| Document |
Document Title |
|
JP2004525127A |
The invention relates to novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
|
|
JP2004215562A |
To obtain an orally administrable material, hardly causing hypoglycemia after administration and applicable to the therapy and prophylaxis of diabetes or elevation of blood glucose level.The additive for food and drink contains a compoun...
|
|
JP2004189682A |
To provide a pharmaceutical composition for suppressing accumulation of platelets into the lung and/or the liver and/or degranulation of the platelets.The pharmaceutical composition comprises glycyrrhizin or glycyrrhetic acid in an activ...
|
|
JP2004518751A |
The present invention discloses a method for preparing Anemone Raddeana extract, comprising the following steps: a) pulverizing a rhizome, stem, leaf, flower, and fruit of Anemone Raddeana to obtain crude powders of Anemone Raddeana; b) ...
|
|
JP2004517875A |
This invention uses acetone/water mixtures at various concnetration and temperatures as a cost effective method for recoveing soy saponins of high purity from soybean-derived materials, while also affording an economical means of recover...
|
|
JP2004517045A |
A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betu...
|
|
JP2004123757A |
To obtain a sulfatase inhibitor having no estrogenic active ingredient, because a compound restricting or preventing utilization of estrogenic substances is required for hormone dependent tumors.A new estratriene of formula (I) containin...
|
|
JP2004115542A |
To provide plum extracts contributing to effective utilization of plum trees and giving various medicines.The extracts are prepared from plum leaf stems, plum kernels and plum flowers by using 5-times volumetric methanol. The extracts ha...
|
|
JP2004509972A |
Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allo...
|
|
JP2004059455A |
To provide a motor nerve cell decrease inhibitor which is effective for inhibiting the advance in the symptom of amyotrophic lateral sclerosis whose specific medicine has not been known.This motor nerve cell decrease inhibitor comprises ...
|
|
JP2004035568A |
To provide a medicinally active extract and fraction, and a method for preparing the same by extracting and fractionating components from the tissues of a plant constitution part of the Anoectochilus family.The medicinally active extract...
|
|
JP3453188B2 |
PURPOSE: To industrially and advantageously obtain an oleanolic acid useful as a production intermediate, etc., for endothelin receptor antagonism, etc., by reducing a specific steroidal lactone compound with an alkali(earth)metal in an ...
|
|
JP2003277267A |
To provide a triterpene-based compound having a sufficient effect against allergy.The antiallergic agent contains at least one kind of a triterpene- based compound selected from the group consisting of heliantriol C and faradiol.
|
|
JP3441488B2 |
PURPOSE: To provide a new saponin compound and desacyl saponin compound, having anti-inflammatory and anti-allergic activity, useful as a medicine. CONSTITUTION: The objective saponin compound of formula I (teasaponin B1) and desacyl tea...
|
|
JP2003522130A |
The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecano...
|
|
JP3418428B2 |
PURPOSE: To provide the novel steroid compounds whose steroid skeleton is bound at carbon atom 17 to a spiromethylene ring having progestational activity and antiprogenstational activities, and useful as contraceptive medicines. CONSTITU...
|
|
JP2003508543A |
The invention relates to novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis.
|
|
JP3359774B2 |
An external preparation for skin comprising at least one member selected from the group consisting of escinol and its salts represented by the following constitutional formula (1): (wherein R<1> is hydrogen atom or hydroxyl group and R<2...
|
|
JP3340610B2 |
|
|
JP2002536382A |
The invention relates to novel betulinic acid derivatives of structural formula having modifications at C2, C3, C17, C20 and/or C29 positions, said derivatives being useful as inhibitors of tumor/cancer cells; process for preparation of ...
|
|
JP2002520376A |
A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, deriv...
|
|
JP2002520375A |
The present invention relates to compositions containing i) from about 0.0001 % to about 99.9 % of certain compounds selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane tri...
|
|
JP2002518515A |
The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprisin...
|
|
JP3282603B2 |
To obtain an adjuvant that can be readily prepared in a commercial scale and can provide high-performance vaccine of high safety by using a specific saponin as an immune activator. This vaccine includes as an immune activator at least on...
|
|
JP3282583B2 |
To obtain an adjuvant composition rich in active ingredients and capable of suppressing side reactions by including a specific oleanane type bisdethmoside saponin. The composition is obtained by including the specific oleanane type bisde...
|
|
JP3279574B2 |
A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: wherein R<1> represents a hydroxyl group, alkoxy,...
|
|
JP2002506077A |
Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17beta-hydroxys...
|
|
JP2002505337A |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have the following formulae:or pharmaceutically acceptable salts ther...
|
|
JP2002030063A |
To provide a method for producing a sulfamate compound, which can be applied to various hydroxyl group-containing compounds having various functional groups and by which the sulfamate compound can be produced from necessary minimal amoun...
|
|
JP2001513769A |
Compositions and methods of treating or preventing hepatotoxicity utilizing asiatic acid derivatives of Formula 1 are disclosed.
