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JP2005538926A |
An ammonium selective ionophore for use in ion selective electrodes.
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JP2005314276A |
To provide a new chemical component contained in natural animals, plants, microorganisms and the like.The melleumin A is represented by formula (1). The melleumin B is represented by formula (2).
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JP2005532784A |
The invention relates to antibiotically effective peptides which are prepared for medical and commercial use by using biotechnological methods and chemical synthesis. The antibiotically effective peptides can be used in a suitable galeni...
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JP2005531486A |
The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to me...
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JP2005529852A |
The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC-CO-R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH- represents deacylated ramoplanin, any of ...
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JP3693366B2 |
PURPOSE: To provide a new compound useful as a endoparasiticide for human beings and animals, etc. CONSTITUTION: A compound of the formula I [R1, R2, R11 and R12 are each 1-8C alkyl, 1-8C halogenoalkyl, 3-6C cycloalkyl, aralkyl or aryl; ...
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JP2005200324A |
To provide a new compound having an inflammatory transmitter production-inhibiting activity.This compound represented by general formula [1] (R1 is H or methyl; R2 is H or OH) or its salt.
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JP2005054194A |
To provide a continuously releasing composition of biologically active medicinal polypeptide.The continuously releasing composition comprises a copolymer containing N-acylated derivative of poly(2-amino-2-deoxy-D-glucose) or a compositio...
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JP3626233B2 |
Control of endoparasites in human beings and animals comprises admin. of cyclic depsipeptide of formula (I); R<1>,R<4> = H or opt. substd. alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl; R<2>,R<3>,R<5>,R<6> = H; 1-8C alk...
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JP3600287B2 |
Novel cyclic depsipeptides having 18 ring atoms, of the formula (I) in which R is hydrogen, straight-chain or branched or cyclic alkyl having up to 8 carbon atoms, and their optical isomers and racemates, and their use in controlling end...
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JP3600300B2 |
Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically a...
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JP2004529065A |
The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptid...
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JP2004528268A |
The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptid...
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JP2004525111A |
The invention relates to the use of crystal form (I) of the cyclic depsipeptide of the formula (I) for preparing medicaments, in particular for controlling endoparasites.
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JP2004168685A |
To provide a compound which has an excellent anti-fungal activity, especially an excellent antifungal activity against fungi including resistant fungi.This compound is represented by formula (I). The method for producing the compound com...
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JP3535217B2 |
PURPOSE: To provide a new compound useful as a endoparasiticide for human beings and animals, etc. CONSTITUTION: A compound of formula I [R1 and R12 are each 2-9C alkyl, 1-8C halogenoalkyl, 3-6C cycloalkyl, aryl or the like; R3-R10 are e...
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JP2004500119A |
The present invention features Dermacentor variabilis GABA-gated chloride channel polypeptides and nucleic acids, and uses of such polypeptides and nucleic acids. D. variabilis is a widely distributed tick associated with different disea...
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JP3480848B2 |
PURPOSE: To obtain a new cyclic peptide useful as an antifungal agent, having low toxicity and strongly sterilizing action on various pathogenic fungi by synthesizing a straight-chain peptide having specific amino acid sequence and subje...
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JP2003535048A |
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making...
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JP3463691B2 |
A cyclopeptolide of formula cyclo(A-B-R1Leu-Leu-C-X-Y) (I) in the free, salt or ester form is new. In (I) A = a glycolic acid residue opt. ~a-substd. by H, Me, Et, propyl or vinyl, opt. substd. by halo, alkoxy, opt. protected OH or NH2, ...
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JP3455542B2 |
Aureobasidins useful as a wide-spectrum antimycotic. They are cyclodepsipeptides composed of one hydroxy acid residue having group A<1>, three amino acid residues having groups C<1>, F<1> and H<1>, four N-methylamino acid residues having...
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JP3431920B2 |
Novel didemnin compounds named didemnin X and didemnin Y have been isolated from the Caribbean tunicate Trididemnum solidum. These compounds have cytotoxic activity and, therefore, are useful as antitumor drugs.
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JP3425763B2 |
PCT No. PCT/EP95/02966 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed Jul. 26, 1995 PCT Pub. No. WO96/03430 PCT Pub. Date Feb. 8, 1996Cyclopeptolides of formula I wherein A, B, R, Leu, Leu, C, X and Y are as defined...
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JP3421855B2 |
This invention relates to micro-organisms capable of selectively producing streptogramin components A and B, the preparation of said micro-organisms, and streptogramin A or B.
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JP2003518020A |
The present invention relates to the use of 24-membered cyclodepsipeptides of the formula (1) in which R1 and R2 are as defined in the description, for controlling animal pests in veterinary medicine, hygiene, agriculture, forests and in...
