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JPH0772193B2 |
A novel steroid of the formula I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carb...
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JPH0745511B2 |
Compounds of formula (I) : in which, inter alia, R<1> is H or C1-8alkyl and M is O or S, processes for their preparation, pharmaceutical compositions containing then and their use as inhibitors of 5- alpha -reductase in the treatment in ...
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JPH07503466A |
PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can...
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JPH0649717B2 |
The intermediate products of formula (II): R' = especially H or optionally substituted alkyl, alkenyl, alkynyl, aryl or aralkyl, hydroxyl, tetrahydropyranyl, tert-butoxy, optionally esterified carboxyl, amino, mono- or dialkylamino, trit...
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JPH0637514B2 |
Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials, and novel intermediates useful in this process.
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JPH0635476B2 |
Oestrane and androstane derivatives of the general formula I in which X is a bromine atom, an iodine atom, a triphenyltin group or a trialkyltin group with 1 to 6 carbon atoms per alkyl radical, Y is two hydrogen atoms or one methylene g...
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JPH0656670A |
PURPOSE: To obtain a new derivative useful for treatment of hyperlipemia, having ability to regulate directly or indirectly, synthesis of LDL receptor at chromosome level. CONSTITUTION: The compound of formula I R<1> is 1-4C alkyl or 1-4...
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JPH0641187A |
PURPOSE: To produce a new compd. having excellent local antiinflammatory action, showing good local to systemic antiinflammatory activity and useful as agents for treating inflammatory and allergic dermatosis. CONSTITUTION: The compd. of...
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JPH0573394B2 |
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JPH0564638B2 |
6,6-ethylene-15,16-methylene-3-oxo-17 alpha -pregn-4-ene-21,17 alpha -carbolactones of general Formula I (I) wherein is a CC-single of CC-double bond, R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, and exhibit st...
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JPH0564639B2 |
1. Claims for Contracting States BE, CH, LI, DE, FR, GB, IT, LU, NL, SE 17-substituted estradienes of general formula I see diagramm : EP0156284,P17,F3 wherein see diagramm : EP0156284,P17,F4 is see diagramm : EP0156284,P17,F5 or see dia...
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JPH0559919B2 |
6 alpha ,16 alpha -Dimethyl corticoids of general Formula I (I) wherein the bond is a single bond or a double bond, X is a hydrogen atom, a fluorine atom, a chlorine atom, or a bromine atom, R1 is a formyl group, an alkanoyl group or alk...
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JPH0559918B2 |
11 beta -Arylestradienes of general Formula I are disclosed (I) wherein R2 is a hydrogen atom, a methyl group, or an ethyl group, R3 is a hydrogen atom or an acyl group, R1 and A-B have various meanings, which possess antigestagen and an...
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JPH05504561A |
A process for preparing oxazoline corticosteroid intermediates of formula (V) wherein R<1> represents hydrogene (H), loweralkyl, phenyl or phenylalkyl; R<4> represents H or loweralkyl, preferably methyl having either the alpha or beta st...
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JPH0535158B2 |
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JPH0533235B2 |
Novel corticoid 17 alpha -alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are useful for the treatment of acute and ...
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JPH0565293A |
PURPOSE: To provide a new compd. which has positive contractive inotropic activity and vasodilation activity and is useful for treatments for diseases in nerve circulatory system, especially for heart failure and hypertension. CONSTITUTI...
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JPH0518838B2 |
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom a...
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JPH0518837B2 |
11 beta -Arylspirolactones in the steroid series of the general formula I in which R1 is with R and R meaning in each case alkyl with 1 to 4 carbon atoms or R and R, with the inclusion of N, meaning a 5- or 6-membered saturated heterocyc...
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JPH0559096A |
PURPOSE: To obtain a new amino steroid compd. having high antiarrhythmic activity and local anesthetic activity and producing no significant effect on cardiac blood output and blood pressure as an aminoalkyl steroid compd. having a speci...
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JPH056558B2 |
Compounds of Formula I and II are useful as potent antiarrythmic agents without significant effect on cardiac output and blood pressure.
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JPH054397B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH0480920B2 |
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JPH0475919B2 |
Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17 alpha -acyl progesterones.
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JPH0470319B2 |
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JPH0466879B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH0466878B2 |
Novel 6-oxygenated corticoid 17 alpha -carbonates are disclosed. These compounds have strong topical anti-inflammatory activity which are accompanied by extremely weak systemic adverse reaction. The present compounds are useful for the t...
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JPH0459297B2 |
Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formulawherein Q isand R1 is a saturat...
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JPH04505324A |
PCT No. PCT/DE90/00383 Sec. 371 Date Jan. 14, 1992 Sec. 102(e) Date Jan. 14, 1992 PCT Filed May 23, 1990 PCT Pub. No. WO90/14354 PCT Pub. Date Nov. 29, 1990.9 alpha -Hydroxy-19,11 beta -bridged steroids of general formula I (I) are descr...
