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Matches 301 - 350 out of 1,827

Document Document Title
WO/2003/086303A2
The invention relates to compounds of formula (I) in which n, R3, R4, R5, R6, R10, R13, R17, X, Y, and Z are defined above. The invention also relates to pharmaceutical compositions each containing an effective amount of one or more comp...  
WO/2003/080642A1
The invention relates to novel 19-nor-17$g(a)-pregna-1,3,5(10)-trien-17$g(b)-ols with a 21,16a lactone ring having a long-chain substituent in the 11$g(b) position of general formula (II), wherein R11 represents a long-chain alkyl radica...  
WO/2003/072109A1
The invention relates to the use of mono-sulfamate prodrugs of estriol, such as estriol-3-sulfamate, for the treatment of autoimmune diseases, such as multiple sclerosis (MS).  
WO/2003/070194A2
Amino acid corticosteroid esters which may function as pro-drugs, and formulations of the amino acid corticosteroid esters with a second active ingredient such as formoterol are disclosed. Composition of the invention include amino acid ...  
WO/2003/068736A2
Disclosed herein are mixed steroidal tetraoxanes having the following structural Formula (I), wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or isopropyl; R2 is H, methyl, or ethyl; R3 is H, ...  
WO/2003/064443A2
Nitrooxy derivatives of steroidal compounds of general formula (I) B− X1 − NO2 or esters or salts thereof, wherein: B is a steroidal radical, X1 is a bivalent linking group comprising an aromatic or heterocyclic ring.  
WO/2003/053365A2
Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.  
WO/2003/053992A2
This invention describes a safe method for the production of sulfamoyl chloride from chlorosulfonyl isocyanate and formic acid in the presence of a amide catalyst, taming the hazardous nature of this reaction by circumventing heat accumu...  
WO/2003/047549A2
The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); whe...  
WO/2003/045972A1
The invention relates to 17$g(a)-alkyl-17$g(b)-oxy-estra-1,3,5(10)-trienes having an anti-oestrogen action, of general formula (I). The invention also relates to 17-oxo-estra-1,3,5(10)-trienes and 17$g(b)-hydroxy-estra-1,3,5(10)-trienes ...  
WO/2003/039480A2
A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I). Also disclosed are methods, kits, combinations, and compositions for treating a...  
WO/2003/038523A2
Mixed carbocycle derivatives containing at least two carbocycles per molecule from the group of anthracenes, adamantanes and steroids with functionalized carbon chains are synthesized and used as modifiers of resist properties and especi...  
WO2002094942A9
The disclosed invention pertains to technology of fabricating and purifying synthetic dyes and may be used in various areas of industry and national economy, particularly in fabrication of materials for polarizing coatings of various pur...  
WO/2003/027132A2
A highly pure 17β-N-tert-butylcarbamoyl-3-one steroid compound of formula (I) is prepared in a high yield under a mild condition, by reacting a 17β-carboxy-3-one steroid compound with a pivaloyl halide to obtain a pivaloyl acid anhydri...  
WO/2003/026568A2
Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating a function of the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of ...  
WO/2003/020214A2
Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administrat...  
WO/2003/018603A1
The invention concerns novel transfecting compounds consisting of an aminoglycoside bound to a lipid via a spacer, and their polyguanidyl derivatives. Said compounds are useful for in vitro, ex vivo or in vivo transfection of nucleic aci...  
WO/2002/100880A1
The invention concerns a method for preparing compounds of formula (I) wherein: R¿1?, R¿2?, R¿3? and n are such as defined in the description, the use of said compounds as intermediates for preparing oestrogen derivatives and the inte...  
WO/2002/094769A1
The invention relates to the use of poly(perfluoroalkylene)sulfonic acids for cataly-zing a reaction between carbonyl containing compounds and hydrazine or hydrazide reagents to form hydrazone derivatives. It also embraces a solid reagen...  
WO/2002/094849A2
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr , β−unsaturated ketone using copper iodide and t−butyl hydroperoxide. A steroid compound containing the &agr , β−unsaturated ketone struc...  
WO/2002/094758A1
The present invention provides methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme. The invention also provides intermediates useful in making such 21-[4'-(nitro...  
WO2001042273A9
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and allevi...  
WO/2002/092100A1
Compounds of formula (I) in which: R?1¿ represents a hydrogen atom or an o-protecting group; R?2¿ represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R?3¿ re...  
WO/2002/090375A2
A compound of formula (I), wherein each of R1, R2, R3, R4, R4', R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally insert...  
WO/2002/083147A1
The present invention relates to the use of a bile acid or bile salt fatty acid conjugate of general formula II W - X - G in which G is a bile acid or bile salt radical, which, if desired, is conjugated in position 24 with a suitable ami...  
WO/2002/079220A2
The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C?17¿ of the s...  
WO/2002/079221A2
The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the ab...  
WO/2002/077007A2
Compounds of the general formula (I) wherein R¿1? is hydrogen, halogen, CH¿3, ?CH¿2?-OH, COOH, CH¿2?-OSO¿3?,CH¿2?-NH-(CH¿2?)¿a?-R¿10?, or C(=O)-NH-(CH¿2?)¿a?-R¿10?wherein R¿10?is-NH¿2?,-NH-(CH¿2?)¿b?-NH¿2?, -NH-(CH¿2?)...  
