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WO/2024/040807A1 |
Disclosed are a cell membrane-based biological material for cross-species cell component delivery and a preparation method. The biological material is based on cell membrane coating, and cross-species cell components are delivered into s...
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WO/2024/041521A1 |
Disclosed are methods for constructing conjugates. An amine-containing component and a thiol-containing component, in comparable mole ratios, react with an ortho-phthalaldehyde in one step, to generate a conjugate bearing a substituted o...
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WO/2024/043282A1 |
The present invention provides a method for producing a modified protein, the method comprising a step for obtaining a modified protein by mechanochemically treating a mixture containing a protein and an acylation agent.
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WO/2024/041532A1 |
The present disclosure relates to a complex comprising a tetravalent platinum moiety and an oligopeptide as an axial ligand chemically linked to the platinum.
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WO/2024/038918A1 |
The present invention pertains to: an aptamer which contains an oligonucleotide (for example, an oligonucleotide containing a base sequence which has at least 90% of the sequence identity of the base sequence represented by SEQ ID NO 14 ...
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WO/2024/039859A1 |
A method of collecting fungal spores includes steps of producing fungal spores by fungal cells within a fungal culture; combining a hydrophobic liquid with the fungal culture; mixing the fungal culture after the step of combining the hyd...
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WO/2024/039920A1 |
Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modifi...
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WO/2024/032081A1 |
The present invention provides a preparation method for semaglutide, and an intermediate. The preparation method comprises the steps of: (1) reacting compound SEM110 and compound SEM120 in a solvent under an alkaline condition to obtain ...
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WO/2024/032812A1 |
Disclosed are preparation and use of a high-activity and high-safety cardamine violifolia selenoprotein standard sample. The preparation method comprises: hydrolyzing cardamine violifolia powder with cellulase, carrying out enzymolysis, ...
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WO/2024/032485A1 |
The present invention relates to a non-phosphorylated and non-ubiquitinated CREPT protein and use thereof. Specifically, the present invention relates to a protein that is obtained by modifying CREPT or a homologous protein thereof. The ...
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WO/2024/032821A1 |
Provided is a new and highly toxic amyloid oligomer Aβo*3F. The Aβo*3F is specifically bound by a 3F antibody, is the most important toxic ingredient in a mixture of Aβ oligomers, and has a strong pathogenic effect. Further provided i...
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WO/2024/036284A1 |
The present disclosure provides methods, compositions and apparatus for generating probes having affinity for analytes of interest, such as polypeptides. Also provided are methods, compositions and apparatus for evaluating and characteri...
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WO/2024/036317A1 |
Provided herein are compositions, systems, methods, and kits for peptide analysis, including peptide sequencing. In some cases, the methods may be used for mapping post-translational modifications on peptides or proteins.
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WO/2024/031963A1 |
Disclosed are a chimeric compound for degrading cyclophilin A, a preparation method therefor, and use thereof. The structural formula of the chimeric compound is represented by formula I. The compound represented by formula I provided by...
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WO/2024/032881A1 |
The present invention relates to an improved method of producing products comprising a target protein (TP) capable of crystallising under salting-in conditions by crystallisation of the TP. The invention makes use of at least two differe...
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WO/2024/033534A1 |
The present invention relates to a method of fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) performing a first change of physicochemical conditions of said sample, wherein said first ...
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WO/2022/150591A9 |
The present disclosure provides methods for determining the presence of at least one biomolecule in a sample. The present disclosure further provides methods for determining the presence of a coronavims antibody in a sample.
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WO/2024/031965A1 |
Disclosed are a PROTAC compound with cyclophilin A degradation activity, a preparation method therefor, and use thereof. The structural formula of the PROTAC compound is represented by formula (I). The compound represented by formula (I)...
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WO/2024/028350A1 |
The invention relates to a method for the preparation of peptides via solid-phase peptide synthesis and particularly to a method of deprotecting of an Fmoc protected amino acid building block linked to a resin R-AA-(AA)n-PF.
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WO/2024/028340A1 |
The present invention relates to the field of industrial fermentation and protein production. In particular, it relates to a method for producing a protein of interest in a fermentation medium comprising the following steps a) inoculatin...
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WO/2024/028088A1 |
The invention relates to a method for introducing a biological sample, to be concentrated, containing biological material into a centrifugal microfluidic cartridge (15) and subsequently analysing the biological sample by means of a centr...
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WO/2024/028498A1 |
The present invention pertains to a chromatography method for the purification and/or separation of target nanoparticles. Said method relies on a hydrophilic stationary phase that comprises rigid beads with throughpores, making these bea...
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WO/2024/028338A1 |
The present invention relates to the field of industrial fermentation and protein production. In particular, it relates to a method for producing a protein of interest in a fermentation medium comprising the following steps a) inoculatin...
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WO/2024/029556A1 |
[Solution] A filter 10 comprises: a base material 20 that is composed of porous polyurethane, in which a plurality of fine pores are formed; and an active group 28 that is fixed to a surface 26 of the base material 20 and is capable of f...
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WO/2024/030092A1 |
The present invention relates to protein-based nanoparticles, synthesis of these nanoparticles and their use in cancer therapy for improving the stabilization and cellular uptake of MS1 peptide that specifically binds to and inhibits Mcl...
