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JPH053479B2 |
The invention relates to a new process for the preparation of 21-hydroxy-20-keto-steroids from 17-(isocyano-sulfonylmethylene)-steroids whereby simultaneously an unsaturated bond is introduced between C16 and C17. Furthermore the inventi...
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JPH053478B2 |
The invention relates to 17-(isocyano-sulfonylmethylene)-steroids and a process for the preparation of these compounds from 17-oxo-steroids. Furthermore the invention relates to 17-formamido-sulfonylmethylene)-steroids, which compounds a...
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JPH04316597A |
PURPOSE: To facilitate dissolving of a ferulic acid ester of a triterpene alcohol which is a principal ingredient of γ-oryzanol in water. CONSTITUTION: A molecular compound is provided by including a ferulic acid ester of a triterpene a...
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JPH04505324A |
PCT No. PCT/DE90/00383 Sec. 371 Date Jan. 14, 1992 Sec. 102(e) Date Jan. 14, 1992 PCT Filed May 23, 1990 PCT Pub. No. WO90/14354 PCT Pub. Date Nov. 29, 1990.9 alpha -Hydroxy-19,11 beta -bridged steroids of general formula I (I) are descr...
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JPH0456839B2 |
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JPH0443916B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0443884B2 |
There is disclosed a new therapeutic use of cyproterone acetate for the manufacture of a medicament for blocking the estrogen signal in the treatment of functional and tumoral estrogen-dependant pathology, in women, caused by intrafollic...
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JPH0443920B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH0440360B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH0437080B2 |
13-Alkyl-11 beta -phenylgonanes of the general formula I in which A and B together are an oxygen atom, a CH2 group or a second bond between carbon atoms 9 and 10, X is an oxygen atom or the hydroxyimino group N-OH, n is the number 0 or 1...
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JPH0436160B2 |
7 alpha -acylthio-1 alpha ,2 alpha -methylene-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactones of Formula I (I) wherein and R is a lower saturated acyl radical of 2 to 4 carbon atoms, have a stronger antialdosterone effect and lower side ...
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JPH0435458B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0434540B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH04502906A |
PCT No. PCT/DE89/00712 Sec. 371 Date May 13, 1991 Sec. 102(e) Date May 13, 1991 PCT Filed Nov. 10, 1989 PCT Pub. No. WO90/05139 PCT Pub. Date May 17, 1990. (I) (a) (II) (III) New 14 alpha ,17 alpha -ethano-estratrienes of general formula...
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JPH0414680B2 |
A multistep process for production of 17 alpha -acetoxy-1,2-methylene-4,6-pregnadiene-3,20-dione involves ketalization of the 20-keto group of 17 alpha -hydroxy-1,4,6-pregnatriene-3,20-dione, then methylenation in the 1,2-position with t...
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JPH0412280B2 |
A monohydrate of a steroid having the structure and the 1,2-dehydro derivatives thereof, is provided which monohydrate is in the form of a particulate material having a stable average particle size of less than about 20 microns. Cream an...
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JPH0411558B2 |
7 alpha -Alkoxycarbonyl-15 beta ,16 beta -methylene-4-androstene compounds of Formula I (I) wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, X is and Y is carbonyl, and the bond between the C-1 and C-2 carbon atoms is a...
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JPH0454194A |
NEW MATERIAL:Steroid glycosides represented by formula I [R1 is β-D- galactose(2←1)β-D-glucose; R2 is β-D-glucose; R3 is H or lower alkyl; Single and double bonds are shown by full line and dotted line] or salts thereof. EXAMPLE: 26...
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JPH049799B2 |
A process for the production of 17 alpha -acyloxy-6-chloro-1 alpha ,2 alpha -methylene-3,20-diones of the general Formula I (I) wherein R represents an alkyl group with up to 5 carbon atoms or a phenyl group, is characterized in that a c...
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JPH0378400B2 |
Novel 6 beta ,7 beta -methylene-17 alpha -pregn-4-ene-21,17-carbolactones of Formula I wherein R and R min each is hydrogen or jointly form a methylene group. These exhibit a good antimineralocorticoid effect with low side effects.
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JPH03275698A |
NEW MATERIAL:22α-Hydroxy-3-oxo-glycyrrhizic acid shown by the formula. USE: 3α-Hydroxysteroid dehydrogenase inhibitor useful as an antiinflammatory drug. PREPARATION: Licorice root of crude drug or root of Glycyrrhizae Radix, a raw pla...
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JPH0373560B2 |
17 alpha -pregn-4-ene-3-oxo-21-carboxylic acid esters of Formula I, wherein C1@@C2 is a CC single or C=C double bond, -A-B- is -C-D- is and R is an alkyl or alkenyl residue of up to 6 carbon atoms, in addition to antialdosterone activity...
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JPH0372080B2 |
7 alpha -acylthio-15,16-methylene-3-oxo-17 alpha -pregna-1,4-diene-21,17-carbolactones of the formula wherein the 15,16-methylene group can be in the alpha - or beta - configuration, and R is a lower alkyl residue, have altialdosterone a...
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JPH0369359B2 |
A simple process for preparing 3-( DELTA 4-3-keto-steroid-17 alpha -yl)propionic acid lactones of the androstane series represented by the general partial formula wherein ABCD represents an optionally substituted cyclopentanophenanthrene...
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JPH0364509B2 |
1512400 16,17-Naphthopregnenes E R SQUIBB & SONS Inc 13 Nov 1975 [25 Nov 1974] 46902/75 Heading C2U The invention comprises #4 and #1'4 steroids of formula wherein R 1 is Cl, F or OH; R1 1 is H; or R 1 and R1 1 together are oxo; R 2 is H...
