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JPH0656670A |
PURPOSE: To obtain a new derivative useful for treatment of hyperlipemia, having ability to regulate directly or indirectly, synthesis of LDL receptor at chromosome level. CONSTITUTION: The compound of formula I R<1> is 1-4C alkyl or 1-4...
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JPH0641187A |
PURPOSE: To produce a new compd. having excellent local antiinflammatory action, showing good local to systemic antiinflammatory activity and useful as agents for treating inflammatory and allergic dermatosis. CONSTITUTION: The compd. of...
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JPH05507912A |
Novel angiostatic DELTA <4,9(11)>-steroids (I), C21-oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are useful in ...
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JPH05286992A |
PURPOSE: To obtain the subject compound for treating rheumatic arthritis, consisting of a sialic acid ester of a steroid such as cortisone, dexamethasone or vitamin D3, reduced in side effects and having antiphlogistic action and antiall...
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JPH0573394B2 |
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JPH0567157B2 |
NEW MATERIAL:A compound expressed by the formula having the following physico-chemical properties. Appearance; white powder. Molecular weight; 344. Molecular formula; C21H28O4. Melting point; 254-256 deg.C. EI mass spectrum; m/Z=344, etc...
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JPH0564640B2 |
1 alpha ,2 alpha -methylene-6-methylene- and 6 alpha -methylpregnenes of Formula I (I) wherein A is and R is a hydrogen atom, an acyl group, or an alkoxymethyl group are strong antiandrogens, and suitable for the topical treatment of seb...
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JPH0564158B2 |
6 alpha ,16 beta -Dimethyl corticoids of general Formula I (I) wherein the bond ----is a single bond or a double bond, and X is a hydrogen atom, a fluorine atom, a chlorine atom, or a bromine atom, Z is a hydrogen atom or, jointly with X...
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JPH0559919B2 |
6 alpha ,16 alpha -Dimethyl corticoids of general Formula I (I) wherein the bond is a single bond or a double bond, X is a hydrogen atom, a fluorine atom, a chlorine atom, or a bromine atom, R1 is a formyl group, an alkanoyl group or alk...
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JPH05194582A |
PURPOSE: To prepare a new compd. inhibiting testosterone 5α-reductase and useful for the treatment of benign prostatic hypertrophy or the like. CONSTITUTION: This is a new compd. of formula I [R is 1-6C alkyl, 1-4C alkoxy, (substituted)...
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JPH05170790A |
PURPOSE: To obtain a catecholestrogen industrially and advantageously by subjecting estrogen 3-acetate to Fries rearrangement, then converting 2-acetyl to hydroxyl and optionally hydrolyzing. CONSTITUTION: A compound of formula I (R1 is ...
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JPH0535158B2 |
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JPH0533235B2 |
Novel corticoid 17 alpha -alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are useful for the treatment of acute and ...
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JPH0533236B2 |
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JPH0518838B2 |
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom a...
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JPH0559092A |
PURPOSE: To obtain a new compd. which is an intermediate for a steroid iodide compd. useful for diagnosis and treatments for human and animal breast cancer, prostate cancer and uterus cancer and for diseases caused by estrodiene acceptor...
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JPH0559095A |
PURPOSE: To obtain a new nitromethylene compd. as a synthesis intermediate of an acetoxy-oxocorticosteroid compd. useful as pharmaceuticals. CONSTITUTION: The nitromethylene compd. is a compd. of formula I (where R1 is H, a 1-4 C alkyl, ...
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JPH05501115A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH054397B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH053477B2 |
17 alpha -[(E)-2-Iodovinyl]-estra-1,3,5(10)-triene-3,17 beta -diol wherein the iodine atom is radioactive can be produced from (E)-[3-acyloxy-17 beta -hydroxyestra-1,3,5(10)-triene-17 alpha -yl]vinyl dihydroxyborane in an excellent yield...
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JPH0481435B2 |
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JPH0480889B2 |
A novel nitromethylation composition comprising nitromethane and a catalytic amount of a bifunctional basic catalyst, optionally in an organic solvent, a method of nitromethylating ketonic compounds with said compositions and novel stero...
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JPH0480038B2 |
Perchloryl fluoride when reacted with the appropriately protected 9 alpha -hydroxyandrostenedione stereoselectively produces the corresponding 6 beta -fluoro steroid.
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JPH0475919B2 |
Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17 alpha -acyl progesterones.
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JPH0469639B2 |
Novel steroids having the formula V wherein R1 is selected from the group consisting of methyl, ethyl, and propyl; R2 is selected from the group consisting of H and methyl; R3 is selected from the group consisting of OXO and H(OR5); (a) ...