WO/2002/068449A1
The present invention relates to a novel process for the preparation of bile esters derivatives of general formula (I), in which R¿0? is H or OH; R¿1? is H, $g(a)-OH or $g(b)-OH; R¿2? and R¿3? are independently hydrogen, straight or ...  
WO/2002/066489A2
The invention relates to a sterol skeleton based compound wherein one or several amphoteric groups with an isoelectric point of between 4 and 9 are substituted on the 3?rd¿ position of the ring system, in addition to liposomes containin...  
WO/2002/066490A2
Disclosed is a sterol derivative having a pKa value of 3.5 - 8 according to the general formula cation - spacer 2 - Y - spacer 1 - X - sterol, wherein Y and X represent bonding groups. The invention also relates to liposomes containing s...  
WO/2002/062302A2
A compound of formula (1), wherein each of R¿1?, R¿2?, R¿4?, R¿4'?, R¿7?, R¿11?, R¿12?, R¿15?, R¿16?, R¿17'?, independently, is hydrogen, hydroxy, amino, carboxyl, oxo, halo, sulfonic acid, -O-sulfonic acid, or alkyl that is op...  
WO/2002/056874A2
Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacy...  
WO/2002/053577A2
The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatm...  
WO/2002/048380A2
The present invention provides a compound capable of acting as a cationic lipid, the compound comprises a cholesterol group and a carbohydrate moiety.  
WO/2002/048170A1
The present invention provides a lipid comprising an aminoxy group having the formula wherein B is a lipid; and wherein R¿2? is H or a hydrocarbyl group. When reacted with a moiety comprising an aldehyde or ketone group, the aminoxy gro...  
WO/2002/038582A2
The invention relates to a method for the production of 4-(17$g(a) substituted 3-oxoestra-4,9-dien-11$g(b)-yl)benzaldehyd-(1E or 1Z)-oximes of general formula (I), where R¿1? = H, C¿1-6? alkyl or a C¿n?F¿2n+1? group; R¿2? = C¿1-4? ...  
WO/2002/038581A2
The invention relates to a method for the production of 4-(17$g(a)-methyl substituted 3-oxoestra-4,9-dien-11$g(b)-yl)benzaldehyd-(1E or 1Z)-oximes of general formula (I), where R¿1? = H, C¿1-6? alkyl or a C¿n?F¿2n+1? group, where n =...  
WO/2002/038583A1
The invention relates to a method for the production of 4-(17$g(a)-alkoxymethyl-17$g(b)-substituted 3-oxoestra-4,9-dien-11$g(b)-yl)benzaldehyd-(1E)-oxime derivatives of general formula (I), where R = amino, O-C¿1-7? alkyl or O-aryl, S-C...  
WO/2002/036606A1
This invention is directed to a method for treating an inflammatory condition, treating haematological and other malignancies, causing immunosuppression, or preventing or treating transplant rejection in man or other animals which compri...  
WO/2002/032922A1
A process for preparing an intermediate compound of formula (II): where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R?2¿, R?3¿, R?4¿ and R?5...  
WO/2002/026763A1
The invention relates to novel 19-nor-17$g(a)-pregna-1,3,5(10)-trien-17$g(b)-ols with a 21,16$g(a)-lactone ring of formula (II), a method for the production thereof and pharmaceutical preparations containing said compounds in addition to...  
WO/2002/024627A1
The present invention relates to cationic lipids, methods for preparing some and methods for effectively transporting anionic molecular substances into cell by using said cationic lipids. The present lipids are compatible to the gene the...  
WO/2002/020510A1
The invention concerns novel acid-sensitive compounds comprising at least a hydrophilic substituent and a cyclic orthoester which is acid-sensitive, and their salts. Said compounds are useful for forming conjugates (liposomes, complexes,...  
WO/2002/020552A1
A process for the preparation of pregnane derivatives which comprises reacting a compound (I) with an alkali metal or an alkaline earth metal in the presence of ammonia or an amine to obtain a compound (II), protecting the hydroxyl group...  
WO/2002/016393A1
There is provided a compound comprising a steroidal ring system and a group R?1¿ selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring o...  
WO/2002/016394A1
There is provided a compound of Formula (I) wherein X is a ring having at least 4 atoms in the ring; K is a hydrocarbyl group: R?1¿ is an optional group of the formula -L?1¿-S-R?1'¿, wherein L?1¿ is an optional linker group and R?1'...  
WO/2002/016392A1
There is provided a compound of Formula (I) wherein X is a ring system ; R?1¿ is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R?2¿ is any one of a sulphamate g...  
WO/2002/014342A1
A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.  
WO/2002/012267A1
A method of producing a salt of general formula (I) wherein A is $g(a)-OH or $g(b)-OH, B is $g(a)-H or $g(b)-H, C is H, $g(a)-OH or $g(b)-OH, or B and C together form a double bond, D is -H, $g(a)-OH or $g(b)-OH, E is H, $g(a)-OH or $g(b...  

Matches 301 - 350 out of 1,827