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Matches 651 - 700 out of 1,827

Document Document Title
WO/1991/000732A1
Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified her...  
WO/1990/015798A1
The invention relates to novel aminoalkyl maleimides of general formula (I) in which R¿1? and R¿2? are the same or different and represent hydrogen or a C¿1?-C¿4? alkyl group and A is a straight or branched-chain, saturated or unsatu...  
WO/1990/010638A1
The invention concerns cytostatic conjugates, e.g., antineoplastic alkylants, antibiotics, anthracene diones, metal complexes and substances of vegetable origin or semisynthetic derivatives, which are linked by means of suitable connecti...  
WO/1990/008128A1
Compounds of formula (I), wherein D represents the dehydrogenated residue of a hydroxyl group-containing drug or the dehydrogenated residue of an NH-acidic group-containing drug; the substituents in the phenyl ring alpha and beta are in ...  
WO/1990/004398A1
The use of fusidic acid or a derivative thereof for the manufacture of a composition for interfering with cytokines in a biological system, in particular for interfering with a cytokine such as a lymphokine, interleukine, monokine, inter...  
WO/1990/003385A1
New 11beta-phenyl-14betaH-steroids of general formula (I), where Z is an oxygen atom or the hydroxyimino-grouping N ~ OH, and M and N are either jointly a second compound or L is a hydrogen atom and M is an alpha-permanent hydroxy group ...  
WO/1990/002748A1
2-Hydroxy-N,N,N-trimethylethanaminium salts of 5beta-cholane-24-acid derivatives of general formula (I), wherein R1 and R2 as well as R3 and R4 jointly denote an oxo group, or denote two hydrogen atoms, or one hydrogen atom and one hydro...  
WO/1990/000174A1
The invention concerns 13-Alkyl-11beta-phenylgonanes of general formula (I), wherein Z, R1, R2, R3 and R4 have the meaning given, a process for their preparation, pharmaceutical preparations containing these compounds, and their use for ...  
WO/1989/012448A1
An 11beta-aryl-19-norprogesterone steroid of formula (I): wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R3 is H, C1-4 alkyl, ...  
WO/1989/012064A1
1beta,15alpha-Dihydroxy-1alpha-methyl-5alpha-androstan-3,17- dione of formula (I) and its subsequent processing to pharmacologically active steroids.  
WO/1989/011282A1
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase including using these compounds...  
WO/1989/010963A1
Genetically engineered host cells containing new expression cassettes are provided which are able to carry out biochemical oxidations of steroids. In particular the oxidation is carried out with cells into which DNA has been introduced w...  
WO/1989/009781A1
New 9alpha-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9alpha-hydroxyandrost-4-ene-3,17-dione. The resulting compounds are useful starting compounds in the synthesis of corticoste...  
WO/1989/009224A1
This invention is a compound of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is fluorine, chlorine or bromine; wherein R2 is hydrogen or (C1-C3) alkyl; wherein n is 1 or 2; wherein R3 is phenyl, 2-furyl, 3-furyl,...  
WO/1989/000558A1
Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl)amides of the formula (I): HOC(O)-(CH2)n-C(O)-N(R1)-CH2CH2SO3 - + HN(R2)3, wherein R1 is selected from the group consisting of hydrogen, C1-C8 alkyl and phenyl, R2 is C1-C...  
WO/1989/000578A1
New 11beta-phenyl-4,9,15-estratrienes have general formula (I) where X is an oxygen atom or an N-OH hydroxyimino grouping, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom, or an alkyl or acyl residue with 1 to 10 carbon at...  
WO/1988/008002A1
This invention provides novel cyclic hydrocarbons of formula (I), wherein R is selected from the group consisting of CH2=CH-CH2-, HO-CH2CH2CH2-, and CH3; wherein R1 is selected from the group consisting of m-trifluoromethylphenylmethyl, ...  
WO/1988/007545A1
Pregnane derivatives represented by general formula (I) (wherein A1 represents a hydrogen atom or a hydroxy group, A2 represents a substituent such as a hydroxy group when A1 represents a hydrogen atom, or A2 represents a hydrogen atom w...  
WO/1988/007051A1
New 19, 11beta-bridged steroids having the general formula (I), in which R' signifies a methyl or ethyl residue; R2 signifies a hydrogen or chlorine atom or a C1-C4 alkyl residue; B and G, which are identical or different, signify respec...  
WO/1988/003534A1
17beta-Cyano-17alpha-hydroxy steroids (I) are transformed to 17alpha-halo silyl ethers (II) which are intermediates useful in the production of progesterones (V), 17-hydroxyprogesterones (VI), corticoids (VII) and 21-halo corticoids (III...  
WO/1988/002753A2
New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.  
WO/1988/001868A1
Steroids of formula (I) which are characterized by a 17alpha-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17beta-hydroxy/esterified hydroxy substituent. The steroids of this invention have glu...  
WO/1988/000470A1
Ova and embryo losses are reduced, and hence fecundity is increased, in a flock of sheep or a group of other domesticated animals by actively immunizing the female animals in the flock or group against a group of steroids which group com...  
WO/1988/000202A1
Compounds obtained from the associative synthesis of sulfur-containig or sulfur-free amino-acids with derivatives of DELTA-4 pregnene 3,20-dione or with derivatives of DELTA-1,4 pregnadiene 3,20-dione having the general formulae (I), (II...  
WO/1987/006936A1
Sodium salt of sialosylcholesterol which has an excellent solubility in water and is useful as a drug for treating various diseases induced by disturbances of a peripheral or central nervous system.  