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JPH03218393A |
NEW MATERIAL: A compound of formula I {X is -CH2CH2- or a bridge of formula II; R1 is H, 1-15C acyl, benzoyl, 1-15C alkyl, 3-9C cycloalkyl or alkylcycloalkyl; R2 is formula III or IV [R3 and R4 are each H or (fluorinated) 1-8C alkyl]}. E...
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JPH03209394A |
NEW MATERIAL: A compound of the formula (R contains at least one saccharide group; R1 H, lower alkyl). USE: A sweeting agent. Useful for chocolate, candy, cake, chewing gum, imitation meat product, protein of vegetable source, soy sauce,...
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JPH0357917B2 |
A process for the preparation of 3 beta ,7 beta ,15 alpha -trihydroxy-5-androsten-17-one and the 3,15-dipivalate thereof comprises epimerizing 3 beta ,7 alpha ,15 alpha -trihydroxy-5-androsten-17-one in the presence of a ketone with or w...
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JPH033678B2 |
Androstane derivatives of Formula I (I) wherein is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, -X- is -(CH2)n-, -CH=CH(CH2)m-, or -C 3BOND C-(CH2)m- wherein n is 2 to 6 and m is 1 t...
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JPH02243698A |
PURPOSE: To provide the subject compsn. for treating uterine cancer containing a diluent or a carrier and a specific (substd.) estrogen nucleus as a part of a molecular structure and a therapeutically effective amt. of a sexual steroid a...
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JPH0242840B2 |
New spirolactones of the formula (I) wherein +tr R is a lower alkyl of up to 5 carbon atoms, and +tr
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JPH02149597A |
PURPOSE: To enable stabilization of the subject compound in storage at low temperatures and uniform solubilization thereof by dissolution thereof into a mixture composed of a polyoxyethylene hardened castor oil, a monoester- containing s...
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JPH02149598A |
PURPOSE: To solubilize γ-orizanol without using ethyl alcohol by dissolving a monoester-containing sucrose fatty ester in purified water, mixing a melt composed of a polyoxyethylene hardened castol oil and γ-orizanol therewith and fusi...
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JPH0214360B2 |
Compounds of the formula wherein the 15,16-methylene group is in the alpha - or beta -position, and E is +TR are useful as diuretics.
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JPH0212479B2 |
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an alpha -oriented lower alkox...
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JPH0236192A |
NEW MATERIAL: Compounds of formula I [wherein R is -COOX (X is H or a 1-8C alkyl) or CH2OH]. EXAMPLE: Methyl 3β-hydroxy-chola-5,23t-diene-24-carboxylate. USE: Prevention and a remedy of hypercholesterolemia, an HMG-COA reductase inhibit...
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JPH021160B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH0155279B2 |
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JPH0148760B2 |
Methylene steroids of the formula wherein X is H, F or CH3; Y is hydroxymethylene, alkanoyloxymethylene or carbonyl; R1 is H, OH or alkanoyloxy; and R2 is H, OH or esterified OH, possess topical anti-inflammatory activity.
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JPH0140040B2 |
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JPH0140014B2 |
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JPH0128760B2 |
PCT No. PCT/DE81/00111 Sec. 371 Date Mar. 11, 1982 Sec. 102(e) Date Mar. 11, 1982 PCT Filed Jul. 2, 1981 PCT Pub. No. WO82/00294 PCT Pub. Date Feb. 4, 1982.The disclosure concerns 5 beta -hydroxy- DELTA 6-steroids of the general formula ...
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JPH0123475B2 |
A process for preparing a DELTA 9(11)- and/or DELTA 16-unsaturated steroid comprises heating the corresponding steroid of the pregnane series substituted by 9 alpha -chloro- and/or 16 alpha -chloro- or 17 alpha -acyloxy, in an inert, apr...
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JPH0121759B2 |
A process for preparing a 3 beta ,7 beta -dihydroxy- DELTA 5-steroid of the formula wherein Q is and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3 be...
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JPH0116810B2 |
The 6-chloro-1,2 alpha -methylene-4,6-pregnadien-17 alpha -ol-3,20-dione-17-acetate (Cyproterone acetate) is a well known compound provided with a remarkably high anti-androgen activity. It has now surprisingly been found that the Cyprot...
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JPS645880B2 |
Methylene steroids of the formula wherein X is H, F or CH3; Y is hydroxymethylene, alkanoyloxymethylene or carbonyl; R1 is H, OH or alkanoyloxy; and R2 is H, OH or esterified OH, possess topical anti-inflammatory activity.
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JPS643880B2 |
24,25-Dihydroxycholestane derivatives of the formula wherein A is a steroid residue and R is an aryl group and a process for preparation of the same are disclosed. The derivatives are intermediates for synthesis of 24,25-dihydroxycholeca...
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JPS64960B2 |
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JPS6360037B2 |
25-Halocholest-5-ene-3 beta ,22-diols and esters thereof which inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase and inhibit the formation of serum cholesterol and their preparation from 3 alpha ,5-cyclo-6 beta -met...
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JPS63503140A |
PCT No. PCT/DE87/00208 Sec. 371 Date Feb. 5, 1988 Sec. 102(e) Date Feb. 5, 1988 PCT Filed May 5, 1987 PCT Pub. No. WO87/06937 PCT Pub. Date Nov. 19, 1987.2,2;6,6-diethylene-3-oxo-17alpha-pregn-4-ene-21,17-carb
olactones of general formul...
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