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Matches 1 - 50 out of 944

Document Document Title
WO/2022/162992A1
The present invention addresses the problem of providing a new pharmaceutical composition that can treat a T cell-independent reaction or an early phase reaction (a symptom in an early phase) of an allergic disease. Examples of the pre...  
WO/2022/115381A1
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein ring D and the substituents are defined herein. Also provided are pharmaceutical compositions comprising a compound of Formula (I) or a p...  
WO/2022/084752A1
The present invention relates to a process for the preparation of 21-(acetyloxy)-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione (VI) having the formula below: Compound (VI) can be used as a precursor for the synthesis of Clascoterone, a steroi...  
WO/2021/262040A1
The present invention relates to medicine and concerns the treatment of diseases associated with aberrant Interleukin-6 activity and the development of cytokine release (cytokine storm) syndrome, preferably the treatment of COVID-19, as ...  
WO/2021/252761A2
Disclosed herein are monomeric and oligomeric compound embodiments for use as contraceptive agents. Monomeric compound embodiments disclosed herein comprise substituents that facilitate the ability of the compounds to exhibit progestogen...  
WO/2021/220061A2
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, b...  
WO/2021/203938A1
The present invention relates to a compound for treating gout, a preparation method therefor and the use thereof. The compound is as represented by formula I. Disclosed in the present invention are a method for preparing the compound and...  
WO/2021/203198A1
The present technology generally relates to the use of an asparaginase compound, and optionally of a chloroquine active agent and/or a serine protease inhibitor and/or a lectin, for inhibiting or treating a Coronaviridae infection in a s...  
WO/2021/194244A1
The present invention relates to a novel method for preparing Inotodiol. The method differs in terms of process from existing methods for preparing Inotodiol, and produces a high yield of Inotodiol. Therefore, the method can be useful fo...  
WO/2021/023213A1
The present invention relates to a steroid derivative regulator, in particular to a compound of formula (I), a salt and crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effect...  
WO/2021/014217A1
The present invention is directed towards articles comprising a steroid material comprising a steroid dimer and at least one therapeutic agent distributed throughout the steroid material and the use of such articles in sustained release ...  
WO/2020/243488A1
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7a, R7a, R11a, R11b, R12a, R12b, R16a, R16b, R19, R11a, R22, RX, RY and n are defined he...  
WO/2020/198878A1
The present application provides compounds, compositions and methods to reduce, alleviate or treat various enteric diseases and disorders, such as inflammatory bowel disease. The compounds are xyloglucan-containing prodrugs, referred to ...  
WO/2020/191477A1
The application relates to a lipid conjugate of formula M-X1-L wherein M is a molecule of interest such as a drug moiety; X1 is a linker group such as ester, ether or carbamate; and L is a lipid scaffold represented by formula (lId): -L1...  
WO/2020/185710A1
The present disclosure relates to methods of alleviating a symptom of, treating, or preventing a sleep disorder by administering a neurosteroid GABAA positive allosteric modulator or pharmaceutically acceptable salt thereof to a subject ...  
WO/2020/181395A1
The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase i...  
WO/2020/161317A1
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.  
WO/2020/154815A1
The disclosure features polymorphs of a prodrug dimer of dexamethasone linked at the 21-C and 21'-C carbons via a carbonate-triethylene glycol-carbonate linker. Also disclosed are pharmaceutical compositions and articles comprising said ...  
WO/2020/020728A1
Disclosed are compounds of formula (I), wherein X, Y, Z are annular atoms comprised in a five-membered carbocyclic or heterocyclic ring, selected from the group consisting of CH, NH, N, O, S; saidcarbocyclic or heterocyclic ring being op...  
WO/2019/154257A1
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical ...  
WO/2019/154247A1
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharma...  
WO/2019/148291A1
The disclosure features ocular inserts for the sustained release of steroids in the treatment ocular conditions. Said ocular inserts are articles formed from a compound of formula D1-L-D2 (A-I), wherein D1 and D2 are steroid radicals sel...  
WO/2019/148294A1
Dimeric dexamethasone prodrugs (I) and articles formed from said dimeric dexamethasone prodrugs are disclosed. The articles comprising Dimeric dexamethasone prodrugs can be heat molded, injection molded, blow molded, electrospun, electro...  
