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JPH03169890A |
NEW MATERIAL: Compounds of formula I (ring D has a double bond shown by the broken line with proviso that ring D is 16-17C containing no double bond when R2 represents two substituents or a divalent substituent; X is keto, H or OH; R1 is...
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JPH0338838B2 |
There is provided the novel compound 11-hydroxypregn-4-en-3-one-20-carbaldehyde, as well as a microbial method for production of the same. This novel compound is of value as a starting material for antiinflammatory corticoids such as hyd...
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JPH03118326A |
NEW MATERIAL: To compounds are represented by formula I [ring D may have a double bond indicated by the broken line, with the proviso that a C16 -C17 double bond is not present when R<2> has a substituent group; X is keto, H or hydroxyl;...
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JPH0323559B2 |
Novel 20-isocyano- DELTA 17(20)-steroids of the formula I wherein R1 is selected from the group consisting of (1) hydrogen, (2) alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, an oxyg...
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JPH0317535B2 |
Derivatives of selenium as dehydrogenation agents employed in the presence of an oxidation agent consisting of oxidized derivatives of possibly substiuted iodoaromatic compounds, particularly where the derivatives of selenium are employe...
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JPH037679B2 |
Novel esters of 9a-fluoro- and chloro-corticosteroids of the formulawherein Y is chlorine or OR1, R1 and R2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R1 and R2 can be the same or different in the same molec...
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JPH033680B2 |
DELTA <1><6> and DELTA <1><7>-21-chloro-20-keto steroids of the formula wherein n is 1 or 2, C1@C2 and C9@C11 represents a CC-single or CC-double bond, R1 is H or OH, R2 is H or CH3, R3 is H or F wherein, when R3 = F, C9@C11 is a CC-sing...
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JPH03500049A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPH0262558B2 |
Novel 20-isocyano- DELTA 17(20)-steroids of the formula I wherein R1 is selected from the group consisting of (1) hydrogen, (2) alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, an oxyg...
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JPH0261480B2 |
Progesterone derivatives having a vinylidene or a 1-alkynyl substituent at the 18-position and further optionally hydroxylated at the 11-position and the 21-position are described herein. Compounds having both an ethynyl substituent and ...
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JPH0260319B2 |
A process for preparing a 3-oxo- DELTA 1,4-steroid comprises fermenting the corresponding 3-oxo- DELTA 4-steroid, saturated in the 1,2-position, witih a living culture of Arthrobacter simplex in the presence of 0.04 g to 0.12 g of cobalt...
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JPH0255406B2 |
Described is the use of sex hormones for the manufacture of a medicament for treatment of immunodeficiency diseases (Fig. 1).
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JPH0250919B2 |
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom a...
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JPH02225417A |
PURPOSE: To provide the title low toxic remedy giving excellent allergic airway anaphylaxis inhibitory effect, containing as active ingredient deprodone propionate. CONSTITUTION: The objective remedy can be obtained by incorporating depr...
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JPH0234958B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH0215559B2 |
Novel esters of 9a-fluoro- and chloro-corticosteroids of the formulawherein Y is chlorine or OR1, R1 and R2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R1 and R2 can be the same or different in the same molec...
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JPH0211600B2 |
Perchloryl fluoride when reacted with the appropriately protected 9 alpha -hydroxyandrostenedione stereoselectively produces the corresponding 6 beta -fluoro steroid.
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JPH0253794A |
NEW MATERIAL:A compound expressed by formula I (R1 is 1-5C alkylthio or methoxy; R2 is H, halogen or 2-3C alkylthio; R3 is H or methyl of α- or β-coordination; X is H or halogen; n is 1 or 2; the dotted line indicates that the bond bet...
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JPH026359B2 |
Novel 17-oxazoline-steroids of the formula I wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, oxygen function and nitrogen...
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JPH0222227A |
PURPOSE: To retard and/or lower cachexia related to acquired immunodeficiency syndrome by administering an effective dose of megestrol acetate into a human patient. CONSTITUTION: Megestrol acetate which is an oral antineoplastic agent fo...
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JPH022104B2 |
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JPH029820A |
PURPOSE: To treat osteoporosis by administering a progestin whose 19th position is unsubstituted by a continuous method, and as necessary, in the presence of estrogen. CONSTITUTION: A progestin whose 19th position is unsubstituted, e.g. ...
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JPH021160B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH02360B2 |
3-enol ethers of 11 beta -hydroxy- DELTA 4-pregnene-3-ones are prepared by reacting triethylorthoacetate with an 11 beta -hydroxy- DELTA 4-pregnene-3-one in a solvent which is at least 40% by weight or more ethanol and 60% by weight or l...
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JPH0159879B2 |
1. Process for manufacturing 11 alpha-hydroxy-20 alpha-hydroxymethyl- 1,4-pregnadien-3-one, characterised in that 20 alpha-hydroxymethyl-1,4-pregnadien-3-one is fermented with a live culture of Aspergillus occhraceus which is capable of ...
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JPH0152399B2 |
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JPH0150207B2 |
A combination of an aromatase-inhibitor and an antiandrogen in a weight ratio of aromatase-inhibitor to antiandrogen of 20:1 to 1:1 is useful in a method of prophylaxis and/or of treatment by therapy of prostatic hyperplasia. The aromata...
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JPH0148917B2 |
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JPH0128758B2 |
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JPH0123476B2 |
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JPH0123475B2 |
A process for preparing a DELTA 9(11)- and/or DELTA 16-unsaturated steroid comprises heating the corresponding steroid of the pregnane series substituted by 9 alpha -chloro- and/or 16 alpha -chloro- or 17 alpha -acyloxy, in an inert, apr...
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JPH0122280B2 |
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JPH0122279B2 |
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JPH0113719B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPH0113718B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPS6411036B2 |
A process for 9 alpha -debromination of 9 alpha -bromo-11 beta -hydroxy steroids without eliminating the 11 beta -hydroxyl group utilizing chromous chloride or chromous sulfate and thioglycolic acid.
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JPS6411038B2 |
The 17 alpha -monoesters and 17 alpha ,21-diesters of corticosteriods are well known and represent nowadays the most efficient group of anti-inflammatory compounds for topical application, having minimal systemic action.
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JPS6411039B2 |
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JPS649320B2 |
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JPS6363555B2 |
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JPS6362516B2 |
The invention relates to a novel process for the preparation of pregnane derivatives of formula I, (I) wherein R1 stands for a methyl or an ethyl group, R2 represents a hydrogen atom or a methyl group, and X is a hydrogen atom or a formy...
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JPS6361000B2 |
In the prodn. of 11 beta-hydroxy-steroids of the pregnane series substd. in the 17 alpha-position by an acetal residue of the formula -3-CHR2-Or1 (I) (where R1 is alkyl opt. interrupted by an O-atom and R2 is H or alkyl; or R1+R2 is tetr...
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JPS6360036B2 |
This invention relates to novel 3,20-dioxo-1,4-pregnadiene-17 alpha -ol 17-aromatic heterocyclic carboxylates, to pharmaceutical formulations thereof, and their use in the treatment and control of inflammatory conditions.
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JPS6360034B2 |
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JPS6360038B2 |
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JPS6356235B2 |
A process for preparing a 6-methylene- DELTA 4-3-keto steroid of the formula wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the CD-r...
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JPS6353999B2 |
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JPS6353998B2 |
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JPS6353996B2 |
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JPS6353997B2 |
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