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JPH04230696A |
PURPOSE: To provide a new steroidal compound synthesized from a diosgenin compound, etc., through epoxidization, reduction, halogenation, alkylation, etc., exhibiting strong cytotoxic action on L1210 leukemia cell and useful as a carcino...
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JPH0443920B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH0443077B2 |
Novel 19-nor-steroids of the formula I wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydrocarbon of 1 to 8...
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JPH0437080B2 |
13-Alkyl-11 beta -phenylgonanes of the general formula I in which A and B together are an oxygen atom, a CH2 group or a second bond between carbon atoms 9 and 10, X is an oxygen atom or the hydroxyimino group N-OH, n is the number 0 or 1...
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JPH0436160B2 |
7 alpha -acylthio-1 alpha ,2 alpha -methylene-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactones of Formula I (I) wherein and R is a lower saturated acyl radical of 2 to 4 carbon atoms, have a stronger antialdosterone effect and lower side ...
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JPH0415800B2 |
Novel 6 alpha -methylprednisolone derivatives of the general formula I (in which R1 represents C2-C6-I-oxoalkyl or benzoyl and R2 represents H, C2-C6- I-oxoalkyl or benzoyl) and a process for their manufacture. The novel compounds are us...
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JPH0415799B2 |
6 alpha -Methyl corticoids of formula I (I) wherein is a single bond or a double bond, R is acyloxy of up to 8 carbon atoms, and X is chlorine, hydroxy, or acyloxy of up to 8 carbon atoms, are pharamacologically effective substances.
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JPH0415239B2 |
Compounds of Formula I wherein the bond is a single bond or a double bond, X is hydrogen, fluorine, chlorine, or bromine, R1 is formyl, alkanoyl or alkoxyalkyl each of which contains 2-8 carbon atoms, or benzoyl, and Y is chlorine, hydro...
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JPH0411558B2 |
7 alpha -Alkoxycarbonyl-15 beta ,16 beta -methylene-4-androstene compounds of Formula I (I) wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, X is and Y is carbonyl, and the bond between the C-1 and C-2 carbon atoms is a...
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JPH0421695A |
PURPOSE: To obtain a new-type therapeutic agent for hypertension capable of significantly suppressing the vasopressor action by using an antagonistic substance against hydroxyandrost-dione as an active component. CONSTITUTION: The object...
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JPH0379329B2 |
An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid...
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JPH0372080B2 |
7 alpha -acylthio-15,16-methylene-3-oxo-17 alpha -pregna-1,4-diene-21,17-carbolactones of the formula wherein the 15,16-methylene group can be in the alpha - or beta - configuration, and R is a lower alkyl residue, have altialdosterone a...
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JPH0370720B2 |
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JPH0369919B2 |
1. Claims for the Contracting States BE, CH, LI, DE, FR, GB, IT, LU, NL, SE 13 alpha-Alkyl gonanes of general formula I see diagramm : EP0129499,P14,F3 wherein R**1 means -N R**II -R**I wherein R**I and R**II are hydrogen or alkyl of 1-4...
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JPH0369359B2 |
A simple process for preparing 3-( DELTA 4-3-keto-steroid-17 alpha -yl)propionic acid lactones of the androstane series represented by the general partial formula wherein ABCD represents an optionally substituted cyclopentanophenanthrene...
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JPH0359918B2 |
A process for preparing 6-methyl-Δ4,6-3-keto steroids ofwherein X is, comprises reacting a corresponding Δ4-3-keto steroid with methoxymethyl acetate (CH3-O-CH2-OAc) in an inert solvent at temperatures above room temperature in the pre...
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JPH03504005A |
Agents for treating cardiac insufficiency, consisting of compounds of general formula (I), where R denotes an alkoxycarbonyl group or an acylthio group each having 2 to 5 C atoms, and the bond between the carbon atoms 1 and 2 is saturate...
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JPH0358359B2 |
11 beta -Chloro- DELTA 15-steroids of Formula I (I) wherein R1 is hydrogen or acyl and R2 is ethynyl, chloroethynyl, or propynyl have strong progestational activity.
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JPH0357116B2 |
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JPH03169890A |
NEW MATERIAL: Compounds of formula I (ring D has a double bond shown by the broken line with proviso that ring D is 16-17C containing no double bond when R2 represents two substituents or a divalent substituent; X is keto, H or OH; R1 is...
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JPH0395120A |
PURPOSE: To obtain a spironolactone composition comprising an effective dose of a spironolactone, an emulsifier, a proper solvent, a buffering agent and water, extremely stable on storage for a long period, and useful for treating acne, ...
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