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WO/2020/032179A1 |
In order to make it possible to supply differentiated T cells steadily, the present invention provides: a method for the production or expansion culture of a CD3-positive cell in which CD3, which serves as a T cell marker, is expressed o...
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WO/2020/027237A1 |
The purpose of the present invention is to provide a method for producing, at a low cost, a peptide having specific binding capability that can be used for target molecule purification. Specifically, this peptide fusion protein includes ...
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WO/2020/027585A2 |
The present invention relates to a polypeptide delivery composition, which comprises porous artificial chaperone particles having an average pore diameter of 1-100 nm, so as to make polypeptides become stapled, thereby fixedly changing t...
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WO/2020/022475A1 |
A protein that recognizes the drug moiety of an antibody-drug conjugate in which a drug represented by the formula is linked to an antibody via a linker; a method for measuring the concentration of the antibody-drug conjugate in the plas...
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WO/2020/018540A1 |
An immunogen includes an antigenic EGFRvIII peptide linked to a Qβ bacteriophage virus-like particle (VLP) carrier. The antigenic EGFRvIII peptide has at least 53%, at least 61%, at least 69%, at least 76%, at least 84%, or at least 92%...
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WO/2020/018936A1 |
The present invention provides systems and methods for concentrating and recovering phosphate from samples. The method comprises using immobilized PBP for binding phosphate and a desorption solution having a pH of 11 or greater to recove...
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WO/2020/004671A1 |
The present invention addresses the problem of providing a separating agent which does not significantly reduce the dynamic binding capacity (DBC) to a target substance even when CIP treatment is continuously carried out under an alkalin...
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WO/2020/006312A1 |
Disclosed are compositions and methods for treating cancers characterized by the presence of solid tumors, which simultaneously target a plurality of targets on cancer cells using single CAR T construct.
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WO/2020/004668A1 |
[Problem] To provide a separating agent with enhanced dynamic binding capacity (DBC) with respect to a target substance. [Solution] Said problem is solved by a separating agent comprising a carrier and a protein, wherein the protein is a...
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WO/2019/244961A1 |
Provided is an affinity carrier using a mutant VHH antibody. The affinity carrier comprises a solid phase carrier and an immunoglobulin-binding protein bound to the solid phase carrier, wherein the immunoglobulin-binding protein contains...
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WO/2019/241249A1 |
Clonally derived barcoded cell populations and methods of generating the same, as well as methods of use thereof, e.g., to evaluate heterogeneity of a starting population of cells.
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WO/2019/238074A1 |
Provided are an LAG-3 antibody having high affinity and high biological activity, and an application thereof. In particular, provided is a new anti-LAG-3 monoclonal antibody. The antibody is capable of binding to an LAG-3 antigen with hi...
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WO/2019/237101A1 |
Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid β peptide into oligomers ...
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WO/2019/229139A1 |
The present disclosure relates to compositions comprising an SpHtp1 peptide translocation sequence and uses of such compositions. Also described are compositions comprising a payload coupled to an SpHtp1 peptide translocation sequence an...
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WO/2019/217654A1 |
Disclosed herein are compositions and methods for the treatment of hepatitis B infection, including chronic hepatitis B (CHB).
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WO/2019/207552A1 |
The present disclosure is directed to compositions (e.g., multianalyte immunoassays) for detecting multiple Zika virus antibodies in a biological sample. Also disclosed herein are methods for identifying suitable donors for preparing a Z...
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WO/2019/208820A1 |
The present invention relates to: a complex that includes (1) nanoparticles, (2) an enzyme inhibitor–containing group represented by formula (A), (3) a ligand-containing group represented by general formula (L1) and supported by the su...
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WO/2019/202260A2 |
The invention relates to a method for functionalizing a surface of a dielectric plate (10) that is transparent to visible light, in order to be able to examine said dielectric plate using optical microscopy. Said method is essentially ch...
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WO/2019/195525A1 |
Disclosed herein are de novo designed beta barrel polypeptides, methods for designing such polypeptides, and methods for their use.
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WO/2019/193328A1 |
The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on an immune cell, conjugated via a linker to a second peptide ligand, which binds to a co...
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WO/2019/187603A1 |
A purpose of the present invention is to provide a peptide that has a high chemical stability to alkalis, etc. Another purpose of the present invention is to provide: a DNA encoding the aforesaid peptide; a vector containing the DNA; and...
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WO/2019/189733A1 |
The present invention provides an oxidized-glutathione-containing solid composition that can be produced by a simple method, has low deliquescence, and is easy to handle. The present invention pertains to a solid composition containing a...
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WO/2019/177056A1 |
This modified protein is characterized by: comprising a protein multimer having an amino acid sequence in which the α1 domain of HLA-G and the α3 domain of HLA-G are linked; and at least one amino acid residue in the amino acid sequenc...
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WO/2019/176860A1 |
This cell adhesive material is obtained by modifying a substrate surface by using a peptide group comprising a peptide that contains: 40% to 75%, inclusive, of one or more types of basic amino acid residues selected from the group consis...
