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Patent Searching and Data


Matches 101 - 150 out of 457

Document Document Title
WO/1999/058550A1
The compound 7$g(b)-methyl-16$g(b)-((4-methylsulfonyl)-phenoxy)-4-aza-5$g (a)-androst-1-en-3-one is an inhibitor of the 5$g(a)-redctase 1 isozyme, and is useful alone or in combination with a 5$g(a)-reductase 2 inhibitor for the treatmen...  
WO/1999/054032A1
The invention relates to a method for carrying out photochemical and thermochemical solar syntheses by means of flat-bed solar collectors without devices for focusing the sunlight. Said method is particularly well suited for producing fl...  
WO/1999/035161A1
A process for producing a compound of formula (I) wherein the dotted lines --- independently represent a single or double bond and R, R¿1?, R¿2? and R¿3? are each hydrogen or an organic radical, comprises treating the corresponding 17...  
WO/1999/027935A1
A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the polycyclic compound comprises at least o...  
WO/1999/021563A1
This invention is concerned with the prevention of precipitated acute urinary retention in a subject male susceptible thereto by the administration of an inhibitor of 5$g(a)-reductase to the subject. The present invention also provides f...  
WO/1999/016449A1
The present invention relates to Ca?2+¿ channel blockers and more particularly to the R-type Ca?2+¿ channel blockers. More specifically, the invention relates to Ca?2+¿ channel blockers activity of $i(Mandevilla velutina) and $i(Mande...  
WO/1999/006050A1
Compounds having general formula (I) are novel compositions which are effective in the treatment of baldness, female hirsutism, or seborrhea or function to prevent prostatic cancer from metastasizing to the bone, wherein R?1¿ and R?2¿ ...  
WO/1998/050419A2
Novel 4-aza-steroid compounds are provided, which have functional groups at one or more of positions 7, 11 and 15, such as hydroxyl or hydroxyl derivative groups. The compounds are active against 5-$g(a)-reductase giving indications of u...  
WO/1998/040398A1
Disclosed is a method of preparing a compound represented by structural formula (a). The method comprises reacting bromine (Br�2?) and an aliphatic organic acid with a compound represented by structural formula (b). R�1? and R�2? a...  
WO/1998/033506A1
This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pha...  
WO/1998/025463A1
The present invention provides for a method of inhibiting bone loss in a subject in need of such treatment comprising administration to the subject of a therapeutically effective amount of a compound of structural formula (I). The presen...  
WO/1998/011124A1
Because of having excellent estrone sulfatase inhibitory effects, estratriene derivatives represented by general formula (I) are useful in the prevention and treatment of diseases caused by estrogens such as mammary cancer, uterus cancer...  
WO/1997/040062A1
Process for preparing steroids having a carboxamide side-chain of formula (I) wherein: the formula - - - are each independently, single or double bonds; z is a single bond, or a straight or branched C1-C5 alkylene; the moiety represents ...  
WO/1997/030069A1
The invention related to 4-aza-17'beta'-(cyclopropoxy)-androst-5'alpha'-androstan-3-o ne, 4-aza-17'beta'-(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these compounds, as well as the inhibi...  
WO/1997/016068A1
The compounds of formula (I) are useful as immunosuppressive agents.  
WO/1997/015564A1
The compounds of the present invention are those of structural formula (I) wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In ad...  
WO/1997/015305A1
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5'alpha'-reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double b...  
WO/1997/015558A1
The novel compounds of the present invention are those of structural formula (I), or a pharmaceutically acceptable salt, or stereoisomer thereof, which are inhibitors of 5'alpha'-reductase, particularly 5'alpha'-reductase type 1. The com...  
WO/1997/014418A1
Compounds of formula (I) are inhibitors of 5'alpha'-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, prostatic carcinoma, prostatitis and ...  
WO/1997/014671A1
The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, A, Q, W, X, Y, Z and n are defined herein. The inven...  
WO/1997/014683A2
Disclosed are novel phenanthridine derivatives of general formul� (I) and (II) and the salts thereof. In the formul�, R1 is a hydrogen atom or aromatic carbocyclic or heterocyclic group, and R2 and R3 can be either identical or diffe...  
WO/1997/010217A1
Compounds of structural Formula (I), and pharmacologically acceptable salts and esters thereof possess 5'alpha'-reductase inhibitory activity. These compounds inhibit 5'alpha'-reductase type 1 and type 2. The compounds of structural Form...  
WO/1997/010257A1
Compounds of formula (I), wherein: the symbol --- represents a single or a double bond; R is a hydrogen atom or a C1-C4 alkyl group; Rf and R'f, each independently, are C1-C4 alkyl groups substituted by one or more fluorine atoms; and R1...  
WO/1997/004002A1
The present invention relates to the epimers: (22R)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5'al pha'-androst-1-ene-17'beta'-carboxamide and (22S)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5'al pha'-androst-1-ene-17'bet...  
WO/1997/001346A1
A cosmetic or pharmaceutical and particularly dermatological composition including, as the active ingredient, an extract of plants of genus Filicium, and particularly an extract of plants of species Filicium decipiens, preferably in an a...  
WO/1996/030391A1