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JPH0466879B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH0466878B2 |
Novel 6-oxygenated corticoid 17 alpha -carbonates are disclosed. These compounds have strong topical anti-inflammatory activity which are accompanied by extremely weak systemic adverse reaction. The present compounds are useful for the t...
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JPH04273893A |
PURPOSE: To provide the subject new compound useful for the prevention, care and treatment of inflammatory diseases in general including intractable dermatopathy owing to its excellent antiinflammatory action and having extremely low sid...
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JPH04273892A |
PURPOSE: To provide the subject new compound useful for the prevention, care and treatment of inflammatory diseases in general owing to its excellent antiinflammatory action and having extremely low side effect. CONSTITUTION: A 21-substi...
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JPH0459297B2 |
Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formulawherein Q isand R1 is a saturat...
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JPH0443920B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH0440360B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH0439479B2 |
The invention relates to 14-aminosteroids of general formula: in which R represents a hydrogen atom or a lower alkyl group containing 1 to 4 carbon atoms, as well as their pharmaceutical acceptable salts. Use in therapy for the treatment...
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JPH04503362A |
The invention relates to the field of organic chemistry and to steroid chemistry in particular. Its particular subject are novel 6-methyl estra 4,6-dienes of general formula (I) in which A is hydrogen or a lower oxoalkyl radical and B is...
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JPH0437080B2 |
13-Alkyl-11 beta -phenylgonanes of the general formula I in which A and B together are an oxygen atom, a CH2 group or a second bond between carbon atoms 9 and 10, X is an oxygen atom or the hydroxyimino group N-OH, n is the number 0 or 1...
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JPH04503361A |
The process of the present invention is a process for the preparation of an 11-oxygenated steroid of formula (II) which comprises (1) contacting a 9 alpha -halo steroid of formula (I) with a metal selected from the group consisting of ti...
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JPH04145024A |
PURPOSE: To obtain a bone resorption suppressing agent exhibiting excellent bone resorption suppressing action, free from side effect such as estrogen action and useful for the remedy of osteoporosis by using an estradiol derivative as a...
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JPH0424358B2 |
Beclomethasone dipropionate in the form of its micronised monohydrate substantially free from water other than water of crystallisation. Pharmaceutical compositions containing the compound are also described. The compositions may be in t...
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JPH04502167A |
Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, co...
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JPH0415799B2 |
6 alpha -Methyl corticoids of formula I (I) wherein is a single bond or a double bond, R is acyloxy of up to 8 carbon atoms, and X is chlorine, hydroxy, or acyloxy of up to 8 carbon atoms, are pharamacologically effective substances.
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JPH0415239B2 |
Compounds of Formula I wherein the bond is a single bond or a double bond, X is hydrogen, fluorine, chlorine, or bromine, R1 is formyl, alkanoyl or alkoxyalkyl each of which contains 2-8 carbon atoms, or benzoyl, and Y is chlorine, hydro...
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JPH0469395A |
NEW MATERIAL:A compound shown by formula I (R1 is OH or 1-6C acyloxy; R2 is H or lower alkyl; R3 is lower alkyl; X and Y are H or halogen; Z is O or S; wavy line is in α or β steric configuration; broken line between the 1 and 2 positi...
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JPH048440B2 |
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JPH04500523A |
The invention, which relates to the domain of chemistry and in particular therapeutic chemistry, essentially has as its subject matter b-methyl 19-nor pregna 4,6-dienes 17$g(a), and if necessary, 21-alkylates of general formula (I) in wh...
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JPH043363B2 |
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JPH03505740A |
PCT No. PCT/DE90/00183 Sec. 371 Date Oct. 19, 1990 Sec. 102(e) Date Oct. 19, 1990 PCT Filed Mar. 8, 1990 PCT Pub. No. WO90/11290 PCT Pub. Date Oct. 4, 1990.A process for the production of 3-deoxy-4-ene steroids of the general formula I (...
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JPH0372605B2 |
The use of a 17 alpha-acyloxy-6-methyl pregna-4,6-dien-3,20 dione (I) in which the acyl group has up to 10C atoms, as a therapeutic agent for oral or parenteral admin. to patients or animals who have undergone mastectomy following breast...
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JPH0364509B2 |
1512400 16,17-Naphthopregnenes E R SQUIBB & SONS Inc 13 Nov 1975 [25 Nov 1974] 46902/75 Heading C2U The invention comprises #4 and #1'4 steroids of formula wherein R 1 is Cl, F or OH; R1 1 is H; or R 1 and R1 1 together are oxo; R 2 is H...
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JPH0359918B2 |
A process for preparing 6-methyl-Δ4,6-3-keto steroids ofwherein X is, comprises reacting a corresponding Δ4-3-keto steroid with methoxymethyl acetate (CH3-O-CH2-OAc) in an inert solvent at temperatures above room temperature in the pre...
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JPH0357919B2 |
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