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WO/2024/029394A1 |
The present invention provides a carrier which is for chromatography, which has a large dynamic binding capacity with respect to an antibody or a fragment thereof, and through which a protein ligand is unlikely to leak even when the carr...
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WO/2024/027553A1 |
The present invention relates to the field of biomedicine, and particularly to a bifunctional fusion protein and the use thereof. The bifunctional fusion protein comprises an Fc fragment, wherein one end of the Fc fragment is connected w...
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WO/2024/025911A1 |
Provided herein are affinity agents comprising ligands that specifically bind target molecules. The affinity agents are useful for binding, isolation, and/or purifications.
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WO/2024/020690A1 |
A device or method for affinity binding on an aluminum oxide surface. A biomolecule provides for immobilizing on the aluminum oxide surface. The biomolecule includes a histidine rich domain, a metal binding domain, or a metal binding moi...
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WO/2024/021228A1 |
The present invention provides an SIRT6 H133Y protein, a method for enriching myristoylation modified-peptide fragments using same, and use thereof. A method for preparing the protein comprises: taking SIRT6-FLAG as a template to obtain ...
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WO/2024/026148A1 |
Provided are stapled peptides and conjugates thereof that have antibacterial activity against microbial pathogens that include, but are not limited to, multidrug-resistant bacteria. Also provided are stapled peptides and conjugates there...
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WO/2024/022313A1 |
Provided is a bioconjugation technique, specifically provided is a protein covalent modification technique, i.e., provided is a protein moiety-linker conjugate, which can be used as an intermediate for synthesizing a protein-active molec...
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WO/2024/023758A1 |
Provided herein are methods of precipitating proteins within compositions that contain a protein and a polysorbate. These methods allow for an accurate determination of the concentration or the amount of polysorbate within the composition.
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WO/2024/024336A1 |
Provided are: a purifying and concentrating device for a liquid comprising a minute useful substance, the device being capable of producing a liquid (purified concentrated liquid of a minute useful substance) comprising a minute useful s...
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WO/2024/026446A1 |
The present application relates to systems and methods for purifying polypeptides, such as His-tagged polypeptides, using immobilized metal chelate affinity chromatography (IMAC). The method includes loading a composition comprising the ...
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WO/2024/022315A1 |
The present invention relates to bioconjugation technology, and in particular, to a method for purifying a protein-nucleic acid conjugate. Specifically, provided are an affinity tag-modified protein-nucleic acid conjugate and a method fo...
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WO/2024/023332A1 |
The invention relates to novel silicon-based fluoride acceptor groups (SiFA groups) of the following formulae (Ia, Ib, Ic) as well as to compounds suitable for use in radiopharmacy comprising such groups, wherein R1 and R2 are each a lin...
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WO/2024/022894A1 |
The present disclosure relates to a process for recovery of a nucleic acid product from a composition. The process (100) comprising: (i) contacting (110) the composition with a chromatography material functionalised with a ligand. The ch...
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WO/2024/021556A1 |
The present invention belongs to the technical field of radiopharmaceutical chemistry. Provided are a radioactive metal complex targeting a prostate specific membrane antigen and a labeling ligand thereof. The general structural formula ...
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WO/2024/017317A1 |
The present invention relates to an HER2 targeting peptide molecule and a use thereof. The HER2 targeting peptide molecule has the following general formulas: X-peptide, X-L-peptide, peptide-X, and peptide-L-X, wherein X represents a mar...
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WO/2024/018489A1 |
The present invention discloses a method for the selective reduction of disulfide bonds in an immunoglobulin composition. More specifically, the method disclosed in the current invention is capable of selectively reducing the inter-chain...
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WO/2024/017379A1 |
A preparation method for a polyethylene glycol conjugate of an active polypeptide or protein, comprising a step of mixing an active polypeptide or protein with polyethylene glycol and reacting same, wherein the polyethylene glycol contai...
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WO/2024/016740A1 |
Provided is a biosynthesis-based preparation method for a structural material of the human body. A polypeptide of the present application contains the structure of a C-terminal region of (repeating unit)n or (repeating unit)n-; the repea...
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WO/2024/016429A1 |
Provided is a molecular peptide mutant having a high ester bond formation efficiency, the amino acid sequence thereof being as shown in SEQ ID NO:1. On the basis of basically not affecting the spatial structure of Catcher, mutations of t...
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WO/2024/017826A2 |
The present invention is directed to a novel process for purifying a recombinant polypeptide from a solution containing one or more impurities. The process may include a chromatography process which includes a wash buffer containing a sm...
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WO/2024/016762A1 |
Provided in the present invention are a galectin 10 (Gal10) crystal, and an antibody IgY and a pharmaceutical preparation prepared thereby, which belong to the technical field of medicine. In the present invention, a yolk neutralizing an...
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WO/2024/013784A1 |
[Problem] To enable, even when the capacity of a reaction vessel is increased, implementation of multiple steps pertaining to solid state synthesis of a peptide using the same reaction vessel. [Solution] A peptide production device 1 is ...
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WO/2024/015653A1 |
Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modifi...
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WO/2024/015080A1 |
A protein preparation may be obtained from dried lipid extracted marine algae. The novel hydrolysate has high solubility and digestibility, low ash content, and high protein content (measured as g amino acid / g of product), with an esse...
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WO/2024/013521A1 |
The invention provided herein relates to methods for protein synthesis, purification and characterisation.
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