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Matches 351 - 400 out of 517

Document Document Title
JP4779971B2
A compound of formula I: or a pharmaceutically acceptable salt thereof, in combination with a topoisomerase II inhibitor, except amrubicin and a pharmaceutically acceptable salt thereof, for use in treatment of cancer.  
JP2011523560A
A pharmaceutical composition can be used for treating or preventing cancer; the composition comprising a pharmaceutically acceptable carrier and a peptide, a nucleic acid encoding said peptide, a vector comprising said nucleic acid, or a...  
JP2011084585A
To provide an alternative immunosuppressant having low cytotoxicity characteristics and controllable side effects.Depsipeptides and congeners thereof having structure (I) are disclosed, wherein m, n, p, q, X, R1, R2 and R3 are as defined...  
JP2011006420A
To provide an NS3 protease-inhibitive new compound.There are provided a new peptide analog which is a macrocyclic compound advantageous as an HCV (hepatitis C virus) NS3 protease inhibitor, a pharmaceutical composition containing such an...  
JP4599567B2
There is provided a temperature responsive polymer compound which comprises a repeating unit represented by the following general formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ-R 1 -Hmb-R 2 -€ƒ€ƒ€ƒ€ƒ€ƒ(I) where, Hmb...  
JP4588634B2
A gene transfer efficiency enhancer of the present invention which contains a histone deacetylase inhibitor (especially compound (A)) as an active ingredient is capable of enhancing gene transfer efficiency in a gene transfer mediated by...  
JP2010265271A
To provide a targeted cytotoxic compound and a method related to its therapeutic use for the treatment of neoplasia and other conditions. This targeted cytotoxic compound is provided by including a cytotoxic part bonded with a targeted p...  
JP2010222361A
To provide a medical or a veterinary preparation for defence from endoparasites.The medical or veterinary pharmaceutical preparation for the control of endoparasites comprises didepsipeptides, salts, optical isomers or racemic forms of t...  
JP4557232B2
The invention relates to nonadepsipeptides and process for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.  
JP4493327B2  
JP4399160B2
The present invention provides methods inhibiting formation of neurofibrillary tangles; and methods for treating disorders relating to apolipoprotein E (apoE) in a subject. The methods generally involve reducing the level of a carboxyl-t...  
JP4386209B2
Peptide mimicks of MUC1 or other cancer peptides which can be included in cancer vaccines and used in therapeutic methods for the treatment of cancer patients.  
JPWO2007145306A1
A phospholipid derivative (1) containing a residue of an alcohol compound and a residue of phospholipids and containing a peptide between the residue of the alcohol compound and the residue of phospholipid, and the above without the inte...  
JP4359238B2
Identifying a compound (I) that binds specifically to the G protein-coupled receptor mas-like-1 (R) by (i) treating at least one cell that expresses R on its surface (or a preparation of the cells that contains R) with at least one test ...  
JP4326178B2
B-Group streptogramin compounds of formula (I):are useful as antimicrobial agents, optionally combined with at least one A-group streptogramin compound.  
JP2009521917A
The invention relates to phenylalanine, cysteine, derivatives of said amino acids, peptides comprising them, and to their use in diseases disorders or conditions whose pathology is caused by or associated with CXCR4 activity and/or cell ...  
JP4277015B2
PCT No. PCT/FR95/01025 Sec. 371 Date Jan. 31, 1997 Sec. 102(e) Date Jan. 31, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/04299 PCT Pub. Date Feb. 15, 1996Streptogramine derivatives of general formula (I) below, wherein the radical R1 ...  
JP4254972B2
Peptides having the formula: T-Gly-Val-D-Ile-Thr-Arg-Ile-U, V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W, X-D-Arg-D-Ile-D-Arg-D-Thr-Ile-D-Val-Y, and Z-Gly-Val-Ile-Thr-Arg-Ile-U wherein T is absent or is selected from N-protecting group and a poly...  
JP4227520B2
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XAxA3A1A2A1Y, or a functional equivalent of ...  
JP4223810B2
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is...  
JP4176077B2
The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance ...  
JP4163746B2
PCT No. PCT/EP95/04255 Sec. 371 Date May 2, 1997 Sec. 102(e) Date May 2, 1997 PCT Filed Oct. 30, 1995 PCT Pub. No. WO96/15121 PCT Pub. Date May 23, 1996The present invention relates to the use of dioxomorpholines of the formula (I) (I) i...  
JP4160149B2  
JP4156235B2
An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nit...  
JP2008517006A
Nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases are described.  
JP2008517004A
The invention relates to nonadepsipeptides and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.  
JP2008092952A
To provide an effective method for preparation of substituted aryl lactic acid containing cyclodepsipeptides.The invention relates to the new method for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 2...  
