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Matches 1 - 50 out of 30,655

Document Document Title
WO/2021/068884A1
Provided is a polypeptide derivative having a sequence of X-Phe-Phe-Gly-Ser-Ser-Ser-Arg, wherein the end group X is Nap or Npx, The Phes are in L configuration or D configuration simultaneously, and the rest are in L configuration, the p...  
WO/2021/072005A1
The present invention provides synthetic peptides comprising an amino acid sequence of any one of SEQ ID NOs: 1-17 or an amino acid sequence having at least 80%, 85%, 90%, or 95% sequence identity to the amino acid sequence of any one of...  
WO/2021/072210A1
Provided herein are processes for manufacturing recombinant ranibizumab or a ranibizumab variant that include providing a liquid comprising recombinant ranibizumab or a ranibizumab variant that is substantially free of cells; capturing t...  
WO/2021/068251A1
A GIP and GLP-1 dual agonist polypeptide compound, related to the technical field of polypeptide medicinal chemistry. The amino acid sequence of the GIP and GLP-1 dual agonist polypeptide compound is: YXaa1EGTFTSDYSIXaa2LDKIAQXaa3AFVQWLI...  
WO/2021/066025A1
Provided is a method for producing a protein derived from a seaweed such as seaweed belonging to the Eucheuma genus. A protein is produced by recovering the protein from a treated supernatant obtained when carrageenan is produced from se...  
WO/2021/064079A1
The invention provides a method for purifying a target protein from a cell culture sample, wherein the cell culture sample comprises the target protein, viral compounds and other product and process related impurities, comprising an affi...  
WO/2021/029740A3
The present invention relates to a botulinum toxin preparation method capable of obtaining botulinum toxin in a high yield through a simplified process that does not include animal-derived ingredients. The botulinum toxin preparation met...  
WO/2021/064066A1
The invention provides a method for eluting a monoclonal antibody from a Protein A affinity chromatography column to which the monoclonal antibody is bound comprising a) contacting the affinity chromatography column with an elution buffe...  
WO/2021/064244A1
There is provided a process for the separation of molecules from a suspension comprising cells at a concentration of at least 56 x 106 cells/ml, comprising the steps of: a) providing magnetic particles having a specific interaction with ...  
WO/2021/058132A1
The invention relates to a chromatography method of producing a target elution volume (238) comprising a first and a second target protein (P1, P2). The method comprises: providing (102) a cation exchange chromatography column (230); app...  
WO/2021/060048A1
The present invention addresses the problem of providing a method for efficiently producing a peptide and provides a method for producing a peptide, said method comprising: step (1) for mixing an N-protected amino acid or an N-protected ...  
WO/2021/057266A1
A high-clarity soybean flavor peptide, a preparation method therefor, and use thereof. The preparation method for the high-clarity soybean flavor peptide comprises the following steps: mixing soybean and/or soybean meal with water and pe...  
WO/2021/058660A1
The present invention is directed to an anti-adsorption solution for the analysis of peptides. Also a process for the preparation of such an anti-adsorption solution and the use of said anti-adsorption solution are described.  
WO/2021/061504A1
Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from...  
WO/2021/056754A1
A method for preparing an antibody-drug conjugate intermediate by means of an acid method. According to the method, an acid additive is used, so that a monomethyl auristatin derivative is changed into salt and then participates in reacti...  
WO/2021/056098A1
Neoglycoconjugates as immunogens and therapeutic/diagnostic tools are described herein. The neoglycoconjugates are produced by conjugating a carbohydrate antigen intermediate to a free amine group of a carrier material (e.g., carrier pro...  
WO/2020/254683A3
The present invention relates to a SorCS2 crystal structure, the atomic coordinates obtained by X-ray crystallography of same, and their use in molecular modelling. The invention further relates to methods of growing crystals of SorCS2. ...  
WO/2021/053578A1
The present application relates to improved and effective purification processes and also relates to method of increasing the solubility of for GLP-1 analog and its derivatives particularly Liraglutide. The purification process of presen...  
WO/2021/054999A1
Compositions of the inventive concept provide a therapeutic protein with less than 2% contamination by the therapeutic protein in denatured form. Such compositions provide enhanced specific activity and improved stability on storage and/...  
WO/2021/054997A1
A method for producing a modified cryo-poor precipitate that can be utilized in chromatography without intervening precipitation steps is provided. While thawing frozen plasma at low temperature a precipitating compound (e.g. a salt of a...  
WO/2021/051861A1
Disclosed is a method for preparing Ularitide, comprising: dividing, according to the feature that the peptide sequence of Ularitide contains two Cys, the Ularitide into three parts: fragment A: H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-...  
WO/2021/055894A1
Methods of analyzing a drug polypeptide conjugate using tandem mass spectrometry involving dual tandem mass tags (TMTs) are described. Provided herein is an integrated method using TMTs to obtain three analytical measurements, termed "tr...  
WO/2021/054998A1
Methods for isolating proteins from solution by precipitation are provided. A nonvolatile precipitation agent is added to an aqueous protein solution at a low concentration. Water is then removed from the resulting solution until the pre...  
WO/2021/051766A1
Disclosed is a method for synthesizing octreotide, the method comprising the following steps: 1) selecting a 2-CTC resin as a starting point of synthesis to prepare an Fmoc-Thr(tBu)-OL-2CTC resin; 2) sequentially coupling orthogonally pr...  
