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WO/2022/265115A1 |
A method of producing a polypeptide compound, wherein a peptide compound represented by formula (P) is obtained by inducing an amide formation reaction between an amino-protected lactam compound represented by formula (R1) and an amino a...
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WO/2022/257831A1 |
Disclosed are polypeptide compounds using PD-1 receptors as targets. The polypeptide compounds comprise a compound 1, a compound 2, a compound 3, a compound 4 and a compound 5. The amino acid sequences of the compounds 1-5 are as shown i...
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WO/2022/260091A1 |
In this synthetic adsorbent, the maximum value of a differential pore volume (mL/g) determined under pressure conditions from 0.5 psia to 30.0 psia as measured by the following method exceeds 0.05 mL/g.
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WO/2022/261127A1 |
Provided herein are fusion proteins engineered from a dysferlin C2 domain sequence linked to a sequence of a homologous fusion partner, vector constructs with cDNA encoding the fusion proteins and viral vectors with the vector constructs...
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WO/2022/255195A1 |
The present invention provides a method for inexpensively and efficiently synthesizing polypeptide compounds comprising various amino acids. The method involves (i) inducing an amide formation reaction between the carboxyl group on the r...
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WO/2022/256383A1 |
Microchip Capillary Electrophoresis (MCE) assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.
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WO/2022/252619A1 |
A fermentation and enzymolysis preparation method for small peptides from a leaf-shaped fish and the use thereof. The preparation process comprises: crushing, degreasing and hydrolyzing a leaf-shaped fish to obtain a hydrolysate; carryin...
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WO/2022/255893A1 |
Provided are methods of diagnosis and differentiation of and between PD and DLB tissue samples.
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WO/2022/253175A1 |
A synthetic polymeric porous medium with a core-shell (s) hierarchical layer structure and has an essentially homogeneous porous structure from inside to outside of the medium, whose core and shell (s) are covalently modified with distin...
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WO/2022/255289A1 |
The present invention relates to a method for producing a glycopeptide, the method including a step for modifying an Fc region of an avian antibody, and a step for lysing the modified Fc region using a proteolytic enzyme, and the glycope...
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WO/2022/251357A1 |
Methods for reducing cleavage of a protein comprising a formylglycine (fGly) amino acid is provided. Such methods can involve protecting the protein from exposure to visible light having a wavelength of 500 nm or lower. Also provided her...
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WO/2022/250036A1 |
[Problem] To provide a method for separating and purifying a minute useful substance. [Solution] A method for separating and purifying a minute useful substance involves filtering a liquid containing the minute useful substance by means ...
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WO/2022/248587A1 |
The invention relates to a novel amino acid having a tetrazine moiety and peptide or protein comprising the novel amino acid compounds. The invention also relates to a method of producing peptide or proteins comprising a tetrazine moiety...
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WO/2022/251194A1 |
Disclosed herein are methods of determining load volumes for capture chromatography in system and methods for continuous manufacture of a biological product.
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WO/2022/247927A1 |
The present invention relates to an indicator molecule for the toxigenicity of aflatoxigenic fungi and the use thereof. The amino acid sequence of the indicator molecule ABFT-YJFZ01 for the toxigenicity of the aflatoxigenic fungi is as r...
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WO/2022/250035A1 |
[Problem] To provide an isolation and purification method for isolating and purifying extracellular vesicles. [Solution] An isolation and purification method of extracellular vesicles, said method being for obtaining a concentrated solut...
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WO/2022/245306A1 |
The present invention relates to the field of antibody purification in biotechnological production. In particular, the present invention provides an improved method for purifying an antibody from a harvested cell culture fluid comprising...
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WO/2022/243320A1 |
Disclosed is a method for producing a biomolecule by a cell cultured in vitro, the method comprising the steps of: (a) propagating the cell in a cell culture, wherein the cell is transformed with a vector, wherein the vector comprises (i...
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WO/2022/245924A1 |
Phenylalanine ammonia-lyase (PAL) variants with a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL for therapeutic uses, including the treatment of adolescent subjects having PKU.
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WO/2022/246086A1 |
Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high...
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WO/2022/242033A1 |
Provided in the present invention are a genetically engineered bacterium for producing porcine myoglobin, and methods for fermenting and purifying same. According to the present invention, the gene of the porcine myoglobin is integrated ...
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WO/2022/246342A1 |
The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The solutions and powders can be used to improve the post-harvest preserv...
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WO/2022/242339A1 |
The present invention provides an oligopeptide, a preparation method therefor, and an application thereof. The amino acid sequence of the oligopeptide is Phe-Pro-Gln-Tyr-Leu-Gln-Tyr-Pro-Tyr, and the IC50 of the oligopeptide to an angiote...
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WO/2022/134395A9 |
Disclosed are a novel BH3 mimetic peptide analog inhibiting PTP1B activity and an application thereof. The structural formula (I) of the novel BH3 mimetic peptide analog is as shown below. The mimetic peptide compound is derived from the...
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WO/2022/242993A1 |
The present invention relates to a method for preparing a library of peptides or an isolated peptide comprising (a) releasing one or more linear dithiol peptides carrying a sulfhydryl group in the N-terminal region of the one or more pep...
