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JPH0381288A |
NEW MATERIAL: A compd. of formula I, [where X is two Hs or one O; R is an amino alkyl residue of -(CH2)n-NR1R2, (where R1 and R2 are each 1-4C alkyl), or a sugar residue -W, (where W is aminodeoxy sugar of D- or L-series); a dotted line ...
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JPH037678B2 |
The invention relates to a method of preparing DELTA 5,7-steroids, in particular 7-dehydrocholesterol compounds, of the general formula: wherein R is a hydrogen atom, a hydroxy group, optionally etherified with a C1-C4 alkanol or esterif...
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JPH03500296A |
Androstane derivatives of the general Formula I (I) in which R1 represents a hydrogen atom or a methyl group, X and Y each mean hydrogen atoms or together a carbon-carbon bond, and R2 symbolizes a hydrogen atom or an alkyl group with 1 t...
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JPH033678B2 |
Androstane derivatives of Formula I (I) wherein is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, -X- is -(CH2)n-, -CH=CH(CH2)m-, or -C 3BOND C-(CH2)m- wherein n is 2 to 6 and m is 1 t...
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JPH033677B2 |
17 alpha -Alkyl-17 beta -hydroxy-1 alpha -methyl-4-androsten-3-ones of the formula wherein R is a straight-chain alkyl residue of 3-8 carbon atoms, i.e., C3-8-n-alkyl, are pharmacologically active compounds distinguished by antiandrogeni...
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JPH0261480B2 |
Progesterone derivatives having a vinylidene or a 1-alkynyl substituent at the 18-position and further optionally hydroxylated at the 11-position and the 21-position are described herein. Compounds having both an ethynyl substituent and ...
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JPH02504519A |
1$g(b),15$g(a)-Dihydroxy-1$g(a)-methyl-5$g(a)-androstan-3,17
-dione of formula (I) and its subsequent processing to pharmacologically active steroids.
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JPH0257559B2 |
6 alpha -methylhydrocortisones of Formula I wherein R1 is alkanoyl of 2-6 carbon atoms or benzoyl and R2 is hydrogen or alkanoyl of 2-6 carbon atoms have valuable antiinflammatory properties.
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JPH0250919B2 |
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom a...
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JPH0249320B2 |
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5 alpha -androstanes having the formula: wherein: R1=H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the N-atom a piperidino, pyrr...
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JPH02243698A |
PURPOSE: To provide the subject compsn. for treating uterine cancer containing a diluent or a carrier and a specific (substd.) estrogen nucleus as a part of a molecular structure and a therapeutically effective amt. of a sexual steroid a...
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JPH0242840B2 |
New spirolactones of the formula (I) wherein +tr R is a lower alkyl of up to 5 carbon atoms, and +tr
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JPH0234958B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH02180895A |
PURPOSE: To obtain an intermediate for brassinosteroids useful as a plant growth regulator by subjecting two specific kinds of compounds to ene reaction, reducing the resultant product, hydrolyzing the reduction product and deprotrecting...
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JPH02180896A |
NEW MATERIAL:A compound expressed by formula I [formula II is formula III or IV (R1 is 1-4C alkyl, 1-4C alkoxyl-1-2C alkyl or tetrahydropyranyl); R is H, lower alkyl or lower alkenyl]. USE: An intermediate for vitamin Ds and brassinoster...
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JPH0216760B2 |
13 alpha -Alkylgonanes of the general formula I in which R<1> is with R and R meaning hydrogen or alkyl with 1 to 4 carbon atoms or R and R with inclusion of N meaning a saturated 5- or 6-membered ring, it also being possible for the rin...
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JPH0215560B2 |
A novel epoxidation agent comprising hydrogen peroxide and hexachloroacetone and a novel process for epoxidizing an acyclic, cyclic or polycyclic compound containing at least one ethylenic unsaturation.
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JPH0214360B2 |
Compounds of the formula wherein the 15,16-methylene group is in the alpha - or beta -position, and E is +TR are useful as diuretics.
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JPH0212480B2 |
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JPH0212479B2 |
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an alpha -oriented lower alkox...
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JPH027959B2 |
11-Methylene- DELTA 15-steroids of Formula I (I) wherein R1 is hydrogen or acyl and R2 is ethynyl, chloroethynyl or propynyl, are distinguished by a strong progestational activity and exhibit only a very low androgenic side effect.