The present invention relates to 17'beta'-substituted-6-azacholesten-3-ones of Formula (I) wherein: R1 and R2 represent independently hydrogen or alkyl and the bond between carbons 1 and 2 is a single or a double bond, or R1 and R2 may b...  
WO/1996/022100A1
Compounds of formula (I) are inhibitors of 5'alpha'-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern...  
WO/1996/020713A1
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5'alpha'-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the...  
WO/1996/020210A2
Compounds of formula (A), wherein the groups X, R1 and Y are as defined, having pharmacological activity and the use thereof as antiandrogen agents.  
WO/1996/012705A1
Compounds of formula (I) wherein: the dotted line indicates that a double bond may be present or absent; R1 is H, methyl or ethyl; R2 is 'alpha'- or 'beta'-C1-10 straight or branched alkyl; R3 is CO2H, CN, CO2R4, COHNR4, or CON(R4)2; R4 ...  
WO/1996/012034A1
The present invention relates to a microbiological process for the transformation of 17'beta'-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5'alpha'-reductase.  
WO/1996/011939A1
A process for providing novel compounds of formula (I), that are useful as 6-azaadrostenone testosterone 5-alpha-reductase inhibitors, from commercially available compounds of formula (II) wherein, R1 and R2 represent: i) indepedently H ...  
WO/1996/008481A1
A plant growth regulator containing an epoxycyclohexane derivative represented by general formula (1) and another plant growth regulator containing both the epoxycyclohexane derivative and a brassidosteroid as the active ingredient. In s...  
WO/1996/007643A1
The novel process of this invention involves the reduction of certain 'DELTA'-5 steroidal alkenes to selectively produce either the 5'alpha' or 5'beta' reduction products. Particularly, this invention involves reduction of 'DELTA'-5 ster...  
WO/1996/003422A1
The present invention provides compounds of formula (I) wherein the symbol --- represents a single or a double bond; R is a hydrogen atom or a C1-C4 alkyl group; A is a single bond or a straight or branched C1-C6 alkylene chain; B is a s...  
WO/1995/032215A1
The instant invention involves a process for oxidizing compounds containing an allylic group, i.e. those containing an allylic hydrogen or allylic alcohol group, to the corresponding enones, using a ruthenium-based catalyst in the presen...  
WO/1995/028928A1
Compounds of formula (I) are inhibitors of 5'alpha'-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern...  
WO/1995/017417A1
A 6-substituted oxa- or azasteroid compound represented by general formula (I), having an excellent aromatase inhibitory activity, and being useful for preventing or treating diseases caused by estrogens, such as mammary cancer, uterus c...  
WO/1995/012398A1
Compounds of formula (I) are inhibitors of 5'alpha'-reductase and are useful alone or in combination with 5'alpha'-reductase 1 and/or 2 inhibitors for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hi...  
WO/1995/011254A1
Compounds of formula (I) are inhibitors of the 5'alpha'-reductase 1 isozyme, and are useful alone, or in combination with a 5'alpha'-reductase 2 inhibitor, for the treatment of androgenic sensitive disorders such as acne vulgaris, seborr...  
WO/1995/007926A1
The present invention relates to compounds of formula (I), wherein carbons 1 and 2 are joined by either a single or a double bond; R1 is hydrogen or methyl; R2 is hydrogen or methyl; R3 is (A) or (B) wherein X, W, Z, R4, R5, R6, R7 and R...  
WO/1995/007927A1
The present invention relates to the compound of formula (I), also known as 17'beta'-N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5 'alpha'-androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation...  
WO/1995/002607A1
Compounds of formula (I) wherein R1 is hydrogen or methyl; R2 is methyl; R3 is hydrogen, Alk-R4, X-Alk, C1-6-X-Alk, XCO-Alk, CN, CO-Alk, CO-Ar, CO-O-Alk, CO-NH-Alk, CO-NH-Ar, CO-NH-Het and CO-N(Alk)2; Alk is C1-12 straight or branched al...  
WO/1995/000532A1
The invention relates to novel 4-azaandrostene derivatives of general formula (I), wherein R represents hydrogen or a C1-3alkyl group; X represents chlorine, bromine or iodine; and the -_-_-_-_ bond line represents a single or double bond.  
WO/1995/000147A1
Compounds of formula (I), wherein: R1 is selected from the group consisting of hydrogen and methyl; R2 is selected from the group consisting of methyl and ethyl; R3 is selected from the group consisting of hydrogen and methyl; and the C1...  
WO/1995/000531A1
The invention relates to a novel process for preparing 17beta-substituted 4-azaandrostane derivatives of general formula (I) wherein R represents hydrogen or a C1-3alkyl group; R1 represents a carboxamido group mono- or disubstituted by ...  
WO/1994/028011A1
Brassinosteroid derivatives represented by formulae (I) and (II), and a plant growth regulator containing at least one of them as the active ingredient. The compounds (I) and (II) are novel brassinosteroid analogues and the growth regula...  
WO/1994/026767A1
Androgen nucleus derivatives having specified substituents at the 17alpha position are disclosed for use as antiandrogens for the treatment of androgen-dependent diseases. In some preferred embodiments, the compound EM-250 is formulated ...  
WO/1994/022900A1
17beta-substituted aza-androstane derivatives of formula (I) wherein carbon atoms 1 and 2 are joined by a single bond or by a double bond, R1 is hydrogen, methyl or ethyl, R2 is hydrogen or lower alkyl, R3 and R4 are each independently o...  
WO/1994/020104A1
Compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 is -H or C1-10 alkyl; R2 is -H or C1-10 alkyl; R3 is C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxyl, cyano, or triphenylthio- C1-6 alkyl; and R4 is a ...  

Matches 101 - 150 out of 457