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WO/2023/189652A1 |
Provided is a method for producing an adeno-associated virus (AAV), the method being characterized by including a step for separating an adeno-associated virus (AAV) bound to an affinity support from the affinity support using a solution...
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WO/2023/187703A1 |
Title: A Method for separating and detecting of free or residual polyethylene glycol in Pegylated proteins. The present invention relates to an improved method for separating and detecting of free or residual polyethylene glycol (PEG) in...
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WO/2023/190402A1 |
Provided is a method for producing a complex of a radioactive metal nuclear species and an antibody, the method comprising a step for reacting a radioactive metal nuclear species with an antibody modified with a coordination compound in ...
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WO/2023/192957A1 |
The present disclosure relates to methods for increasing recovery and purity of a secreted protein of interest using salting-out with ammonium sulfate and pH adjustment to about or below the isoelectric point of the protein of interest. ...
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WO/2023/191009A1 |
A production method for an active ingredient of a biological medicine, the method involving: linking, to a linkage line, a culture unit that performs a culture step for culturing cells in a liquid culture medium retained in a culture tan...
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WO/2023/191008A1 |
In this method for manufacturing a biopharmaceutical drug substance, a culturing unit for carrying out a culturing step for obtaining a culture supernatant containing a cellular product by culturing cells in a culture solution retained i...
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WO/2023/180525A1 |
Provided is a thermo-regulated process for the recombinant production of an Fc-peptide fusion protein in prokaryotic host cells comprising a single mild temperature shift in the induction phase.
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WO/2023/178449A1 |
There is provided peptidic compounds of Formula I, A or B(Rrad n6-[linker]-RL-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-ψ-Xa
a9-NH2). Xaa1 is D-Phe, Cpa, D-Cpa, Nal, D-Nal, 2-Nal, or D-2-Nal; Xaa2 is Asn, Gln, Hse, Cit or His. Xaa3 is Trp...
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WO/2023/183705A1 |
Provided are methods of modifying the solubility properties of individual peptides and sets of peptides of which an example embodiment includes sets of overlapping peptides prepared to be suitable for use as vaccines to modulate the immu...
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WO/2023/178421A1 |
The present document describes antibodies or antigen-binding fragments that bind specifically to a target antigen, wherein the antibodies or antigen-binding fragments comprise complementarity determining regions (CDR1, CDR2 and CDR3) and...
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WO/2023/181655A1 |
This simulated moving-bed chromatographic separation method comprises: separating, with use of an eluent, a component weakly-adsorptive to an adsorbent, a component strongly-adsorptive to adsorbent, and an intermediately-adsorptive compo...
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WO/2023/178396A1 |
The invention relates to a process for extracting prolamins from cereal grains and residues in an acidic or basic ethanol medium, using as a starting medium dried distillers grains (DDG), dried distillers grains with solubles (DDGS), cor...
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WO/2023/174860A1 |
An aspect of the invention relates to a method for identifying an amino acid is proposed. The method comprises immobilising an amino acid on the surface of a FET sensor, acquiring a fingerprint of the immobilized amino acid, the acquisit...
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WO/2023/175190A1 |
The invention relates to an automated process for extracting a peptide of interest located in periplasmic space and/or comprising an acidification step.
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WO/2023/174823A1 |
A first aspect of the invention relates to a method for removing a terminal amino acid from a peptide. The method comprises providing a reaction cell configured as an electrochemical transducer translating an applied voltage or current i...
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WO/2023/174315A1 |
The invention relates to the technical field of the deep processing of rice, in particular to a method for producing a high-purity rice protein powder and a rice syrup. The method comprises: homogenizing a rice slurry, adding amylase the...
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WO/2023/178329A1 |
The present disclosure is directed methods of isolating and/or purifying a species of a protein, comprising contacting a mixture comprising the species and one or more impurities with two or more chromatography columns in a continuous op...
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WO/2023/174765A1 |
The present invention relates to a separation matrix for affinity chromatography and separation of biomolecules based on the presence of a kappa light chain. More specifically, the present invention relates to a separation matrix compris...
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WO/2023/178313A2 |
The present invention provides processes of producing the following compound: and methods of using the compound in targeted PET and SPECT imaging.
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WO/2023/178327A1 |
Described are peptides comprising a membrane translocation domain having one or more cell penetrating peptide motifs, where at least one cell penetrating peptide motif is from 3 to 10 amino acid residues in length and has at least three ...
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WO/2023/175064A1 |
The present disclosure provides methods of purifying asymmetric bispecific antibodies using light chain affinity chromatography.
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WO/2023/174194A1 |
Provided are a deacetylation-modified Septin4 protein and the pharmaceutical use thereof. Also provided is a deacetylation-modified Septin4 protein or an active fragment thereof. Compared with a wild-type Septin4 protein, the deacetylati...
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WO/2023/170925A1 |
[Problem] To provide an adsorbent for columns which has an excellent balance between adsorptivity and durability; and an adsorption device. [Solution] An adsorbent for columns which comprises a powder composed of aggregates of porous par...