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WO/2022/245150A1 |
The present invention provides a method for preparing a macrocosine compound, and a pharmaceutical composition for the treatment and prevention of infection of a specific strain comprising a macrocosine compound, a solvate thereof, a hyd...
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WO/2022/242386A1 |
A bifunctional bean-derived polypeptide having antihypertensive activity and antioxidant activity, and a preparation method therefor. The method comprises: firstly, extracting a bean-derived protein isolate from beans by using an alkali-...
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WO/2022/242464A1 |
A novel CRISPR-associated transposase derived from pseudoalteromonas translucida KMM 520, wherein 16 PAMs can be identified and cargo genes can be inserted into 8 sites at a time with an efficiency of 100%, higher than a CRISPR-associate...
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WO/2022/238174A1 |
The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of ...
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WO/2022/241310A1 |
Provided is a modified B-type natriuretic peptide (BNP) comprising a covalently attached polymer comprising amino acids, where the polymer inhibits degradation and/or elimination of the BNP in a subject, and where the modified BNP retain...
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WO/2022/237510A1 |
The present invention relates to a molecular peptide mutant, and an amino acid sequence as shown in SEQ ID NO: 1. By means of the invention, SpyCatcher is designed and modified on the basis of not affecting the formation of isopeptide bo...
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WO/2022/238319A1 |
The present invention relates to protein purification, primarily in the chromatographic field. More closely, the invention relates to affinity chromatography using a split intein system comprising a C-intein tag and N-intein ligand, wher...
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WO/2022/236863A1 |
A microsphere having a functionalized spot on the surface, comprising a microsphere main body and a functionalized spot embedded in the top of the microsphere main body. A gravity ball is embedded in the bottom of the microsphere main bo...
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WO/2022/241276A1 |
The present disclosure provides methods and systems for generating biological molecules. The methods and systems may comprise use of a porous membrane or a proteoliposome. The present disclosure also provides methods and systems of gener...
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WO/2022/238173A1 |
The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of ...
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WO/2022/239704A1 |
The present invention addresses the problem of providing a method for eliminating a glycosylation isomer from an antibody drug, etc. The present invention provides, for example, a purification method of an antibody composition, said puri...
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WO/2022/197780A9 |
Apparatus and method for disassociating protein complexes, e.g., to allow recovery and/or analysis of at least one of the proteins or metabolites released from a complex. Disassociation is done using focused acoustic energy and without s...
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WO/2022/234852A1 |
Discovered were: a cyclic peptide compound that interacts with Ras; and a pharmaceutical composition comprising the cyclic peptide compound, a salt thereof, or a solvate thereof.
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WO/2022/233106A1 |
The present invention relates to the technical field of biochemical detection, and in particular relates to a preparation method for alkaline phosphatase-labelled thyroxine. In the preparation method provided in the invention, after bein...
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WO/2022/234864A1 |
It has been found that a cyclic peptide compound can be efficiently produced by linking an N-terminal amino acid residue of a peptide compound to a C-terminal amino acid residue of the peptide compound in a solvent including one or more ...
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WO/2022/227702A1 |
Disclosed is a preparation method for an interfering peptide targeting a SARS-CoV-2 N protein, the method comprising the following steps: designing an interfering peptide fragment to target amino acids located in a dimerization domain of...
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WO/2022/224259A1 |
In one aspect of the invention, there is a compound comprising N-protected tyrosine, modified with phosphorylcholine. Furthermore, use of the compound such as for SPPS, is also provided.
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WO/2022/226031A1 |
The present invention relates to the treatment of chronic wounds, and in particular to treatment of chronic wounds by via the use of growth factors conjugates that are immobilized in the wound. Specifically, the growth factor (GF) conjug...
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WO/2022/226360A1 |
Presented is a method to incorporate 2-thiohistidine (2-thioHis) into a peptide. Also provided are peptides incorporating 2-thioHis, compositions, and methods of using the peptides incorporating 2-thioHis. The methods may be methods for ...
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WO/2022/226536A1 |
The disclosure relates to compositions that can serve as anchors for the chemical synthesis of peptides. Anchor molecules can include GAP constituents, linker constituents, amino acid constituents, and/or stopper constituents. Anchor mol...
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WO/2022/222700A1 |
Disclosed is a combination of peptide linkers for protein covalent self-assembly using a spontaneous isopeptide bond, comprising a peptide linker 1 and a peptide linker 2. The peptide linker 1 contains a peptide chain having an amino aci...
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WO/2022/223344A1 |
Method of clarifying a crude protein solution, the method comprising to provide (100) a volume of the crude protein solution, mixing (101) Na2HPO4 and CaCl2 in water, forming a first solution, adding (102) the first solution to the volum...
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WO/2022/220042A1 |
The purpose of the present disclosure is to provide a method for purifying a protein derived from a membrane protein complex by eluting the membrane protein complex in the form of a complex even when the protein complex is formed. The pr...
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WO/2022/221163A1 |
A solid-phase glycan remodeling (SPGR) system for the glycoengineering of glycoproteins to provide glycoprotein compositions comprising particular predominant glycoforms is described.
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WO/2022/217395A1 |
The present invention belongs to the technical field of preparation methods for polypeptides, and particularly relates to high-purity corticotropin (human-derived sequence) or an analog thereof, and a large-scale preparation method there...
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