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WO/2011/111253A1 |
Disclosed is a complex of a protein and metal nanoparticles wherein a particular distance between metal nanoparticles is maintained. In the complex, which is of a plurality of metal nanoparticles and an apoprotein derived from a heme pro...
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WO/2011/103668A1 |
Cancer targeting peptides and methods for the identification of peptide markers for cancer are described. The peptides may be used in the treatment and/or diagnosis of cancer and also in the identification of receptors on cancer cells. A...
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WO/2011/085602A1 |
Provided are a protein hydrolysate, a polypeptide solution and a polypeptide, and a preparation method and use thereof. The method comprises steps of: adding extraction agent to brewer's spent grain and obtaining a crude protein or a cru...
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WO/2011/072596A1 |
The invention belongs to the field of collagen/gelatine preparation, and provides a method for the preparation of soluble collagen. The invention employs a dual 90 bone gelatine prepared by alkaline process, adds acid protease to control...
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WO/2011/060598A1 |
Disclosed is a method for determining the relative absorption coefficient of a molecule to be determined on the polypeptide molecules by means of scanning tunneling microscopic technology, the molecule to be determined is dye, antibody, ...
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WO/2011/041691A1 |
The present invention provides a process called "Immune Banking" that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody...
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WO/2011/028195A2 |
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part...
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WO/2011/024887A1 |
The purpose of the present invention is to provide a conjugate which is obtained by linking a cyclic peptide that contains an unnatural amino acid with a functional moiety by a peptide bond, and to provide a method for producing the conj...
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WO/2011/017837A1 |
A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa repres...
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WO/2011/006069A1 |
Compositions and methods for targeting substances to fibrinogen, fibrin monomers, or fibrin polymers are provided. These compositions and methods generally involve the use of fibrin knob peptides that bind fibrin(ogen), which can be used...
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WO/2010/147998A2 |
Disclosed are dithio compounds that include a quenched fluorophore and a non-fluoropbore peptide linked via a dithio bond to the fluorophore The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-c...
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WO/2010/129537A1 |
We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have ...
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WO/2010/123898A1 |
Rotamer libraries and methods of use thereof are provided.
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WO/2010/122298A1 |
A material comprising elongate filamentous peptide- or protein-based nanostructures. The nanostructures are assembled to be connected together and aligned substantially parallel with respect to each other. The alignment of the nanostruct...
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WO/2010/121125A1 |
A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodi...
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WO/2010/112911A2 |
The invention relates to an article having a substantially non-cell adhesive surface and comprising on said surface a coating effective to render the article cell adhesive, wherein the coating comprises an oligomer having terminal amine ...
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WO/2010/096418A2 |
The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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WO/2010/081731A2 |
The present invention relates to syringolin A derivatives, the use of the syringolin A derivatives for prophylaxis and treatment of neurodegenerative diseases and proliferative diseases such as cancer, pharmaceutical compositions contain...
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WO/2010/054212A1 |
Hybrid antibodies and antibody binding fragments thereof having decreased immunogenicity and methods of making them are provided. The methods involve replacing one or more amino acid residues within at least one donor framework region of...
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WO/2010/053518A2 |
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion p...
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WO/2010/048582A1 |
Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and ...
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WO/2010/045723A1 |
A peptide-comprising extract derived from fish is described. Also disclosed is a process for obtaining a peptide-comprising extract derived from fish, as well as an extract obtained by this process. Compositions comprising such an extrac...
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WO/2010/039899A2 |
The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further ...
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WO/2010/014236A2 |
The present invention provides cleavable linker compounds of Formula (I): wherein: X is a cleavable linker comprising an acylhydrazone; and Y and R are each independently selected from the group consisting of covalent coupling groups and...
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WO/2010/011928A1 |
Various methods for diagnosing and treating heart conditions are disclosed herein. According to one method, nitric oxide is delivered to a patient's lungs when the patient has one or more symptoms of a heart condition. The patient is dia...
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WO/2005/097421A9 |
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WO/2009/158704A2 |
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, i...
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WO/2009/149554A1 |
The bioassay guided isolation and characterization of a novel antimicrobial peptide called myxinidin from an acidic extract of the epidermal mucus of hagfish (Myxine glutinosa L.) is disclosed. Detection of myxinidin in the extract of ex...
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WO/2009/151591A2 |
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
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WO/2009/149339A2 |
The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides...
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WO/2009/140833A1 |
A collagen peptide having immunoenhancing activity from Cyanea nozakii and the preparation method thereof are provided. The collagen peptide comprises 80-90 wt.% protein and 10-20 wt.% sugar, whose average molecular weight is ranged from...
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WO/2009/133408A2 |
A composition comprises a biological molecule that is susceptible to aggregation, dimerisation or hydrolysis, wherein the ionic strength is less than 40 mM.
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WO/2009/131052A1 |
Disclosed is a method for improving the filtering properties of a defatted soymilk peptide. Also disclosed is a defatted soymilk peptide having improved filtering properties. The filtering properties of a defatted soymilk peptide can be ...
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WO/2009/127130A1 |
Provided are an Achyranthes bidentata polypeptide and production methods and uses thereof. The Achyranthes bidentata polypeptide is prepared by adding ammonium sulfate into Achyranthes bidentata water solution, centrifuging the solution,...
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WO/2009/118375A2 |
Peptide aldehydes or ketone derivatives are particularly efficient for stabilizing subtilisin-type proteases in aqueous compositions such as liquid detergents, including peptide compounds with OH-substituted phenylalanine aldehyde as the...
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WO/2009/108252A2 |
Provided is a method for stimulating in an individual an immune response against M. catarrhalis. The method is performed by administering to an individual a composition that contains at least one isolated M. catarrhalis protein in an amo...
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WO/2009/108812A2 |
The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucl...
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WO/2009/089066A2 |
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma i...
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WO/2009/079693A1 |
The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site ...
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WO/2009/054873A9 |
The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RAN...
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WO/2009/075881A2 |
Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incomp...
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WO/2009/075788A1 |
Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: (I), where L is a linker group and Z is a non-fouling group including...
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WO/2009/076581A1 |
The present invention provides biomarkers for Alzheimer's disease, as well as methods of using the biomarkers to diagnose Alzheimer's disease, monitor the progression of Alzheimer's disease, monitor the treatment of Alzheimer's disease, ...
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WO/2009/070786A2 |
This invention encompasses compositions and methods for treating and imaging vulnerable plaque and other inflamed regions in a subject.
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WO/2009/059379A1 |
The present invention provides antimicrobial peptides and analogs thereof that are cytostatic or cytotoxic toward at least one gram-negative bacterium of the genus Acinetobacter including laboratory or clinical isolates of A.baumannii wi...
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WO/2009/057281A1 |
Disclosed is an agent for promoting the differentiation of an osteoblast and inhibiting the differentiation of an osteoclast, which comprises a milk protein fraction having the following chracteristic properties (1) to (4): (1) the milk ...
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WO/2009/057287A1 |
Disclosed is an agent for inhibiting the formation of an osteoclast, which comprises a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption, and ...
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WO/2009/057282A1 |
Disclosed is a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption and is therefore useful for the prevention or treatment of a bone disease: (1...
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WO/2009/043163A1 |
Paralytic shellfish toxins (PSTs) are the agents of paralytic shellfish poisoning (PSP). a potentially fatal foodborne illness linked to the consumption of PST-contaminated shellfish worldwide. We have isolated bacteria from toxic blue m...
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WO/2009/039413A2 |
The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.
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