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Matches 151 - 200 out of 1,040

Document Document Title
WO/2002/072084A2
The present invention provides use of a compound in the manufacture of a medicament to inhibit 11$g(b)-HSD activity, wherein the compound is selected from glycyrrhetinic acid derivatives, progesterone and progesterone derivatives.  
WO/2002/066672A2
Compounds that are antagonists of D-amino acid oxidase and D-aspartate oxidase, methods of treating CNS disorders including bipolar disorder, psychosis and schizophrenia using the compounds, and pharmaceutically acceptable compositions t...  
WO/2002/058634A2
The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16$g(a)-carboxylic acid substituted steroids sand their es...  
WO/2002/053577A2
The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatm...  
WO/2002/051422A1
Preventives and/or remedies for inflammatory airway diseases which contain as the active ingredient steroid derivatives represented by the following general formula (1): (1) wherein R represents hydrogen, halogeno, hydroxy or -OCOR?1¿ (...  
WO/2002/036106A2
The invention relates to novel medicament compositions based on anticholinergics and corticosteroids, a method for the production thereof and the use thereof for treating respiratory conditions.  
WO/2002/032432A1
The present invention relates to methods and uses for inducing apoptosis in a cell, in particular a breast cancer cell, by the administration of antiprogestins, in particular the antiprogestin 11$g(b)-(4-acetylphenyl)-17$g(b)-hydroxy-17$...  
WO/2002/032430A1
The present invention relates to methods and uses for preventing or treating hormone-dependent disease, in particular breast cancer, in a mammal by antiprogestins, in particular antiprogestin 11$g(b)-(4-acetylphenyl)-17$g(b)-hydroxy-17$g...  
WO/2001/098322A1
The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hor...  
WO/2001/097860A2
The present invention describes novel compounds of the formula (I):(Q)¿d?-L¿n?-C¿h?, useful for the diagnosis and treatment of cancer in combination therapy in a patient. The present invention provides novel compounds useful for the t...  
WO/2001/096293A1
Provided are vitamin D derivatives which exhibit excellent physiologic activities suitable for drugs, particularly remedies for dermatoses such as psoriasis, and are lowered in the calcium increasing activity. The derivatives are represe...  
WO/2001/074840A2
The present invention relates, $i(inter alia), to compounds having the general formula (I) in which: R?1¿ is a member selected from the group consisting of -OCH¿3? -SCH¿3?, -N(CH¿3?)¿2?, -NHCH¿3?, -NC¿4?H¿8?, -NC¿5?H¿10?, -NC¿...  
WO/2001/070234A1
A stable anaesthetic composition is described which is particularly suitable for use in cats and dogs. The composition comprises an aqueous solution of an anaesthetically effective amount of a water soluble cyclodextrin or a cyclodextrin...  
WO/2001/055171A1
Mometasone (9$g(a),21-dichloro-1 $g(b),17$g(a)-dihydroxy-16$g(a)-methyl-pregna-1,4-dine-3,20- dione) is prepared from icomethasone (9$g(a)-chloro-11$g(b),17$g(a),21-trihydroxy-16$g(a)-methyl- pregna-1,4-diene-3,20-dione) by reaction ther...  
WO/2001/052856A2
The invention concerns the use of at least a compound selected in the group consisting of dehydroepiandrosterone, its chemical precursors, its chemical derivatives, its biological precursors and metabolic derivatives, for preparing a com...  
WO/2001/051055A2
There is provided a pharmaceutical composition comprising (i) a compound of formula (I) wherein: X is a hydrocarbyl ring having at least 4 atoms in the ring; K is a hydrocarbyl group; Rs is a sulphamate group; (ii) optionally admixed wit...  
WO/2001/049280A2
Pregnanes of formula (I) where R¿1?=H, C¿1-4? alkyl, C¿1-4? alkanoyl, SO¿3?H, or a salt thereof, R¿2?=C¿1-4? alkyl, R¿3?=H or methyl, and one or two non-adjacent members of a, b, c, and d are optional double bonds, and pharmaceuti...  
WO/2001/047945A1
The present invention provides a process for preparing the antiprogestational agent, 17$g(a)-acetoxy-11$g(b)-[4-N,N-(dimethylamino)phenyl]-21-met hoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes ...  
WO/2001/045677A1
Nanometer particles of poorly water-soluble or substantially water-insoluble compound are produced by finely-spraying a non-aqueous solution of said compound into a heated and fluidized bed of carrier excipient. The resulting product con...  
WO/2001/045674A1
Nanometer particles of poorly water-soluble or substantially water-insoluble compound are produced by finely-spraying a non-aqueous solution of said compound into a heated and fluidized bed of carrier excipient. The resulting product con...  
WO/2001/032680A2
The invention relates to novel 18-norsteroids (gonatrienes) of general formula (I), wherein R?1¿, R?2¿, R?3¿, R?6¿, R?7¿, R?8¿, R?9¿, R?11¿, R?11"¿, R?14¿, R?15¿, R?15"¿, R?16¿, R?17¿ and R?17"¿ have the meaning cited in t...  
WO/2001/029036A2
An allosteric site on muscarinic receptors is disclosed, together with its use for screening for compounds capable of modulating the binding of a primary ligand such as acetylcholine to the receptor. The site is characterised herein a se...  
WO/2001/026618A2
The invention relates to composition containing at least one steroid selected from: dihydroepiandrosterone and/or a biological precursor and/or a metabolic derivative thereof, in a physiologically suitable medium and characterised in tha...  