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JPH027600B2 |
Novel DELTA 4,9-gonadiene-21-ol-3,20-diones of the formula I wherein X is selected from the group consisting of hydrogen and tritium, R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 12 carbon atoms and R3 is alkyl of 1 to 4 carbo...
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JPH021159B2 |
Aromatase inhibitors are provided having the formula +TR wherein represents a single or double bond; R is hydrogen or C1-4 alkyl; R1 is methyl or ethyl; R2 is (H) (OR8) or =O; R3 is H or C1-3 alkyl; R4 is H or OR8; R5 is H, C1-3 alkyl or...
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JPH0153280B2 |
17 alpha -substituted steroids of the formula wherein R1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, R2 is alkyl or alkenyl of 2-6 carbon atoms, X is oxygen or the...
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JPH0149278B2 |
6 alpha -Methylprednisolone derivatives of Formula I (I) wherein R1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl and R2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious compounds, e.g., as antiinflammatories.
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JPH0133115B2 |
Novel steroids of the formula I' wherein R is selected from the group consisting of R1 and R2, R1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R2 is -(CH2)n-R3, n is...
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JPH0128760B2 |
PCT No. PCT/DE81/00111 Sec. 371 Date Mar. 11, 1982 Sec. 102(e) Date Mar. 11, 1982 PCT Filed Jul. 2, 1981 PCT Pub. No. WO82/00294 PCT Pub. Date Feb. 4, 1982.The disclosure concerns 5 beta -hydroxy- DELTA 6-steroids of the general formula ...
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JPH0123476B2 |
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JPH0122280B2 |
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JPH0121759B2 |
A process for preparing a 3 beta ,7 beta -dihydroxy- DELTA 5-steroid of the formula wherein Q is and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3 be...
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JPH0121158B2 |
Irreversible aromatase inhibitors are provided having the formulae I II wherein represents a single or a double bond; R1 is CH3 or C2H5; R2 is (H) (OR8) or O; R3 is H or C1-3 alkyl; R4 is H or OR8; R5 is H2, O or (H) (C1-3 alkyl); R6 and...
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JPH01500903A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPH0112758B2 |
What is disclosed is corticoid 17-(alkyl carbonates) of the formula as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of suspensions, ointments, creams, sprays and the like,...
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JPS6357438B2 |
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JPS63503066A |
A process is used for producing 7$g(a)-propylsteroids having general formula (I), wherein R?1 is a $g(b)-hydroxy group and R?2 is hydrogen or a $g(a) linked -CH2?-CH2?COOR?5 residue, R?1 and R?2 form together the residue (A), R?3 and R?4...
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JPS6356237B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6356235B2 |
A process for preparing a 6-methylene- DELTA 4-3-keto steroid of the formula wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the CD-r...
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JPS6355520B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6355488B2 |
Pharmaceutically utilisable 3-ketosteroids which are disubstituted in position 16 and have the formula I in which R3 are alkyl radicals with 1 to 5 carbon atoms, alkenyl or cycloalkyl radicals with 3 to 6 carbon atoms or phenylalkyl radi...
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JPS63258893A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6352635B2 |
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JPS63246394A |
NEW MATERIAL:A compound expressed by formula I (R1 is H or OH protecting group; R2 is O or ketone protecting group). EXAMPLE: (20R/S)-20-Aetoxy-5α-pregna-2-ene-6-one. USE: A precursor of pregnan-20-one derivative having steroid nucleus....
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JPS63201197A |
11 beta -substituted steroids of the formula wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pen...
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JPS6340198B2 |
17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially...
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JPS6337800B2 |
A process for the synthesis of 1 alpha ,3 beta -dihydroxy- DELTA 5-steroids from steroids such as 1 alpha ,2 alpha -epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and sub...
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JPS6337799B2 |
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JPS63159395A |
PURPOSE: To industrially and advantageously obtain the titled compound useful as a synthetic intermediate for vitamin Ds, brassinolides which are plant growth regulators and ecdysone derivatives which are insect molting hormones, by appl...
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JPS634560B2 |
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JPS631320B2 |
Novel 11 beta -substituted- DELTA 9-ene-5 alpha -ols of the formula I wherein K is a blocked ketone in the form of a ketal, thio-ketal or methyloxime, X is a pentagonal or hexagonal ring optionally substituted, R1 is selected from the gr...
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JPS6257638B2 |
Novel 11 beta -substituted- DELTA 1,3,5(10)-estratrienes of the formula I wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon ...
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