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JP2683395B2 |
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JP2677626B2 |
The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula wherein each of R and R3, independently, is hydrogen or C1-C6 alkyl; R1 is hydrogen, halogen or C1-C6 alkyl; R2 is hydrogen or C1-C6 al...
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JP2675418B2 |
Compounds of formula (I) in which X<1>, X<2> and X<3> are hydrogen, halogen, CF3, C1-6alkyl, OH, C1-6alkoxy, CN, NO2, N(R<1>)2, CHO or CO2R<1>; A is O or S, n is 0 or 1, R<1> is H or C1-8alkyl and R<3> is alpha -H, alpha -OH, or alpha -a...
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JP2660413B2 |
Compounds (I): in which: R1 is hydrogen or methyl, R2 is methyl or ethyl, the nuclei A, B, C and D carry optionally one or more double bonds and are optionally substituted by one or more functional groups or by one or more atoms or radic...
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JP2660404B2 |
1. The products of formula I : see diagramm : EP0245170,P90,F1 in which R1 represents an alkynyl radical having from 2 to 8 carbon atoms optionally substituted by a radical selected from the radicals, hydroxyl, halogen, trialkylsilyl, al...
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JPH09509959A |
Compounds having a broad range of antimicrobial activity generally have a structure including a steroid nucleus with a cationic, preferably polyamine, side chain (X) and an anionic side chain (Y). The invention is also directed to compou...
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JP2659279B2 |
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JP2652007B2 |
PCT No. PCT/FR87/00096 Sec. 371 Date Nov. 25, 1987 Sec. 102(e) Date Nov. 25, 1987 PCT Filed Mar. 26, 1987 PCT Pub. No. WO87/05908 PCT Pub. Date Oct. 8, 1987. (I) (II) (III) (IV) (V) (VI) Products having the formula (I) wherein R1 is an a...
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JP2647882B2 |
A compound of general formula, in substantially pure form, wherein A is a cation. A method for preparation is also disclosed, together with compositions and methods of use thereof.
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JP2642089B2 |
Bile acid derivatives of the formula I W-X-G in which G is a bile acid residue, W is an active substance portion of a medicament and X is a linker between bile acid residue and active substance portion, are outstandingly suitable for int...
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JP2642090B2 |
Bile acid derivatives of the formula I W-X-G in which G is a bile acid residue, W is an active substance portion of a medicament and X is a linker between bile acid residue and active substance portion, are outstandingly suitable for int...
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JPH09208597A |
To obtain a (24R)-24,25-dihydroxysteroid compound in a high yield in a highly excessive diastereomer rate by subjecting a specific steroid compound to a catalytic dihydroxylation reaction in the presence of a specified osmium complex in ...
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JPH09169650A |
To prepare the subject composition, comprising an antioxidizing dose of a specific dehydroestrone, etc., and useful for treating or inhibiting disease conditions induced by free radicals. This preparation comprises an antioxidizing dose ...
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JP2599606B2 |
A compound of the formula I wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, the A,B,C and D rings optionally have one or more double bonds and are optionally substituted with one or more members of the group consisting of haloge...
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JPH09503514A |
PCT No. PCT/EP94/03296 Sec. 371 Date Jul. 10, 1996 Sec. 102(e) Date Jul. 10, 1996 PCT Filed Oct. 6, 1994 PCT Pub. No. WO95/10528 PCT Pub. Date Apr. 20, 1995The invention relates to a process for the production of sulfuric acid semi-ester...
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JPH09503228A |
The present invention provides a compound of formula (I), wherein A is a bond or a straight or branched C1-C6 alkylene chain; W is a group -R1, -OR2, -NR3R4 or (a) wherein: Y is oxygen or sulphur; R1, R2 and R4 are: a C1-C10 alkyl group,...
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JP2593685B2 |
This invention is directed to 17 beta -(cyclopropyloxy)androst-5-en-3 beta -ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Sim...
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JP2588267B2 |
New 19,11 beta -bridged steroids of the general formula I (I) where R1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrog...
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JPH09501433A |
The applications discloses the treatment of inflammatory disorders, in particular those associated with rheumatoid, arthritis, gout, gouty arthritis and Behcet's syndrome, with 2-methoxyestradiol.
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JP2577771B2 |
Compounds of the general Formula (I) (I) in which R is a hydrogen atom or a bromine atom, and R1 is a hydrogen atom, an SO2OM group wherein M is a hydrogen or sodium atom, various sulphatide or phosphatide groups or a glucuronide group a...
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JP2568306B2 |
Bile acid derivatives of the formula I W-X-G in which G is a bile acid residue, W is an active substance portion of a medicament and X is a linker between bile acid residue and active substance portion, are outstandingly suitable for int...
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JP2554878B2 |
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JP2550777B2 |
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JP2549724B2 |
Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl)amides of the formula (I): HOC(O)-(CH2)n-C(O)-N(R1)-CH2CH2SO3 <-> <+> HN(R2)3, wherein R1 is selected from the group consisting of hydrogen, C1-C8 alkyl and phenyl, R2 is ...
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JP2545522B2 |
This invention provides novel tetrahydro steroids which are useful in inhibiting angiogenesis and have the following structure: A compound of the formula: wherein R1 is beta -CH3 or beta -CH2H5; wherein R2 is H, and R3 is =0, -OH, -0-alk...