WO/2000/056758A1
The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use...  
WO/2000/048604A1
The invention relates to the use of high doses of dienogest for reducing the mammary corpus. Regressions of mastopathic changes if the mammary corpus can also be effected. Dienogest is also remarkably suitable for the prophylaxis of mast...  
WO/2000/039148A1
The invention relates to new 7$g(a), 17$g(a), 17$g(b)-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent diseases, notably for the long-term ant...  
WO/2000/034307A1
The invention relates to sterol phosphates of formula (I) in which R?1¿, R¿2? and R?4¿, independent of one another, represent H and/or methyl and R?3¿ represents linear and/or branched alkyl radicals and/or alkenyl radicals with 1 to...  
WO/2000/034306A1
The invention is directed to a novel class of 17$g(b)-acyl-17$g(a)-propynyl steroids which exhibit potent antiprogestational activity.  
WO/2000/032313A1
The present invention is a method of milling materials to form a fine powder with a median particle size below 10 micrometers which is suitable for inhalation and which has substantially no amorphous content generated during milling. The...  
WO/2000/023460A1
The invention pertains to a process for the preparation of a high purity composition of (7$g(a),17$g(a))- 17-hydroxy- 7-methyl- 19-nor-17-pregn- 5(10)-en-20-yn-3-one. The process provides for a composition with less than 0.5 % of (7$g(a)...  
WO/2000/021511A2
One aspect of the present invention is a method of human female menopause treatment which comprises subcutaneous administration of a menopausely effective amount of a hormonal replacement agent selected from the group consisting of a pro...  
WO/2000/021977A1
This invention provides 5$g(a)-pregnane-3$g(b), (20S), 21-triol, 20-O-$g(b)-glucuronide and 5$g(a)-pregnane-3$g(b),20R-diol, 20-O-$g(b)-glucuronide and pharmaceutically acceptalbe salts thereof which are useful as progestational agents.  
WO/2000/020437A1
The invention relates to substituted propanolamine derivatives and their pharmaceutically acceptable salts and physiologically functional derivatives. The invention relates to compounds of formula (I), wherein the radicals have the defin...  
WO/1999/054032A1
The invention relates to a method for carrying out photochemical and thermochemical solar syntheses by means of flat-bed solar collectors without devices for focusing the sunlight. Said method is particularly well suited for producing fl...  
WO/1999/052930A1
The invention relates to a new method comprising different ways of producing compounds of formula (1). The invention further relates to the hitherto unknown compounds of formulas (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13),...  
WO/1999/032506A1
The invention relates to 17$g(b)-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R¿1? is (H,OR), (H,OSO¿3?H) or NOR; with R being H, (C¿1-6?)alkyl or (C¿1-6?)acyl; each of R¿2? and R¿3? is ...  
WO1998020151A9
Disclosed is a method for the production of an adrenocorticoid steroid represented by general formula (I), wherein R1 and R3 may be H, alkyl, substituted alkyl, silyl, acyl, acyloxy or carbamoyl (and wherein R1 need not be the same as R3...  
WO/1999/018971A1
An aqueous nebulizer suspension contains water, mometasone furoate monohydrate, a nonionic surfactant, a soluble salt and optionally a pH buffer. The suspension may be prepared by ultrasonication or jet milling techniques.  
WO/1998/055498A1
The invention relates to 17$g(b)-allyloxy(thio)alkyl-androstane derivatives having general formula (I) wherein R�1? is (H, OR), (H, OSO�3?H) or NOR; with R being H, (C�1-6?)alkyl or (C�1-6?)acyl; each of R�2? and R�3? is inde...  
WO/1998/055074A2
The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (burns), surgica...  
WO/1998/050415A1
This invention provides a compound having formula (I) wherein R and R?1� are each, independently, hydrogen or SO�3??-�X?+�; X?+� is alkali metal, alkaline earth metal, ammonium, alkylammonium containing 1-6 carbon atoms, or dia...  
WO/1998/046243A2
A pharmaceutical composition contains an extract obtainable from a plant of the genus $i(Trichocaulon) or $i(Hoodia) containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for s...  
WO/1998/033506A1
This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pha...  
WO/1998/032718A1
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...  
WO/1998/031702A1
The present invention relates to 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives according to formula (I), wherein R�1? is C�1-6?alkyl, C�3-6?cycloalkyl, C�1-6?alkoxy, triflate, pyridyl or phenyl where the phenyl m...  
WO/1998/028266A1
Vitamin D derivatives of general formula (1) wherein X represents oxygen or sulfur; R�11? represents saturated or unsaturated aliphatic hydrocarbyl which may be substituted by hydroxyl or protected hydroxyl, or -COR�12? (wherein R�...  
WO/1998/014194A1
The invention relates to a method of alleviating the symptoms of anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The st...  
WO/1998/009935A1
A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R�1? and R�2? independently is optionally substituted C�1?-C�6? alkyl; each of W and X is independently hydrogen or C�1?-C�6? a...  
WO/1998/007741A1
The present invention pertains to a process for producing eltanolone (I), wherein epi-sarsasapogenine (II) is broken down in the presence of ammomium chloride and pyridine and acetane hydride to obtain 3$g(a), 26-diacetoxy-5$g(b), 25S-fu...  
WO/1998/005679A2
A third class of PR-ligand (i.e. mixed agonist) is identified which induces a progesterone receptor conformation distinct from that induced by a PR agonist or antagonist. PR mixed agonists exhibit partial agonist activity which is influe...  

Matches 151 - 200 out of 1,040