WO/1987/006706A1
Qualitative and quantitive electrochemiluminescent assays for analytes of interest present in multicomponent liquids. These methods comprise contacting a sample with a reagent labeled with an electrochemiluminescent chemical moiety and c...  
WO/1987/005908A1
Products having the formula (I) wherein R1 is an aryl or aralkyl, R2 is a hydrocarbonated radical (1-18 carbon atoms), the dotted lines indicate an optional bond, the cycles A, B and C represent (II), (III), (IV), (V), (VI); R' and R'' a...  
WO/1987/005028A1
Compounds of formula (I), wherein one X is COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; remaining X's are H, F, CH3, OH, COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; Y is (i1), (i2), (i3), (i4), or (i5); R is H, alkyl of 1-5 ca...  
WO/1987/004166A1
Compounds (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta: and e...  
WO/1987/002672A1
Novel tetrahydro steroids which are useful in inhibiting angiogenesis and have the following structure: A compound of formula (I), wherein R15 is = O or -OH; wherein R23 with R10 forms a cyclic phosphate of formula (II) or wherein R23 is...  
WO/1987/002367A2
Provided are cyclic hydrocarbons of Formula (I) with an aminoalkyl sidechain that are useful for treating phospholipase A2-mediated conditions, diabetes and obesity.  
WO/1987/001706A2
Disclosed are DELTA9(11)-steroids (VI) and amino substituted steroids of formula (XI), which contain an amino group attached to the terminal carbon atom of the C17-side chain, more particularly amino steroids (Ia and Ib), aromatic steroi...  
WO/1987/000175A1
9alpha, 11beta and 11beta-susbstituted estranes which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.  
WO/1986/003299A1
An immunoassay for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently bonded bridge...  
WO/1986/001502A1
A process for the production of amino compounds from hydroxyl compounds (Voelter reaction), according to which a hydroxyl compound is converted with trifluormethanesulphonic acid anhydride in water-free conditions, the corresponding trif...  
WO/1986/000907A1
A process for the manufacture of 6alpha-methyl steroids having general formula (I) in which X is a hydroxy group and Y a hydrogen atom, or X and Y are together a carbon-carbon bond and R1 is a cyano group, an acetyl group or an alkanoylo...  
WO/1986/000908A1
Derivatives of 11-desoxy-17alpha-oxicorticosterone of general formula (I) where R = -OC(CH2)nC6H4N(CH2CH2Cl)2, n = 1, 3, having antitumoral, hormonal and immunodepressive activity.  
WO/1986/000311A1
Derivatives of steroids of androstane series constituting compounds of a general formula (I); where R1 = -OCOCH2C6H4N(CH2CH2Cl)2; -OH; -O-; R2 = -OCO(CH2)n C6H4N (CH2CH2X)2, where n = 1,3; X = Cl, Br, J; -OH; -O-; formula (II); R3 = -CH3...  
WO/1986/000066A1
New butyramide derivatives corresponding to formula (I), wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tet...  
WO/1985/005361A1
Novel compounds having the general formula (I), wherein: R1 is hydrogen or an acyl substitutent of formula -(C=O)-R2, wherein: R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkylene, haloalkyl, aryl, haloaryl or arylalkylene. T...  
WO/1985/000520A1
Ester derivatives of gamma-aminobutyric acid (GABA) and GABA analogues which cross the blood-brain barrier, as well as methods of synthesizing and using the compounds. The ester derivatives have the formula (I), where A is a radical comp...  
WO/1983/003414A1
The esters are represented by the formula (I), wherein R1 and R2, which may be the same or different, are the rest of an amino acid, from the carbon atom in the beta position (if it is present), R3 is the rest of a steroid or of a pharma...  
WO/1983/003099A1
The invention relates to products having the general formula I, wherein R1 is thienyl or phenyl optionally substituted, furyl, cycloalkyl, naphtyl, phenyl-phenyl, alkyl or alkenyl; R2 is methyl or ethyl; R3 is H, OH, alkyl, alkenyl, opti...  
WO/1983/000694A1
A nondenaturing zwitterionic detergent for proteins which, for example, consists of an effective amount of 3- AD(3-cholamidopropyl)dimethylammonio BD-1-propanesulfonate (CHAPS). This detergent is of extreme interest in the biological stu...  
WO/1982/003175A1
Waster-soluble complex compounds obtained by binding albumin to a half ester of organic dibasic acid such as succinic acid or phthalic acid with 7-hydroxycholesterol, represented by the general formula: (FORMULA) wherein R represents a p...  
WO/1980/002024A1
Lepidoptericidal and herbicidal active compounds having the generic formula (FORMULA) wherein R, R1, R2 and R3 are as disclosed herein. In general, these compounds show enhanced lepidoptericidal activity and show reduced phytotoxic effec...  
JP2022543242A
The present invention relates generally to novel aminosterol compounds, compositions containing the same, and methods of making and using the novel aminosterol compounds and compositions. [Selection drawing] Fig. 1C  
JP2022543244A
This application relates generally to novel aminosterol compounds, compositions containing them, and methods of making and using the novel aminosterol compounds and compositions. [Selection drawing] Fig. 1  
JP7136802B2
The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II) or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR o...  
JP2022116318A
To provide compositions and methods for treating CNS disorders.The invention provides a compound of a formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), A is aryl, heterocyclyl or heteroaryl; R1 and R2a are C1...  

Matches 651 - 700 out of 1,827