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WO/2023/171671A1 |
By reacting a cyclic amide precursor given by general formula (2) with a condensing agent given by general formula (3) and a tertiary amine compound given by general formula (4) (but excluding tributylamine, diisopropylethylamine, and tr...
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WO/2023/170553A1 |
An affinity chromatographic method of preparing from an IgG-containing starting material an IgG formulation that includes one or more of IgG1, IgG2, IgG3 and IgG4 is provided. A method of the invention includes contacting the IgG-contain...
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WO/2023/168881A1 |
Disclosed are a polypeptide nanoprotein ubiquitination degradation agent PROTAC molecule, and a preparation method therefor and the use thereof. The polypeptide nanoprotein ubiquitination degradation agent is a proteolysis-targeting chim...
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WO/2023/173011A1 |
The present disclosure provide novel methods of large-scale production of recombinant proteins, e.g., therapeutic proteins such as antibodies, comprising concentrating an eukaryotic cell culture to a high density and transiently transfec...
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WO/2023/170922A1 |
[Problem] To provide: an adsorbent having improved durability and improved ability to adsorb a substance to be adsorbed; and a method for producing an adsorbent, the method being capable of producing said adsorbent. [Solution] An adsorbe...
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WO/2023/171809A1 |
A method for producing an Fc-containing molecule modifying reagent, the method comprising causing, in the presence of a base that is more basic than pyridine, a protein or a peptide to react with a cross-linking agent to form a bond betw...
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WO/2023/166026A1 |
The present invention relates to cell lines in which DNA fragmentation is inhibited, uses of cell lines in which DNA fragmentation is inhibited for the production of Adeno-associated virus (AAV), related methods of producing AAV, and met...
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WO/2023/167850A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/167852A2 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/165831A1 |
The present disclosure is directed to a method for separating supercoiled plasmid DNA (pDNA) from a liquid sample, the method comprising the steps of: (a) adding a liquid sample comprising pDNA to a first chromatography material comprisi...
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WO/2023/167871A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/166975A1 |
The present invention strengthens an α-helix structure involved in a bioactivity of a peptide. The present invention provides causing a reaction between a side chain of a tryptophan residue and a side chain of a cysteine residue provide...
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WO/2023/167238A1 |
[Problem] To establish a method for producing an Fc-containing molecule having a highly pure and uniform sugar chain structure while using as small amount of sugar chain donor molecules as possible, etc., said method allowing free select...
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WO/2023/167855A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/165476A1 |
A targeting peptide specifically targeting Sortilin/SORT1 protein, and a targeting peptide-drug conjugate comprising the targeting peptide. The targeting peptide is a linear peptide or cyclic peptide with non-natural chemical modificatio...
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WO/2023/164769A1 |
A radiopharmaceutical 177Lu-DOTATATE compound, a composition comprising one or more ascorbate compounds with the substantial or complete absence of a gentisate compound, a single or multiple dosage kit, and a sealed container are provide...
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WO/2023/167857A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/167863A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/167340A1 |
The present invention relates to a chimeric peptide containing a first domain and a second domain, wherein the first domain contains (i) a peptide containing at least an amino acid sequence shown by any of ID SEQ NOS: 1-4, (ii) a peptide...
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WO/2023/160721A1 |
Provided in the present disclosure are IL-15 variants, IL-15/IL-15Rα-Fc fusion proteins comprising the IL-15 variants and IL-15/IL-15Rα fusion protein comprising the IL-15 variants the methods of producing the same and the uses thereof...
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WO/2023/164258A1 |
Provided herein are capillary electrophoresis methods for separating and detecting double-stranded ribonucleic acid (dsRNA) contaminants in samples of single-stranded ribonucleic acids (ssRNA) such as RNA therapies (e.g., mRNA vaccines).
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WO/2023/155318A1 |
Provided are a broad-spectrum anti-SARS-CoV-2 lipopeptide, a preparation method therefor, a virus membrane fusion inhibitor comprising the lipopeptide, and use of the lipopeptide in the preparation of a pharmaceutical composition for pre...
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WO/2023/158599A1 |
A method is disclosed for washing an amino acid that has been added to a solid phase resin during solid phase peptide synthesis (SPPS), comprising: adding a first quantity of wash solvent, wherein once the wash with the first quantity of...
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WO/2023/157457A1 |
Conventional protein-containing specimen pretreatment methods preceding analysis using LC-MS or electrophoresis are time-consuming, which is a limitation for various applications of the methods. Said methods also have problems such as sa...
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WO/2023/154822A2 |
Provided herein are embodiments relating to affinity chromatography purification and separation of contaminant species, including HCPs (Host Cell Proteins), from desired molecular and chemical species.
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WO/2023/154467A1 |
Provided herein are methods for preparing a protein composition having a reduced quantity of a recombinant cell byproduct which provides an undesirable color to a protein. The methods involve the use of absorbents or flocculants that cap...
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WO/2023/153878A1 |
Disclosed is a method of purifying factor XIII comprising (a) first salt precipitation, (b) heat treatment, and (c) second salt precipitation, in which factor XIII can be purified at high yield from a plasma sample or the like through a ...
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