WO/2021/048633A1
Disclosed are methods for critical point drying a composite material. After exposing the composite material to a supercritical fluid, the composite material dries as the supercritical fluid evaporates with reduced pressure. The composite...  
WO/2021/049552A1
A method for producing a peptide compound comprising a step in which a hydrazine derivative represented by formula (1) is used, a reagent for forming a protecting group including said compound, and a hydrazine derivative. In formula (1),...  
WO/2021/046616A1
The present invention relates to a method for characterising major histocompatibility complex-bound peptides via mass spectrometry, wherein sample peptides are labelled with isobaric tags and analysed together with non-sample carrier pep...  
WO/2021/004973A9
The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.  
WO/2021/051011A1
This disclosure describes methods and compositions for protein and peptide sequencing.  
WO/2021/044029A1
A method for removing chromatin from a cell culture harvest comprising the steps: — providing a cell culture harvest containing a desired biological product selected from the group consisting of a parvovirus or an adeno-associated viru...  
WO/2021/042732A1
The present invention provides an osteogenic growth peptide carbon-terminal pentapeptide derivative, a preparation method therefor, and use thereof. The osteogenic growth peptide carbon-terminal pentapeptide derivative includes one or mo...  
WO/2021/043345A1
The present invention relates to the fields of biotechnology and medicine and describes a pharmaceutical composition of recombinant human erythropoietin having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-ant...  
WO/2021/042701A1
An extraction method for Fructus Cannabis globulin, and a product and use thereof. The extraction method comprises: dehydrating and degreasing Fructus Cannabis, mixing same with a salt solution, and performing extraction, filtration, and...  
WO/2021/045210A1
The present invention provides a peptide delivery means capable of avoiding disruption of a cell membrane, immunogenicity, and toxicity. More specifically, the present invention provides the following (1) to (3). (1) A ferritin enclosing...  
WO/2020/252266A9
The present disclosure provides coupling methods and systems for producing peptides or proteins using semi-continuous or continuous manufacturing techniques to enable rapid production of peptides and proteins using solid phase peptide sy...  
WO/2021/037109A1
Provided herein are thiosuccinyl-crosslinked hemoglobin analogs useful as blood replacement agents, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.  
WO/2021/036057A1
Disclosed is a method for preparing nesiritide, comprising the following steps: 1) synthesizing an intermediate 1 by means of a solid phase synthesis method; 2) synthesizing an intermediate 2 by means of a solid phase synthesis method; a...  
WO/2021/041199A1
Embodiments of the invention include systems and methods that enable the identification of candidate proteins that have desired features of a target protein. An example method comprises receiving first and second input proteins. The meth...  
WO/2021/040703A1
The present disclosure relates to atypical split N- and C-inteins and variants thereof. This disclosure also relates to complexes comprising the split N- or C-inteins of this disclosure and a compound of interest and compositions compris...  
WO/2021/041904A1
Described are methods for producing recombinant Arginase, such as PEGylated, cobalt-substituted recombinant human Arginase 1. Also described are pharmaceutical compositions comprising such recombinant Arginase, as well as methods of trea...  
WO/2021/036063A1
The present invention relates to a cyclic peptide from a novel bone morphogenetic protein 2 (BMP2), a preparation method therefor and an application thereof. The cyclic peptide from the novel BMP2 is selected from one of the following cy...  
WO/2021/039681A1
The purposes of the present invention are to provide a method for fractionating soybean proteins, to provide a method for analyzing protein composition in soybeans, and to provide a method for evaluating a soybean species, etc. by determ...  
WO/2021/039901A1
The present invention addresses the problem of providing a method for highly efficiently producing a peptide. The present invention provides a method for producing a peptide, said method comprising steps (1) and (2): (1) a step for rem...  
WO/2021/035184A1
Provided herein are methods of improving solubilization, extraction, and isolation of recombinant spider silk proteins with a salt and alcohol buffer. Provided herein are methods of solubilizing a recombinant spider silk protein from a h...  
WO/2020/013696A9
The present invention pertains to novel thiocycloheptyne derivatives of general formula (I) : and in particular to thiacycloalkynesulfoimine derivatives and their synthesis. The invention also relates to the use of the novel thiocyclohep...  
WO/2021/033176A1
A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ...  
WO/2021/031471A1
Provided is a method for preparing carbetocin, comprising the following steps: sequentially coupling Gly, Leu, Pro, Cys(CH2CH2CH2CO2R1), Asn(R2), Gln(R3), Ile, and Tyr(Me) to an amino resin to obtain an Fmoc-fully-protected peptide resin...  
WO/2021/034727A1
Described herein are cholix-IL-10 fusion proteins, and methods of use thereof, which can be characterized by a distinct response in an individual when administered. This distinct response can comprise changes in levels of one or more mar...  
WO/2021/026800A1
Disclosed is a method for synthesizing Degarelix acetate. The method comprises: S1, carrying out a condensation reaction with the first six amino acids of Degarelix in sequence by using a Rink Amide MBHA resin as a carrier so as to obtai...  
WO/2021/030427A2
The present invention provides a protein separation microgel having a first plate having a first opening; a second plate; a gel substrate formed between the first plate and the second plate; and a plurality of wells positioned at a first...  

Matches 1 - 50 out of 30,655