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WO/2019/166594A1 |
The invention relates to a hydrogel useful for promoting neurotization, osteogenesis and angiogenesis.
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WO/2019/163919A1 |
Provided are: an Fc-binding protein having improved stability against acids compared to native-form human FcγRIIa; a production method for the protein; and an antibody-adsorbing agent using the protein. The problem is solved by: an Fc-b...
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WO/2019/161491A1 |
A device, interface complex, diagnostic system, kit or method for use in binding analyte of interest, wherein immobilizing is on an aluminum oxide surface. An interface molecule is immobilized on the aluminum oxide surface. Attached to t...
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WO/2019/162682A1 |
The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the mu...
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WO/2019/157597A1 |
A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell linea...
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WO/2019/157362A1 |
Provided herein are in situ generated conformationally constrained peptide arrays, methods for synthesizing such arrays, and methods, systems and assays comprising the use of the synthesized constrained peptide arrays for characterizing ...
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WO/2019/136560A1 |
The present application discloses biofunctional surfaces that have self-assembled monolayers of fluorine groups with "built-in" functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific bi...
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WO/2019/126308A1 |
Methods and apparatus for improving expressed human milk (EHM0 shelf-life as well as maintaining or improving EHM taste and smell comprising the utilization of specific lipase inhibitors and antibodies.
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WO/2019/115525A1 |
The present invention refers to a rigid material composition containing a luminescent protein immobilized therein, a process for preparing it, as well as to a hybrid light emitting-diode comprising a light-emitting diode and a color down...
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WO/2019/118831A1 |
This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.
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WO/2019/103151A1 |
[Problem] The purpose of the present invention is to provide a novel intracellular delivery means for delivering a nucleic acid to within a cell and thereby causing a desired function to be exhibited more efficiently, namely, for deliver...
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WO/2019/093280A1 |
The present invention relates to a bundle of highly oriented collagen fibers which has a major-axis-direction length of 1 m or larger.
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WO/2019/092742A1 |
The present disclosure discloses a process for immobilizing polypeptides on a surface, said method comprising: (a) coating a surface with a molecule to capture biotin tagged polypeptide to obtain a coated surface; and (b) contacting at l...
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WO/2019/084661A1 |
A method for making metal nanorods comprises combining a source of metal cations with at least one surfactant to form a mixture, wherein the metal cations are reduced and the metal nanorods are produced. Metal nanorods produced by the me...
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WO/2019/083048A1 |
The present invention relates to an Fc-binding protein exhibiting improved alkaline resistance, a method for producing said protein, an antibody adsorbent obtained by immobilizing said protein on a carrier, and a method for separating an...
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WO/2019/074523A1 |
The present disclosure is drawn to a biological fluid, including water, from 0.05 wt% to 3 wt% protein having an acidic isoelectric point (pl) less than about 6.5, and from 0.5 wt% to 20 wt% ionic protein stabilizer system. The ionic pro...
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WO/2019/073992A1 |
The present invention provides an antibody-modified filter capable of specifically adsorbing or removing a target substance, and a material used in the filter. An antibody-binding surface-modified substrate that includes a substrate-bind...
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WO/2019/068022A1 |
The present disclosure provides a flow-through electroporation device configured for use as a stand-alone module or as one module in an automated multi-module processing system.
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WO/2019/064297A1 |
The present invention provides cytotoxic peptides, analogs thereof and fragments thereof, conjugates of said peptides, analogs or fragments as well as compositions comprising same. In addition, uses of these compounds and compositions in...
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WO/2019/054198A1 |
The present disclosure provides an antibody binding to an intranuclear protein of influenza virus and use of the same. The present disclosure provides an antibody which recognizes a peptide comprising the 205th-231st amino sequence in SE...
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WO/2019/052405A1 |
Disclosed are a maleimide group-modified angiogenesis inhibitor HM-1 and the use thereof, which fall within the technical field of polypeptide drugs. The selection of a suitable maleimide group to modify the N-terminus of the angiogenesi...
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WO/2019/050283A1 |
The present invention relates to: a composition comprising cell fate regulatory factor-supported porous silica particles; and a method for regulating cell fate, comprising a step of treating various cells with the same. The present inven...
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WO/2019/046699A1 |
The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor o...
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WO/2019/040973A1 |
A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan- arginine pentapeptide of Formula A; wherein R1 and R2 are, independently, -H, or -C(O)R3 where R3 is -Ch2Ph, - CH2CH2Ph, -CH=CHPh, -C(NHAC)CH2Ph; th...
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WO/2019/041013A1 |
Disclosed is a hybrid protein that consists of the fusion of: a protein from the TRIM21 family (or only the C-terminal domain PRYSPRY thereof) fused to the enzymes peroxidase, alkaline phosphatase or luciferase (for enzymatic detection) ...
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WO/2019/039777A1 |
The present invention relates to a porous silica carrier for stabilizing proteins and enzymes, and a production method and use thereof. A silica carrier according to the present invention is harmless to the human body, is based on silica...
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