WO/2019/148293A1
Steroid dimers and articles formed from steroid dimers are disclosed. Said steroid dimers are represented by D1-L-D2 wherein D1 and D2 are steroid moieties and L is a covalent linker. The articles comprising the steroid dimers can be mac...  
WO/2019/128154A1
Provided is a method for synthesizing the 17-position side chain of a steroid drug, wherein same is characterized in using compound I as a starting material, and the 17-position side chain is synthesized by nucleophilic, esterification, ...  
WO/2019/126741A1
Provided herein are compounds of Formula (I-I): and pharmaceutically acceptable salts thereof; wherein p, R1, R3a, R2a, R11a, R11b, R6a, and R6b are defined herein. Also provided herein are pharmaceutical compositions comprising a compou...  
WO/2018/164715A1
The present invention relates to methods of treating or preventing cancer in a subject in need thereof comprising administering a therapeutically effective amount of a compound of the invention.  
WO/2018/037423A1
The present invention discloses a process for the preparation of pregnadiene derivatives having formula I, their stereoisomer and intermediate thereof. Formula I wherein each substituent is independently, R1 and R2 is hydrogen or C1 –C...  
WO/2017/192668A1
Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based o...  
WO/2017/153497A1
The invention provides a co-crystal, which co-crystal comprises beclomethasone dipropionate and a co-crystal former, which co-crystal former is adipic acid, maleic acid or isonicotinic acid. The invention also concerns a pharmaceutical c...  
WO/2017/150723A1
Algae that generates a sterol and a sterol production method that uses the algae. According to the present invention, a sterol is produced by culturing algae, such as strain AJ7867 (FERM BP-22304) and strains derived therefrom, that has ...  
WO/2017/106957A1
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.  
WO/2017/037081A1
The present invention relates to new compounds of formula (1) wherein R is -C(=O)CH2OH or -CH(OH)CH2OH; R1, is =O or OH; R2 is H or OH; R3 is H or C1-C4alkyl; R4 is H or C1C4alkyl. These compounds are obtained by a process using at least...  
WO/2016/123117A1
The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppre...  
WO/2016/120891A1
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alk...  
WO/2016/055533A1
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, ...  
WO/2016/023082A1
H:\dar\Interwoven\NRPortbl\DCC\DAR\8230712_1.doc-12/08/2015 Abstract The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymp...  
WO/2015/180679A1
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as def...  
WO/2015/177469A1
The present invention relates to chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, the invention enables improvement of muscular quality in sarcopenic mammals ...  
WO/2015/121840A1
The present invention relates to a process for the synthesis of compounds of formula (I), (I) wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R' is dimethylam...  
WO/2015/089471A2
Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparat...  
WO/2015/063408A2
The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.  
WO/2013/135744A1
The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.  
WO/2013/122112A1
Provided is a prodrug of a therapeutically active organic compound having: an amino group, a cyclic amino group or a hydroxyl group in the molecule; and a 2-nitro-1-imidazole propionic acid. In particular, provided is a prodrug in which ...  
WO/2013/056181A1
Provided herein are 3,3-disubstituted 19-nor- steroidal compounds according to Formula (I) and (III): where R1,R2, R3, R3', R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful fo...  
WO/2012/079279A1
The present invention relates to pregnane glycoside compounds containing orthoester groups, pharmaceutical compositions containing the compounds, and use thereof in the preparation of an immunosuppressant. More particularly, disclosed ar...  
WO/2011/150209A1
The present invention resides in the discovery that glucocorticoid receptor antagonists are effective for treating muscular dystrophy including type 1 or type 2 myotonic dystrophy. Treatment methods and kits are provided.  
WO/2011/130877A1
A crystalline form of methylprednisolone aceponate monohydrate exhibits an X-ray powder diffraction pattern having characteristic peaks at the diffraction angles 2θ= of 8.6°, 12.2°, 13.6°, 15.3°, and 19.3°. The method for preparing...  
WO/2011/087441A1
It is provided apharmaceutical composition comprising 3-beta-hydroxy-5-alpha- pregnan-20-one, at least one sterol or an ester thereof and a mixture of acylglycerols with a solid fat content of less than 25% at 25°C and 0% at 37°C.In ad...  
WO/2011/019821A2
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in...  

Matches 1 - 50 out of 944