (1). The cyclic structure Ain Formula (1) is a sugar or sugar derivative...
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JP2018199706A |
To provide a novel oligosaccharide or polysaccharide containing a 1,2-cis form of amino sugar.The present invention provides a sugar chain compound described in (g), the sugar chain compound containing a 1,2-cis form of sugar residue. (g...
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JP6370490B2 |
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing ...
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JP6347742B2 |
There is provided a novel gelator containing a sugar derivative. A gelator comprising a compound of Formula (1) or Formula (2): wherein each of R 1 and R 3 is independently a linear or branched alkyl group having a carbon atom number of ...
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JP6342968B2 |
To provide novel sugar derivative production methods which can prepare novel sugar derivatives simply and securely, and to provide novel sugar derivatives which can be produced by the production methods.The present invention provides a s...
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JP6334676B2 |
Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl
-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
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JP6193513B2 |
Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting a...
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JP6175138B2 |
The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug...
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