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JPH08245687A |
PURPOSE: To obtain the subject new compound which is an N-substituted carbamide derivative of 3-carboxy-androst-3,5-diene and useful for treatment, etc., of acne, seborrhoica, hirsutism, alopecia, etc., as a testosterone 5α-reductase in...
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JPH08508506A |
PCT No. PCT/DE94/00316 Sec. 371 Date Nov. 6, 1995 Sec. 102(e) Date Nov. 6, 1995 PCT Filed Mar. 18, 1994 PCT Pub. No. WO94/24146 PCT Pub. Date Oct. 27, 1994Novel androgens having one or more substituents providing radical trapping propert...
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JPH08225590A |
To obtain the subject new compound, a specific steroid with a 17- spiromethylene lactone group or the like, with low affinity for a progesterone receptor and slight side effects, and usable as a contraceptive, or in treating menstrual di...
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JP2525664B2 |
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JPH08503473A |
Invented are novel 17 alpha -acyl steroidal 5 alpha -reductase inhibiting compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alpha -reductase. Also invented are ...
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JPH08503471A |
Invented are 17 alpha and 17 beta -substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alpha...
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JPH0826062B2 |
9-Alpha-hydroxy- steroids (I) contg. a D-ring of formula (A) are new; R2 = ethynyl (provided R5 is not acetoxy if R4 = H), haloethynyl, opt. protected OH, cyano, 1'-Ra-ethenyl; or 1',1'-trimethylene dithio-ethyl; Ra = 1-6C alkoxy or alky...
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JPH08500821A |
Invented are 17 alpha and 17 beta -alkylketone-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alph...
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JPH08500576A |
The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
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JPH07116222B2 |
A process for preparing 21-desoxyprednisolone 17-esters of formula (IV) is disclosed. The process comprises reacting a prednisolone 17 alpha ,21-cyclic orthoester with an acid in a 40-60% lower alcohol solution to produce a prednisolone ...
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JPH07316186A |
PURPOSE: To obtain a novel nor-bile derivative obtained by bonding plural bile acid groups, having high affinity with a bile acid-transporting system of intestine, capable of inhibiting bile acid absorption and useful as antihyperlipidem...
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JPH07112350B2 |
An electric power apparatus, namely a variable inductor comprising a magnetic core provided with a center limb and two outer limbs all having first and second ends. The first ends are interconnected through a first common point of the ma...
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JPH0791312B2 |
1. The products of general formula I : see diagramm : EP0237397,P31,F2 in which R represents : - either a hydrogen atom, - or an alkyl, alkenyl or alkynyl radical having at most 8 carbon atoms possibly substituted by a radical chosen fro...
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JPH07508034A |
PCT No. PCT/US93/04633 Sec. 371 Date Mar. 20, 1995 Sec. 102(e) Date Mar. 20, 1995 PCT Filed May 17, 1993 PCT Pub. No. WO93/23038 PCT Pub. Date Nov. 25, 1993Novel amino substituted 4-azasteroid 5 alpha -reductase inhibitors of formula (I)...
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JPH07215992A |
PURPOSE: To obtain a new derivative which is a 6- or a 7-substituted androsta-1,4-diene derivative, having excellent inhibiting actions on an aromatase, capable of inhibiting the biosynthesis of estrogens and useful as a therapeutic agen...
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JPH0772193B2 |
A novel steroid of the formula I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carb...
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JPH07196684A |
PURPOSE: To provide new steroid compounds of substituted 2β-morpholino- androstane derivatives having very potent anaesthetic activity and fast onset times and ideal sleep duration vs. recovery to full coordination profiles which are us...
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JPH07506363A |
PCT No. PCT/US93/03778 Sec. 371 Date Oct. 28, 1994 Sec. 102(e) Date Oct. 28, 1994 PCT Filed Apr. 22, 1993 PCT Pub. No. WO93/22333 PCT Pub. Date Nov. 11, 1993Invented are 17 alpha and 17 beta -substituted acyl-3-carboxy aromatic A ring an...
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JPH0764804B2 |
There are disclosed herein novel derivatives of 26,26,26,27,27,27-hexafluorovitamin D3 providing excellent pharmacological effects, and a process for the preparation thereof. These novel compounds are represented by the general formula w...
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JPH0764869B2 |
The invention refers to compounds having anti-inflammatory activity characterized by the formula or a stereoisomeric component thereof, in which formula X1 represents a hydrogen, chlorine, bromine or fluorine atom; X2 represents a hydrog...
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JPH0753750B2 |
The invention provides novel pregnane derivatives having the formula: wherein X = F, Cl or Br; R1 = F or Cl; R2 = H( beta OH) or O; R3 = alkyl(1-4 C); R4 = alkyl(1-4 C); and the dotted line indicates the optional presence of a double bon...
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JPH0749437B2 |
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JPH0745511B2 |
Compounds of formula (I) : in which, inter alia, R<1> is H or C1-8alkyl and M is O or S, processes for their preparation, pharmaceutical compositions containing then and their use as inhibitors of 5- alpha -reductase in the treatment in ...
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JPH0742306B2 |
This invention provides a new method for preparing 26,26,26,27,27,27-hexafluoro-1,25-dihydroxycholesterol. The method permits the use of cholenic acid or an ester of cholenic acid as the starting material and the preparation of a compoun...
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JPH0742305B2 |
This invention provides a new method for preparing 26,26,26,27,27,27-hexafluoro-1,25-dihydroxycholesterol. The method permits the use of cholenic acid or an ester of cholenic acid as the starting material and the preparation of a compoun...
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