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JP5150607B2 |
According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
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JP5065019B2 |
The present invention provides methods of producing compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use...
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JP5061061B2 |
The invention provides an improved process for the preparation of 17-esters of 9 alpha ,21-dihalo-pregnane-11 beta ,17 alpha -diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids according to the...
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JP5004234B2 |
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JP5005127B2 |
Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver.
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JP5000294B2 |
There is provided a compound of Formula I wherein (I) R 1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R 2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substitu...
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JP2012149076A |
To provide a process for the preparation of 17-esters of 9 α,21-dihalo-pregnane-11β,17α-diol-20-ones.The process for the preparation of related 17-esters, represented by the following formula, includes reacting 17α-hydroxy of 9α,21-...
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JP4959276B2 |
Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 posi...
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JP4903922B2 |
Compounds having an ansamycin anitibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic ...
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JP2012036222A |
To provide a corticosteroid which is therapeutically effective in treating a disease of an airway passage and a lung such as asthma and which also exhibits low bioavailability and low systemic side-effects when it is administered intra-n...
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JP4856071B2 |
A synthetic method of 20(s)-ginsenoside Rh2, that is 20(S)-protopanaxdiol-3-O-beta-D-glucopyranoside, is comprised of: protecting protopanaxdiol (A1) selectively first to produce monosubstituted protopanaxdiol (A2); and Glycosidating the...
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JP4838493B2 |
There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I)or a solvate thereof.
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JP4838494B2 |
A pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein (a) a glucocorticoid of formula (I) wherein R represents a 5 membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O, N ...
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JP4838895B2 |
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JP4838894B2 |
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JP4824223B2 |
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JP4811953B2 |
The present invention herein provides a proliferation inhibitor of Helicobacter pylori comprising a compound that can simply be mass-produced, can specifically inhibit the proliferation of H. pylori, which has high safety and never gener...
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JP4787752B2 |
Novel isolated and purified withanamides and withanolides are described. In particular, compounds from Withania somnifera fruit are the preferred source of the withanamides and withanolides, although they can be from other plant sources....
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JP4728805B2 |
A drug product which can maximize the effect of a cholestanol glycoside useful as an anticancer agent. The present invention provides a liposomal composition containing a glycoside exhibiting antitumor activity, a phospholipid, and a pos...
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JPWO2009110612A1 |
The present invention has an object of finding a new function of a germinated brown rice-containing component, which is highly safe, can be continuously ingested, can be produced in large quantities, can be easily added to foods and the ...
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JP2011057585A |
To pay an attention on sterol glycosides contained in germinated unpolished rice to clarify a new action mechanism thereof.There are provided an antidepressant agent containing sterol glycosides originated from germinated unpolished rice...
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JP2011507878A |
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: wherein L, R1, R2, R3, R4, R5, and R6 are...
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JP4647909B2 |
The present invention relates to the use of the glucocorticoid receptor antagonist (11²,17²)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propy
nyl)estra-4,9-dien-3-one (Org 34517) for the preparation of a medicament for the treatment of...
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JP4648891B2 |
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, ...
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JP4610734B2 |
Compounds having the following structure which are provided to provide glyco-steroid compounds having a potent anti-inflammatory effect and little side effects. The above compounds are easily metabolizable steroid compounds substituted a...
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JP2010280701A |
To provide a pharmaceutical formulation for administration by inhalation having a therapeutically useful effect in the treatment of inflammatory disorders of the respiratory tract.The pharmaceutical formulation containing a compound of f...
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JP4589869B2 |
A process for producing a raw material for the formation of proton-exchanged zeolite analogues whose cations are wholly or partially exchanged by H<+> and which contain zeolite having tektosilicate structure, characterized by the step of...
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JP4580041B2 |
To provide an antioxidant which is highly safe, inhibits oxidation of a biological component, in particular, a lipid, and is used as a drug, food or drink, a food additive, an external preparation for skin, or the like. The antioxidant c...
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JP4580242B2 |
There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (compound K), a chief metabolite of ginseng sa...
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JP4549625B2 |
Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin obtained by conversion of glucose, i.e. compound K (20-O- beta -D-glucopyranosyl-20(S)-protopanaxadiol), ginsenoside F1 (20-O- beta -D-glucopyra...
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JP4545929B2 |
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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JP4541166B2 |
Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
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JP4530851B2 |
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, V represents a...
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JP2010159211A |
To provide a new method for producing a withanolide compound. There is provided a method for producing a compound represented by formula (2) (wherein, R1, R2are each H, methyl or the like; R3, R4are each H or OH; R5is OH, a sugar chain, ...
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JP4508651B2 |
There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in that the crystalline complex is of space group P212121 having u...
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JP4495456B2 |
There are provided compounds of formula (I) wherein R1 represents O, S or NH; R2 represents -C(-O)-aryl or -C(-O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the alpha or beta configuration) or methylene; R4 and R5...
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JP4474101B2 |
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
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JP4464679B2 |
This invention relates to a process for producing sapogenins and ginsenosides comprising the steps of mixing a ginsenoside extract with water, mixing the ginsenoside extract and water with an alkali-metal alcoholate solution or a hydroxi...
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JP2010100529A |
To provide an ADHD-related disease medicine exhibiting simple and high effects.There is provided a compound of structural formula (1), wherein R1 and R2 are each independently H, OH, a sugar moiety, or the like.
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JP2010095528A |
To provide a non-thermally reversible photochromic compound.The invention relates to a photochromic compound which may be thermally reversible or non-thermally reversible, and the like. The invention also relates to a photochromic dichro...
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JP4436041B2 |
According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
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JP4427900B2 |
The invention provides a medicament comprising a sialic acid derivative represented by the following formula and have superior solubility and absorbability. A solid dispersion comprising a water soluble macromolecule such as hydroxypropy...
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JP2010500323A |
The invention provides the use of a glucocorticoid receptor antagonist for the manufacture of a medicament for immune stimulation, such as prevention or treatment of infections or infectious conditions, in an aging mammalian subject, a m...
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JP2009256388A |
To provide a new hybrid drug for cancer treatment and for releasing the drug by setting a target on cancer cells.Provided is a hybrid drug for cancer treatment, having a targeting moiety specifically bonding with proteins, receptors and ...
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JP4338306B2 |
The invention relates to the steroidal saponin compounds for the propylaxis or treatment dementia, the new steroidal saponin compounds and the pharmaceutical composition containing the same.
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JP4272518B2 |
The cholesterol derivative, represented by the following formula (1): wherein R represents a C3-C23 saturated or unsaturated aliphatic hydrocarbon residue having an optional substituent, and, to the cholesterol backbone, -OH, -CHO, -COOH...
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JP2009102226A |
To provide a drug for recovery from a spinal cord injury recovery exhibiting simple and high effects, to provide a food, a medicine composition containing the same, and to provide a spinal cord injury recovery method.Provided is Withanos...
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JP4263817B2 |
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JP2009515828A |
The disclosure provides androsterone derivatives. The derivatives of the disclosure are useful in the treatment of androgen- and estrogen-associated diseases and disorders, including breast cancer.
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JP2009512422A |
The present invention discloses osteogenic and anti-adipogenic oxysterols. Agents and methods for protecting, blocking or rescuing marrow stromal cells from the inhibitory effects of oxidative stress on their osteoblastic cellular differ...
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