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WO/2023/192574A1 |
A method of preparing a triterpenoid compound of formula (I): formula (I), including a step of converting a compound of formula (II) into the compound of formula (I), formula (II) wherein R1 and R2 independently represent hydrogen or a p...
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WO/2023/149727A1 |
Betulin is a natural pentacyclic triterpene, and is contained in birch tree, especially its outer bark. Betulin can be used as a hydrophobic building block for production of biobased surfactants. This invention is related to amphiphilic ...
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WO/2023/087103A1 |
Agents having cytotoxic activity, as well as compositions, uses, and methods relating thereto, are described herein. Certain steroid acid-peptide conjugates or moieties have the ability to induce killing or inhibition of proliferation of...
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WO/2023/023869A1 |
Steroid acid-based hydrogels and methods of production thereof are described herein. More specifically, the present description relates to steroid acid-peptide conjugates for the formation of a hydrogel. Peptides are covalently conjugate...
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WO/2022/165512A9 |
Described herein are novel LIF/LIFR inhibitors that exhibit improved cytotoxicity and bioavailability. These LIF/LIFR inhibitors are particularly useful for the treatment of tumors associated with overexpression of LIF.
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WO/2021/220061A2 |
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, b...
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WO/2021/194244A1 |
The present invention relates to a novel method for preparing Inotodiol. The method differs in terms of process from existing methods for preparing Inotodiol, and produces a high yield of Inotodiol. Therefore, the method can be useful fo...
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WO/2021/184128A1 |
Disclosed are methods of treating a coronavirus infection (e.g., a SARS-CoV-2 infection) using colchicine, and methods of treating Kawasaki Disease or Kawasaki Disease Shock Syndrome, e.g., by administering colchicine to a subject in nee...
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WO/2021/064205A1 |
The present invention relates to a method for preparing alkenyl aminoboranes and their derivatives, and uses thereof. The method for preparing alkenyl aminoboranes comprises contacting, preferably in a single synthesis step, a terminal a...
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WO/2021/025973A1 |
The present application relates generally to novel aminosterol compounds, compositions comprising the same, and methods of making and using the novel aminosterol compounds and compositions.
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WO/2021/014217A1 |
The present invention is directed towards articles comprising a steroid material comprising a steroid dimer and at least one therapeutic agent distributed throughout the steroid material and the use of such articles in sustained release ...
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WO/2020/245641A1 |
The present disclosure relates to novel ester forms of medroxyprogesterone, process for their preparation and pharmaceutical compositions comprising the same. The present disclosure also relates to use of the novel ester forms in hormona...
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WO/2020/176668A1 |
Monk fruit extracts containing mogrol glycosides such as mogroside V may be treated with enzymes under specific reaction conditions to shift distribution of the Siamenoside I reaction product. Modified enzymes are also employed to shift ...
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WO/2020/161317A1 |
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.
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WO/2020/051329A1 |
The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds...
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WO/2019/148291A1 |
The disclosure features ocular inserts for the sustained release of steroids in the treatment ocular conditions. Said ocular inserts are articles formed from a compound of formula D1-L-D2 (A-I), wherein D1 and D2 are steroid radicals sel...
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WO/2019/148293A1 |
Steroid dimers and articles formed from steroid dimers are disclosed. Said steroid dimers are represented by D1-L-D2 wherein D1 and D2 are steroid moieties and L is a covalent linker. The articles comprising the steroid dimers can be mac...
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WO/2019/145977A1 |
The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also ...
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WO/2019/140272A1 |
Provided herein is a compound of Formula (I-I), or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I-I), and met...
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WO/2019/050430A1 |
The invention relates to the wood chemical industry and concerns a method for extracting phytosterols from tall oil pitch. The present method of extracting phytosterols from tall oil pitch involves saponifying tall oil pitch using an alk...
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WO/2019/024920A1 |
The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, ...
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WO/2018/214327A1 |
The present invention pertains to the technical field of drug synthesis and relates to a preparation method for a novel anti-cancer drug lanosterol derivative. In the method, lanosterol is used as a starting material to produce an interm...
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WO/2018/215908A1 |
The present invention provides a process for preparation of deoxycholic acid or salt thereof; the process comprises the steps of reacting the compound of formula II to obtain a compound of formula III; the compound of formula III is conv...
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WO/2018/185783A1 |
The present invention provides a single pot process for the synthesis of 19-Norethisterone of Formula (I), comprising contacting 19-Norandostene-3,17-dione of Formula–II with a first base, an organic gas/solution and an acid to obtain ...
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WO/2018/147345A1 |
Provided is a method by which a compound, which is useful as an intermediate and in which an oxo group is introduced specifically at the 15-position of a steroid skeleton, can be produced at a high yield without involving a complex proce...