|
|
JP3202229B2 |
PCT No. PCT/EP91/02239 Sec. 371 Date Sep. 28, 1993 Sec. 102(e) Date Sep. 28, 1993 PCT Filed Nov. 27, 1991 PCT Pub. No. WO92/09618 PCT Pub. Date Jun. 11, 1992.8-En-19,11 beta -bridged steroids of general formula I (I) that have the 8,9-do...
|
|
JP2001199996A |
To provide a new substance having ACAT(acyl-CoA cholesteryl acyltransferases) inhibitory action. An ACAT inhibitor composed of a compound obtained by purifying llex cornuta and represented by general formula (I) (wherein R1 is H or an ac...
|
|
JP2001199995A |
To provide a new substance having ACAT(acyl-CoA cholesteryl acyltransferases) inhibitory action. An ACAT inhibitor composed of a compound obtained by purifying Ilex cornuta and represented by general formula (I) (wherein R1 is an acyl gr...
|
|
JP3166103B2 |
To provide a method for producing a saponin essence liquid extracted with fructose, capable of extracting a saponin derivative from customary, physiologically and pharmacologically effective ginseng or its related crude medicine in an ex...
|
|
JP2001504514A |
Disclosed is the use of 2-oxoasiatic acid in the treatment of dementia or cognitive disorders.
|
|
JP2000319287A |
To obtain a new compound capable of inhibiting developing sialyl- Lewis-X on leukocyte surface and useful as an anti-inflammatory agent. This compound is a compound of the formula (R is an ethyl, normal propyl or isopropyl), e.g. MK13089...
|
|
JP3099058B2 |
|
|
JP2000256391A |
To obtain a new saponin having an inhibitory action on acylcoenzyme A cholesterol acyltransferase(ACAT) activity, useful for prevention, therapy, or the like, of arteriosclerosis. This compound is expressed by formula I (R1-R7 are each a...
|
|
JP2000256392A |
To obtain an ACAT inhibitor having ACAT inhibiting action useful for prevention and therapy of arteriosclerosis such as atherosclerosis, or the like, by including a specific triterpene. The inhibitor comprises triterpentine compounds of ...
|
|
JP2000247993A |
To obtain the subject medicine acting through a σ-receptor without generating extrapyramidal tract disturbance, further having an affinity to the σ-receptor and useful for the treatment of psychosis, schizophrenia, etc., by including a...
|
|
JP2000239297A |
To obtain the subject extract which can contribute to effective use for plum and is used as an antioxidant by extracting from the trunks, branches, leaves, etc., of plum trees. This extract is obtained by extracting from at least one obj...
|
|
JP3073803B2 |
The invention relates to the compounds: either n = 1, K = oxygen, R17 = hydroxyl, R'17 = hydrogen, ethynyl, RA = methyl, RA' = isopropyl, butyl, heptafluorobutyl, X = methylene, phenylene or phenyloxy, Y = -(CH2)7; -(CH2)8-; -(CH2)5-C ID...
|
|
JP2000212047A |
To obtain a hair tonic having excellent epilation inhibiting effect and trichogen accelerating effect by making the hair tonic include eclalbasaponin recognized in a specific vegetable extract. This hair tonic contains eclalbasaponin of ...
|
|
JP2000159673A |
To obtain the subject inhibitor having an inhibitory action on transformation growth factor β, useful for treating chronic glomerular nephritis, renal interstitial fibrosis, diabetic nephropathy, hepatocirrhosis, etc., by making the inh...
|
|
JP2000159793A |
To obtain the subject new inhibitor useful as a therapeutic agent or a preventive for diseases such as chronic glomerulus nephritis, arteriosclerosis, adult T-cell leukemia, etc., comprising a low molecular weight compound as an active i...
|
|
JP3048637B2 |
PCT No. PCT/EP91/02495 Sec. 371 Date Feb. 25, 1994 Sec. 102(e) Date Feb. 25, 1994 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11279 PCT Pub. Date Jul. 9, 1992.New D-homo-(16-ene)-11 beta -aryl-4-estrenes of general formula I (I) as well as...
|
|
JP2000136130A |
To obtain the subject suppressant by including alnusenol and multiflorenol as active ingredients. This suppressant is obtained by including alnusenol represented by formula I and/or multiflorenol represented by formula II as active ingre...
|
|
JP3041232B2 |
To provide a new-type the above agent containing ursolic acid or its salt as an active component, having low toxicity, administrable by oral administration and causing little side effect. The objective agent contains ursolic acid or its ...
|
|
JP3030152B2 |
PURPOSE: To obtain a new compound, having excellent inhibiting action on a testosterone 5α-reductase and useful for prostatic hypertrophy. CONSTITUTION: The objective compound of formula I [R1 is H or (substituted)1-6 C alkyl; R2 is (su...
|
|
JP3026997B2 |
New products (I): in which R1 denotes an aliphatic hydrocarbon radical (C1-8), Ra and Rb denote a hydrogen or an alkyl (C1-4), R2 denotes a hydrogen or an optionally substituted alkyl (C1-12), n denotes one of the values from 1 to 6, Z d...
|