JP4054576B2
By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl...  
JP4054063B2
PCT No. PCT/EP96/05190 Sec. 371 Date Jun. 4, 1998 Sec. 102(e) Date Jun. 4, 1998 PCT Filed Nov. 25, 1996 PCT Pub. No. WO97/20945 PCT Pub. Date Jun. 12, 1997The present invention relates to a new process for the preparation of substituted ...  
JP4033920B2
Endoparasitic activity of cyclic depsipeptides (I) comprising amino acid and hydroxycarboxylic acid units and having 6-30 ring atoms is increased by praziquantel (II) and epsiprantel (III). An endoparasitic agent contg. (I) together with...  
JP2007314580A
To enhance the endoparasiticidal activity of cyclic depsipeptides. The present invention relates to the use of praziquantel and epsiprantel for enhancing the endoparasiticidal activity of cyclic depsipeptides in endoparasiticidal composi...  
JP3987909B2
The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceut...  
JP3990284B2
Strains belonging to the genus Pseudomonas; and antiviral agents containing as the active ingredient at least one member selected from among peptides, derivatives and salts thereof and the novel strains.  
JP3947229B2
Depsipeptides represented by the formula (1): (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is -A-B, -A-B-W, -A-B-W-D or -A-B-W-D-E, R3 is a ...  
JP2007125021A
To provide an assay for identifying a β-selectase inhibitor and a method for screening.The assay for identifying the β-selectase inhibitor comprises a step of immobilizing a β-selectase protein on a solid support, a step of bringing t...  
JP3910634B2
A method for transforming strain PF1022, which produces a cyclic depsipeptide (substance PF1022) and belongs to the order Agonomycetales of the class Hyphomycetes have established by using a plasmid constructed with a promoter, a termina...  
JP3893030B2
To provide a new lipopolysaccharide absorbent (a bacterial endotoxin absorbent) and a screening method for the same capable of easily synthesizing, easily controlling various similar structures, and using in absorbing various lipopolysac...  
JP2007056046A
To provide a polydepsipeptide equipped with both temperature-responding property and biodegradable property suitable as a medical material, and a method for producing the same.This polydepsipeptide is expressed by general formula (I) [wh...  
JP2007031434A
To provide a streptogramin derivative which is a new pseudopeptide, namely a new antibiotic derivative.The streptogramin derivative is represented by general formula of the figure (wherein R1 is ethyl and R2 and X are each H and Y is H o...  
JP2006527772A
The present invention provides methods of treating metabolic disorders, including, for example, obesity, diabetes mellitus, cachexia, sarcopenia, and cardiovascular disorders, methods of inducing weight loss and increasing muscle mass in...  
JP2006523214A
The present invention is directed to a compound of Formula I wherein R1, R2, R3, R4, R5, R6, W, X, Y, and Z are defined herein. The compounds of the present invention are useful as anticancer agents. Specifically, the compounds are usefu...  
JP3830964B2
The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the stra...  
JP3798825B2
PURPOSE: To combat endoparasites in human, domestic animals and pet animals by using an open-chain tetradepsipeptide. CONSTITUTION: This compound is an open-chain tetradepsipeptide represented by formula I (A is H, an alkyl, aralkyl or a...  
JP3798824B2
PURPOSE: To combat endoparasites in human, domestic animals and pet animals by using an open-chain hexadepsipeptide. CONSTITUTION: This compound is represented by formula I (A is H, an alkyl, aralkyl, an aryl, acyl or the like; R1, R3 an...  
JP2006180840A
To obtain a polypeptide that has hardly adverse effect, is produced without requiring such a high technique and a plenty of people, promotes plasmin activity, t-PA activity and urokinase activity and a use thereof.The polypeptide promote...  
JP2006516024A
The present invention is directed to the identification and use of agents, particularly peptides and monoclonal antibodies that disrupt the interaction between Collagen XIII and alpha1beta1 integrin.  
JP3775686B2
PCT No. PCT/FR95/01025 Sec. 371 Date Jan. 31, 1997 Sec. 102(e) Date Jan. 31, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/04299 PCT Pub. Date Feb. 15, 1996Streptogramine derivatives of general formula (I) below, wherein the radical R1 ...  
JP3758613B2
To provide a cleaning composition capable of completely eliminating cut scraps and other fine dust in a short time as well as the removal of a liquid crystal material intruded in a gap of a liquid crystal panel difficult to be cleaned by...  
JP2005538926A
An ammonium selective ionophore for use in ion selective electrodes.  
JP2005314276A
To provide a new chemical component contained in natural animals, plants, microorganisms and the like.The melleumin A is represented by formula (1). The melleumin B is represented by formula (2).  

Matches 351 - 400 out of 517