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WO/2018/134278A1 |
The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.
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WO/2018/109508A1 |
The invention relates to the last step of a synthetic process, in which Nomegestrol- acetate of formula (I) is synthesized from 17α-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and ac...
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WO/2018/109622A1 |
The present invention relates to process for the preparation of dydrogesterone.
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WO/2018/037423A1 |
The present invention discloses a process for the preparation of pregnadiene derivatives having formula I, their stereoisomer and intermediate thereof. Formula I wherein each substituent is independently, R1 and R2 is hydrogen or C1 –C...
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WO/2017/208132A1 |
A process for the synthesis of 3β-hydroxy-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula (I) given below.
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WO/2017/180051A1 |
There are provided odorless shea based esters as an ingredient composition comprising: a) 81- 97 wt% of at least one short chain alcohol alkyl ester, at least partially from a natural source, b) 3-19 wt% of triterpene esters where at lea...
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WO/2017/130127A1 |
The present invention relates to extraction of phytosterolsfrom alkaline tall oil soap which is obtained from the Kraft process black liquor by skimming.In the method according to the present invention, phytosterols are extracted using d...
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WO/2017/093980A1 |
The present invention relates to a process for purification of 4-androsten-3,17-dione (II) and its conversion to testosterone (I) having purity > 99 % as measured by HPLC.
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WO/2017/088080A1 |
The present invention relates to a method for obtaining and purifying saponins from plant extracts, which comprises extracting saponins and subsequently removing impurities by adding a salt selected from the group of alkaline earth metal...
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WO/2017/072719A1 |
The present invention relates to a new process for the synthesis of 17β-hydroxy- des-A-androst-9,10-en-5-one, the compound of the following formula (1), which can be used as an intermediate in the synthesis of retroprogesterones.
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WO/2017/019524A1 |
The present application relates to a method of preparing compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, R1 is H, α-OH, β-ΟΗ, or an oxo group.
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WO/2016/189200A1 |
Method of recovering sterols from tall oil pitch which contains steryl esters. In the method the tall oil pitch is subjected to a transefterification reaction with a lower alcohol in a reaction zone to provide a reaction product mixture ...
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WO/2016/173397A1 |
The present invention relates to a cholic acid derivative, and a preparation method and a medical use thereof. In particular, the present invention relates to a cholic acid derivative with the structure of formula (I), a stereoisomer, or...
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WO/2016/154772A1 |
The present invention relates to a method for preparing 9β,10α-pregnane-4,6-diene-3,20-dione. The preparation method uses 9β,10α-pregnane-5,7-diene-3,20-dione diethyl diacetal (compound A) as a raw material, which is deprotected unde...
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WO/2016/126875A1 |
The automated synthesis of clinically relevant amounts of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yiel...
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WO/2016/096988A1 |
The present invention relates to method of extracting cholesterol from milk fat.
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WO/2016/054280A1 |
A method of preparing a thioic acid intermediate of fluticasone propionate includes: treating a 17β-[(N,N-dimethyl carbamoyl)thio]carbonyl compound in a solution including an alcohol and an alkali metal hydroxide, an alkaline-earth meta...
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WO/2016/039359A1 |
The present invention relates to: a terpenoid derivative which is capable of activating a Keap1/Nrf2/ARE signaling pathway and has an excellent anti-inflammatory activity and an excellent cell-protecting activity; and a sustained-release...
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WO/2015/168523A1 |
A liquid crystalline drug delivery system for ocular administration. The drug delivery system, which is mucoadhesive, biocompatible, non-irritating, and tissue permeable, contains nanoparticles stably dispersed in an aqueous solution and...
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WO/2015/158163A1 |
The present invention relates to cyclopentanoperhydrophenanthrene framework compounds and a preparation method therefor. The compounds have certain biological activity, can also be used as an intermediate synthon for synthesizing some co...
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WO/2015/057047A9 |
The invention relates to a method for the enzymatic synthesis of lithocholic acid oleate and for the efficient purification of same. The lithocholic acid oleate is a molecule that serves as an antimicrobial peptide elicitor and has an in...
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WO/2015/095339A1 |
The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
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WO/2015/081778A1 |
The present invention belongs to the field of organic synthesis, relates to a method for synthesizing a saponin, and in particular, to a method for constructing a glycosidic bond in a saponin, and comprises the following steps: directly ...
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WO/2015/047187A1 |
A new process for enrichment of triterpene esters, said process comprises the steps of: a) providing a mixture comprising a non-distilled vegetable oil and/or a non-distilled vegetable fat, further comprising triterpene esters, b) perfor...
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WO/2014/188353A2 |
The present application relates to a regioselective and stereoselective processes for the preparation of dehydroepiandrosterone (DHEA) and processes for its intermediates.
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