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JP2003155207A |
To obtain a fungicidal and/or bactericidal composition which has high stability to the human body and to the environment, does not cause resistant microbes even by repeated use, a wide antimicrobial spectrum and excellent antimicrobial e...
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JP2003517037A |
The invention provides novel peptide-based pharmacophores and compounds which bind somatostatin receptors with high affinity and which exhibit improved pharmacokinetic properties over known somatostatin analogs. The pharmacophores and co...
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JP2003505396A |
A pseudomycin prodrug represented by structure (A) where R1 is an acyloxyalkylcarbamate linkage is described. The prodrug demonstrates antifungal activity with less adverse side effects.
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JP2003502318A |
The invention relates to cyclo-imino depsipeptides of formula (I), especially 24-membered cyclo-imino depsipeptides. The invention also relates to methods for their preparation and to their utilization in controlling endoparasites.
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JP2003501012A |
The compounds of the invention are generally described by the formula: B1Z*2B3Z*4X*5Q6F7X8X9X10X11, (1) B1X2X3X4X5Q6F7X8X9X10X11, or (2) B1Z2B3X4Z5Q6F7Z8X9X10X11 (3) and the salts, esters, amides, and acyl forms thereof. Each position re...
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JP2002542258A |
The invention relates to P. syringae depsidecapeptides, method for making such peptide, and methods employing antifungal activity of these peptides. The P. syringae depsidecapeptides include a compound having formula (a) where R is a lip...
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JP2002542262A |
A method for producing one or more pseudomycins is described including cultures of Pseudomonas syringae that produce one or more pseudomycins having general formula (I) where R is a lipophilic moiety.
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JP2002527533A |
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypepti...
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JP3310298B2 |
The process according to the present invention allows expression and isolation of polypeptides with the proteolytic activity of HCV NS3 protease in a pure, catalytically active form, and in amounts that are sufficient for discovery of NS...
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JP2002522555A |
A process for the synthetic generation of high affinity, iron binding compounds known as Exochelins, and more particularly, to a synthetic process for making Exochelins and to modifications to these newly synthesized compounds to vary th...
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JP2002522060A |
A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-...
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JP2002518520A |
The invention relates to new substituted cyclooctadepsipeptides of formula (I) wherein R<1>, R<2>, m and n are as defined in the description, a method for their preparation and their use for fighting endoparasites, as well as drugs conta...
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JP2002513402A |
Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shelless mollusk Dolabella auricularia. Methods of using the substances to inhibit malig...
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JP2001322997A |
To provide a substance that is useful as an active ingredient for antifungal agents.The objective substance is a novel dipeptide represented by the following formula (I) (wherein R is hydroxyl or amino group) or pharmaceutically acceptab...
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JP2001517604A |
A composition of matter, denominated herein as 12a-r, having structural formula (12a-r) wherein R is selected from the group consisting of: a) R = NHPh; (CH3O)2Ph; b) R = NHCH2Ph; c) R = NH(CH2)2Ph; d) R = NH(CH2)2-4-F-Ph; e) R = NH(CH2)...
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JP2001231561A |
To obtain a gene encoding iturin A which shows high safety almost without adverse effects on environments or organisms and exhibits an effective action on deleterious cells and an agent which contains iturin A as an active ingredient and...
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JP3178835B2 |
A novel polypeptide having an antiviral activity against human immunodeficiency virus (HIV), represented by the above formula (I), a pharmaceutically acceptable salt thereof, and an anti-HIV drug containing the same as the active ingredi...
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JP2001504814A |
Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as "AipDidemnin A" (8). These compounds have the following structures:
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JP3148850B2 |
PURPOSE: To obtain a peptide useful as a medicine, showing inhibitory action on allergic and anallergic inflammations, antimicrobial action, by culturing Streptomyces nobilis, an actinomyces, in a medium. CONSTITUTION: This new peptide i...
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JP3148851B2 |
PURPOSE: To obtain a new antitumor substance useful as an antitumor agent, having low adverse actions and high effects, comprising a new peptide having inhibitory activity against multiplication of tumor cells, by culturing a bacterium b...
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JP2001503746A |
Disclosed are semi-synthetic methods for the preparation of Didemnin Analogs. The compounds of this type are illustrated in Formula (I).
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JP3107564B2 |
The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a process stream, which comprises extractio...
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JP2000295989A |
To provide a method which activates a biologically inactive (inactivated) protein due to no active steric structure or other every reason and produces an activating protein capable of easily being converted in a short time into a biologi...
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JP2000290293A |
To obtain a new compound which is highly active, low toxic and useful for treating fungus infections. The compound having a structure expressed by the formula and its pharmaceutically acceptable base is obtained, for example, by inoculat...
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JP2000245497A |
To provide a new chemical substance cailluin E produced by the culture of a microorganism belonging to the genus Vibrio and capable of producing cailluin E, having high safety and excellent biodegradability and useful as an antifouling a...
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